Assessment of Lethal Dose and Lethal Time of Diazinon in SwissAlbino Mice

Authors

  • Muna Salem M Solyman Department of Molecular Diagnostic, Faculty of Biomedical Sciences, University of Benghazi, Benghazi, Libya Author
  • Fatma Hassan Boshahma Basic Medical Sciences Program, Faculty of Medical and Health Sciences, Libyan International Medical University, Benghazi, Libya Author
  • Huda Mohamed Department of Environmental health, Faculty of public health, University of Benghazi, Benghazi, Libya Author
  • Fawzeia H Elmhalli Department of Infectious Disease, Public Health Faculty, University of Benghazi, Libya Author
  • Abdalla I Mohamed Department of Zoology, Faculty of Science, University of Benghazi, Libya Author
  • Abeer H Amer Department of Histology, Faculty of Medicine, University of Benghazi, Benghazi, Libya Author

DOI:

https://doi.org/10.47363/JCET/2024(5)144

Keywords:

Organophosphorus Pesticides, Diazinon, Libya, Ld50, Lt50

Abstract

Approximately two thirds of deaths and millions of nonfatal cases are attributed to organophosphorus pesticides (OPP) annually. Diazinon, a prominent member of the OP pesticides, was introduced for both agriculture and public health usages during. For several decades, the compound was among the top pesticides in use in many countries, including Libya. The toxicity of this compound is based on its ability to inhibiting the acetylcholinesterase enzyme (AchE), which is vitally important for normal nerve impulse transmission. This study evaluated the acute toxicity of diazinon through acute exposure testing on female Swiss albino mice. In the acute toxicity test, 72 mice were subcutaneously injected with doses of diazinon ranging from 320 to 480 μL/ kg. Mortality and symptoms were recorded over four days, with the median lethal dose found to be 403.5 μL/kg. Based on the findings, the present study suggests that stringent controls and surveillance must be placed on diazinon and similar chemicals.

Author Biographies

  • Muna Salem M Solyman, Department of Molecular Diagnostic, Faculty of Biomedical Sciences, University of Benghazi, Benghazi, Libya

    Department of Molecular Diagnostic, Faculty of Biomedical Sciences, University of Benghazi, Benghazi, Libya

  • Fatma Hassan Boshahma, Basic Medical Sciences Program, Faculty of Medical and Health Sciences, Libyan International Medical University, Benghazi, Libya

    Basic Medical Sciences Program, Faculty of Medical and Health Sciences, Libyan International Medical University, Benghazi, Libya

  • Huda Mohamed, Department of Environmental health, Faculty of public health, University of Benghazi, Benghazi, Libya

    Department of Environmental health, Faculty of public health, University of Benghazi, Benghazi, Libya

  • Fawzeia H Elmhalli, Department of Infectious Disease, Public Health Faculty, University of Benghazi, Libya

    Department of Infectious Disease, Public Health Faculty, University of Benghazi, Libya

  • Abdalla I Mohamed, Department of Zoology, Faculty of Science, University of Benghazi, Libya

    Department of Zoology, Faculty of Science, University of Benghazi, Libya

  • Abeer H Amer, Department of Histology, Faculty of Medicine, University of Benghazi, Benghazi, Libya

    Department of Histology, Faculty of Medicine, University of Benghazi, Benghazi, Libya 

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Published

2024-11-13

Issue

Vol. 5 No. 4 (2024): Volume 5 Issue 4

Section

Articles