Journal of Gastroenterology & Hepatology Reports
type: channel
description: Journal of Gastroenterology & Hepatology Reports is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Gastroenterology & Hepatology Reports. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Article acceptance will be in the form of research, review, case reports, analysis, magazines, editorials, opinion, communications, mini-review, short communications, picturized, book review, video type and power point presentations (PPTS). You can submit manuscripts online at: https://srcpublishers.com/gastroenterology-hepatology-repo/user/register or Email: gastroreports@onlinescientificresearch.info 1.023 Impact Factor 84.5% Citations 90% Acceptance
publisher: Scientific Research and Community
language: en
publication name: Journal of Gastroenterology & Hepatology Reports
issn: 2754-4931
items: Chronic Hyperinsulinemia Masquerading as Neuropsychiatric Disease: A Case of Uncinate Process Insulinoma Managed with Pancreaticoduodenectomy
items: Clinical Aspects of Pathomorphological Diagnosis of Hepatocellular Cacinoma in Practical Oncology
items: The Ambivalent Role of Food in Crohn’s Disease: An IDI Perspective
items: Prevalence, Quality of Life and Factors Associated with Dysmotility Among Outpatients in Dar Es Salaam, Tanzania: A Cross-Sectional Study
items: Genetic and Molecular Characteristics of Rare Malignant Tumors of The Colorectal Tract: A Comprehensive Genomic Profiling Study
items: Prevalence of Irritable Bowel Syndrome and Associated Factors Among Medical Students: A Cross-Sectional Study
items: Determination of the ED50 of Diarrhea Stop Capsule in Rats
items: The Difference in Metabolic and Chronological Age is Associated with Steatosis and Liver Fibrosis
items: Series of Clinical Studies on the Eradication of Helicobacter Pylori with the Potassium - Competitive Acid Blocker- Amoxicillin Dual - Therapy Regimen
items: Toward an Etiology of Celiac Disease
items: Successful Surgical Treatment of Anterior Fusion Implants Injury of the Cervical Esophagus: Two Case Reports
items: Endoscopy after Bariatric Surgery Case Series
items: Gastroenterology Viewed Through a Glass Darkly – An IDI Focused Perspective
items: Meditation, Yoga and Spiritual Fitness Heal Dementia and Brain Disorders
items: A Case Report of Non-Puerperal Galactorrhea Induced by Long Term Use of Domperidone and Literature Review
items: Log Odds of Positive Lymph Nodes Predict Surgical Prognosisin Intrahepatic Cholangiocarcinoma based on Seer Cohort and Nomogram Model
items: Effect of Combined Ethanol Leaf Extracts of Vernonia Amygdalina(Bitter Leave) and Gongronema Latifolium (Utazi) on Lead Induced Hepatoxicity in Wistar Rats
items: Pegylated Granulocyte Colony Stimulating Factor Combined with Anti-Pd-1/Pd-L1 Inhibitors in the Treatment of Recurrent or Metastatic Biliary Tract Cancer
items: Management of Gastrointestinal Failure in the Adult Critical Care Environment
items: Polyprenol-Based Nanoformulations: Dual-Platform Innovation for Parenteral and Diagnostic Applications
items: Novel Ultrasensitive Eco-Friendly Spectrophotometric Determination of Carvedilol in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing
items: Clinical Case: Colonic Metastasis of Operated Hepatocellular Carcinoma
items: The Dermatological Manifestations of Inflammatory Bowel Disease: Looks Might be Deceiving!
items: The Clinical Brilliance of Immunohistochemistry “IHC” in Gastrointestinal Oncology
items: Life After Breast Cancer: How Lymphedema Affects the Quality of Life in Women
items: https://srcpublishers.com/gastroenterology-hepatology-repo/article/view/4508
items: Gastric Outlet Obstruction Due to Actinomycosis, An Uncommon Presentation of a Rare Disease: A Case Report
items: Pulmonary Vascular Complications in Liver Disease: A Comprehensive Review of Porto-Pulmonary Hypertension and HepatopulmonarySyndrome with Illustrative Case Studies
items: The Clinical Spectrum of Liver Masses: Know Before You Judge
items: The Significance of Biliary Anatomical Variation as a Key Indicator in Laparoscopic Bile Duct Injuries

Chronic Hyperinsulinemia Masquerading as Neuropsychiatric Disease: A Case of Uncinate Process Insulinoma Managed with Pancreaticoduodenectomy
type: item
description: Insulinoma is the most surgically curable cause of endogenous hyperinsulinemia, yet it carries one of the longest average diagnostic delays in clinical endocrinology. The central reason is deceptively simple: its symptoms sweating, tremor, behavioral change, loss of consciousness are not intuitively hormonal. They are intuitively psychiatric, neurological, or cardiac. Patients are investigated for epilepsy, panic disorder, and cardiac arrhythmia while their fasting insulin levels remain unmeasured. This case illustrates that pattern in its most striking form: a 33-year-old woman whose recurrent episodes of syncope and progressive weight gain were attributed to lifestyle factors for two years before a structured biochemical evaluation revealed glucose of 26 mg/dL with a simultaneously elevated insulin and C-peptide. The clinical question this case raises is not merely how this was missed but why the correct diagnostic test was never ordered, and what structural changes in clinical practice might prevent the same delay from recurring. Case Presentation: A 33-year-old Albanian woman presented electively to Barleti University Polyclinic, Tirana, requesting a definitive diagnostic evaluation. She described a twoyear history of episodic weakness, profuse diaphoresis, dizziness, and recurrent loss of consciousness, with symptoms reliably occurring in the fasting state or during prolonged physical exertion. She had gained 20 kilograms over the same period and reported persistent hunger as a constant companion between episodes. Multiple emergency department visits had not yielded a diagnosis. Blood glucose had been recorded around 60 mg/dL on at least one occasion; she had been administered intravenous saline and counselled to eat sweets when symptoms arose. No hormonal investigation insulin, C-peptide, proinsulin had been ordered at any of these visits. No endocrinological referral had been made. On the day of her elective presentation, fasting blood samples were drawn duri…
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Insulinoma, Pancreatic Neuroendocrine Tumor, Endogenous Hyperinsulinemia, Uncinate Process, Pancreaticoduodenectomy, Non-Diabetic Hypoglycemia, Diagnostic Delay, Multidisciplinary Management, C-Peptide, Whipple Procedure
creator: Vrenos Hodaj
creator: Erti Ismahili
creator: Arben Baboci
creator: Ermira Goxha
creator: Erald Vasili
rights: Copyright (c) 2026 Journal of Gastroenterology & Hepatology Reports
date: 2026-06-22
publication date: 2026-06-22
starting page: 1
ending page: 6
doi: 10.47363/JGHR/2026(7)193

Clinical Aspects of Pathomorphological Diagnosis of Hepatocellular Cacinoma in Practical Oncology
type: item
description: In modern clinical oncology, pathomorphological verification of the tumor substrate is key, the purpose of which is to determine the type and genotypic affiliation of the tumor process, which in turn determines further treatment tactics, the sequence of existing treatment methods, determination of sensitivity to treatment, and also determines the prognosis of the disease. Some nosologies known to oncology require not only a standard set of cytological and histological tests for malignant neoplasms, but also additional immunohistochemical and molecular genetic profiling, performed through biopsy, excisional biopsy, or diagnostic surgery. Furthermore, definitive diagnosis based on radiological examination (CT, MRI, PET/CT) and tumor marker titers in peripheral blood remains clinically relevant. Currently, liver cancer hepatocellular carcinoma and/or cholangiocarcinoma is of greatest interest and complexity in the aforementioned verification. HCC ranks eighth in the oncological morbidity structure, with the number of newly diagnosed cases worldwide ranging from 820,000 to 850,000, with a consistent mortality rate of approximately 700,000 to 720,000 patients annually. This confirms the high mortality rate due to late staging of this pathology and the late onset of symptoms. This, in turn, determines the need for the introduction and application in clinical practice of periodic diagnostic and treatment protocols, the essence of which comes down to the existing algorithms for both diagnosis and treatment, according to which, in the case of widespread hepatocellular carcinoma/cholangiocarcinoma, when it is impossible to take biopsy material with the remaining risk of bleeding, CT/MRI confirmation of the characteristic pathognomonic signs of HCC/CCC with an increased titer level of the inherent tumor marker - AFP, CEA is sufficient. In clinical oncology, discrepancies between clinical and radiological confirmation of the tumor’s progression are common during specialized tre…
subject: Articles
  topic: section
subject: Hepatocellular Carcinoma, Undifferentiated Carcinoma, Morphological Verification, Rebiopsy
  topic: keywords
creator: Kurmanov Talgat Amanzholovich
creator: Issametov Davran Rashitovich
rights: Copyright (c) 2026 Journal of Gastroenterology & Hepatology Reports
date: 2026-06-17
publication date: 2026-06-17
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2026(7)192

The Ambivalent Role of Food in Crohn’s Disease: An IDI Perspective
type: item
description: Being astute interpreters of experiments-in-nature (diseases), ancient physicians thought of food as medicine. Food selection formed a significant part of their pharmacopeia. The pathogenesis of Crohn’s disease has now put into evidence food’s ability to both induce one of the major chronic diseases of industrialized nations and its ability to induce prolonged remission (and potentially permanent remission) of the very same disease that it had created. The induced addiction to therapy via pharmacopeia has obscured what ancient healers of men understood: food is medicine. With Crohn’s disease, food demonstrates its ambivalent potential. It is the first major chronic disease. For surgeons, the lesson is anatomical: the uncinate process is among the most technically demanding regions of the pancreas, and tumor location not tumor size determines whether enucleation is safe. When a lesion in this region lies in close proximity to the main pancreatic duct and the superior mesenteric vessels, pancreaticoduodenectomy is not an escalation of treatment but the anatomically correct response. Framing this choice accurately prevents both under-treatment and unnecessary patient anxiety about receiving a ‘bigger operation’ than expected. Insulinoma is a curable disease. The diagnostic and surgical tools to cure it exist and are accessible. What this case demonstrates is that multidisciplinary awareness spanning emergency medicine, endocrinology, radiology, and surgery is the non-negotiable prerequisite for translating those tools into outcomes.
subject: Articles
  topic: section
subject: Dietary Therapy, Mycobacterium Avium Subspecies Paratuberculosis, Crohn’s Disease, Food Adulteration
  topic: keywords
creator: Gilles RG Monif
rights: Copyright (c) 2026 Journal of Gastroenterology & Hepatology Reports
date: 2026-06-24
publication date: 2026-06-24
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2026(7)194

Prevalence, Quality of Life and Factors Associated with Dysmotility Among Outpatients in Dar Es Salaam, Tanzania: A Cross-Sectional Study
type: item
description: Background: Dysmotility (the most common form of dyspepsia) is highly prevalent in Western countries; however, there is little data regarding its prevalence, pattern, associated factors and impact on the quality of life in African countries. The aim of this study was to determine the prevalence, pattern, quality of life and factors associated with dysmotility among outpatients attending a regional hospital in Dar es Salaam, Tanzania. Methods: Between June 2013 and July 2013, a total of 1062 adults aged 18 years and above were recruited into this cross-sectional study and completed validated Swahili-language self-administered questionnaires. The Frequency Scale for the Symptoms of GERD Questionnaire was used as a diagnostic tool for dysmotility. Quality of life was assessed using the Quality of Life in Reflux and Dyspepsia (QOLRAD) Questionnaire. The prevalence of dysmotility was expressed as a proportion. The quality of life was expressed as Mean Quality of Life in Reflux and Dyspepsia (QOLRAD) dimension scores and was compared between subjects with dysmotility and subjects without dysmotility. Logistic regression analysis was used to test the significance of the associations between predictor variables and dysmotility. A p value of < 0.05 was considered significant. Results: The mean age ± standard deviation of the study subjects was 46.0±19.5 years and 60.5% were females. The prevalence of dysmotility was 35.0%. Current alcohol consumption (OR = 1.65, 95% CI; 1.01-2.71) was independently associated with dysmotility while male gender (OR = 0.71 95% CI; 0.53-0.94) was associated with 29% decreased odds of having dysmotility. The quality of life in subjects with dysmotility was lower than that of subjects without dysmotility in all five domains of the QOLRAD Questionnaire. Majority of patients with dyspepsia (66.9%) had sought medical advice and 67.7% took medications for their symptoms. Conclusions: The prevalence of dysmotility is high in this hospital-based popula…
subject: Articles
  topic: section
subject: Dysmotility, Prevalence, Associated Factors, HRQOL
  topic: keywords
creator: Komba E Komba E
creator: Nkandala I Nkandala I
creator: Mugusi F (Late) Mugusi F (Late)
rights: Copyright (c) 2026 Journal of Gastroenterology & Hepatology Reports
date: 2026-06-18
publication date: 2026-06-18
starting page: 1
ending page: 6
doi: 10.47363/JGHR/2026(7)191

Genetic and Molecular Characteristics of Rare Malignant Tumors of The Colorectal Tract: A Comprehensive Genomic Profiling Study
type: item
description: While the vast majority of colorectal tract malignancies are adenocarcinomas, a subset of rare histological subtypes including neuroendocrine carcinomas (NECs), gastrointestinal stromal tumors (GISTs), and primary colorectal lymphomas account for approximately 1–5% of cases. Due to their low incidence, the genomic landscape of these rare tumors remains poorly characterized. This study aimed to delineate the distinct genetic and molecular profiles of rare malignant colorectal tumors using next-generation sequencing (NGS) to identify potential therapeutic targets and elucidate their pathogenesis.
subject: Articles
  topic: section
subject: Genetic and Molecular
  topic: keywords
subject: Malignant Tumors
  topic: keywords
creator: Dejie Zheng Zheng
rights: Copyright (c) 2026 Journal of Gastroenterology & Hepatology Reports
date: 2026-04-30
publication date: 2026-04-30
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2026(7)190

Prevalence of Irritable Bowel Syndrome and Associated Factors Among Medical Students: A Cross-Sectional Study
type: item
description: Background: Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder with significant impact on quality of life. Medical students are considered a high-risk population due to increased psychological stress and lifestyle-related factors. Objective: This study aimed to determine the prevalence of IBS and associated factors among medical students. Methods: A cross-sectional study was conducted among 104 medical students. Data were collected through a structured questionnaire assessing demographic characteristics, gastrointestinal symptoms, and lifestyle-related factors. IBS diagnosis was based on self-reported symptoms. Results: IBS was identified in 31 students, corresponding to a prevalence of 29.8%. Gastrointestinal symptoms were reported by 93.5% of participants. Female students showed a higher tendency toward IBS. Most symptoms were mild, though some students experienced moderate to severe symptoms. Conclusion: IBS is highly prevalent among medical students. Stress, gender, and lifestyle factors appear to play significant roles. Early screening and preventive strategies are recommended.
subject: Articles
  topic: section
subject: Irritable Bowel Syndrome, Medical Students, Prevalence, Stress, Gastrointestinal Symptoms
  topic: keywords
creator: Hasret Ayyıldız Civan Civan
creator: Nour Sawas Sawas
creator: Maya al Halabi Halabi
rights: Copyright (c) 2026 Journal of Gastroenterology & Hepatology Reports
date: 2026-04-15
publication date: 2026-04-15
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2026(7)189

Determination of the ED50 of Diarrhea Stop Capsule in Rats
type: item
description: Introduction: Diarrhea remains a significant cause of morbidity and mortality globally, particularly in developing countries. The ED50 represents the doseat which 50% of the treated population exhibits a therapeutic response in case cessation of diarrhea. Objective: The aim of this study was to determine the median effective dose (ED50) of Diarrhea Stop Capsule in albino rats. Methods: A total of 70 rats were divided into seven groups (n=10/group) and administered increasing oral doses: 25, 50, 75, 100, 125, and 150 mg/kg, withone group as control. Diarrhea was induced by administered 2ml castor oil orally for each rat. Results: Responses were observed and recorded over 6 hours. The ED50 was calculated using the Probit method. The results show a dose-dependent effect,with an estimated ED50 of 83.4 mg/kg. Conclusion: The Diarrhea Stop Capsule demonstrated dose-dependent antidiarrheal activity in rat, with an ED₅₀ of approximately 83.4 mg/kg. These results support further pharmacological and clinical studies to standardize dosing protocols for human use.
subject: Articles
  topic: section
subject: Diarrhea
  topic: keywords
subject: Stop
  topic: keywords
subject: Capsule
  topic: keywords
subject: ED50
  topic: keywords
subject: Rats
  topic: keywords
creator: Hussien O Kadi
creator: Ismail Hamoud Ali Al geobri
creator: Abdulmalek Abu Donia
creator: Abdullalh Alharzi
creator: Mohammed H Kadi
rights: Copyright (c) 2026 Journal of Gastroenterology & Hepatology Reports
date: 2026-06-27
publication date: 2026-06-27
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2026(7)188

The Difference in Metabolic and Chronological Age is Associated with Steatosis and Liver Fibrosis
type: item
description: Background: The two most common types of fatty liver disease (steatosis) are nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD). NAFLD affects about 30% of people in Western countries and 10% of people in Asia. In the United States, rates are about 35%, with about 7% having severe NASH. NAFLD affects about 10% of children in the United States. Fat accumulation in the liver is accompanied by a disorder of a series of metabolic processes, i.e. metabolic dysfunction with multiple parallel metabolic shocks throughout the body. Material and Methods: A monocentric, controlled, randomized study was conducted involving 20 practically healthy individuals and 31 patients with hepatomegaly without additional specific symptoms of liver pathology. Liver steatosis degree measurement by the Controlled attenuation parameter (CAP) transient elastography. Metabological age (Met-age) was determined based on tetrapolar multifrequency bioimpedancemetry with vector analysis (BIM-V). Results and Discussion: MET-age younger to CHR-age has significantly more Body Cells Mass (BCM) proportion (50,5 (95%CI =50,0-51,1) vs. 43,9(95%CI =42,8-45,0) and less content of Fat Mass (in kg) fixed -14,7 (95%CI =13,7-15,6) vs. 27,9(95%CI =25,3-30,5. The parallel comparition analysis the MET-age, steatosis (STe) and liver fibrosis (F) show following. In practically healthy people Met-age oldest 2 years or more than CHR-age (Age Diff) was found in the subgroup with severe steatosis (S=3) in 88,9% (8 of 9)(95%CI=51,8 – 99,7) and in 1 of 11 individuals with mild.
subject: Articles
  topic: section
subject: Metabolic
  topic: keywords
subject: Chronological
  topic: keywords
subject: Liver Fibrosis
  topic: keywords
creator: Marakhouski Yury
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-26
publication date: 2025-04-26
starting page: 1
ending page: 1

Series of Clinical Studies on the Eradication of Helicobacter Pylori with the Potassium - Competitive Acid Blocker- Amoxicillin Dual - Therapy Regimen
type: item
description: In recent years, the Potassium - competitive acid blocker (P-CABs) - amoxicillin dual - therapy regimen has been recommended for the eradication of Helicobacter pylori (H.pylori). However, there are still uncertainties about the optimal drug dosage and treatment duration. Our research group carried out a series of multi - center clinical studies in Fujian Province, China, aiming to explore the efficacy and safety of this dual - therapy regimen for H.pylori eradication. The study covered different treatment durations (7 - day, 10 - day, and 14 - day), various types of P-CABs (vonoprazan, tegoprazan, and keprazan), and different dosages of P-CABs. The results demonstrated that the 10 - day and 14 - day dual - therapy regimens outperformed the 7 - day one, and the 10 - day regimen was non - inferior to the 14 - day one. Moreover, all dual - therapy regimens with different P-CABs achieved an eradication rate of over 90%, and the low - dose P-CABs-amoxicillin dual - therapy regimen was as effective as the high - dose one. These findings hold significant implications. In China, they can directly guide clinicians in Fujian and other regions to select more appropriate treatment options for H.pylori eradication, potentially improving the overall treatment efficiency and reducing unnecessary medical costs. On a global scale, considering the high prevalence of H.pylori infection worldwide, our research provides valuable references for international medical communities. It offers a new perspective on optimizing the P-CABs - amoxicillin dual - therapy regimen, which may contribute to the development of more standardized and effective treatment strategies for H.pylori eradication globally.
subject: Articles
  topic: section
subject: Clinical
  topic: keywords
subject: Helicobacter
  topic: keywords
subject: Amoxicillin Dual
  topic: keywords
subject: Therapy Regimen
  topic: keywords
creator: Xueping Huang
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-26
publication date: 2025-04-26
starting page: 1
ending page: 1
doi: 10.47363/tk4fvn87

Toward an Etiology of Celiac Disease
type: item
description: The review proposes a model of the etiology of celiac disease. It describes how an enteroviral attack by a lytic virus leads to hyper-extracellular Transglutaminase 2, (Tg2), evident at all stages of the disease by the presence of anti-tTG. The demand for Tg2 is supplied by both the cell and the lytic virus. The demand leads to excess Tg2 passing through the cell wall, excess ingress of Ca2+, the destruction of the mitochondria by Ca2+, and pyroptosis of the cell. The increase in extracellular Tg2 during the cell’s life and following pyroptosis has two effects. First, it binds a C1r inhibitor to the vascular wall, preventing C1r-LP from converting prehaptoglobin (zonulin) into haptoglobin, causing the weakening of the tight junctions among the epithelial cells and allowing the entry of extraneous luminal materials and particularly the access of Tg2 arterial and luminal, as it is now open directly to the lumen and the mesenchyme structure. It is this Tg2 that damages the villus structure as the Tg2 binds fibronectin into the mesenchyme, causing scarring, shrinkage, and turning the villi into the rigid scarred structures characteristic of CD. The model suggests why CD is a chronic lifelong disease reactivated upon the resumption of gluten consumption. A discussion of refractory CD follows. The paper explains how extracellular transglutaminase causes prehaptoglobin (zonulin) and damages the extracellular membrane. Thus, prehaptoglobin (zonulin) is a symptom, not a cause. Notably, the paper demonstrates that the basic tenet of autoimmune diseases that the cells destroy themselves is incorrect, at least for CD. Applying this etiology to other conditions may be relevant because of the almost universal glutaminolysis in cells and the substantial amount of Gluten in modern diets.
subject: Articles
  topic: section
subject: Etiology
  topic: keywords
subject: Celiac
  topic: keywords
subject: Disease
  topic: keywords
creator: Simon Williams
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-25
publication date: 2025-04-25
starting page: 1
ending page: 1
doi: 10.47363/841yn430

Successful Surgical Treatment of Anterior Fusion Implants Injury of the Cervical Esophagus: Two Case Reports
type: item
description: We report of two patient’s cases, who underwent anterior cervical fusion for polytrauma due to car accident. The patients suffered very rare complications of the surgery: cage dislocation into the cervical esophagus in first case and injury of esophageal wall with fistulae formation in the second one. By surgical treatment the extraction of the cage, removal the ventral plate and repair of the esophageal wall defect were performed. To prevent failure of the sutures placed on the wound of the esophagus, the method of covering the suture line with a pedicled flap cut from the medial portion of the sternocleidomastoid muscle was used. Feeding gastrostomy was also created. The control X-Ray examination was performed at 6th p/o day, which reveals no extravasation and free passage of contrast to the stomach. We consider, that the method of covering the suture line by pedicled flap from sternocleidomastoid muscle in cases of difficult suturing of defects of the cervical esophagus, is a good surgical option. Surgeons should be aware of the risk of implant injury of esophageal wall and cage dislocation of cervical fusion procedure.
subject: Articles
  topic: section
subject: Surgical
  topic: keywords
subject: Anterior Fusion
  topic: keywords
subject: Injury
  topic: keywords
subject: Cervical Esophagus
  topic: keywords
creator: Merab Kiladze
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-25
publication date: 2025-04-25
starting page: 1
ending page: 1
doi: 10.47363/rbwj8f58

Endoscopy after Bariatric Surgery Case Series
type: item
description: Morbid Obesity contributes to the constellation of medical comorbidities that comprise Metabolic Syndrome. As >2/3 of America is Overweight (BMI 25-29.9) or Obese (BMI 30+). There are many treatment modalities for Morbid Obesity, but none is more effective long term than Bariatric Surgery, not even the newest GLP-1 agonists can compete with the Laparoscopic Sleeve Gastrectomy (LSG) or the Roux-en-Y Gastric Bypass (RYGB). About 300,000 Metabolic and Bariatric Surgery (MBS) procedures were performed yearly (1/1000 population of the US per year). As surgical treatment for Morbid Obesity becomes more common, we as Gastroenterologists must continue to learn about the topic and how to treat potential complications. Sleeve Gastrectomy continues to be the most performed procedure, RYGB continues to be 20-25% of the MBS volume yearly. RYGB complications that may require Endoscopic interventions may include: Leak (which is usually at the Gastro-Jejunostomy/GJ) and may require stenting, Stricture (which may require dilation with either an endoscopic balloon or with a bougie, Formation of Marginal Ulcers, Bleeding (which can require any number of methods to control endoscopically, owing to the stomach’s rich blood supply), Perforation, Pouch or GJ enlargement. The Gastrogastric Fistula (GGF) is a rare (1%) but complex problem that requires clinical insight and suspicion. GGF typically presents with: weight regain, pain, worsening GERD symptoms. It may occur because of a complication from surgery (leak, infection, bleed) where a fistula forms between the gastric pouch and the remnant stomach due to a staple line breakdown. Alternatively, it may result from iatrogenic methods.
subject: Articles
  topic: section
subject: Endoscopy
  topic: keywords
subject: Bariatric
  topic: keywords
subject: Surgery
  topic: keywords
creator: Evelyn Inga
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2026-03-05
publication date: 2026-03-05
doi: 10.47363/enw17967

Gastroenterology Viewed Through a Glass Darkly – An IDI Focused Perspective
type: item
description: The linear expansion of medical information has already precipitated fragmentation of physician-based clinical care into multiple subspecialties predicated on site of disease dysfunction. Through the widespread expansion and dissemination of information in the areas of diagnostic and case-management, Artificial Intelligence (AI) stands to erode exclusivity of patient care and redirect committed populations to alternate healthcare providers. Governing a broad area of patient care, gastroenterologists have the responsibility to identify the canaries in the coal mine within their area of expertise. When canaries have been disregarded, the fiscal fallout has been significant: e.g. Individuals lacking production of gastric acid who developed peptic ulcer disease are just such canneries. When it was documented that PUD was of infectious disease causation and curable using antibiotics, the income of gastroenterologists dramatically decreased. Largely due to disease entities grouped under the term, Inflammatory Bowel Disease (IBD), gastroenterologists are currently the second-best compensated subspecialists within internal medicine. Not having addressed the discipline’s scientific deficiencies that were unmasked by the PUB debacle, gastroenterologists have set the stage for another fall from fiscal grace. This IDI Perspective is an analysis of gastroenterology’s vulnerable scientific underbelly, why history stands to repeat itself, and what can be done to minimize the consequences.
subject: Articles
  topic: section
subject: peptic ulcer disease
  topic: keywords
subject: Inflammatory Bowel Disease
  topic: keywords
subject: ulcerative colitis
  topic: keywords
creator: Gilles RG Monif
rights: Copyright (c) 2026 Journal of Gastroenterology & Hepatology Reports
date: 2026-03-05
publication date: 2026-03-05
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2026(7)187

Meditation, Yoga and Spiritual Fitness Heal Dementia and Brain Disorders
type: item
description: Older adults underestimate their level of life stress and early adversity, and kind of the impact that has. For some people, early adversity can affect their entire lives, but for other people, it seems like it catches up to them once they’re aging. our frontal lobes helping moderate our emotional responses. But the frontal lobes are also one of the main areas of the brain that begins to decline with age in terms of function. By sitting in any posture, standing, lying or walking for few minutes meditation include general wellbeing improvement, like decreasing depression and anxiety and improving sleep hygiene. By meditation like this one, you’re turning on the frontal lobes as you repeat the sounds and touch your fingers. Another area that becomes activated is the thalamus, which is a very core structure of the brain that helps regulate neuronal information flow. Most beneficial aspect of meditation training is increased self-control of emotions and attention. Psychologists are fond of touting the popular phrase “willpower is like a muscle,” meaning that the more a person practices delaying gratification, the easier it becomes to deny oneself in the short term for a better payoff later. As per the genetic makeup and climatic conditions different person will observe different sensation on body parts. The Gamma, Beta, Alpha, Theta and Delta ray regulate the brain activities as per sleep and function Fig. And so when you have these areas turned on, what that is basically doing is helping you better concentrate and regulate different parts of the brain. If you right now focus for the next few seconds or minutes on your breathing-breathe in and breathe out very slowly results in you’re going to reduce your heart rate, blood pressure and calm your brain down. So it is important to make sure that you can fully engage the practice whether it is meditation, prayer, yoga, or some other spiritual practice.
subject: Articles
  topic: section
subject: Spiritual Fitness
  topic: keywords
subject: Lifestyle
  topic: keywords
subject: Meditation
  topic: keywords
subject: Brain Disorders
  topic: keywords
subject: Memory Loss Improvement
  topic: keywords
subject: Prevention
  topic: keywords
subject: Stress
  topic: keywords
subject: Psychospiritual Well-Being
  topic: keywords
subject: Reduction of Risk Factors
  topic: keywords
creator: Ven Dr. Sumedh Thero
creator: Dr Aditya Suman
creator: Dr Pransuta Verma
rights: Copyright (c) 2026 Journal of Gastroenterology & Hepatology Reports
date: 2026-01-15
publication date: 2026-01-15
starting page: 1
ending page: 6
doi: 10.47363/JGHR/2026(7)186

A Case Report of Non-Puerperal Galactorrhea Induced by Long Term Use of Domperidone and Literature Review
type: item
description: Objective: To investigate the clinical features, pathogenesis, and key points of diagnosis and treatment of non-puerperal galactorrhea induced by long-term use of domperidone, aiming to enhance clinicians’ awareness of this adverse drug reaction and promote rational drug use. Method: The clinical data of a 54-year-old female patient with non-puerperal galactorrhea caused by long-term oral domperidone were reported. The case was discussed and analyzed in conjunction with a review of relevant literature. Results: The patient was a 54-year-old woman who presented with “intermittent galactorrhea for two weeks” and significant anxiety. For gastric discomfort, she had been taking domperidone (brand name: Motilium) 10 mg three times daily for two consecutive months. Upon admission, her serum prolactin level was found to be significantly elevated. Based on her medication history, a diagnosis of drug-induced hyperprolactinemia was considered. Domperidone was discontinued without any other specific treatment. Two weeks after cessation, the galactorrhea symptoms resolved, and a re-examination of serum prolactin returned to a normal level. Conclusion: As a peripheral dopamine D2 receptor antagonist, long-term use of domperidone can lead to hyperprolactinemia and galactorrhea by blocking dopamine receptors in the tuberoinfundibular pathway. Clinicians should pay close attention to its endocrine side effects, strictly adhere to the treatment duration recommended in the drug’s label, and strengthen physician-patient communication and adverse reaction monitoring during therapy to avoid unnecessary patient anxiety and waste of medical resources.
subject: Articles
  topic: section
subject: Domperidone
  topic: keywords
subject: Adverse Drug Reaction
  topic: keywords
subject: Hyperprolactinemia
  topic: keywords
subject: Galactorrhea
  topic: keywords
subject: Physician-Patient Communication
  topic: keywords
creator: Zijian Pan
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-11-25
publication date: 2025-11-25
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2025(6)185

Log Odds of Positive Lymph Nodes Predict Surgical Prognosisin Intrahepatic Cholangiocarcinoma based on Seer Cohort and Nomogram Model
type: item
description: Background: Intrahepatic cholangiocarcinoma (ICC) has a high postoperative recurrence rate, but quantitative assessment of lymph node metastasis (LNM) by AJCC staging remains inadequate. The log odds of positive lymph nodes (LODDS) have prognostic value in digestive system tumors, but its application in ICC has yet to be studied. Method: Based on the SEER database (2010-2017), 593 ICC patients after hepatectomy or choledochotomy surgery, Cox regression was applied to analyze the association between LODDS and the risk of all-cause mortality (ACM) and cancer-specific mortality (CSM), and risk thresholds were determined by restricted cubic spline (RCS), and a nomogram predictive model was constructed based on variables screened by Boruta’s algorithm. Patients were stratified by optimal nomogram cutoff, and survival was compared via Kaplan-Meier curves. Results: LODDS was positively linear correlated with ACM (HR=2.062, 95% CI: 1.683, 2.527, P<0.001) and CSM (HR=2.068, 95% CI: 1.632, 2.622, P<0.001), with the optimal cutoff value of -0.63. The risk of death was increased 1.7 times in the high LODDS group (>-0.477) compared with the baseline group. The nomogram integrating variables such as LODDS, T-staging, and tumor size had a C-index of 0.711, which had a good predictive performance. Survival differences were statistically significant for both LODDS-based stratification and nomogram-based risk groups. Conclusion: LODDS is an independent prognostic factor for post-operative ICC survival, enabling optimized risk stratification and personalized followup strategies.
subject: Articles
  topic: section
subject: Intrahepatic Cholangiocarcinoma
  topic: keywords
subject: Log Odds of Positive Lymph Nodes (LODDS)
  topic: keywords
subject: Clinical Predictive Model
  topic: keywords
subject: Nomogram
  topic: keywords
subject: SEER Database
  topic: keywords
creator: Shan Li Shan Li
creator: Guoxia Jia
creator: Fan Luo
creator: Jiaxin Yin
creator: Shaochong Deng
creator: Jianfu Zhao
creator: Huizhong Wang
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-11-20
publication date: 2025-11-20
starting page: 1
ending page: 9
doi: 10.47363/JGHR/2025(6)184

Effect of Combined Ethanol Leaf Extracts of Vernonia Amygdalina(Bitter Leave) and Gongronema Latifolium (Utazi) on Lead Induced Hepatoxicity in Wistar Rats
type: item
description: This study evaluated the effect of leaf extract of Vernonia Amygdalina and Gongronema Latifolium on the liver of lead-induced toxicity wistar rats. A total of thirty (30) albino wistar rats were used for this study. Five (5) albino wistar rats were used for acute toxicity of the leave extracts of Vernonia Amygdalina andGongronema latifolium; while the remaining 25 albino wistar rats were divided into 5 groups: Group 1 which served as normal control received only water. Group 2 (NC) negative control received only lead. Group 3 (PC) positive control received lead + Vit. C. (standard drug for lead) via oral administration. Group 4: animals received lead + ethanol fraction of Vernonia Amygdalina and Gongronema Latifolium through oral administration (200 mg/Kg)/. Group 5: animals received lead + ethanol fraction of Vernonia amygdalina and Gongronema Lafifolium via oral administration (400 Mg/Kg). The combined effect of Vernonia amygdalina and Gongronema Latifolium thus has protective and curative properties against lead-induced liver damage.
subject: Articles
  topic: section
subject: Gongronema Latifolium
  topic: keywords
subject: Wistar rats
  topic: keywords
subject: Vernonia amygdalina
  topic: keywords
creator: Mbah Chikodili Adolphus
creator: Ofoego Uzozie Chikere
creator: Odo Jude Emeka
creator: Oyate Godwin Bernard
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-11-20
publication date: 2025-11-20
starting page: 1
ending page: 5
doi: 10.47363/JGHR/2025(6)183

Pegylated Granulocyte Colony Stimulating Factor Combined with Anti-Pd-1/Pd-L1 Inhibitors in the Treatment of Recurrent or Metastatic Biliary Tract Cancer
type: item
description: Background: Biliary tract cancer (BTC) is a malignancy with an extremely poor prognosis. For patients with recurrent or metastatic BTC who have failed first-line chemotherapy, treatment options are limited. Although anti-PD-1/PD-L1 inhibitors have shown efficacy in various tumors, their single-agent activity in BTC is limited, particularly in previously treated patients. Preclinical evidence suggests that granulocyte-colony stimulating factor (G-CSF) may enhance the efficacy of anti-PD-1/PD-L1 inhibitors by remodeling the tumor immune microenvironment. This study aimed to evaluate whether the addition of long-acting G-CSF (pegylated recombinant human G-CSF, pegfilgrastim) could restore or enhance the efficacy of anti-PD-1/PD-L1 inhibitors in patients with resistant BTC. Methods This was a single-arm, prospective, Phase II clinical trial. The inclusion criteria were histologically confirmed recurrent or metastatic BTC that had progressed after at least one line of systemic chemotherapy. All patients received an anti-PD-1 inhibitor (sintilimab 200mg IV q3w) or an anti-PD-L1 inhibitor (atezolizumab 1200mg IV q3w). On day 2 of each cycle, pegfilgrastim (6mg subcutaneously) was administered. The primary endpoint was the Objective Response Rate (ORR) as assessed by the investigator according to RECIST v1.1. Secondary endpoints included Disease Control Rate (DCR), Progression-Free Survival (PFS), Overall Survival (OS), duration of response (DoR), and safety. Results A total of 42 patients were enrolled. The median follow-up time was 12.8 months (95% CI: 10.5-15.1 months). The confirmed ORR was 21.4% (95% CI: 10.3%-36.8%), with 1 patient achieving a complete response (CR) and 8 patients achieving a partial response (PR). The DCR was 66.7% (95% CI: 50.5%- 80.4%). The median PFS was 4.2 months (95% CI: 3.1-5.3 months), and the median OS was 11.5 months (95% CI: 9.2-13.8 months). The most common treatment-related adverse events (TRAEs) of any grade were leukopenia (45.2%), neu…
subject: Articles
  topic: section
subject: Biliary Tract Cancer
  topic: keywords
subject: Immunotherapy
  topic: keywords
subject: Anti-PD-1/ PD-L1
  topic: keywords
subject: Granulocyte-Colony Stimulating Factor
  topic: keywords
subject: Drug Resistance
  topic: keywords
subject: Prospective Study
  topic: keywords
creator: Haipeng Ren
creator: Baoheng Yan
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-10-28
publication date: 2025-10-28
starting page: 1
ending page: 4
doi: 10.47363/JGHR/2025(6)182

Management of Gastrointestinal Failure in the Adult Critical Care Environment
type: item
description: Most healthcare professionals concur on the necessity of providing nutrition to patients and acknowledge the heightened morbidity and mortality associated with malnutrition [1]. However, the delayed consequences of acute underfeeding complicate this responsibility, often relegating it to nursing staff, similar to the tasks of early mobilization and pressure injury prevention. Patients in the ICU typically present with acute organ failure(s) and the management thereof. While cardiac, pulmonary, and renal failures are routinely evaluated and monitored, gastrointestinal failure remains inadequately addressed and acknowledged. This critical organ system has, until now, been omitted from the evaluation criteria of multiple organ failure scores, such as the SOFA score, which only includes the liver to represent the entire gastrointestinal tract [2].
subject: Articles
  topic: section
subject: Gastrointestinal Failure
  topic: keywords
subject: Intensive Care Unit
  topic: keywords
subject: dysfunction
  topic: keywords
subject: Intra Abdominal Pressure
  topic: keywords
creator: Evangelia Michail Michailidou
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-10-28
publication date: 2025-10-28
starting page: 1
ending page: 6
doi: 10.47363/JGHR/2025(6)181

Polyprenol-Based Nanoformulations: Dual-Platform Innovation for Parenteral and Diagnostic Applications
type: item
description: Polyprenols, long-chain isoprenoid alcohols of plant origin, possess notable hepatoprotective, antioxidant, antiviral, and immunomodulatory properties and function as metabolic precursors to dolichols, keyessential in for glycoprotein synthesis. Despite growing pharmaceutical interest, their hydrophobic nature hampers bioavailability in aqueous systems. We address this challenge via patented liposomal and nanoemulsion technologies, enhancing solubility, stability, and controlled parenteral release. To bridge research and regulatory application, we propose three novel indices-IMMPREN, TRANSPREN, and STERILPREN—designed to quantify immunomodulatory potential, translational readiness, and sterilization resilience, respectively. IMMPREN evaluates immune traceability through macrophage polarization and Receiver Operating Characteristic (ROC)-based justification; TRANSPREN structures regulatory narratives for GRAS (Generally Recognized As Safe) and Novel Food dossiers; STERILPREN quantifies colloidal and structural integrity post- moist-heat sterilization, aligning with SAL Sterility Assurance level (SAL) standards. Each index enables formulation traceability, clarity in health claims, and stratification by cytokine/cell marker response, supporting injectable and diagnostic deployment. Collectively, our platform offers a modular, regulatory-explainable framework for polyprenol-based therapeutics—positioning these nanofor emulations as dual-use innovations in clinical translation and safety compliance.
subject: Articles
  topic: section
subject: Polyprenols
  topic: keywords
subject: Nanoemulsion
  topic: keywords
subject: Objective Assessment Indices
  topic: keywords
creator: Rubens J Rubens J
creator: Marakhouski YKh Marakhouski YKh
creator: Bartkevics V Bartkevics V
creator: Rubens A Rubens A
creator: Zajakina A Zajakina A
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-08-18
publication date: 2025-08-18
starting page: 1
ending page: 5
doi: 10.47363/JGHR/2025(6)179

Novel Ultrasensitive Eco-Friendly Spectrophotometric Determination of Carvedilol in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing
type: item
description: A simple, novel, accurate, precise, rapid, economical and sensitive Ultra violet spectrophotometric method has been developed for the determination of Carvedilol in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 242 nm in methanol. Beer’s law was obeyed in the range of 0.5 -10 μg/ ml, with molar absorptivity of 5.4467×104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.6%, and accuracy (average recovery %) was 100 ± 1.3. No interference was observed from common excipients and additives often accompany with Carvedilol in pharmaceutical preparations. The method was successfully applied to the determination of Carvedilol in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Carvedilol in true samples.
subject: Articles
  topic: section
subject: Carvedilol
  topic: keywords
subject: Spectrophotometry
  topic: keywords
subject: Pharmaceutical Preparations
  topic: keywords
subject: Environmental Samples
  topic: keywords
creator: Nief Rahman Ahmad Ahmad
creator: Naif Rahman Ghfran
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-06-26
publication date: 2025-06-26
starting page: 1
ending page: 4
doi: 10.47363/JGHR/2025(6)180

Clinical Case: Colonic Metastasis of Operated Hepatocellular Carcinoma
type: item
description: Background: Hepatocellular carcinoma (HCC) is the most common liver tumor and ranks as the second leading cause of cancer-related mortality worldwide due to its poor prognosis. Its prognosis is influenced by metastatic spread, mainly intrahepatic but also extrahepatic, which carries a more unfavorable prognosis. The most frequent hepatic metastases occur in the lungs, lymph nodes, bones, and adrenal glands. Atypical sites such as colonic involvement are exceptionally rare and scarcely documented in the literature. Case Presentation: A 60-year-old female was referred for an atypical hepatic lesion in segment VII, which developed in an otherwise healthy liver. She underwent laparoscopic right hepatectomy in 2016. In 2022, she presented with tumor recurrence, elevated AFP levels, and the appearance of a tumor nodule in the right hypochondrium, suggestive of peritoneal metastatic localization from her previously operated HCC. She underwent right colectomy, and histopathological analyses confirmed the metastatic nature of the lesion, not peritoneal but colonic. Conclusion: Elevated AFP levels in the context of HCC, even after surgery, should raise suspicion of metastatic recurrence, particularly extrahepatic. Even though rare, colonic metastasis could appear, sometimes in the form of very late recurrence. This underscores the importance of lifelong biological monitoring, including abdominal-pelvic CT scans.
subject: Articles
  topic: section
subject: Hepatocellular Carcinoma
  topic: keywords
subject: Extrahepatic Metastasis
  topic: keywords
subject: Colonic Metastasis
  topic: keywords
subject: Surgery
  topic: keywords
creator: Duhamel L Duhamel L
creator: Schwarz L Schwarz L
creator: Regnier A Regnier A
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-06-18
publication date: 2025-06-18
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2025(6)177

The Dermatological Manifestations of Inflammatory Bowel Disease: Looks Might be Deceiving!
type: item
description: Inflammatory bowel diseases (IBD) is a poorly understood autoimmune clinical entity that include indeterminate colitis, Crohn’s (CD) and ulcerative colitis (UC). Being a chronic relapsing illness, IBD is a multi-system disorder than can involve the eyes, skin, joints, Liver and kidneys, but mostly characterized by chronic relapsing intestinal inflammation. Although IBD, is a chronic inflammatory disorder of the gut, the manifestations of CD and UC are not limited to the gastrointestinal tract. Extraintestinal manifestations (EIMs) are frequently observed in patients with IBD, with a reported frequency of 6-46% [1]. The skin, musculoskeletal, joints, eyes, and hepato-biliary tract are the organs most affected by EIMs.
subject: Articles
  topic: section
subject: Inflammatory Bowel Disease
  topic: keywords
subject: ulcerative colitis
  topic: keywords
subject: Erythema Nodosum
  topic: keywords
creator: Klara Missling
creator: Anna Lauren Winter
creator: Bobby Owens
creator: McCoy Matt
creator: Ahmed Swi Ahmed Swi
creator: Faisal A Bukeirat
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-12
publication date: 2025-04-12
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2025(6)175

The Clinical Brilliance of Immunohistochemistry “IHC” in Gastrointestinal Oncology
type: item
description: Immunohistochemistry, or “IHC,” is a powerful tool in clinical diagnostics within the field of gastrointestinal oncology and anatomical pathology. It is utilized to assist in classification of neoplastic, infectious, and inflammatory diseases. The technique generally involves the specific binding between an antibody and antigen to detect and localize specific antigens within tissue samples, usually examined with light microscopy. Biopsies are collected in a number of ways, including snaring, fine needle aspiration, endoscopic mucosal resection, and more; these samples are then processed by a pathologist. This information can be vital in clinical decision making for patients with potential malignancy.
subject: Articles
  topic: section
subject: Immunohistochemistry
  topic: keywords
subject: squamous cell carcinoma
  topic: keywords
subject: Esophageal Adenocarcinoma
  topic: keywords
creator: Hannah Bell
creator: Wichman Thomas Grant
creator: Ernest Moses Lam
creator: Drew Mulkey Mulkey
creator: Swi Ahmed
creator: Bobby Owens
creator: Faisal A Bukeirat
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-12-08
publication date: 2025-12-08
doi: 10.47363/JGHR/2025(6)176

Life After Breast Cancer: How Lymphedema Affects the Quality of Life in Women
type: item
description: According to data from the World Health Organization, more than 10 million new cases of breast cancer (BC) are diagnosed each year. This type of cancer ranks as the leading malignancy among women, accounting for up to 16% of all cancer cases. For every 100 women diagnosed with breast cancer, there is 1 man. In Europe, over 370,000 new cases are registered annually, with approximately 130,000 women succumbing to this disease. The highest mortality rates from breast cancer are observed in the United Kingdom, Denmark, and France, while countries such as India, Ethiopia, China, and Mongolia report significantly lower rates [1].
subject: Articles
  topic: section
subject: Breast Cancer
  topic: keywords
subject: Lymphedema
  topic: keywords
subject: Lymphaticovenular anastomosis
  topic: keywords
creator: Mukueva MI Mukueva MI
creator: Balayan DA Balayan DA
creator: Gugnina AS Gugnina AS
creator: Romanov DS Romanov DS
creator: Tsalko SE Tsalko SE
creator: Mchedlidze TG Mchedlidze TG
creator: Abdugaffarov SA Abdugaffarov SA
creator: Kopytich IV Kopytich IV
creator: Andreeva VA Andreeva VA
creator: Vorotnikov VV Vorotnikov VV
creator: Sharavina MV Sharavina MV
creator: Soynov AV Soynov AV
creator: Konovalova ON Konovalova ON
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-03-06
publication date: 2025-03-06
starting page: 1
ending page: 4
doi: 10.47363/JGHR/2025(6)174

https://srcpublishers.com/gastroenterology-hepatology-repo/article/view/4508
type: item
title: A Smart, Sensitive Estimation of Thiamine Chloride Hydrochloride(Vitamin B1) in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity TestingA Smart, Sensitive Estimation of Thiamine Chloride Hydrochloride(Vitamin B1) in Pharmaceutical Preparations and EnvironmentalWastewater Samples: Application to Content Uniformity Testing
description: A fast, greener, simple, accurate, precise, rapid, economical and high sensitive ultraviolet spectrophotometric method has been developed for the determination of Thiamine Chloride Hydrochloride (Vitamin B1) in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 235 nm in distilled water. Beer’s law was obeyed in the range of 2.5-30μg/ ml, with molar absorptivity of 1.028x104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.9%, and accuracy (average recovery %) was 100 ± 0. 8. No interference was observed from common excipients and additives often accompany with Thiamine Chloride Hydrochloride in pharmaceutical preparations. The method was successfully applied to the determination of Thiamine Chloride Hydrochloride in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Thiamine Chloride Hydrochloride in true samples.
subject: Articles
  topic: section
subject: Thiamine Chloride Hydrochloride (Vitamin B1)
  topic: keywords
subject: Spectrophotometry
  topic: keywords
subject: Pharmaceutical Preparations
  topic: keywords
subject: Environmental Samples
  topic: keywords
creator: Ghfran Naif Rahman
creator: Nief Rahman Ahmad
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-02-27
publication date: 2025-02-27
starting page: 1
ending page: 4
doi: 10.47363/JGHR/2025(6)173

Gastric Outlet Obstruction Due to Actinomycosis, An Uncommon Presentation of a Rare Disease: A Case Report
type: item
description: Background: Actinomyces is gram positive Bacterium part of normal human flora. Even though actinomyces infect various organ systems, including the gastrointestinal tract (GIT), gastric outlet obstruction is extremely uncommon. Case Presentation: We present a case of a 66-year-old female patient who presented with nausea, vomiting and unintentional weight loss. Clinical imaging and upper GI endoscopy revealed narrowed gastric pylorus diagnosed as gastric outlet obstruction (GOO). The Patient required multiple gastroscopies with balloon dilatation and biopsy specimens. Histopathology was consistent with Actinomyces. Subsequent appropriate antibiotics therapy led to GOO resolution and clinical improvement. Discussion: Actinomyces presenting as GOO is a rarely seen clinical diagnosis that may mimic malignancy. It must be considered in the differential diagnosis of abdominal masses broadly and tumor-like infiltrative lesions of the stomach particularly. Proper antibiotic therapy renders favorable outcomes and eliminates unwarranted invasive intervention. Conclusion: Actinomyces presenting as GOO is a rare differential diagnosis of abdominal masses broadly, and tumor-like infiltrative lesions of the stomach particularly. Proper antibiotic therapy facilitates favorable outcomes and eliminates unwarranted invasive interventions. Our patient is such an example where gastric actinomycosis was managed medically and the patient improved, avoiding unnecessary surgical interventions.
subject: Articles
  topic: section
subject: Gastric Outlet Obstruction
  topic: keywords
subject: Actinomycosis
  topic: keywords
subject: Gastric Cancer
  topic: keywords
creator: Umar Saddique Muhammad
creator: Moutaz Farouk Mahmoud Derbala
creator: Ahmed Abdelmola Abdelatif Al
creator: Ahmed M Hashim Samar Mahmoud
creator: Hanan Ibrahim Farghaly
creator: Maslamani Muna A Rahman S Al
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-12-26
publication date: 2024-12-26
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2024(5)172

Pulmonary Vascular Complications in Liver Disease: A Comprehensive Review of Porto-Pulmonary Hypertension and HepatopulmonarySyndrome with Illustrative Case Studies
type: item
description: Background: Porto-pulmonary hypertension (PoPH) and hepatopulmonary syndrome (HPS) are significant pulmonary vascular complications in liver disease patients. Understanding their distinct features is crucial for optimal care. Objectives: To provide an updated overview of PoPH and HPS, compare these conditions, and highlight diagnostic and treatment challenges using illustrative case studies. Methods: A comprehensive literature review was conducted using PubMed, Embase, and Cochrane databases. Two case studies illustrate key clinical features and management considerations. Results: Orthotopic liver transplantation (OLT) generally improves outcomes more consistently in HPS than in PoPH. Appropriate bridging therapy can significantly improve PoPH prognosis prior to OLT. Case studies highlight these approaches, including an atypical HPS presentation with acute liver injury, Budd-Chiari syndrome, and portal hypertension without pre-existing cirrhosis. Conclusion: PoPH and HPS present distinct challenges in liver disease. Early recognition, accurate diagnosis, and tailored management strategies are crucial for improving outcomes. Clinicians must maintain a high index of suspicion for these complications, even in atypical presentations, to ensure timely diagnosis and optimal management.
subject: Articles
  topic: section
subject: Porto Pulmonary Hypertension
  topic: keywords
subject: Hepatopulmonary Syndrome
  topic: keywords
subject: Liver Cirrhosis
  topic: keywords
subject: Pulmonary Hypertension
  topic: keywords
subject: Liver Transplantation
  topic: keywords
creator: Ritesh Bhandari
creator: M Javaid Muhammad
creator: Shembrey Jack
creator: Pratima Gurung
creator: Adel Ekladious
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-12-24
publication date: 2024-12-24
starting page: 1
ending page: 8
doi: 10.47363/JGHR/2024(5)171

The Clinical Spectrum of Liver Masses: Know Before You Judge
type: item
description: Liver Masses present a common clinical dilemma, particularly with the wide spread use of cross-sectional imaging in the Emergency Departments. The accurate and reliable determination of the nature of the liver mass is critical, not only to reassure individuals with benign lesions but also to ensure that malignant lesions are diagnosed correctly. In general, Liver Mass can be divided into two main categories: benign lesions and malignant lesions. Benign asses are usually Inflammatory masses including an abscess which can be divided into amebic and pyogenic and truly tumor masses which can be divided into malignant or benign tumors.
subject: Articles
  topic: section
subject: Liver Masses
  topic: keywords
subject: Arterial and Venous
  topic: keywords
subject: Des-y-carboxyprothrombin
  topic: keywords
creator: Rose Lydia
creator: Ahmed Swi Ahmed Swi
creator: Yassmin Hegazy
creator: Faisal A Bukeirat
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-11-01
publication date: 2024-11-01
starting page: 1
ending page: 5
doi: 10.47363/JGHR/2024(5)170

The Significance of Biliary Anatomical Variation as a Key Indicator in Laparoscopic Bile Duct Injuries
type: item
description: Introduction: The science of Gastrointestinal (GI) endoscopy is the science and art of millimeters that has marvelously evolved over the past 30 years. Cholecystectomy, most of which is done laparoscopically, is one of the most common procedures performed today (approximately 750,000 cases are performed annually in the USA) and is considered relatively safe. However, laparoscopic cholecystectomy is associated with bile duct injuries. Several studies examining bile duct injuries have found significant rates of complication (0.39%---1.5%, that comes roughly to over 3,000 patient per year). Therefore, bile duct injuries are commonly encountered, and a clear understanding of the extensive variation in biliary anatomy is imperative to appropriately and successfully manage this common clinical problem to ultimately provide the highest level of patient care. Aim: To educate gastroenterologists, general surgeons, and Hepato-Pancreato-Biliary (HPB) surgeons regarding the definition of anatomical variation and its various anatomical markers. Materials and Methods: A Survey research about our GI department in addition to an online research of published literature was made on PubMed, Ovid Medline, Science Direct, and Springer. Results: This paper presents the various anatomical variations of the biliary tree which is critical in defining bile duct injuries during surgical hepatopancreato-biliary (HPB) procedures.
subject: Articles
  topic: section
subject: Normal Biliary Anatomy
  topic: keywords
subject: Cholecystectomy
  topic: keywords
subject: Laparoscopic
  topic: keywords
creator: Anna Lauren Winter
creator: Klara S Missling
creator: Himmat S Brar
creator: Faisal A Bukeirat
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-10-18
publication date: 2024-10-18
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2024(5)169