Journal of Diabetes Research Reviews & Reports
type: channel
description: Journal of Diabetes Research Reviews & Reports is committed to promoting scientific communication and knowledge sharing in the rapidly developing field of diabetes research. It offers an open-access avenue for publishing research articles, reviews, reports, and other valuable scientific contributions. The journal aims to connect researchers worldwide and provide readers with access to meaningful developments and emerging perspectives in diabetes science. Article acceptance will be in the form of Research, Review, Case Reports, Analysis, Magazines, Editorials, Opinion, Communications, Mini-Review, Short Communications, Picturized, Book Review, Video Type and Power Point Presentations (PPTS). Articles can be submitted through online from: https://srcpublishers.com/diabetes-research-reviews/user/register or can send through an E-mail with attachment to: diabetessciences@onlinescientificresearch.info 1.023 Impact Factor 84.5% Citations 90% Acceptance
publisher: Scientific Research and Community
language: en
publication name: Journal of Diabetes Research Reviews & Reports
issn: 2755-0184
items: Cholesterol Removal in Goat Milk Cheese and its Chemical, Texturaland Sensory Evaluation During Storage
items: Role of Textiles in Diabetes Management
items: Impact of Sodium-Glucose Cotransporter-2 Inhibitors on Hemoglobinand Hematocrit: A Retrospective Analysis (SGLT-2 Inhibitors &Hemoconcentration)
items: The Gut Brain Skin Axis in Acne: Impact of Polenoderm
items: Formulation and Optimization of Natural Polymer MediatedSustained Release Tablets for Metformin Hydrochloride
items: Insulin Signaling Abnormality and Insulin Resistance A Common Pathogenic Mechanism Between Type 2 Diabetes Mellitus and Alzheimer's Disease
items: Macroeconomic and Climatic Determinants of Diabetes Mellitus in Jamaica: An ARIMA and ARIMAX Time-Series Analysis, 2011–2024
items: AI-Driven E-Healthcare Prediction and Monitoring: Leveraging Big Data Intelligence for Immediate Impact
items: Impact of GLP-1 Receptor Agonists and Dual/Triple IncretinTherapies on Cardiometabolic Outcomes Beyond Glycemic Control:Evidence from Recent Randomized Trials
items: The Rising Burden of Diabetes in Jamaica: Challenges and Implications
items: The Relationship Between Blood Pressure Salt Sensitivity and Metabolic Syndrome
items: Occupational Therapy-Based Health Promotion for Diabetes and Weight Management in Correctional Facilities
items: In-Vitro Combo Treatments of Human Melanoma Cell Lines (BLM, 1205Lu, WM238) with Curcumin, Steroids and Vitamins
items: Effect of Diabetes Self-Management Education on Glycaemic Control in Sudanese Adults with Type 2 Diabetes
items: A New Era in Fitness: Holistic Support for Individuals ManagingObesity
items: Effectiveness of a Short-Term OT-Based Health Promotion ProgramFocused on Improving the Quality of Life and Weight Management
items: Complication and Assessment of Time Sensitive Tablets InvolvingDesign Expert Software
items: Crossed Nerve Palsies in Sinonasal Mucormycosis: A Diabetic’sFacial-Hypoglossal Puzzle
items: An Animal Model for the Study of Compressive (Constrictive) CervicalRadiculopathy
items: Progressive Blood Morphology Restoration in a Diabetic Patient Using Biophoton Therapy: A Live Blood Cell Analysis Over SixWeeks
items: The Prevalence of Dyslipidemia in South Indian Type 2 DiabetesMellitus Patients: A Cross-Sectional Study
items: Factors Associated with Mortality in Patients Affected by Covid-19
items: A Tablet as an Environment for Investigation of the Reactions in the Solid States
items: Diabetes Mellitus as a Disease and its Current Scenario - A Review
items: Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss and Cardiovascular Protection in Obesity and Type2 Diabetes: A Systematic Review and Meta-Analysis
items: Efficacy of School-Based Life Skill Training to Boost MentalHealth Status and Well-Being of Young People
items: Use of Technology in the Management and Treatment of Prediabetes,A New Era: A Case Report Series
items: Prediabetes: A Review of Current Trends
items: Evaluation of the Effects of Non-Invasive Auricular AcupointStimulation on Postprandial Blood Glucose Regulation using aCGM Device
items: The Case for Strategic Integration of Diabetes Education in SouthernNigeria, Informed by Insights from a Pilot Study

Cholesterol Removal in Goat Milk Cheese and its Chemical, Texturaland Sensory Evaluation During Storage
type: item
description: The experiment was conducted in a 2 x 3 x 3 factorial arrangement by having two types (control and cholesterol reduced) goat milk cheeses, which were assigned to three different storage temperatures (-18, 4, and 22°C) and three different storage periods (0, 2, and 4 months). The objectives of this study were to: (1) evaluate cholesterol removal rate of the CR cheese, (2) determine nutrient composition of CC and CR cheeses and (3) compare pH, lipolysis, textural and sensory characteristics of the 2 types of cheeses stored at 3 different temperatures for 3 storage periods. Results showed that mean contents (%) of moisture, fat, ash, protein, and carbohydrate of CC cheeses were: 41.4, 26.9, 3.87, 28.2 and 3.87, and those of CR cheeses were: 41.1, 22.9, 4.84, 35.1, and 3.93, respectively. The fat content of CR cheese was significantly lower than that of CC cheese, indicating that significant part of fat was lost during cream separation of the original cheese milk. Mean cholesterol concentration (mg/100g cheese) of control and cholesterol removed cheese were 115.062 and 81.97 respectively, suggesting that the cholesterol removal rate was only 28.7 %, which is substantially lower than previous reports on bovine milk cheese studies. With respect to pH changes in CC and CR cheeses during the 4-month storage at -18, 4 and 22 °C temperatures, CC cheese had lower pH than CR cheese. There were no significant differences in pH values for the different temperatures. However, the 2-way interaction effect of cheese type x storage period showed significant (P<0.01) differences in pHs, concerning textural characteristics of the experimental cheeses, the textural parameters of CC cheese had higher mean values than those of CR cheese for fresh samples. The ADV values of control cheeses were higher than that of CR cheese samples. The 3-way interaction effect of cheese type x temperature x storage period showed highly significant effect on acid degree value in both CC and CR cheeses. The…
subject: Articles
  topic: section
subject: Goat Milk
  topic: keywords
subject: Goat Milk Cheese
  topic: keywords
subject: Sensory Evaluation
  topic: keywords
subject: Storage
  topic: keywords
creator: Krishna Prasad Bastola
creator: Aftab Siddique
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2026-08-18
publication date: 2026-08-18
starting page: 1
ending page: 8
doi: 10.47363/wb0rzz95

Role of Textiles in Diabetes Management
type: item
description: Textiles play a pivotal and evolving role in diabetes management, moving beyond traditional clothing to become "smart" wearable systems that aid in monitoring, therapeutic support, and complication prevention. These advanced textiles, often integrated with sensors, provide a non-invasive, continuous, and comfortable method for managing chronic conditions.
subject: Articles
  topic: section
subject: Diabetes
  topic: keywords
subject: Diabetes Management
  topic: keywords
creator: Narayanan Gokarneshan
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2026-07-17
publication date: 2026-07-17
starting page: 1
ending page: 2
doi: 10.47363/JDRR/2026(8)121

Impact of Sodium-Glucose Cotransporter-2 Inhibitors on Hemoglobinand Hematocrit: A Retrospective Analysis (SGLT-2 Inhibitors &Hemoconcentration)
type: item
description: Background: Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors, such as Dapagliflozin and Empagliflozin, are a class of medications used in the management of type 2 diabetes mellitus and, more recently, heart failure and chronic kidney disease. An observed secondary effect of these drugs is anincrease in hematocrit (Hct) and hemoglobin (Hb) levels. The mechanisms and clinical significance of these changes are still under investigation. Largecardiovascular outcome trials did not demonstrate a consistent signal for increased thromboembolic events; details on this subject will be mentioned in thediscussion section. This study aims to analyze the effect of dapagliflozin and empagliflozin treatment on Hct and Hb in a cohort of 97 patients in our hospital. Methods: We conducted a retrospective analysis of a dataset containing information on 97 patients treated with either Dapagliflozin (n = 58) or Empagliflozin(n = 39). The dataset included baseline and 3–6-month follow-up measurements of Hct and Hb, along with demographic and clinical data such as age, BMI,smoking status, and diabetes mellitus (DM) status. Results: Both Dapagliflozin and Empagliflozin were associated with a numerical increase in mean Hct and Hb levels over a 3–6-month period. The increasein hemoglobin/hematocrit was statistically significant for the Empagliflozin group (p = 0.0107), but not for the Dapagliflozin group (p = 0.0642). Therewas no statistically significant difference in the magnitude of change in either Hct or Hb between the two drug classes. ANOVA revealed a significantdifference in Hct change across different dose groups (p = 0.0327), with Dapagliflozin 10mg and Empagliflozin 25mg showing the largest increases. Asignificant negative correlation was found between baseline hematological parameters and their subsequent change, suggesting a greater effect in patientswith lower baseline values. Conclusion: This analysis supports existing evidence that SGLT2 inhibitors increase hematocrit and hem…
subject: Articles
  topic: section
subject: SGLT2 Inhibitors
  topic: keywords
subject: Hematocrit
  topic: keywords
subject: Hemoglobin
  topic: keywords
subject: Empagliflozin
  topic: keywords
subject: Dapagliflozin
  topic: keywords
creator: Hussam Abusahmin
creator: Altayeb Abdalaziz
creator: Basma Eliaser
creator: Ibrahim Tfayli
creator: Mohamed Ahmed
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2026-07-25
publication date: 2026-07-25
starting page: 1
ending page: 6
doi: 10.47363/JDRR/2026(8)120

The Gut Brain Skin Axis in Acne: Impact of Polenoderm
type: item
description: The role of skin microbiota in acne remains to be fully elucidated. The emotions of stress (e.g., depression and anxiety), for instance, have been hypothesized to aggravate acne by altering the gut microbiota and increasing intestinal permeability, potentially contributing to skin inflammation. It is increasingly believed that the interaction between skin microbes and host immunity plays an important role in this disease, with perturbed microbial composition and activity found in acne patients. Acne also has close connections with the gastrointestinal tract, and many argue that the gut microbiota could be involved in the pathogenic process of acne. Diet also shapes the gut microbiota. Emerging data suggest that dietary factors (i.e., the Western diet) may influence acne development. Growing evidence indicates that probiotics modify the pathophysiologic factors that contribute to acne, potentially improving patient compliance. Probiotics also have immunomodulatory properties on keratinocytes and epithelial cells. Taken together, the findings suggest that the microbiota plays an important role in acne pathogenesis and can be modulated for clinical improvement, but efforts should be made to identify the exact mechanisms and therapeutic effects of oral/topical probiotics in acne. This presentation concentrates on the skin and gut microbes in acne, the role that the gut–brainskin axis plays in the immunobiology of acne, and newly emerging microbiome-based therapies that can be applied to treat acne. With the help of Deniplant brand natural remedies, the authors have developed several products for acne that act as immunomodulators of the human microbiome.
subject: Articles
  topic: section
subject: Acne
  topic: keywords
subject: Microbiota
  topic: keywords
subject: Skin
  topic: keywords
subject: Gut
  topic: keywords
subject: Brain
  topic: keywords
subject: Therapeutic Implications
  topic: keywords
creator: Gheorghe Giurgiu
creator: Manole Cojocaru
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2026-06-30
publication date: 2026-06-30
starting page: 1
ending page: 3
doi: 10.47363/JDRR/2026(8)119

Formulation and Optimization of Natural Polymer MediatedSustained Release Tablets for Metformin Hydrochloride
type: item
description: Metformin HCl is a common medication for Type 2 diabetes, but the short half-life of metformin means patients must take it multiple times throughout the day. This makes it difficult for many patients to adhere to their metformin regimen. The objective of this study was to create and optimize natural polymerbased sustained release metformin tablets to create tablets that would extend drug release time and improve therapeutic efficacy. Fenugreek gum was then used as the natural polymer matrix for these tablets along with other excipients. A Box-Behnken design methodology was used to evaluate how different formulation ingredients would affect both the physical characteristics of the tablets and how well metformin would be released from the tablets during in-vitro dissolution. Based on the results, the tablets have satisfactory physical characteristics and provided a sustained drug release for a long period of time. When compared with other studies that have shown sustained metformin release, the final optimized formulation could provide controlled release of metformin for a long period of time, indicating that natural polymers may be suitable for development of sustained release matrix tablets.
subject: Articles
  topic: section
subject: Metformin Hydrochloride
  topic: keywords
subject: Sustained Release Matrix Tablet
  topic: keywords
subject: Fenugreek Gum
  topic: keywords
subject: Natural Polymer
  topic: keywords
subject: Box Behnken Design
  topic: keywords
creator: Bhupendra Mourya
creator: Akash Yadav
creator: Dinesh Kumar Jain
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2026-04-29
publication date: 2026-04-29
starting page: 1
ending page: 12
doi: 10.47363/JDRR/2026(8)218

Insulin Signaling Abnormality and Insulin Resistance A Common Pathogenic Mechanism Between Type 2 Diabetes Mellitus and Alzheimer's Disease
type: item
description: Alzheimer’s disease (AD) is one of the major neurodegenerative disorders, accounting for 60%–80% of dementia cases. Its pathogenesis is complex, and there is a lack of effective intervention strategies. Type 2 diabetes mellitus (T2DM) is an independent risk factor for AD, and the two diseases share common pathogenic mechanisms. Abnormal insulin signaling and insulin resistance are key convergence points in the pathogenesis of both T2DM and AD. Meanwhile, factors such as inflammation, oxidative stress, and mitochondrial dysfunction further exacerbate AD-related pathology. This review summarizes the shared pathogenic mechanisms of abnormal insulin signaling and insulin resistance in T2DM and AD, as well as other common pathogenic mechanisms. The aim is to identify potential therapeutic targets for T2DM-associated AD, provide a basis for early intervention by regulating metabolic pathways, and thereby achieve the research goal of preventing the occurrence and progression of AD.
subject: Articles
  topic: section
subject: Alzheimer's Disease (AD)
  topic: keywords
subject: Type 2 Diabetes Mellitus (T2DM)
  topic: keywords
subject: Abnormal Insulin Signaling
  topic: keywords
subject: Insulin Resistance
  topic: keywords
creator: Ren Xinru
creator: Li Xiang
creator: Niu Yu
creator: Qu Qiumin
creator: Ma Louyan
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2026-04-15
publication date: 2026-04-15
starting page: 1
ending page: 6
doi: 10.47363/JDRR/2026(8)2117

Macroeconomic and Climatic Determinants of Diabetes Mellitus in Jamaica: An ARIMA and ARIMAX Time-Series Analysis, 2011–2024
type: item
description: Diabetes mellitus represents a growing public health challenge in Jamaica, with substantial morbidity and mortality. While behavioural risk factors such as obesity, diet, and physical inactivity have been studied extensively, structural determinants, particularly macroeconomic and climatic influences, remain underexplored. This study examines annual diabetes prevalence in Jamaica from 2011 to 2024 and evaluates the impact of GDP, inflation, unemployment, exchange rate fluctuations, and rainfall using ARIMA and ARIMAX time-series models. Descriptive analyses indicate a decline in diabetes prevalence from 15.7% to 12.5%, alongside GDP growth, declining unemployment, and currency depreciation. ARIMAX results show that inflation is the only statistically significant exogenous determinant (β = −0.1181, p = 0.015), while prior-year prevalence exhibits strong temporal dependence (φ₁ = 0.7434, p = 0.032). Findings highlight the interaction between macroeconomic conditions and chronic disease, emphasising the need for integrated fiscal and health policy strategies. Policymakers should consider macroeconomic monitoring alongside behavioural interventions to mitigate diabetes prevalence.
subject: Articles
  topic: section
subject: Diabetes Mellitus
  topic: keywords
subject: Jamaica
  topic: keywords
subject: ARIMA
  topic: keywords
subject: ARIMAX
  topic: keywords
subject: Macroeconomic Determinants
  topic: keywords
subject: Inflation
  topic: keywords
subject: Time-Series Analysis
  topic: keywords
creator: Paul Andrew Bourne
creator: Nicola Brown
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2026-04-05
publication date: 2026-04-05
starting page: 1
ending page: 5
doi: 10.47363/JDRR/2026(8)212

AI-Driven E-Healthcare Prediction and Monitoring: Leveraging Big Data Intelligence for Immediate Impact
type: item
description: Smart diagnosis has been used successfully in a variety of healthcare applications over the last decade. Early detection and diagnosis of heart disease is critical; heart patients can be treated very effectively if they are treated before they suffer a heart attack. Researchers in this field have recently introduced a number of deep learning-based systems for predicting and diagnosing heart disease. However, because of the lack of an intelligent framework that can use multiple sources of data to predict heart disease, these systems are incapable of handling high-dimensional data sets. In this paper, an intelligent health monitoring / prediction model is proposed to predict Cardiovascular disease using modern AI algorithms, which aids in correctly diagnosing heart disease and attempting to reduce the expected error rate. For training the proposed model, a dataset is prepared here, and modern AI algorithms such as K-NN, DT, NB, MLP Classifier, Feed forward ANN, and CNN were used. The proposed system has demonstrated reliability, with an accuracy of 91.27% using the convolutional NN. As a result, the proposed model can be used in an intelligent healthcare system as a disease diagnosis tool.
subject: Articles
  topic: section
subject: Big Data Intelligence
  topic: keywords
subject: Classification
  topic: keywords
subject: Data Science
  topic: keywords
subject: Deep Learning
  topic: keywords
subject: E-Health
  topic: keywords
subject: Healthcare Analytics
  topic: keywords
subject: Intelligent Diagnosis
  topic: keywords
subject: Machine Learning
  topic: keywords
creator: Shadi Alzu’bi
creator: Mohammed Elbes
creator: Yousef Jaradat
creator: Ala Mughaid
rights: Copyright (c) 2025 Journal of Diabetes Research Reviews & Reports
date: 2025-12-29
publication date: 2025-12-29
starting page: 1
ending page: 7
doi: 10.47363/JDRR/2025(7)180

Impact of GLP-1 Receptor Agonists and Dual/Triple IncretinTherapies on Cardiometabolic Outcomes Beyond Glycemic Control:Evidence from Recent Randomized Trials
type: item
description: Glucagon-like peptide-1 (GLP-1) receptor agonists and emerging dual/triple incretin therapies, such as tirzepatide (a GLP-1/GIP dual agonist) and retatrutide (a GLP-1/GIP/glucagon triple agonist), have demonstrated significant cardiometabolic benefits beyond glycemic control in patients with type 2 diabetes (T2D) and obesity, as evidenced by recent randomized controlled trials (RCTs). These agents promote substantial weight loss, improve lipid profiles, reduce blood pressure, and lower the risk of major adverse cardiovascular events (MACE), including cardiovascular death, nonfatal myocardial infarction (MI), and stroke, while also conferring renal protection through reductions in composite kidney outcomes such as kidney failure, sustained estimated glomerular filtration rate (eGFR) decline, and macroalbuminuria. For instance, in trials like SUSTAIN-6 and SELECT, semaglutide reduced MACE by 26% and 20%, respectively, with consistent benefits across subgroups regardless of baseline body mass index (BMI) or cardiovascular disease (CVD) history; similarly, tirzepatide in SURPASS-2 outperformed semaglutide in weight reduction (up to 20.2% vs. 13.7%) and lipid improvements, including greater decreases in triglycerides (24% vs. 17%) and increases in high-density lipoprotein cholesterol (HDL-C) (6.8% vs. 4.4%). Renal outcomes were notably enhanced in the FLOW trial, where semaglutide lowered the risk of major kidney events by 24%, and post-hoc analyses from SURMOUNT-5 indicated tirzepatide's superior 10-year CVD risk reduction (2.4% absolute reduction vs. 1.4% with semaglutide), potentially preventing up to 2 million CVD events in eligible U.S. populations over a decade. Triple agonists like retatrutide showed promising phase 2 results with up to 24.2% weight loss at 48 weeks, alongside dose-dependent improvem ents in blood pressure and lipids, though long-term safety data remain limited. Overall, these therapies exhibited a favorable safety profile, with gastrointestinal a…
subject: Articles
  topic: section
subject: GLP-1 Agonists
  topic: keywords
subject: Dual Incretin
  topic: keywords
subject: Triple Agonists
  topic: keywords
subject: Cardiometabolic Outcomes
  topic: keywords
subject: Cardiovascular Events
  topic: keywords
subject: Renal Protection, Weight Loss
  topic: keywords
creator: Abdulgafar Dare Ibrahim
creator: Nadira Tamanna Tamim
creator: Prasansa Giri
creator: Javaria Ismail
creator: Hannah Jeyakkodi
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2026-03-24
publication date: 2026-03-24
starting page: 1
ending page: 7
doi: 10.47363/JDRR/2026(8)211

The Rising Burden of Diabetes in Jamaica: Challenges and Implications
type: item
description: Diabetes mellitus represents a growing public health challenge in Jamaica, contributing to increased morbidity, mortality, and strain on the healthcare system. This study analyses longitudinal secondary data from national surveys, hospital records, and the International Diabetes Federation spanning 1995–2024 to evaluate trends in prevalence, demographic disparities, and healthcare access. Findings indicate that diabetes prevalence rose from approximately 7.9% in 2007 to 12.5% in 2024 among adults aged 20–79, with higher rates among women and urban populations. Contributing factors include ageing, rising obesity, nutritional transitions, and limited access to healthcare services. Comparative analysis shows Jamaica’s prevalence exceeds that of Sub-Saharan Africa and Western Europe but remains slightly below North American rates. Despite policy efforts, awareness, treatment, and glycaemic control remain suboptimal. The study underscores the need for integrated prevention strategies, community-based interventions, and strengthened surveillance systems to curb the growing diabetes burden in Jamaica.
subject: Articles
  topic: section
subject: Diabetes Prevalence
  topic: keywords
subject: Jamaica
  topic: keywords
subject: Public Health
  topic: keywords
subject: Obesity
  topic: keywords
subject: Healthcare Access
  topic: keywords
subject: Chronic Disease Prevention
  topic: keywords
creator: Paul Andrew Bourne
creator: Nicola Brown
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2026-03-13
publication date: 2026-03-13
starting page: 1
ending page: 4
doi: 10.47363/JDRR/2026(8)210

The Relationship Between Blood Pressure Salt Sensitivity and Metabolic Syndrome
type: item
description: Blood pressure salt sensitivity (BPSS) is a physiological trait characterized by significant changes in blood pressure in response to dietary sodium intake. Emerging evidence suggests that BPSS is closely associated with metabolic abnormalities and may represent an early marker of cardiometabolic risk. This study explores the relationship between blood pressure salt sensitivity and metabolic syndrome (MetS), a cluster of conditions including central obesity, insulin resistance, dyslipidemia, and hypertension. Salt-sensitive individuals often exhibit impaired renal sodium handling, endothelial dysfunction, heightened sympathetic nervous system activity, and activation of the renin–angiotensin–aldosterone system. These mechanisms overlap with the pathophysiological pathways underlying metabolic syndrome. Insulin resistance, a core feature of MetS, may enhance renal sodium reabsorption and contribute to increased vascular stiffness, thereby amplifying salt-induced blood pressure responses. Furthermore, chronic low grade inflammation and oxidative stress—common in metabolic syndrome—may exacerbate vascular reactivity to sodium. Clinical and epidemiological data indicate that individuals with metabolic syndrome are more likely to demonstrate salt sensitivity and are at higher risk of cardiovascular complications, including left ventricular hypertrophy, stroke, and chronic kidney disease. Identifying salt-sensitive phenotypes within patients with metabolic syndrome may facilitate personalized dietary sodium recommendations and targeted therapeutic interventions. Understanding the interplay between BPSS and metabolic syndrome has significant implications for prevention strategies in diabetes and endocrinology practice. Early detection and lifestyle modification, particularly sodium restriction and weight management, may reduce long-term cardiometabolic morbidity and mortality.
subject: Articles
  topic: section
subject: Blood pressure salt sensitivity
  topic: keywords
subject: Metabolic syndrome
  topic: keywords
subject: Insulin resistance
  topic: keywords
subject: Hypertension
  topic: keywords
subject: Sodium intake
  topic: keywords
subject: Endothelial dysfunction
  topic: keywords
subject: Cardiometabolic risk
  topic: keywords
creator: Jihong Hu
rights: Copyright (c) 2025 Journal of Diabetes Research Reviews & Reports
date: 2025-05-08
publication date: 2025-05-08
starting page: 5
ending page: 5
doi: 10.47363/zk7awy93

Occupational Therapy-Based Health Promotion for Diabetes and Weight Management in Correctional Facilities
type: item
description: Background Chronic diseases, particularly diabetes and obesity, are prevalent in correctional facilities. Factors such as sedentary lifestyles, limited access to resources, and high stress contribute to escalating health care costs and poor health outcomes. Occupational Therapy (OT) provides an evidence-based, holistic framework to address these challenges. Purpose This abstract presents an OT-based health promotion program tailored for incarcerated adults managing diabetes and weight issues. By integrating key theoretical models and frames of reference, the program aims to foster sustainable lifestyle changes and reduce the burden of chronic disease. Theoretical Frameworks and Intervention Guided by the Model of Human Occupation (MOHO), the Person-Environment-Occupation-Performance (PEOP) model, and supporting frames of reference (e.g., Cognitive Behavioral, Biomechanical, and Lifestyle Redesign®), OT practitioners implement a comprehensive approach focusing on individualized goal setting, education, and skills training. The Chronic Disease Self Management Program (CDSMP) serves as an evidence-based intervention to address diet, exercise, and medication adherence. Interdisciplinary collaboration, environmental modifications (e.g., healthier commissary options, designated exercise areas), and peer support enhance program efficacy. Results Preliminary outcomes in correctional facilities that have adopted OT-based health promotion interventions demonstrate improved glycemic control, weight reduction, and decreased medical emergencies. Cost-savings are achieved through reduced off-site medical transports, fewer hospitalizations, and lower reliance on acute care. The long-term impact extends beyond prison walls, as participants develop skills that support community reintegration and reduce recidivism. Conclusion Occupational therapy’s client-centered, holistic approach addresses the multifaceted health needs of incarcerated individuals. By leveraging established models …
subject: Articles
  topic: section
subject: Therapy-Based Health
  topic: keywords
subject: Weight Management
  topic: keywords
creator: De Andre Nunn
rights: Copyright (c) 2025 Journal of Diabetes Research Reviews & Reports
date: 2025-05-08
publication date: 2025-05-08
starting page: 3
ending page: 3
doi: 10.47363/6e5hng87

In-Vitro Combo Treatments of Human Melanoma Cell Lines (BLM, 1205Lu, WM238) with Curcumin, Steroids and Vitamins
type: item
description: Results of our previous in-vitro studies on the inhibition of human melanoma cell growth by steroids (progesterone (P), RU-486), curcumin (cur) and vitamins (A and D3), gave the idea for a combination treatment of melanoma cells in-vitro. The aim was to study the combined effects of curcumin, vitamins (D3 and A), and steroids (P4 and RU-486) on human melanoma (BLM, 1205Lu, WM238) cell growth and interleukin-8 (IL-8) secretion in vitro. Human melanoma cells were incubated in a 96-well plate with a single (solo) compound or a double combo of the compounds or a triple combo of the compounds in various combinations. Supernatants were subjected to Elisarray and quantitation of the cytokine IL-8 secreted by the cells. Results from the three cell lines (BLM, 1205Lu and WM238) were compared. Solo or single compound treatment of Cur, P, RU, A and D3 resulted in 40 to 57% of BLM cell growth compared to its untreated control cell growth at 100%. Similarly, 1205Lu cell line treatments resulted in 37 to 59% cell growth compared to its untreated control cell growth at 100%. A double combo of compounds such as Cur+D3, Cur+P treatments resulted in 19 to 42% of BLM cell growth and 17 to 37% of 1205Lu cell growth. Whereas WM238 cell line showed 18 to 22% cell growth. A triple combo such as Cur+P+RU, treatments resulted in 21 to 30% of BLM cell growth and 19 to 30% of 1205Lu cell growth. Whereas WM238 cell line showed 19 to 20% cell growth. Elisarray of the supernatants pointed to the two combo treatments A+RU and Cur+P+RU as having a basal secretion profile of various proinflammatory cytokines by the three cell lines with IL-8 secretion significantly suppressed. Hence, IL-8 in the supernatants of the two combo treatments was quantitated by Elisa. IL-8 secretion by the BLM cell line was 46.1 pg/ml and 31.08 pg/ml respectively in the supernatants of the combos A+RU and Cur+P+RU. Whereas IL-8 secretion by the 1205Lu cell line was 17.5 and 8.0 pg/ml respectively and IL-8 secretion by the…
subject: Articles
  topic: section
subject: Combo Treatments
  topic: keywords
subject: Human Melanoma
  topic: keywords
subject: Vitamins
  topic: keywords
creator: Pandurangan Ramaraj
rights: Copyright (c) 2025 Journal of Diabetes Research Reviews & Reports
date: 2025-05-08
publication date: 2025-05-08
starting page: 2
ending page: 2
doi: 10.47363/dd713c28

Effect of Diabetes Self-Management Education on Glycaemic Control in Sudanese Adults with Type 2 Diabetes
type: item
description: Background Diabetes mellitus significantly affects patients’ quality of life (QoL), particularly among women in low-resource settings. This study assessed the impact of diabetes on QoL among Sudanese women attending a diabetes center in Port Sudan, Red Sea State, from 2023 to 2024. Methods A cross-sectional study was conducted among 246 female patients with type 2 diabetes. QoL was assessed using the WHOQOL BREF tool, and data were analyzed using SPSS version 26.0. Results Participants had a mean age of 54.7 ± 13.6 years, with a disease duration ranging from 6 months to 40 years (mean 9.1 ± 7.7 years). Most women (69.9%) reported an average QoL, with domain scores of 56.4 (physical), 62.4 (psychological), 52.0 (social), and 53.2 (environmental). Neuropathy was the most common complication. Key determinants of QoL included age, marital status, education, socioeconomic status, and insurance coverage (p ≤ 0.05). Women using both oral medication and insulin had the highest QoL, while those on oral medication alone had the lowest. Although glycemic control was associated with better QoL, the relationship was not statistically significant. Conclusion Demographic and disease-related factors play a crucial role in shaping QoL among diabetic women. Tailored interventions addressing these factors are essential to improve health outcomes and overall well-being in this population.
subject: Articles
  topic: section
subject: Self-Management
  topic: keywords
subject: Glycaemic Control
  topic: keywords
creator: Sahar Moawia Balla Elnour
rights: Copyright (c) 2025 Journal of Diabetes Research Reviews & Reports
date: 2025-05-08
publication date: 2025-05-08
starting page: 1
ending page: 1
doi: 10.47363/jdm6qn40

A New Era in Fitness: Holistic Support for Individuals ManagingObesity
type: item
description: Starting in Q1 2024, the health and fitness sector became engaged through various conference presentations, panel discussions, focus groups, and podcasts-both virtual and live-regarding the potential impact that Anti-Obesity Medications (AOMs) could have on the industry.
subject: Articles
  topic: section
subject: Fitness
  topic: keywords
subject: Holistic
  topic: keywords
subject: Obesity
  topic: keywords
creator: Bob Esquerre
creator: Ann Gilbert
rights: Copyright (c) 2025 Journal of Diabetes Research Reviews & Reports
date: 2025-04-05
publication date: 2025-04-05
starting page: 1
ending page: 5
doi: 10.47363/kv7z5z38

Effectiveness of a Short-Term OT-Based Health Promotion ProgramFocused on Improving the Quality of Life and Weight Management
type: item
description: The effectiveness of a Lifestyle Redesign program on improving the quality of life and functioning of the elderly has been documented thoroughly in the [1]. However, there has been little research conducted on other populations such as young and middle-aged adults. As recently as 2008 the Center for Disease Control and Prevention (CDC) estimated that the medical cost of people who were obese was $1,400 higher than people of normal weight costing a total of $147 billion dollars [2]. Despite this information, the number of people in the US who are overweight or obese has continued to rise. One-third of all adults in the United States are obese [3]. Furthermore, Obesity negatively impacts a person’s mental health and decreases the quality of life [4].
subject: Articles
  topic: section
subject: Effectiveness
  topic: keywords
subject: Weight
  topic: keywords
subject: Weight Management
  topic: keywords
creator: De Andre Nunn
creator: Mark Kovic
rights: Copyright (c) 2025 Journal of Diabetes Research Reviews & Reports
date: 2025-02-17
publication date: 2025-02-17
starting page: 1
ending page: 4
doi: 10.47363/0yhz1f66

Complication and Assessment of Time Sensitive Tablets InvolvingDesign Expert Software
type: item
description: This research investigated the creation of fast-dissolving tablets containing glipizide, utilizing a Box-Behnken design and direct compression method. The study aimed to incorporate natural super disintegrants such as Plantago ovata seed mucilage and the natural binder Guar gum, in addition to the synthetic super disintegrant cross-povidone. Detailed pre-formulation studies were carried out to verify the compatibility between glipizide and all the excipients used in the formulation. The resulting fast-dissolving tablets were thoroughly assessed for weight variation, hardness, friability, disintegration time, in vitro drug release profile, and stability. The Box-Behnken design proved to be an effective approach for optimizing the amounts of both natural and synthetic super disintegrants, with the goal of achieving quick disintegration and an optimal drug release profile. The expected result is a promising formulation of fastdissolving glipizide tablets that could greatly enhance patient compliance, particularly for diabetic patients who have trouble swallowing. This formulation has the potential to improve therapeutic effectiveness and patient ease in managing diabetes.
subject: Articles
  topic: section
subject: Diabetes Mellitus
  topic: keywords
subject: Box-Behnken Design
  topic: keywords
subject: Plantago Ovata Seed Mucilage
  topic: keywords
subject: Glipizide
  topic: keywords
subject: Fast Dissolving Tablet
  topic: keywords
creator: Tushar Sonare
creator: Aman Kumar
creator: Kratika Khadsondni
creator: Krutika Mandloi
creator: Akash Yadav
creator: Dinesh Kumar Jain
rights: Copyright (c) 2025 Journal of Diabetes Research Reviews & Reports
date: 2025-02-10
publication date: 2025-02-10
starting page: 1
ending page: 11
doi: 10.47363/2pfjw158

Crossed Nerve Palsies in Sinonasal Mucormycosis: A Diabetic’sFacial-Hypoglossal Puzzle
type: item
description: Introduction: Sinonasal mucormycosis is an acute invasive fungal infection of the nose and paranasal sinuses, which is rare, opportunistic and potentially fatal, occurring in both normal and immunocompromised individuals. Uncontrolled diabetics and immunocompromised patients are more prone to this invasive fungal infection. Sinonasal mucormycosis is approximately 1.7 cases per 1,000,000 inhabitants per year. Incidence of VII Cranial nerve palsy is 11% in these cases, and coexistence of ipsilateral Facial nerve and contralateral hypoglossal nerve is not documented in existing literature. Case Report: A 53-year-old woman was diagnosed with Sinonasal Mucormycosis with extension to the skull base and Infratemporal fossa with involvement of ipsilateral facial nerve palsy and contralateral hypoglossal nerve palsy, in the setting of newly diagnosed and uncontrolled diabetes mellitus. She was promptly started on Liposomal Amphotericin-B and underwent “Endoscopic trans-nasal trans-maxillary trans-pterygoid debridement”. Conclusion: Mucormycosis is a rare condition that is still fatal in the era of medical and surgical advancements. A combination of endoscopic surgical debridement followed by intravenous Amphotericin B therapy is quintessential in the management of such patients and has less morbidity compared with conventional treatment. Rare presentations like multiple cranial nerve palsy, which would otherwise raise the suspicion onwards granulomatous disease, need to be scrutinised and aspects ruled out in effective treatment of patients.
subject: Articles
  topic: section
subject: Sinonasal Mucormycosis
  topic: keywords
subject: Cranial Nerve Palsy
  topic: keywords
subject: Amphotericin B
  topic: keywords
subject: Transpterygoid Debridement
  topic: keywords
creator: Vikas Sharma
creator: Siddalingesh Hugar
creator: Tanuj Madan
creator: Dibangkar Das Das
creator: Prashant Sengupta
creator: Bala Krishnan V
creator: Zia Zafar
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2025-06-15
publication date: 2025-06-15
starting page: 1
ending page: 4
doi: 10.47363/2bxf2k60

An Animal Model for the Study of Compressive (Constrictive) CervicalRadiculopathy
type: item
description: Purpose: The purpose of this study was to investigate the basis for the clinical and anatomical findings associated with C7 cervical radiculopathy in an animal model. In the diabetic population cervical radiculopathy is particularly more severe and symptomatic, especially C7. Materials and Methods: A total of 60 Sprague-Dawley rats were randomly divided into six groups of 10 each. In each group, the nerve roots of C4, C5, C6, C7 and cervical plexus were exposed under the operating microscope with general anesthesia with pentobarbital and ketamine. Group 1 served as the sham operation group. In groups II-VI, different cervical roots were exposed and ligated by using 9.0 nylon at the point where they emerged from the foramina. In Group II C5, C6, and C7 were exposed and ligated, in Group III C4 was litigated, in Group IV C5 was ligated, in Group V C6 was ligated, and in Group VI C7 was ligated. Results: After six weeks of ligation Groups III, IV and V improved and the allodynia completely resolved. In Groups II and VI improvement was noted but never recovered to the level of the other groups. Allodynia and hypoesthesia persisted throughout the study period. Conclusion: Ligation of cervical roots independently or in combination can produce syndromes that resemble human CRPS I and II (International Association for Study of Pain Criteria), but the changes are more pronounced and persistent with C7 involved primarily or in combination with other roots
subject: Articles
  topic: section
subject: Animal Model
  topic: keywords
subject: Cervical Radiculopathy
  topic: keywords
subject: C7 Brachial Plexus
  topic: keywords
subject: Infectious Neuropathies
  topic: keywords
creator: Jose J Monsivais
creator: Sun Y
rights: Copyright (c) 2025 Journal of Diabetes Research Reviews & Reports
date: 2025-01-29
publication date: 2025-01-29
starting page: 1
ending page: 3
doi: 10.47363/JDRR/2025(7)201

Progressive Blood Morphology Restoration in a Diabetic Patient Using Biophoton Therapy: A Live Blood Cell Analysis Over SixWeeks
type: item
description: Diabetes Mellitus is associated with increased blood viscosity, oxidative stress, and compromised microcirculation. In this observational study, live blood cell imaging under dark-field microscopy was used to monitor hematologic changes in a patient with type 2 diabetes treated with four strong biophoton generators over a six-week period. Progressive improvements were observed in red blood cell (RBC) morphology, dispersion, oxidative debris clearance, and immune homeostasis. By Week 6, the patient’s blood profile exceeded baseline morphology norms, suggesting systemic rejuvenation. This study highlights the potential of biophoton therapy to reverse microvascular dysfunction and restore bioenergetic balance in diabetic individuals.
subject: Articles
  topic: section
subject: Biophoton Therapy
  topic: keywords
subject: Live Blood Analysis
  topic: keywords
subject: Diabetes
  topic: keywords
subject: Dark-Field Microscopy
  topic: keywords
subject: Red Blood Cells
  topic: keywords
subject: Microcirculation
  topic: keywords
subject: Oxidative Stress
  topic: keywords
subject: ATP
  topic: keywords
subject: Regenerative Medicine
  topic: keywords
creator: Ya Hu
creator: Helen Y Gu
creator: James Z Liu
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2025-07-15
publication date: 2025-07-15
starting page: 1
ending page: 5
doi: 10.47363/JDRR/2025(7)205

The Prevalence of Dyslipidemia in South Indian Type 2 DiabetesMellitus Patients: A Cross-Sectional Study
type: item
description: Objective: In South India, there's limited research on dyslipidemia in Type 2 diabetes mellitus (T2DM) patients, despite the global burden of T2DM. This study aims to investigate the prevalence of elevated lipid profiles in Type 2 diabetic patients from Coimbatore, South India. The scope of dyslipidemia in this population and its potential implications for cardiovascular health can be better understood by assessing the lipid profiles of these patients. Methods: To address this knowledge gap, a comprehensive cross-sectional study was conducted, collecting essential patient information, including the following: age, sex, diagnosis, disease duration, fasting blood sugar levels (BSL), post-breakfast BSL, hemoglobin A1c (HbA1c) levels, LDL cholesterol (low density lipoprotein cholesterol), triglyceride levels, and any relevant notes or observations. Conducting a cross-sectional study in Tamil Nadu with 100 T2DM patients, we found a high prevalence of dyslipidemia. Results: Elevated lipid levels indicate the prevalence of dyslipidemia among the T2DM patients in Coimbatore. This emphasizes the need for effective management to reduce cardiovascular risks in T2DM. Conclusion: Our findings call for a comprehensive approach, including vigilant lipid profile monitoring alongside glycemic control, to improve patient outcomes. Addressing dyslipidemia alongside glycemic control can substantially reduce the burden of cardiovascular complications, ultimately leading to improved patient outcomes. This study contributes crucial data for region-specific guidelines and interventions in South India. Main Points • Novel Demographic Representation: This study offers new insights into the prevalence of dyslipidemia in Type 2 diabetes patients from a hospital associated with a public charitable trust in Coimbatore, South India. This setting provides a unique perspective due to its diverse range of patients from various socioeconomic and demographic backgrounds, which enhances the generalizab…
subject: Articles
  topic: section
subject: Dyslipidemia
  topic: keywords
subject: Diabetes
  topic: keywords
subject: Mellitus Patients
  topic: keywords
creator: Ananya Mishu Manoj
creator: Gurumoorthi Ponnuswamy
rights: Copyright (c) 2024 Journal of Diabetes Research Reviews & Reports
date: 2024-11-15
publication date: 2024-11-15
starting page: 1
ending page: 6
doi: 10.47363/JDRR/2024(6)195

Factors Associated with Mortality in Patients Affected by Covid-19
type: item
description: Objective: To investigate the clinical conditions and sociodemographic characteristics associated with mortality due to COVID-19 during the first year of the pandemic in an intensive care unit in a capital city in northeastern Brazil. Method: This was an exploratory, retrospective documentary study based on secondary data obtained from medical records of patients admitted to an intensive care unit of a public hospital in northeastern Brazil. Data collection occurred between July and September 2021. The data were analyzed via descriptive and inferential statistics. The chi-square test, Fisher’s exact test, Student’s t test, and binary logistic regression modeling were employed. The study was approved by the Research Ethics Committee. Results: A total of 274 patients, predominantly male, mixed-race, and aged over 65 years, were included. The variables male sex, age 65 years or older, marital status (married), and length of hospital stay were significantly associated with clinical outcomes. Logistic regression analysis revealed that male individuals, those aged 65 years or older, those requiring invasive mechanical ventilation, and patients in the prone position had higher odds of mortality as an outcome. Conclusions: Observing the factors associated with mortality outcomes in patients affected by novel coronavirus infection can aid healthcare professionals and public health managers in decision-making.
subject: Articles
  topic: section
subject: Coronavirus Infections
  topic: keywords
subject: Mortality
  topic: keywords
subject: Public Health
  topic: keywords
subject: Critical Care
  topic: keywords
subject: Epidemiology
  topic: keywords
creator: Cindhy Mífia da Silva Moreira
creator: Fabiana Maria Rodrigues Lopes de Oliveira
creator: João Victor Batista Cabral
creator: Maria Hellena Ferreira Brasil
creator: Deysianne Ferreira da Silva
creator: Keylla Talitha Fernandes Barbosa
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2025-08-05
publication date: 2025-08-05
starting page: 1
ending page: 6
doi: 10.47363/JDRR/2025(7)207

A Tablet as an Environment for Investigation of the Reactions in the Solid States
type: item
description: Objective In this study, a tablet’s matrix was considered a solid environment to investigate the reactions in the solid states. The tendency of molecules to each other and their interaction in the solid state was studied through the advent of impurities in the tablet caused by the interaction of the active pharmaceutical ingredient with an excipient. Significance Investigation of solid-state reactions and their prediction in the matrix of tablets will reveal the possible appearance of impurities in pharmaceutical dosage forms and help formulators prevent impurities in drug products. Methods Principal Component Analysis (PCA) was used to predict the interaction between Gliclazide as a secondary amine and Lactose in the manufactured powders. The infrared spectra of binary mixtures of Gliclazide with Lactose at different weight ratios were recorded and the obtained data matrix was analyzed with PCA. High-performance Liquid Chromatography (HPLC) was used for the identification and quantification of the impurity. Results The incompatibility was seen theoretically by PCA and also experimentally by HPLC. A kinetic model was proposed for this solid-state reaction in the tablets. The presence of some excipients was investigated on the appearance of the impurity and also on the kinetics of the reaction. This reaction was faster when Hydroxy propylmethylcellulose (HPMC) was present in the tablet formulation. Conclusion The chemical reaction in a tablet could be considered as a solid-state reaction. This reaction was predicted and modeled and the effect of the matrix of the tablet was investigated on the reaction.
subject: Articles
  topic: section
subject: Tablet
  topic: keywords
subject: Impurity
  topic: keywords
subject: Principal Component Analysis
  topic: keywords
subject: Kinetic Model
  topic: keywords
subject: High-Performance Liquid Chromatography
  topic: keywords
creator: Farzad Khajavi
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2025-07-28
publication date: 2025-07-28
starting page: 1
ending page: 8
doi: 10.47363/JDRR/2025(7)158

Diabetes Mellitus as a Disease and its Current Scenario - A Review
type: item
description: Diabetes mellitus is a chronic heterogeneous common metabolic disorder and a group of insulin resistance syndrome characterized by elevated blood glucose levels or hyperglycemia with complex pathogenesis. Diabetes mellitus results from abnormalities in either insulin secretion or insulin action or both. In current scenario Diabetes Mellitus is detected all over the world and a leading cause of death worldwide. This review includes different sections including classification, Clinical manifestation and complications, etiology, pathogenesis, diagnosis, treatment, and its relation with COVID-19. The common signs & symptoms observed in Diabetes Mellitus are Fatigue Polyphagia, Polydipsia, polyuria, vomiting, and dehydration. This disorder is mainly caused by the destruction of pancreatic beta cells and because of that it becomes autoimmune disorders. Some genetic factors, prior family history, environmental factors, autoimmune destruction and high insulin resistance increase the risk of the development of diabetes mellitus. In COVID-19-infected patients the Diabetes mellitus increases the significant complications and mortality rate.
subject: Articles
  topic: section
subject: Diabetes Mellitus
  topic: keywords
subject: Disease
  topic: keywords
creator: Showkat Ahmad Bhat
creator: Omar Rashid
creator: Rayees ul Hamid Wani
rights: Copyright (c) 2026 Journal of Diabetes Research Reviews & Reports
date: 2025-10-31
publication date: 2025-10-31
starting page: 1
ending page: 6
doi: 10.47363/JDRR/2025(7)208

Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss and Cardiovascular Protection in Obesity and Type2 Diabetes: A Systematic Review and Meta-Analysis
type: item
description: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly recognised as dual-action therapies for obesity and type 2 diabetes, with emerging evidence of cardiovascular protection. Despite widespread use, uncertainty remains regarding long-term efficacy, safety, and potential publication bias across trials. We conducted a systematic review and meta-analysis of major randomised controlled trials, including weight-loss studies and cardiovascular outcome trials (CVOTs). Data were pooled for weight reduction, major adverse cardiovascular events (MACE), and treatment discontinuation due to adverse events. Subgroup and sensitivity analyses assessed the influence of trial design, dose, and sponsorship. Publication bias was evaluated using funnel plots and Egger’s tests. GLP-1 RAs produced substantial and durable weight reduction, particularly at higher doses and with longer treatment durations. Consistent reductions in MACE were observed across diverse populations, reinforcing their cardioprotective role. Gastrointestinal adverse events were the primary driver of treatment discontinuation, but serious adverse events were not consistently increased. Safety concerns regarding pancreatitis, thyroid cancer, or neoplasia were not supported by current evidence, though gallbladder events were more frequent in select trials. Funnel plots suggested modest asymmetry in weight-loss studies, largely reflecting small-study effects; however, sensitivity analyses excluding high-risk or industry-sponsored trials confirmed the robustness of findings. GLP-1 RAs provide a favourable benefit–risk profile, combining clinically meaningful weight loss with cardiovascular protection. Their integration into clinical practice has transformative potential for obesity and diabetes management. Future research should clarify long-term safety signals, optimise dosing strategies, and evaluate real-world effectiveness to guide equitable access and sustainable implementation.
subject: Articles
  topic: section
subject: GLP-1 Receptor Agonists
  topic: keywords
subject: Obesity
  topic: keywords
subject: Cardiovascular Outcomes
  topic: keywords
subject: Weight Loss
  topic: keywords
subject: Systematic Review
  topic: keywords
subject: Meta-Analysis
  topic: keywords
subject: Safety
  topic: keywords
subject: Tolerability
  topic: keywords
subject: Publication Bias
  topic: keywords
subject: Cardiometabolic Risk
  topic: keywords
creator: Maria Sultana
creator: Farzana Jahangir
creator: Farzana Rahman
creator: Abdulgafar Dare Ibrahim
creator: Javaria Ismail
creator: Ishtiaq Ahmad
rights: Copyright (c) 2024 Journal of Diabetes Research Reviews & Reports
date: 2026-02-26
publication date: 2026-02-26
starting page: 1
ending page: 8
doi: 10.47363/pstgch08

Efficacy of School-Based Life Skill Training to Boost MentalHealth Status and Well-Being of Young People
type: item
description: This study aims to assess the efficacy of school-based life skills training on mental health status and wellbeing of young people. A classical experimental research design with control group and random sampling method were used. The study population comprises 720 school going young people (both girls and boys in the age group of 16 to 19yrs) from six higher secondary schools in Ernakulam Educational district of Kerala, India. The respondents were selected on the basis of inclusion and exclusion criteria. Informed written consent was obtained from the participants prior to the study. The respondents weresequentially assigned into intervention group and control group with 360 each for determining the effect of the intervention comparatively. The standard tools administered to evaluate the mental health status and wellbeing in three-time lines are: GHQ-28 and WEMWS-14 respectively. Researcher conducted life skills training to the intervention group after pre- intervention. The same assessment tools were administered for post-intervention (one – three months) and follow -up intervention (six- nine months) to evaluate the impact of intervention on mental health and well-being. The current version of Statistical Package for Social Sciences (SPSS) was used to analyze the data and correlations were obtained. Repeated Measures Analysis of Variance (RMANOVA) was performed to test whether there is any significant effect due to intervention in the scores. Independent sample t-test was used to compare the equality of baseline scores of various components. Data were analyzed by descriptive and inferential statistics in three-time lines under different sections. The result shows that there was highly significant intervention effect between the scores of mental health status and wellbeing. The p value is less than 0.05 (normal value) the null hypothesis rejected and alternate hypothesis accepted i.e., intervention is effective.
subject: Articles
  topic: section
subject: Mental Health Status
  topic: keywords
subject: Wellbeing
  topic: keywords
subject: Life Skill Training
  topic: keywords
subject: Young People
  topic: keywords
creator: Jessy Mavarayil John
rights: Copyright (c) 2024 Journal of Diabetes Research Reviews & Reports
date: 2024-12-31
publication date: 2024-12-31
starting page: 1
ending page: 3
doi: 10.47363/JDRR/2024(6)25656

Use of Technology in the Management and Treatment of Prediabetes,A New Era: A Case Report Series
type: item
description: Introduction: The escalating prevalence of prediabetes has positioned it as a silent precursor to a looming public health crisis, particularly as it paves the way for type 2 diabetes mellitus (T2DM). This case series report explores the transformative role of technology, specifically the Sugar Fit’s Diabetes Reversal and Management Program (SDRMP), in the treatment and management of prediabetic patients. Methods: The case series follows the progress of two patients aged 31-44 with prediabetes utilizing the SDRMP to prevent the progression to diabetes. The interventions for both patients involved continuous glucose monitoring, personalized nutrition plans, fitness strategies, and behavioral modifications. The patients also engaged in regular communication with their life coaches through the Sugar Fit application, ensuring ongoing support and adherence to the program. Results: The results revealed significant improvements in glycemic control, lipid profiles, and overall well-being. The first patient, a 44-year-old male, demonstrated a successful return to normal glycemic control in 177 days through a comprehensive approach involving dietary changes, exercise, and lifestyle modifications. The second patient, a 31-year-old male, achieved normal glycemic control in a comparable timeframe, showcasing the effectiveness of the SDRMP. Discussion and Conclusion: These cases demonstrate that patients were able to adhere to the goals of care, preventing the progression of prediabetes to diabetes and improving insulin resistance. The study also underscores the potential impact of technology on public health outcomes, bridging the gap between traditional interventions and the evolving needs of a tech-savvy population. The synergy between healthcare expertise and technological innovation not only arrests the progression of prediabetes but also contributes to a broader societal shift towards metabolic well-being, paving the way for a healthier future. Future monitoring is essential…
subject: Articles
  topic: section
subject: Prediabetes
  topic: keywords
subject: Treatment
  topic: keywords
creator: Chhavi Goyal Mehra
creator: Annie Mattilda Raymond
creator: Ankitha Sequeira
creator: Shefali Mehra
rights: Copyright (c) 2024 Journal of Diabetes Research Reviews & Reports
date: 2024-09-18
publication date: 2024-09-18
starting page: 1
ending page: 4
doi: 10.47363/JDRR/2024(6)192

Prediabetes: A Review of Current Trends
type: item
description: Different organizations have used different criteria to define prediabetes. In order to define prediabetes, the World Health Organization (WHO) use two specific parameters: Impaired Glucose Tolerance (IGT), Oral Glucose Tolerance Test (OGTT). A person who has impaired glucose tolerance or fasting glucose and at high risk of developing type 2 diabetes is said to have prediabetes. Changes in lifestyle, such as losing weight and exercising or taking metformin is considered as the first line treatments for prediabetes. Nearly 8% of the world’s population is expected to have prediabetes by 2040, and 70% of those people will eventually develop type 2 diabetes. Before fully developing diabetes, most people go through a stage of prediabetes. HbA1c or fasting plasma glucose should be used to screen for diabetes in people over 40 and other high-risk individuals. Despite its preventable nature, prediabetes often goes undiagnosed, leading to delayed interventions that can result in long-term health complications. This underscores the importance of widespread awareness, effective screening methods, and access to healthcare resources for early diagnosis and management. Moreover, emerging evidence suggests a link between prediabetes and cognitive decline, indicating that the ramifications of this condition extend beyond physical health. This short overview speaks about risk factors, diagnosis and therapy of prediabetes.
subject: Articles
  topic: section
subject: Impaired Glucose Tolerance
  topic: keywords
subject: Fasting Plasma Glucose
  topic: keywords
subject: Body Mass Index
  topic: keywords
subject: Diabetes
  topic: keywords
subject: Metformin
  topic: keywords
subject: Prediabetes
  topic: keywords
creator: Swetha Anilkumar
creator: Bineesh C P
creator: Jans Jose
creator: Riju Mathew
rights: Copyright (c) 2024 Journal of Diabetes Research Reviews & Reports
date: 2024-10-28
publication date: 2024-10-28
starting page: 1
ending page: 4
doi: 10.47363/JDRR/2024(6)191

Evaluation of the Effects of Non-Invasive Auricular AcupointStimulation on Postprandial Blood Glucose Regulation using aCGM Device
type: item
description: Background: Postprandial blood glucose regulation is critical for diabetes management. Non-invasive auricular acupoint stimulation may influence metabolic functions through the autonomic nervous system. This study aimed to evaluate its effects on postprandial glucose regulation using Continuous Glucose Monitoring (CGM). Methods: Thirteen healthy Japanese adults (10 males, 3 females) had 1.5 mm gold beads applied to six acupoints. Glucose levels were monitored over seven days using CGM. Key metrics included postprandial peak, 2-hour glucose levels, time to peak, and normalization time. Results: Auricular acupoint stimulation reduced time to glucose peak after breakfast (-14.6 min, p = 0.01) and glucose normalization time for breakfast and lunch combined (-20.8 min, p = 0.04). A significant reduction in 2-hour postprandial glucose was observed after lunch (-10.8 mg/dL, p = 0.03). No significant effect was found on peak glucose levels. Conclusion: Auricular acupoint stimulation may promote postprandial glucose normalization, particularly after breakfast and lunch, and could serve as a complementary approach to glucose management.
subject: Articles
  topic: section
subject: Postprandial
  topic: keywords
subject: Blood
  topic: keywords
subject: Glucose
  topic: keywords
creator: Takahiro Fujimoto
creator: Takeshi Hataoka
creator: Takanori Kobayashi
creator: Kazuo Taniguchi
creator: Miyuki Oikawa
creator: Hidetake Kobayashi
rights: Copyright (c) 2024 Journal of Diabetes Research Reviews & Reports
date: 2024-10-19
publication date: 2024-10-19
starting page: 1
ending page: 4
doi: 10.47363/JDRR/2024(6)193

The Case for Strategic Integration of Diabetes Education in SouthernNigeria, Informed by Insights from a Pilot Study
type: item
description: The surge in diabetes cases affecting 3.6 million individuals in Nigeria demands a proactive response. Despite the high prevalence, the current Nigerian model is reactive leading to delayed treatment, heightened complications, elevated healthcare expenses, and diminished quality of life. This document proposes the solution of integrating culturally adapted Diabetes Self-Management Education and Support (DSMES) programs into Nigerian health policy as standard practice. Additionally, it recommends establishing diabetes educator training programs and a nationwide accreditation process. The development of such a program, in collaboration with the University of Port Harcourt Teaching Hospital, is outlined, highlighting both successes and failures during its initial implementation. These insights emphasize the importance of enhanced collaboration, sustainable funding, and a comprehensive monitoring and evaluation framework. These observations are currently driving ongoing program development.
subject: Articles
  topic: section
subject: Strategic Integration
  topic: keywords
subject: Diabetes
  topic: keywords
creator: Lolia M Abibo
creator: Kariba Akhidue
creator: Amjad Rabia
creator: Sunday Chinenye
creator: Chioma Unachukwu
creator: Theodore MacKinney
rights: Copyright (c) 2024 Journal of Diabetes Research Reviews & Reports
date: 2024-08-05
publication date: 2024-08-05
starting page: 1
ending page: 6
doi: 10.47363/JDRR/2024(6)190