Journal of Diagnosis & Case Reports
type: channel
description: Editor-in-chief: Hadi Nobari Professor Spanish Ministry for the Science and Innovation University of Extremadura Cáceres Extremadura Spain ORCID: https://orcid.org/0000-0001-7951-8977 Journal of Diagnosis & Case Reports is an international, open-access, peer-reviewed journal dedicated to advancing diagnostic science and the dissemination of significant clinical case reports. The journal provides a distinguished platform for physicians, clinicians, researchers, academicians, and healthcare professionals to share valuable diagnostic insights, clinical experiences, and emerging medical evidence. The journal is committed to providing free, open, and unrestricted online access to the complete content of all published articles, enabling readers worldwide to conveniently access, review, and benefit from valuable scientific and clinical research. Special Issue Title: Case Reports, Rare Diseases, Diagnostic Challenges, Clinical Research, Imaging-Based Diagnosis, Laboratory Diagnosis, Treatment Innovations, and multidisciplinary medical cases. This Special Issue explores case reports, rare diseases, diagnostic challenges, clinical research, imaging-based diagnosis, laboratory diagnosis, treatment innovations, and multidisciplinary medical cases. It aims to bring together clinicians, researchers, and healthcare professionals to share valuable clinical experiences, novel diagnostic approaches, innovative treatments, and evidence-based insights that contribute to improved diagnosis, patient care, and clinical outcomes. Article acceptance will be in the form of research, review, case reports, analysis, magazines, editorials, opinion, communications, mini-review, short communications, picturized, book review, video type and power point presentations (PPTS). Articles can be submitted through online from https://srcpublishers.com/diagnosis-case-reports/user/register or can send through an e-mail with attachment for editor.jdcr@onlinescientificresearch.info and jdscr@onlinescientific…
publisher: Scientific Research and Community
language: en
publication name: Journal of Diagnosis & Case Reports
issn: 2754-4923
items: Babesia odocoilei Abounds in Canada: Anaplasma phagocytophilumis Scarce
items: A Multisystem Presentation of Secondary Syphilis with Optic Neuritis: A Diagnostic Challenge
items: Native Tricuspid Valve Endocarditis in A Non-Intravenous Drug User
items: From Burden to Regulation: Why Sub-Saharan Africa Should Lead on Pragmatic Phage Therapy Implementation
items: Surgical Management of Multiple Giant Oral Exostoses - Case Report
items: Magnitude of Cardiovascular Disease Admissions and Their Outcomes in Ethiopia: A Systematic Review and Meta-Analysis(2025)
items: Magnitude and Determinants of Uncontrolled Blood Pressure among Adult Hypertensive Patients in Ethiopia: A Systematic Review and Meta-Analysis (2025)
items: Factors Affecting the Uptake of Human Papillomavirus Vaccine among Children of Rural Women in South Eastern Nigeria: A Cross-Sectional Study
items: Hepatic Follicular Dendritic Cell Sarcoma with a History of Cervical Cancer: A Rare Case Report of Multiple Primary Malignant Neoplasms
items: AI Approach for Predicting Superhyrophobicity of Thermal Sprayed Copper Coated Aluminum Surfaces
items: The Expression and Role of MAN2A1 in Triple-Negative Breast Cancer
items: Reimagining Sustainable Development: The Role of Creative Industries and Design Education in India
items: Bilateral Retinoblastoma: Management and Impact on the Lives of Survivors
items: The Effect and Significance of Mild Hypothermia Adjuvant Therapy on Serum IL-6 and TNF-α in Neonatal Hypoxic-Ischemic Encephalopathy
items: Von Meyenburg Complex in a Cat and a Dog, and Mini Literature Review
items: Effect of Continuous Veno-Venous Hemodiafiltration Combined with Hem Perfusion on NLRP3 Levels and Prognosis in Children with Severe Sepsis
items: Enhancing Paediatric Diagnostic Accuracy: A Case Report on the Clinical Utility of Med Brain in Nigeria
items: Successful Conversion Surgery of Common Hepatic Arterial and Portal Vein Resection Combined with Preoperative Chemotherapy and Coil Embolization for Locally Advanced Pancreatic Cancer: A Case Report
items: https://srcpublishers.com/diagnosis-case-reports/article/view/5054
items: Effect of COVID-19 Period on Tuberculosis Treatment Success; A Mixed Methods Study among Tuberculosis Patients at Jinja Regional Referral Hospital
items: Relapsed Bacterial Meningitis in an Adolescent Patient with Aberrant Patent Foramen Caecum
items: Fortified Pregnancy: A Case Report of Heterotopic Gestation with A Successful Obstetrical Outcome
items: Microscopic Analysis on Structural Morphologies of Total Protein Isolates from Two Varieties (DAS and BS) of Nigerian CultivatedSolojo Cowpea (Vigna Unguiculata L. Walp)
items: Reviewing the Awareness of Mental Health Staff of the Possible Visual Side Effects of Antipsychotic Medications
items: Unruptured Ovarian Ectopic Pregnancy- A Case Report
items: A Rare Cause of Neck Mass in an Adult Woman- Cervical Thymic Cyst - A Case Report
items: Perception and Practice of Cervical Cancer Screening among Female Professionals Attending Gynaecology Clinic at A University Teaching Hospital
items: An Epiduroscopy Complication Mimicking a Subarachnoid Haemorrhage: Case Report
items: Bleeding and its Management
items: The Biophysical Modelling of the Criteria in the Living Systems

Babesia odocoilei Abounds in Canada: Anaplasma phagocytophilumis Scarce
type: item
description: Multiple healthcare providers contend that anaplasmosis is the second most prevalent tick-borne zoonotic disease across Canada. However, in reality, human babesiosis caused by B. odocoilei is in second place. Patients are often bitten by Ixodes ticks, but can obtain this zoonosis via blood transfusion, organ transplantation or maternal-fetal transmission. Babesia odocoilei, a sequestering Babesia sp. has innate survival strategies that occlude capillaries and venules throughout the body. Fibrin-bonded entanglements form self-sustaining pockets, and block these tiny vessels. Immune systems become stuck in overdrive, and inflammation is unending. Chronic human babesiosis develops in 6 months as a result of persistent infection. Symptoms persist, and they may include crushing fatigue, brain fog, and cognitive impairment. Since fibrin-bonded entanglements occlude capillaries and venules, these compacted vessels are hard to penetrate and, consequently, this tick-borne zoonotic disease is recalcitrant to treat.
subject: Articles
  topic: section
subject: blacklegged tick
  topic: keywords
subject: Ixodes scapularis
  topic: keywords
subject: Babesia odocoilei
  topic: keywords
subject: human babesiosis
  topic: keywords
subject: Anaplasma phagocytophilum
  topic: keywords
subject: seguestering Babesia species
  topic: keywords
subject: fibrin-bonded entanglements
  topic: keywords
creator: John Donald Scott
creator: Catherine Marie Scott
rights: Copyright (c) 2026 Journal of Diagnosis & Case Reports
date: 2026-08-06
publication date: 2026-08-06
starting page: 1
ending page: 2
doi: 10.47363/JDCRS/2026(7)170

A Multisystem Presentation of Secondary Syphilis with Optic Neuritis: A Diagnostic Challenge
type: item
description: Syphilis is a re-emerging sexually transmitted infection known for its diverse and often deceptive clinical presentations. It can mimic a wide variety of systemic diseases, resulting in delayed or missed diagnoses. This case report describes a 39-year-old male from the Middle East who presented to ophthalmology with photopsia in the right eye. Over the preceding two months, the patient had experienced multiple unexplained systemic symptoms, started with transient skin rashes, fever, headache with hearing dysfunction followed by small and big joints polyarthritis of one month duration along with blurred vision. The patient disclosed high-risk sexual behavior, raising the suspicion of syphilis. Serological testing confirmed secondary syphilis with optic neuritis. Treatment with intravenous ceftriaxone and oral corticosteroids led to full resolution of the ocular findings, hearing dysfunction and polyarthritis. This case highlights the protean nature of syphilis, the importance of detailed social history, and the need for interdisciplinary awareness to prevent diagnostic delays in complex cases.
subject: Articles
  topic: section
subject: Optic Disc Swelling
  topic: keywords
subject: Polyarthritis
  topic: keywords
subject: Hepatitis
  topic: keywords
subject: Sensory Neural Hearing Loss
  topic: keywords
subject: Neuro-Syphilis
  topic: keywords
creator: Mohamad Zaher Kanaan
creator: Azza Elamin
creator: Majid Abi Saab
rights: Copyright (c) 2026 Journal of Diagnosis & Case Reports
date: 2026-07-22
publication date: 2026-07-22
starting page: 1
ending page: 4
doi: 10.47363/JDCRS/2026(7)169

Native Tricuspid Valve Endocarditis in A Non-Intravenous Drug User
type: item
description: We report a case of staphylococcal tricuspid valve endocarditis in a young patient with no history of intravenous drug abuse. Echocardiography revealed two large vegetations, one on each of the lateral and septal cusps of the tricuspid valve complicating an asymptomatic peri-membranous ventricular septal defect with a closing pseudomembrane and a left to right shunt. Treatment with intravenous antibiotics resulted in significant improvement in symptoms and patient was discharged home on I.V antibiotics after two weeks of admission.
subject: Articles
  topic: section
subject: Tricuspid Valve Endocarditis
  topic: keywords
subject: Vegetation
  topic: keywords
subject: Ventricular Septal Defect
  topic: keywords
subject: Staphylococcus
  topic: keywords
subject: Non-IV Drug User
  topic: keywords
creator: Fatima Muhammed Bashir
creator: Shehu Abubakar Kana
creator: Ruqayya Nasir Sani
creator: Mahmoud Umar Sani
rights: Copyright (c) 2026 Journal of Diagnosis & Case Reports
date: 2026-05-12
publication date: 2026-05-12
starting page: 1
ending page: 4
doi: 10.47363/JDCRS/2026(7)167

From Burden to Regulation: Why Sub-Saharan Africa Should Lead on Pragmatic Phage Therapy Implementation
type: item
description: Sub-Saharan Africa cannot afford to treat access to phage therapy as a distant objective. Antimicrobial resistance (AMR) is already altering clinical treatment options, prolonging hospital stays, and increasing healthcare costs. Both WHO Africa and the Africa CDC have identified AMR as an urgent continental threat that requires concrete implementation rather than further declarations [1,2]. Zambia and its neighbouring countries should immediately initiate a regulated magistral phage-access pathway, sustained through regional cooperation.
subject: Articles
  topic: section
subject: Pragmatic Phage
  topic: keywords
subject: Therapy Implementation
  topic: keywords
subject: prolonging
  topic: keywords
creator: Frank Chilombolwa Nyondo
rights: Copyright (c) 2026 Journal of Diagnosis & Case Reports
date: 2026-03-16
publication date: 2026-03-16
starting page: 1
ending page: 2
doi: 10.47363/JDCRS/2026(7)166

Surgical Management of Multiple Giant Oral Exostoses - Case Report
type: item
description: Intraoral bone overgrowths (IBO), including exostoses and tori, are non-pathological developmental anomalies affecting the maxillary and mandibular alveolar ridges. These lesions are generally asymptomatic and often identified during routine clinical or radiographic examinations. Nevertheless, in rare and extensive presentations, they may result in functional impairment or aesthetic concerns, justifying surgical intervention. This report describes an uncommon case of synchronous and exuberant intraoral bone overgrowths involving multiple anatomical sites in a 40-year-old male, highlighting its clinical features and treatment outcome.
subject: Articles
  topic: section
subject: Bone Tissue
  topic: keywords
subject: Mouth
  topic: keywords
subject: Exostoses
  topic: keywords
creator: Bruno Teixeira Gonçalves Rodrigues
creator: Ana Carolina Silva Custódio
creator: Verônica dos Santos Lopes Serrano
creator: Danilo Passeado Branco Ribeiro
creator: Mônica Simões Israel
rights: Copyright (c) 2026 Journal of Diagnosis & Case Reports
date: 2026-02-21
publication date: 2026-02-21
starting page: 1
ending page: 3
doi: 10.47363/JDCRS/2026(7)165

Magnitude of Cardiovascular Disease Admissions and Their Outcomes in Ethiopia: A Systematic Review and Meta-Analysis(2025)
type: item
description: Introduction: CVDs pose a significant burden, particularly in developing countries, affecting individuals, families, healthcare systems, and economies. Cardiovascular diseases are the leading cause of death worldwide, with a disproportionate burden observed in low- and middle-income countries where access to preventive and acute care is limited. So this review is aimed to estimate pooled magnitude of cardiovascular disease admissions and its outcome in Ethiopia. Methods and Materials: A systematic search of published studies from PubMed, Scopus, web of science, google scholar, and reference lists of identified studies were conducted. This meta-analysis follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The quality of studies was assessed by the modified Newcastle-Ottawa Scale (NOS). Meta-analysis was carried out using a random-effects method using the STATA™ Version 14 software. Result: Ten studies involving 38,440 participants were included in this meta-analysis. The magnitude of cardiovascular admission were ranged from 17.5 - 53.9 %; with pooled magnitude of cardiovascular admission with a random-effects model in Ethiopia was 36.3% (95% CI: 27.6- 45.0). Whereas the magnitude of cardiovascular admission in Addis Ababa region was 40.19 %; 95% CI: (28.3- 51.9) and 45.2%; 95% CI :( 28.1- 62.2) in Tigray region. The magnitude of cardiovascular disease admission outcome ranges from 13.2- 24.3%. Conclusion: According to this study, there is a significant burden of cardiovascular disease admissions in the region. Notably, the Addis Ababa region reports an admission rate of 40.19%, while the Tigray region has an even higher rate of 45.2%. Therefore, urgent targeted interventions and healthcare strategies are needed.
subject: Articles
  topic: section
subject: Magnitude
  topic: keywords
subject: Cardiovascular Disease
  topic: keywords
subject: Admissions
  topic: keywords
subject: Outcome
  topic: keywords
subject: Ethiopia
  topic: keywords
creator: MohammedSeid Ahmed Seid
creator: Yohannes Chemere Wondmeneh
creator: Gemechis Teshome Geleta
creator: Michael Amare Hailu
creator: Tewodros Challa Tollosa
creator: Nardos Yimer Aynalem
creator: Abrham Getachew Alemu
creator: Roman Tadele Atnafu
creator: Dagim Belay Habtie
creator: Nesra Omer
creator: Dagmawi Sileshi Teklemariam
creator: Alemu Sugi Melis
creator: Samson Negasi Woldemariam
creator: Bethlehem Mesfin Daba
creator: Ekram Mohammed Omer
creator: Zerubabel Yohans
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2025-08-30
publication date: 2025-08-30
starting page: 1
ending page: 6
doi: 10.47363/JDCRS/2025(6)162

Magnitude and Determinants of Uncontrolled Blood Pressure among Adult Hypertensive Patients in Ethiopia: A Systematic Review and Meta-Analysis (2025)
type: item
description: Background: According to the World Health Organization, an estimated 1.28 billion adults worldwide have hypertension, with two-thirds residing in low- and middle-income countries. Despite the serious health consequences of this condition, 46% of adults with hypertension are unaware that they have it, only 42% receive treatment, and only 1 in 5 individuals has adequately controlled blood pressure. So this study aimed to estimate the pooled magnitude and determinants of uncontrolled blood pressure among Hypertensive Patients in Ethiopia. Methods: We conducted a systematic search of published studies from PubMed, Scopus, web of Science, and manually on Google Scholar. This meta-analysis follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, The quality of studies was assessed by the JBI assessment tool. Meta-analysis was carried out using a random-effects method using the STATA™ Version 14 software. Result: The 19 studies included 7013 participants were included in this meta-analysis. The pooled magnitude of uncontrolled blood pressure among hypertensives after correction of Duval and Tweedie’s trim and fill analysis with random effect model was 56.6 % (95% CI: 48.6-62.6) Whereas the highest prevalence 67.8%; (95% CI: 28.2- 107.4) seen in Amhara region and the lowest 44.2 %;( 95% CI: 32.3, 56.1) seen in Tigray region. Conclusion: Despite of it had serious health impact; the magnitude of uncontrolled blood pressure in Ethiopia is a significant public health issue. The observed variation across different regions highlights the need for targeted interventions.
subject: Articles
  topic: section
subject: Uncontrolled Blood Pressure
  topic: keywords
subject: Ethiopia
  topic: keywords
subject: MetaAnalysis
  topic: keywords
subject: Systematic Review
  topic: keywords
creator: Alemu Sugi Melis
creator: Mohammed Seid Ahmed Seid
creator: Michael Amare Hailu
creator: Mihret Derbie Asfaw
creator: Bethlehem Mesfin Daba
creator: Gemechis Teshome Geleta
creator: Abrham Getachew Alemu
creator: Roman Tadele Atnafu
creator: Dagmawi Sileshi Teklemariam
creator: Nardos yimer Aynalem
creator: Dagim Belay Habtie
creator: Samson Negasi Woldemariam
creator: Milkias Tsigabu Araya
creator: Nejat Nuredin Ahmed
creator: Nesra Omer
creator: Zerubabel Yohans
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2025-08-30
publication date: 2025-08-30
starting page: 1
ending page: 6
doi: 10.47363/JDCRS/2025(6)161

Factors Affecting the Uptake of Human Papillomavirus Vaccine among Children of Rural Women in South Eastern Nigeria: A Cross-Sectional Study
type: item
description: Human papilloma virus (HPV) infection is implicated in the cause of cervical dysplasia and cancer as well as genital warts. Cervical cancer is the second most common cancer in women worldwide and also the third leading cancer worldwide irrespective of gender.
subject: Articles
  topic: section
subject: Uptake of Human Papillomavirus Vaccine
  topic: keywords
subject: Children of Rural Women
  topic: keywords
creator: Winifred Oniah
creator: Okpechukwu Chidubem Peter
creator: Christian Elochukwu Offiah
creator: Oluka Chinwuba Benedict
creator: Evi Akarogbe
creator: Oranu G ibekie
creator: Nwakpa Festus Nnabuife
creator: Okonkwo Mary Jane chioma
creator: Frank Rita Ogadima
creator: Okeke Miracle Chidiebere
creator: Gandu TY Purity
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2025-05-12
publication date: 2025-05-12
starting page: 1
ending page: 11
doi: 10.47363/JDCRS/2025(6)156

Hepatic Follicular Dendritic Cell Sarcoma with a History of Cervical Cancer: A Rare Case Report of Multiple Primary Malignant Neoplasms
type: item
description: The follicular dendritic cell sarcoma (FDCS) is a rare entity, accounting for only 0.4% of all soft tissue sarcomas. Hepatic FDCS, which represents approximately 30% of extranodal FDCS cases, has been reported in only 30 cases in the English literature. The clinical and imaging features of FDCS are non-specific, and its diagnosis relies heavily on pathological examination. Given that the morphology of FDCS resembles several hepatic tumors, diagnosing it poses significant challenges, requiring the exclusion of multiple differential diagnoses. The final diagnosis is based on immunohistochemical expression results. Multiple primary malignant neoplasms (MPMN) are defined as two or more primary tumors occurring either simultaneously or successively in the same organ (tissue) or different organs (tissues) within the same individual. This is the first reported case of MPMN involving intrahepatic FDCS and cervical cancer.
subject: Articles
  topic: section
subject: Hepatic Follicular
  topic: keywords
subject: Dendritic Cell Sarcoma
  topic: keywords
subject: History of Cervical Cancer
  topic: keywords
creator: Chun-hui Peng
creator: Bao-qin Bai
creator: Li-li Zhao
creator: Weihua Guo
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2025-05-28
publication date: 2025-05-28
starting page: 1
ending page: 4
doi: 10.47363/JDCRS/2025(6)159

AI Approach for Predicting Superhyrophobicity of Thermal Sprayed Copper Coated Aluminum Surfaces
type: item
description: Wettability, characterized by the contact angle of a liquid on a surface, is a critical property that influences numerous natural and industrial applications. In this study, I have developed a CNN-based model to predict the hydrophobicity or super-hydrophobicity of copper-coated aluminum surfaces treated with various reagents or etchants. The data set has been created by analyzing copper-coated aluminum samples with a 3D non-contact profilometer, and contact angle measurements were done to correlate surface properties with the resultant contact angle values. After reagent treatments, the approach had been to preprocess 3D profilometer images to extract surface morphology and structure features. These images and associated contact angle measurements were used as inputs to train the CNN model to classify whether the treated surfaces are hydrophobic or super-hydrophobic. Although the model may initially have limited training accuracy, this study demonstrates the potential of deep learning to predict wettability based on surface characteristics. The results also highlight the need for improvements, such as data set expansion, the inclusion of more varied reagent treatments, and the exploration of hybrid modeling approaches to enhance the model.
subject: Articles
  topic: section
subject: Artificial Intelligence
  topic: keywords
subject: Medical Implants
  topic: keywords
subject: Material Science
  topic: keywords
subject: Surface Engineering
  topic: keywords
creator: Mahule Roy
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2025-05-27
publication date: 2025-05-27
starting page: 1
ending page: 6
doi: 10.47363/JDCRS/2025(6)157

The Expression and Role of MAN2A1 in Triple-Negative Breast Cancer
type: item
description: Background: This study investigated MAN2A1's role in regulating the proliferation, invasion, and migration of triple-negative breast cancer (TNBC) cells and its clinical significance. Methods: We enrolled 220 TNBC patients treated at our institution from January 2020 to December 2022. MAN2A1 protein expression was detected, and its correlation with TNBC clinicopathological features was analyzed. Western blot and immunohistochemistry measured MAN2A1 protein levels. CCK-8, colony formation, and EdU assays evaluated MAN2A1's impact on TNBC cell proliferation. Wound healing and Transwell assays assessed its effects on migration and invasion. Results: MAN2A1 protein expression positively correlated with TNBC malignancy. Functional assays demonstrated that MAN2A1 overexpression promoted TNBC cell growth, clonogenicity, migration, and invasion, while its knockdown suppressed these processes. Conclusion: As a key glycosylation enzyme, MAN2A1 is highly expressed in TNBC and positively correlates with malignancy. MAN2A1 overexpression acts as an oncogene by promoting TNBC progression, whereas its knockdown suppresses tumor growth, suggesting its potential as a therapeutic target to improve patient prognosis.
subject: Articles
  topic: section
subject: Triple-Negative Breast Cancer
  topic: keywords
subject: MAN2A1
  topic: keywords
subject: Proliferation
  topic: keywords
subject: Invasion
  topic: keywords
subject: Metastasis
  topic: keywords
creator: Baoqing Wang
creator: Yu Sun
creator: Tianshu Rong
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2025-05-05
publication date: 2025-05-05
starting page: 1
ending page: 5
doi: 10.47363/JDCRS/2025(6)155

Reimagining Sustainable Development: The Role of Creative Industries and Design Education in India
type: item
description: As nations strive for sustainable futures, India emerges as a unique nexus of creativity, heritage, and technological transformation. This paper explores the role of Indian design education in advancing sustainable development within the creative industries. By blending traditional knowledge systems with Industry 4.0 tools like AI, IoT, and data-driven practices, India’s creative sectors hold immense potential to foster resource-efficient, eco-conscious solutions. Through curriculum innovation, interdisciplinary approaches, and strategic collaborations, design education becomes a driver of sustainability and cultural preservation.
subject: Articles
  topic: section
subject: Sustainable Development
  topic: keywords
subject: Creative Industry
  topic: keywords
subject: Indian Design Education
  topic: keywords
subject: Indigenous Knowledge
  topic: keywords
subject: Digital Innovation
  topic: keywords
subject: Resource Efficiency
  topic: keywords
subject: Sustainability
  topic: keywords
subject: Industry 4.0
  topic: keywords
subject: Cultural Heritage
  topic: keywords
subject: Eco-conscious Design
  topic: keywords
creator: Ritesh Ranjan
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2025-05-26
publication date: 2025-05-26
starting page: 1
ending page: 5
doi: 10.47363/JDCRS/2025(6)158

Bilateral Retinoblastoma: Management and Impact on the Lives of Survivors
type: item
description: Introduction: Retinoblastoma is a malignant tumor of neuroepithelial origin occurring in infants and young children. Despite its rarity, it is the most common intraocular malignancy in children. It is unilateral in 2/3 of cases and bilateral in 1/3, and may represent a genetic predisposition to cancer. RB survivors are at risk of disease- and treatment-related adverse effects, including loss of vision or one eye, second cancer, genetic predisposition to cancer and reduced quality of life. The aim of our study is to investigate the management Bilateral Retinoblastoma and its impact on the lives of survivors. Method: We report in this retrospective study of 15 cases collected at the Department of Hematology and Pediatric Oncology at CHU Mohammed VI in Marrakech over a 12-year period, from January 2012 to June 2O24. Result: The mean age was 1 year and 5 months with a slight male predominance (60%). No patients had a family history of retinoblastoma. Consanguinity was present in 26%. The most frequent reasons for consultation were: leukocoria (86.6%), strabismus (33.3%) and exophthalmos (13.33%). The majority of patients (80%) were seen within 6 to 14 months, with an average delay of 9 months. Diagnosis was based on ophthalmoscopic examination, ultrasound and CT scan data, while histological examination of the surgical specimen enabled confirmation of the diagnosis and prognostic classification. Optic nerve invasion was found in 3 cases, and choroidal involvement in 3 patients. Therapeutically, enucleation was required in most cases, given the advanced stage of the tumours (86.66%): enucleation of the right eye in 4 patients, enucleation of the left eye in 2 patients, and bilateral enucleation in 8 patients, given the advanced stage of the tumours. Neoadjuvant chemotherapy was indicated in 46.6% of cases, to facilitate enucleation. Eleven 11 patients (73.3%) received post-operative chemotherapy, 3 patients received unilateral conservative treatment (thermotherapy, cryot…
subject: Articles
  topic: section
subject: Bilateral Retinoblastoma
  topic: keywords
subject: Enucleation
  topic: keywords
subject: Chemotherapy
  topic: keywords
subject: Survivor
  topic: keywords
creator: Banane NK
creator: Saadi F
creator: Hanafi J
creator: El Houdzi
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-12-20
publication date: 2024-12-20
starting page: 1
ending page: 3
doi: 10.47363/JDCRS/2024(5)152

The Effect and Significance of Mild Hypothermia Adjuvant Therapy on Serum IL-6 and TNF-α in Neonatal Hypoxic-Ischemic Encephalopathy
type: item
description: Objective: To investigate the effect of systemic mild hypothermia therapy on peripheral blood interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) in neonates with hypoxic-ischemic encephalopathy (HIE) within 6 hours after birth. Methods: Forty neonates with HIE within 6 hours after birth, who were admitted to the neonatal intensive care unit of Shangqiu First People's Hospital in Henan Province from October 2021 to October 2023, were selected as the research objects. They were divided into the mild hypothermia group and the conventional treatment group according to the treatment method. The children in the conventional treatment group received conventional supportive treatment, while those in the mild hypothermia group were given head mild hypothermia treatment and conventional supportive treatment. Peripheral blood IL-6 and TNF-α were measured in all children at admission and 72 hours after treatment. Neonatal Behavioral Neurological Assessment (NBNA) scale scores were performed at 14 and 28 days after birth. Results: There was no significant difference in the levels of blood IL-6 and TNF-α in HIE children of the conventional treatment group 72 hours after treatment compared with those at admission (P > 0.05). 2. The levels of blood IL-6 and TNF-α in HIE children of the mild hypothermia group 72 hours after treatment were significantly lower than those at admission (P < 0.05). 3. 72 hours after treatment, the levels of blood IL-6 and TNF-α in moderate HIE children of the mild hypothermia group were significantly lower than those in moderate HIE children of the conventional treatment group (P <0.05). 4. 72 hours after treatment, the levels of blood IL-6 and TNF-α in severe HIE children of the mild hypothermia group were significantly lower than those in severe HIE children of the conventional treatment group (P < 0.05). 5. At 14 and 28 days after birth, the NBNA scores of HIE children in the mild hypothermia group were significantly higher than those in the conve…
subject: Articles
  topic: section
subject: Mild Hypothermia
  topic: keywords
subject: Hypoxic-ischemic Encephalopathy
  topic: keywords
subject: Regulatory
  topic: keywords
subject: Tumor Necrosis Factor
  topic: keywords
subject: Interleukin-6, NBNA Score
  topic: keywords
creator: Wang Shengli
creator: Mi Nan
creator: Liu Yulu
creator: Wang Dong
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2025-01-24
publication date: 2025-01-24
starting page: 1
ending page: 3
doi: 10.47363/JDCRS/2025(6)153

Von Meyenburg Complex in a Cat and a Dog, and Mini Literature Review
type: item
description: Biopsies of liver from a 10-year-one-month-old male, neutered dog and an adult, male, domestic short haired cat of unknown age were received and microscopically examined. In both cases ectatic bile ducts consistent with von Meyenburg complex also known as bile duct hamartoma (BDH) was diagnosed. The epithelium reacted positive for E-cadherin and CK7 by immunohistochemistry (IHC). Bile duct hamartoma is rare in dogs and cats. BDH is reported to be due to failure of involution of embryological remnant during embryogenesis. The current brief report describes cases of bile duct hamartoma in an adult dog and a cat and would contribute to the literature on BDH in felines and canines.
subject: Articles
  topic: section
subject: Bile Duct Hamartoma
  topic: keywords
subject: Cat
  topic: keywords
subject: CK7
  topic: keywords
subject: Dog
  topic: keywords
subject: E-Cadherin
  topic: keywords
subject: Von Meyenburg
  topic: keywords
subject: Complex
  topic: keywords
creator: Woldemeskel M
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-11-30
publication date: 2024-11-30
starting page: 1
ending page: 2
doi: 10.47363/JDCRS/2024(5)151

Effect of Continuous Veno-Venous Hemodiafiltration Combined with Hem Perfusion on NLRP3 Levels and Prognosis in Children with Severe Sepsis
type: item
description: Objectives: To explore the effect of continuous veno-venous hemodiafiltration (CVVHDF) + hemoperfusion (HP) on the level of nucleotide-binding oligomerization receptor protein 3 (NLRP3) and prognosis in children with severe sepsis. Methods: This study is a prospective study. The research subjects are children with severe sepsis who were admitted to the Pediatric Intensive Care Unit (PICU) of the First Affiliated Hospital of Xinxiang Medical College from October 2021 to December 2023. The general information of the children, NLRP3 inflammasome levels in peripheral blood before and after treatment, Pediatric Sequential Organ Failure Assessment (pSOFA) score, incidence of sepsisassociated organ dysfunction (SAOD) during hospitalization, total hospital stays, PICU stay, and 28 Statistical analysis was performed on the prognosis of the day. Results: Fifteen children underwent blood purification treatment (blood purification group) while another fifteen children underwent conventional treatment (conventional treatment group). After 72 hours, both groups showed a significant decrease in serum NLRP3 inflammasome levels (p<0.01), with the blood purification treatment group exhibiting a faster decline rate than the conventional treatment group. The pediatric sequential organ failure score (pSOFA) in the blood purification treatment group (CVVHDF+HP) decreased more than in the conventional treatment group. Additionally, the incidence of sepsis-associated organ dysfunction (SAOD) during hospitalization was lower in the blood purification treatment group compared to the conventional treatment group (p=0.039). Moreover, the hospitalization duration was significantly shorter in the blood purification treatment group than in the conventional treatment group (p<0.05). Conclusion: Blood purification treatment (CVVHDF+HP) can reduce the early levels of NLRP3 in children with severe sepsis, reduce organ damage, and improve prognosis.
subject: Articles
  topic: section
subject: NLRP3 Inflammasome
  topic: keywords
subject: Sepsis
  topic: keywords
subject: Blood Purification
  topic: keywords
subject: Children
  topic: keywords
creator: Shujun Li
creator: Peng Shen
creator: Xue Liu
creator: Zhiyuan Wang
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-09-20
publication date: 2024-09-20
starting page: 1
ending page: 5
doi: 10.47363/JDCRS/2024(5)145

Enhancing Paediatric Diagnostic Accuracy: A Case Report on the Clinical Utility of Med Brain in Nigeria
type: item
description: Diagnosing childhood illnesses can often be challenging, particularly with conditions that share overlapping symptoms. This case report examines the role of MedBrain, a Clinical Decision Support System (CDSS), in diagnosing common childhood illnesses. The report discusses two clinical cases involving a 9-year-old child diagnosed with chickenpox and a 4-year-old child diagnosed with measles, both in Nigeria. For each case, MedBrain provided a differential diagnosis with a ranked list of diseases and associated diagnostic scores based on the system's algorithms. The predicted diagnoses were evaluated and validated by paediatricians, demonstrating the diagnostic clinical utility of MedBrain. This case report offered valuable insights into MedBrain's functionality, clinical relevance, and potential in clinical research, with the capability to improve diagnostic accuracy in paediatric care.
subject: Articles
  topic: section
subject: CDSS
  topic: keywords
subject: Childhood
  topic: keywords
subject: Paediatric
  topic: keywords
subject: Overlapping Symptoms
  topic: keywords
subject: Ranking
  topic: keywords
creator: George Uchenna Eleje
creator: Paul Chibuike Dinwoke
creator: Emeka Stephen Edokwe
creator: Nnanyelugo Chima Ezeora
creator: Chukwuemeka Chidindu Njoku
creator: Isaiah Chukwuebuka Umeoranefo
creator: Chigozie Geoffrey Okafor
creator: Ezinne Ifeyinwa Nwaneli
creator: Joshua Alexander Usuah
creator: Ohireime Lawrence Ikhide
creator: Denis Richard Shatima
creator: Chiesonu Dymphna Nzeduba
creator: Obinna Chukwuebuka Nduagubam
creator: Chisom Adaobi Nri-Ezedi
creator: Johnbosco Emmanuel Mamah
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2025-02-10
publication date: 2025-02-10
starting page: 1
ending page: 4
doi: 10.47363/JDCRS/2025(6)154

Successful Conversion Surgery of Common Hepatic Arterial and Portal Vein Resection Combined with Preoperative Chemotherapy and Coil Embolization for Locally Advanced Pancreatic Cancer: A Case Report
type: item
description: The standard treatment for unresectable locally advanced pancreatic ductal adenocarcinoma (UR-LA PDAC) is chemotherapy or chemoradiotherapy except for surgery. Although conversion surgery (CS) for UR-LA PDAC has been useful strategy, owing to recent advances in the other treatment, the significance and safety of CS remains unclear. We described a case of successful conversion surgery of common hepatic arterial and portal vein resection combined with chemotherapy and preoperative coil embolization for locally advanced pancreatic cancer. A 65-year-old man was diagnosed with UR-LA PDAC which was in contact with common hepatic artery (CHA) -gastroduodenal artery (GDA)-proper hepatic artery (PHA), with invasion extending from the superior mesenteric vein (SMV) to portal vein (PV) without distant metastasis. After gemcitabine plus nab-paclitaxel, the primary tumor had decreased and tumor contacts with the CHA and invasion extending from the SMV to PV were still observed, indicating to the change of borderline resectable PDAC (BR-A). We performed preoperative CHA and GDA embolization to prevent postoperative ischemic complications. Five days after embolization, pancreaticoduodenectomy (PD) with common hepatic arterial resection and portal vein resection were performed, preserving right gastric artery (RGA). Arterial reconstruction was not performed as intraoperative ultrasonography confirmed RGA-PHA blood flow was sufficient to cover the bilateral lobes of the liver. Although liver enzymes levels were moderately increased, the patient was discharged on postoperative day 15 without any ischemic liver event. He had received adjuvant chemotherapy with S-1 for 12 months and alive at 36 months after initial treatment without any tumor recurrence.
subject: Articles
  topic: section
subject: Unresectable Pancreatic Cancer
  topic: keywords
subject: Conversion Surgery
  topic: keywords
subject: Preoperative Arterial Embolization
  topic: keywords
creator: Atsushi Miyamoto
creator: Shingo Noura
creator: Kazuhiro Nishikawa
creator: Ryohei Kawabata
creator: Akihiro Kuriu
creator: Mitsunobu Imazato
creator: Yumiko Yasuhara
creator: Masahisa Nakamura
creator: Tomohira Takeoka
creator: Nobuyoshi Ohara
creator: Yuki Ushimaru
creator: Shin Nakahira
creator: Masahiro Murakami
creator: Hideo Tomihara
creator: Sakae Maeda
creator: Akihiro Kitagawa
creator: Hiroki Ohzato
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-07-30
publication date: 2024-07-30
starting page: 1
ending page: 4
doi: 10.47363/JDCRS/2024(5)144

https://srcpublishers.com/diagnosis-case-reports/article/view/5054
type: item
title: Safety and Efficacy of Low-Dose Regorafenib Combined with Nivolumab in Patients with Advanced HCC in Progression Beyond Two or More Lines of Tyrosine Kinase Inhibitors: Case Reportsand Short Review of the Literature
description: Background and Aims: A few clinical studies have suggested that low doses of anti-angiogenic molecules might enhance the therapeutic effects of anti-PD1 in HCC and may improve their tolerance. Here, we present case reports of patients treated with low-dose regorafenib combined with nivolumab after the failure of at least two lines of oral chemotherapy. Design: We report 12 observations of patients with advanced HCC in progression after at least two lines of tyrosine kinase inhibitor (TKI) therapy who received regorafenib (starting with 80 mg/day) combined with nivolumab (3 mg/kg/14 days/IV) until progression or unacceptable toxicity.The safety based on NCI-CTCAE 4 and the clinical efficacy (progression free survival, overall response rate, disease control rate, time to treatment response and median duration of response) were retropectively assessed. Results: Median age was 68 years (IQR [64; 71.5]), and 75% had BCLC-C. The median follow-up was 18.8 months (IQR [11.5; 23.4]) and the median duration of treatment was 10 months (IQR [3.8 ;17]). Because of the frequent early adverse events associated with regorafenib, this treatment remained at an initial dose of 80 mg/day in all patients. Of note, most grade III adverse events (AEs) occurred later after a median duration of combined treatment of 10.5 months (IQR ), were also mainly due to regorafenib, but allowed the pursuit of nivolumab alone [5,11,5]. The therapeutic combination led to a partial response in three patients (30 %) and a stable disease in two patients (20 %), corresponding to a disease control rate of 50% at 12 months in the 10 patients who were trated more than 2 months. The median TTR was 2 months (IQR) [1-9]. The median duration of disease control and response was 22 (IQR [21; 24] ) and 24 months (IQR), respectively [23-25]. Conclusion: Combination of low-dose regorafenib and nivolumab might be associated with an interesting disease control rate and manageable safety profile in patients with progressi…
subject: Articles
  topic: section
subject: Hepatocellular Carcinoma
  topic: keywords
subject: Checkpoint Inhibitor
  topic: keywords
subject: Tyrosine Kinase Inhibitor
  topic: keywords
subject: Nivolumab
  topic: keywords
subject: Regorafenib
  topic: keywords
creator: Olivier Rosmorduc
creator: Pascal Hammel
creator: Audrey Coilly
creator: Jean-Charles Duclos-Vallee
creator: Emma Goldschmidt
creator: Jamila Faivre
creator: Alina Pascale
creator: Antoinette Lemoine-Corbel
creator: Catherine Guettier
creator: Maite Lewin
creator: Astrid Laurent Bellue
creator: Yasmina Ben Merabet
creator: Didier Samuel
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-07-15
publication date: 2024-07-15
starting page: 1
ending page: 9
doi: 10.47363/JDCRS/2024(5)146

Effect of COVID-19 Period on Tuberculosis Treatment Success; A Mixed Methods Study among Tuberculosis Patients at Jinja Regional Referral Hospital
type: item
description: Introduction: Before the COVID-19 pandemic, over 4000 people were dying from TB every day. TB is still a major public health threat globally, but the TB epidemic may be exacerbated by the COVID-19 pandemic. The lockdown in response to the pandemic and the events related to it can have an adverse epidemiologic impact on TB treatment outcome through its effect on poverty, and dietary intakes. Objectives: Therefore, this study during COVID-19 would determine the effect of COVID-19 period on Tuberculosis Treatment success among TB patients. Methods: Sequential explanatory mixed methods were used. A retrospective cohort study was employed for the quantitative component to determine the association between COVID-19 period and Tuberculosis treatment success among Tuberculosis Patients at Jinja Regional Referral Hospital. A data abstraction sheet was used to extract the required data from the TB treatment registers. Treatment outcomes was dichotomized as successful treatment outcome and poor treatment outcome. Modified possion regression was used to explore associations between treatment outcome and other independent variables. A qualitative study with a phenomenology approach was adopted to get an in-depth understanding to the barriers and facilitators to treatment success during the COVID era among Tuberculosis Patients at Jinja Regional Referral Hospital. The lived experience of the TB patients who had participated in the quantitative component was captured. Data from audio recordings was transcribed and analyzed using a deductive thematic analysis to explore barriers and facilitators. Results: There was no significant effect of COVID-19 Period on TB treatment Success (aRR=1.04: 95% CI 0.78-1.38). In addition, sex, HIV status, age, distance from the health facility, disease classification and treatment mode were not significantly associated with treatment success. The barrier to treatment success were lack of adequate health care information, fearing the COVID thing in t…
subject: Articles
  topic: section
subject: Corona Virus Disease 2019
  topic: keywords
subject: Directly Observed Treatment
  topic: keywords
subject: Short-course
  topic: keywords
subject: Tuberculosis
  topic: keywords
subject: Pulmonary TB
  topic: keywords
subject: Severe Acute Respiratory Syndrome
  topic: keywords
subject: Multidrug-Resistant Tuberculosis
  topic: keywords
creator: Higenyi James
creator: Achilles Katamba
creator: Mupere Ezekiel
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-08-12
publication date: 2024-08-12
starting page: 1
ending page: 16
doi: 10.47363/JDCRS/2024(5)150

Relapsed Bacterial Meningitis in an Adolescent Patient with Aberrant Patent Foramen Caecum
type: item
description: Bacterial meningitis is a serious life-threatening condition. Recurrent meningitis is defined as two independent episodes of meningitis that are separated by a period of convalescence and full recovery. Therefore, true recurrence results from a re-infection with the same or a different bacterial organism. In contrast, recrudescence and relapsed meningitis (RBM) represent persistence of the initial infection resulting from treatment failure. Both are uncommon and could be due to anatomic anomalies of the skull, traumatic head injury with secondary CSF fistula, complement deficiency or spread from a para meningeal infection. We present a case of a 13 years old healthy adolescent boy with no significant past medical history, who presented with flu like symptoms and altered mental status. His work up showed Streptococcus pneumoniae meningitis. While receiving effective IV treatment, on day 7 the patient became symptomatic again with fever, vomiting and prostration. Repeat blood tests showed an increase in total white cell count, neutrophils and inflammatory markers. In order to determine the underlying pathology, a repeat CT-scan of head followed by an MRI was done that showed an aberrant patent foramen caecum, that appeared to be the most likely cause of the relapse. This case report illustrates the importance of a search for an anatomical abnormality to be a cause of RBM, even in an adolescent.
subject: Articles
  topic: section
subject: Relapsed Bacterial Meningitis
  topic: keywords
subject: Adolescent Patient
  topic: keywords
creator: Sobia Nawaz
creator: Stephen Kohlhoff
creator: Mathew Hansen
creator: Ratna Basak
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-07-15
publication date: 2024-07-15
starting page: 1
ending page: 2
doi: 10.47363/JDCRS/2024(5)149

Fortified Pregnancy: A Case Report of Heterotopic Gestation with A Successful Obstetrical Outcome
type: item
description: Heterotopic pregnancy is a rare condition when at least two pregnancies are present simultaneously at different implantation sites. Such cases may lead to devastating outcomes if nor properly handled. The index patient is a 38 year old Gravida 6 Para 4 (4014), who presented with severe hypogastric pain, pallor, amenorrhea with positive pregnancy test and a transvaginal ultrasound showing a strong consideration of heterotopic gestation. Emergency exploratory laparotomy for ruptured tubal pregnancy, Left salpingectomy, and evacuation of hemoperitoneum was done, with a bulbously enlarged left fallopian tube with a 2-cm point of rupture seen intraoperatively. The procedure was well tolerated and postoperative course was generally uneventful. Repeat transvaginal ultrasound on hospital day three prior to discharge revealed a live intrauterine gestation at 10 weeks and 1 day. At 38 weeks and 1 day age of gestation, the patient delivered vaginally to a term, live, baby boy in cephalic presentation, birth weight of 3600 grams, APGAR score of 8, 9 followed by postpartum intrauterine device insertion. The patient was eventually discharged on hospital day 2 without fetomaternal complications. In conclusion, a successful intrauterine pregnancy with a ruptured heterotopic gestation who underwent surgical intervention though rare is a great possibility. Still, high index of suspicion, complete history and physical examination, sonographic findings in the light of a pregnancy test positive are all imperative to its diagnosis and appropriate management.
subject: Articles
  topic: section
subject: Heterotopic Pregnancy
  topic: keywords
subject: Ectopic Pregnancy
  topic: keywords
subject: Viable Pregnancy
  topic: keywords
creator: Ciela Kadeshka A Fuentes
creator: Auran Rosanne B Cortes
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-06-29
publication date: 2024-06-29
starting page: 1
ending page: 4
doi: 10.47363/JDCRS/2024(5)148

Microscopic Analysis on Structural Morphologies of Total Protein Isolates from Two Varieties (DAS and BS) of Nigerian CultivatedSolojo Cowpea (Vigna Unguiculata L. Walp)
type: item
description: Structural morphologies of total protein isolate of two varieties of solojo cowpea were studied by scanning electron microscope (SEM). The morphological properties of raw and germinated protein isolates of DAS and BS are presented in Figures. 4.42 – 4.53. Results showed the apparent structural differences between them. The Raw DAS showed plate like structure with relatively smooth surface topography with large cavities while Raw BS showed flaky structure like that of Albumins. This pattern is similar to that of albumin shapes of the Great Northern Bean, field pea protein and that of Crotalaria pallida. The SEM micrographs results of DAS isolates revealed smooth lamella with flake-like structures on it, having large particle sizes and irregular geometry shapes. Large vacuum spaces were also observed. After six hours of modification, a change in morphology of the original isolate was observed with disappearance of the plate-like and flake-like structure and the vacuum space; DAS 24 h protein isolates then exhibited a spongy plate like structure. Rise in the germination period to 36 h led to disappearance of the cloudy mass and formation of smooth non homogeneous mass. Further increase in the germination time to 48 and 72 h led to smoother mass with a few dispersed particles with cracked surface. The observation of the microstructure presentation from 36 h is also comparable to that obtained for bitter vetch (Vicia ervilia) protein films strengthened by microbial transglutaminase, in this case, the images of BVPC films containing mTGase clearly indicate a more compact microstructure, with evident continuous zones. The BS isolates morphology which presented a thin wafer-like structure like that of albumin, possessing wide surface area could in part justify the great solubility of albumins in neutral environment, enabling better access to water molecules. The structure was observed to become more homogeneous and compact, with no cavities as germination proceeded. The DAS…
subject: Articles
  topic: section
subject: Solojo Cowpea
  topic: keywords
subject: Under-Utilized Legumes
  topic: keywords
subject: BS
  topic: keywords
subject: DAS
  topic: keywords
subject: SEM
  topic: keywords
subject: Microstructure
  topic: keywords
subject: Total Protein Isolate
  topic: keywords
creator: Henry O Chibudike
creator: Olubamike A Adeyoju
creator: Kayode O Adebowale
creator: Bamidele I Olu-Owolabi
creator: Chinedum E Chibudike
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-04-15
publication date: 2024-04-15
starting page: 1
ending page: 5
doi: 10.47363/JDCRS/2024(5)147

Reviewing the Awareness of Mental Health Staff of the Possible Visual Side Effects of Antipsychotic Medications
type: item
description: Objective: A staff awareness project was undertaken in order to assess the awareness of clinical staff working in a UK community psychiatry practice of the visual side effects of antipsychotic medications. Study Design: A staff questionnaire was provided to assess baseline knowledge of the visual side effects of antipsychotic medication (the First Questionnaire). Subsequently, a short information sheet was provided regarding the visual side effects of antipsychotic medications. A Second Questionnaire for clinical staff was provided to assess reflections on knowledge gained. Results: 100% of respondents to the Second Questionnaire found the information sheet informative in refreshing or providing knowledge. 100% of the respondents to the Second Questionnaire also found the information sheet had improved their knowledge of the impact of antipsychotic on vision, and how it can be managed. 100% of respondents stated the information provided would influence their care of patients on antipsychotics and how they might approach care. Conclusion: Antipsychotic medications can cause ocular complications and visual side effects. Staff and patient education regarding these potential side effects can help promote patient safety.
subject: Articles
  topic: section
subject: Antipsychotics
  topic: keywords
subject: Vision
  topic: keywords
subject: Side Effects
  topic: keywords
creator: Merina Kurian
creator: Robeena Ismail
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-02-15
publication date: 2024-02-15
starting page: 1
ending page: 10
doi: 10.47363/JDCRS/2024(5)143

Unruptured Ovarian Ectopic Pregnancy- A Case Report
type: item
description: Background: Ectopic pregnancy complicates 2% of all pregnancies, and accounts for 6% of pregnancy-related mortality [1]. It ends with rupture before the end of the first trimester [2]. Case Report: We report a case of a 27 yr old primigravida with unruptured left ovarian ectopic pregnancy treated with a wedge resection of ovary laparoscopically. Post-operative period of the patient was uneventful. Conclusion: Ovarian pregnancies are rare, and unruptured ovarian pregnancies are rarer. Early detection and treatment plays an important role in prevention of serious complications.
subject: Articles
  topic: section
subject: Ectopic Pregnancy
  topic: keywords
subject: Unruptured
  topic: keywords
subject: Laparoscopic Ovarian Resection
  topic: keywords
creator: Nidhi Sapolia
creator: Samar Qasem
creator: Shushma Shetiya
creator: Wael Hosni
rights: Copyright (c) 2024 Journal of Diagnosis & Case Reports
date: 2024-02-09
publication date: 2024-02-09
starting page: 1
ending page: 3
doi: 10.47363/JDCRS/2024(5)142

A Rare Cause of Neck Mass in an Adult Woman- Cervical Thymic Cyst - A Case Report
type: item
description: Background: Cervical thymic cysts (CTCs) develop from the thymo-pharyngeal duct, representing less than 0.5% of all neck masses. Most of the cases are diagnosed in the first decade of life, being rarely described in adults. The majority of CTCs are located on the left side, the rest develop on the right side or in the midline. The patients present usually with a painless mass, rarely with compressive signs. The mechanisms of CTCs occurrence are still debated, failure of involution of thymopharyngeal duct, arrest in migration or retained thymic tissue during descent, being considered. Case Presentation: We report a case of a 49-year-old woman who presented a left laterocervical mass, with rapid growth over several months. The lump was soft, mobile and painless, no other clinical abnormalities were noticed. The ultrasound described an anechoic nodule of 57/38/63 mm at the inferior pole of the left thyroid lobe, raising the suspicion of a parathyroid cyst or branchial cyst. Contrast-enhanced CT scan confirmed the well-defined, homogeneous cystic lesion of 35/25 mm, located between the trachea and common carotid artery, being delimitated inferiorly by the left brachiocephalic vein. The aspiration of the cyst resulted in 40 ml of water-clear fluid, cytology examination confirmed the absence of thyroid or parathyroid cells. Surgery was performed, the pathological diagnosis confirmed the CTC. Conclusion: Although the thymic cyst is a very rare cause of a cervical mass in adult, the diagnosis should be kept in mind, based on clinical presentation, ultrasound and CT features, respectively aspirated fluid characteristics.
subject: Articles
  topic: section
subject: Cervical Thymic Cyst
  topic: keywords
subject: Thymo-Pharyngeal Duct
  topic: keywords
subject: Cervical Ultrasound
  topic: keywords
subject: Neck Mass
  topic: keywords
creator: Ana-Silvia Corlan
creator: Ioana Golu
creator: Melania Balas
creator: Mărioara Cornianu
creator: Daniela Amzar
creator: Ioana Natalia Milos
creator: Mihaela Vlad
rights: Copyright (c) 2025 Journal of Diagnosis & Case Reports
date: 2023-10-26
publication date: 2023-10-26
starting page: 1
ending page: 4
doi: 10.47363/JDCRS/2023(4)141

Perception and Practice of Cervical Cancer Screening among Female Professionals Attending Gynaecology Clinic at A University Teaching Hospital
type: item
description: Background: By using the right screening tools and preventative measures, cervical cancer can be avoided. However, the underuse of preventative measures is caused by a lack of information and awareness. Professional women with sufficient knowledge can have a significant positive impact on the attitudes and behaviours of the broader public. So, we evaluated how professional women perceived and used cervical cancer screening. Objectives: To evaluate how female professionals who visit gynaecology clinics view and approach cervical cancer screening. Methods: A cohort of 160 consenting female professionals working at the Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria, were used in this facility-based, single-center, descriptive, cross-sectional study. Participants filled up questionnaires about their knowledge assessment, screening for cervical cancer, and personal characteristics that influence them. Simple percentages, charts, and IBM SPSS Statistics 26 for Windows, version 26.0 (IBM Corp., Armonk, NY, USA) were used to portray and analyse the data. Results: The analysis employed a total of 160 questionnaires completed by research participants. All of the selected female professionals knew about cervical cancer screening, with nurses (49.3%) making up the majority. However, just 29.6% of them were aware that cervical cancer is connected to sexually transmitted diseases, and 33.2% were unaware that it is connected to age at first sexual activity. Only 93.2% of respondents had heard of Pap smears, despite the fact that every respondent had heard and read about cervical cancer and its screening. Despite the knowledge, only 44 (27.5%) had performed Pap tests and only 76(47.5%) had ever recommended cervical cancer screening to people. Of the women surveyed, 148 (92.5%) said they would be willing to have a cervical cancer screening, while 18 (11.25%) said they would decline. Conclusion: Despite more knowledge and awareness, the rate of cervical cancer sc…
subject: Articles
  topic: section
subject: Cervical Cancer Screening
  topic: keywords
subject: Female Professionals
  topic: keywords
subject: Nnewi
  topic: keywords
creator: George U Eleje
creator: JohnBosco E Mamah
creator: Uchenna C Chijioke-Ofoma
creator: Chinekwu S Anyaoku
creator: Theophilus N Agbo
creator: Obiora Donatus Ugwu
creator: Kingsley E Ekwuazi
creator: Arinze A Onwuegbuna
creator: Boniface C Okpala
creator: Obinna K Nnabuchi
creator: Toochukwu B Ejikeme
creator: Stanley C Egbogu
creator: Ngozichukwu G Uzoewulu
creator: Ifeanyi J Onyekpa
creator: Nnanyereugo L Onah
creator: Chika I Ofiaeli
creator: Charlotte B Oguejiofor
creator: James E Okonkwo
creator: John E James
creator: Obinna C Okafor
creator: Chukwuemeka C Okoro
creator: Chigozie G Okafor
creator: Chijioke O Ezeigwe
creator: Michel C Egbuniwe
creator: Emmanuel C Egwuatu
creator: Boniface U Odugu
creator: Sylvester O Nweze
creator: Ekene A Emeka
creator: Onyeka C Ekwebene
rights: Copyright (c) 2023 Journal of Diagnosis & Case Reports
date: 2023-07-21
publication date: 2023-07-21
starting page: 1
ending page: 6
doi: 10.47363/JDCRS/2023(4)135

An Epiduroscopy Complication Mimicking a Subarachnoid Haemorrhage: Case Report
type: item
description: Epiduroscopy is an endoscopic technique which permits to explore lumbosacral epidural interspace. It is a useful technique for pharmacological treatment in failed back surgery syndrome, which represents a chronic waist pain. Even if it is a risky procedure, epiduroscopy should be included in the diagnosis and treatment of patients whit post-surgical lower back pain. Several complications can occur during the procedure as infection, meningeal irritation, epidural bleeding. We report a failed procedure with injection in subdural space causing headache, vomiting, seizures, and hyperthermia, mimicking subarachnoid hemorrage in CT scan. The radiological findings and neurological symptoms underwent rapid and spontaneous complete resolution.
subject: Articles
  topic: section
subject: Epiduroscopy
  topic: keywords
subject: Back Pain
  topic: keywords
subject: Subarachnoid Hemorrage
  topic: keywords
creator: Antonello Curcio
creator: Marcello Passalacqua
creator: Gerardo Caruso
creator: Fabio Cacciola
creator: Giulio Di Noto
creator: Rosaria Abbritti
rights: Copyright (c) 2023 Journal of Diagnosis & Case Reports
date: 2023-08-31
publication date: 2023-08-31
starting page: 1
ending page: 3
doi: 10.47363/JDCRS/2023(4)151

Bleeding and its Management
type: item
description: Blood is a connective tissue in fluid form. It carries oxygen from lungs to all parts of the body and CO2 from all parts of body to lungs. Blood contains blood cells (RBC, WBC, PLATELETS) and liquid portion known as plasma.
subject: Articles
  topic: section
subject: Bleeding
  topic: keywords
subject: Coagulation
  topic: keywords
subject: Clotting Factor
  topic: keywords
creator: Hemalatha DM
creator: Arjun MR
creator: Jilu Jessy Abraham
creator: Harfath P
creator: Gopika T V
rights: Copyright (c) 2023 Journal of Diagnosis & Case Reports
date: 2023-07-21
publication date: 2023-07-21
starting page: 1
ending page: 5
doi: 10.47363/JDCRS/2023(4)137

The Biophysical Modelling of the Criteria in the Living Systems
type: item
description: Generally, the excitation is correlated with a local modification of the membrane potential; but if the depolarization is intense, it „propagates” and the electric features of the membrane of the entire cell change. The adaptation concept can have a narrower sphere, including only the functional, biophysical and anatomical modifications; in a wider meaning, the sphere extends to everything that represents changed functions and structures, which allow the development of life, even in extremely unfavourable environment conditions, until non lethal pathological alterations. Sexuality does not have only a reproductive biological function, but it has others as well: multiplicative, fortifying, selective, diversifying. The adaptation of organism to the life conditions is realized mainly by the adaptation of metabolism. Knowing the biophysical and biochemical regulation leads amongst others – to an even wider conception about the functions of the metabolism in the living organism.
subject: Articles
  topic: section
subject: Metabolism
  topic: keywords
subject: Secondary Criteria
  topic: keywords
subject: Biophysical Modelling
  topic: keywords
creator: Janos Vincze
creator: Gabriella Vincze-Tiszay
rights: Copyright (c) 2023 Journal of Diagnosis & Case Reports
date: 2023-07-17
publication date: 2023-07-17
starting page: 1
ending page: 4
doi: 10.47363/JDCRS/2023(4)138