Authors
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Rosa Martha Pérez Gutiérrez
1Natural Products Research Laboratory. Higher School of Chemical Engineering and Extractive Industries. National Polytechnic Institute (IPN) Adolfo López Mateos Professional Unit S/N Av. National Polytechnic Institute Mexico City, Zip Code 07708, Mexico
Author
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Julio Téllez Gómez
Natural Products Research Laboratory. Higher School of Chemical Engineering and Extractive Industries. National Polytechnic Institute (IPN) Adolfo López Mateos Professional Unit S/N Av. National Polytechnic Institute Mexico City, Zip Code 07708, Mexico
Author
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Mónica Corea Téllez
Polymer and Nanomaterials Research Laboratory Higher School of Chemical Engineering and Extractive Industries. National Polytechnic Institute (IPN) Adolfo López Mateos Professional Unit S/N Av. National Polytechnic Institute Mexico City, Zip Code 07708, Mexico
Author
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Alethia Muñiz-Ramírez
CONAHCYT- IPICYT/Advanced Materials Division. San José Dam Road, Lomas 4th Section, Zip Code 76216 San Luis Potosí, Mexico
Author
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José María Mota Flores
Natural Products Research Laboratory. Higher School of Chemical Engineering and Extractive Industries. National Polytechnic Institute (IPN) Adolfo López Mateos Professional Unit S/N Av. National Polytechnic Institute Mexico City, Zip Code 07708, Mexico
Author
Keywords:
Alzheimer’s Disease, Baicalin, Myricetin, Selenium Nanoparticles
Abstract
Background: AD disease involves deposition of Aβ amyloid in the mitochondria of cells, reducing consumption of glucose by neurons reducing enzyme functions. Contemporary drugs therapy for AD are unable to alleviate this disease; since in the short term it only produced symptomatic alleviation, thus is necessary to develop new drugs with curative effects. Objective: To determine the neuroprotective effect of flavonoids combined with selenium nanoparticles (EM@Se).
Methods: Was successfully synthesized selenium nanoparticles of Baicalin-Myricetin, characterized using different techniques: UV/vis, Fourier-transforminfrared spectroscopy, transmission electron microscopy, DTS, energy dispersive X-ray, vitro drug release, cytotoxicity and in vivo in AD induced by AlCl3.
Results: EM@Se showed optimum particle size (94.52 nm), polydispersity index (0.153), and zeta potential (−-30.3 mv) with high entrapment efficiency (88. 7%) NPs achieve significantly maintain EM in vitro release, possesses low cytotoxicity in RAW264.7 macrophage cells. In vivo experiments restore cognitive function to the normal level, reducing hippocampal oxidative damage and decrease Aβ amyloid in plasma.
Conclusion: This study provides evidence of the neuroprotective effects of flavonoids combined with nanoparticles.
Author Biography
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Rosa Martha Pérez Gutiérrez, 1Natural Products Research Laboratory. Higher School of Chemical Engineering and Extractive Industries. National Polytechnic Institute (IPN) Adolfo López Mateos Professional Unit S/N Av. National Polytechnic Institute Mexico City, Zip Code 07708, Mexico
Rosa Martha Pérez Gutiérrez, Natural Products Research Laboratory. Higher School of Chemical Engineering and Extractive Industries. National Polytechnic Institute (IPN) Adolfo López Mateos Professional Unit S/N Av. National Polytechnic Institute Mexico City, Zip Code 07708, Mexico.
