Decreased GAD2 in Schizophrenia

Authors

  • A J Russo Department of Translational Biomedical Research Management, Hartwick College, Oneonta, USA Author
  • Albert Mensah Mensah Research Institute, Warrenville, Il 60555, USA Author
  • Judith Bowman Mensah Research Institute, Warrenville, Il 60555, USA Author

DOI:

https://doi.org/10.47363/JCCSR/2024(6)283

Keywords:

Schizophrenia, Decreased GAD2

Abstract

Introduction Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms, including hallucinations, delusions, cognitive impairments, and changes in emotional expression. The etiology of schizophrenia is multifactorial, involving genetic, environmental, and neurobiological factors. Among the various hypotheses proposed to explain the pathophysiology of schizophrenia, the role of the glutamate neurotransmitter system, and specifically the glutamic acid decarboxylase 2 (GAD2) gene, has been a subject of research interest.

GABA, the major inhibitory neurotransmitter in mammalian brain, has been implicated in both brain development and schizophrenia. Two genes, GAD1 and GAD2, control GABA synthesis.

Author Biographies

  • A J Russo, Department of Translational Biomedical Research Management, Hartwick College, Oneonta, USA

    A J Russo, Department of Translational Biomedical Research Management, Hartwick College, Oneonta, USA

  • Albert Mensah, Mensah Research Institute, Warrenville, Il 60555, USA

    Albert Mensah, Mensah Research Institute, Warrenville, Il 60555, USA

  • Judith Bowman, Mensah Research Institute, Warrenville, Il 60555, USA

    Judith Bowman, Mensah Research Institute, Warrenville, Il 60555, USA

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Published

2024-05-20

Issue

Vol. 6 No. 5 (2024): Volume 6 Issue 5

Section

Articles

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