Necrotizing Fascitiis (NF) Treated with Fasciectomy and Surgical Decompression Followed by Application of Dermal Substitute and 3 Cycles of Negative Pressure Therapy: Case Report of Complete Healing in a Asian 54-Year-Old Septic Patient

Abstract

Background: Necrotizing fascitiis is a rapidly progressive, aggressive bacterial infection that causes extensive necrosis of the subcutaneous tissue and fascia. NF can be type I (polymicrobial, most common) or type II (monomicrobial). Early diagnosis is mandatory because delay in starting treatment negatively affects the results. In 80% of cases, it is a direct consequence of altered skin integrity. Primary therapies include the use of broad-spectrum antibiotics and surgical removal of infected tissue; regenerative medicine as Negative Pressure Wound Therapy (NPWT) can provide support in the final stage of healing.

Case History: A 54-year-old asian patient came to the emergency room in severe septic state with wet gangrene of the left lower limb extended to the lateral leg region. Transferred to a dedicated ward, he received broad-spectrum antibiotic treatment and a fasciectomy with surgical decompression. After application of the dermal replacer and three cycles of NPWT, complete resolution of the condition was achieved.