Vascular Endothelial Dysfunctions with Hyperlipoproteinemia

Abstract

Background: Cardiovascular diseases and, primarily coronary heart disease, remain among the leading causes of disability and mortality worldwide.

Aim: To study the relationship between vascular endothelial dysfunction and hyperlipoproteinemia in experimental atherosclerosis.

Materials and Methods: The experiments were carried out on 28 Chinchilla rabbits with an average weight of 2.5-3.0 kg. The action of drugs was studied in dynamics: the initial 3-month condition and after one month of drug administration. The results obtained were compared with those of the control and intact groups.

Results: Long-term administration of cholesterol is accompanied by the development of hypertriglyceridemia, the severity of which depends on the duration of the experiment.

Conclusion: An important role in the development of endothelial dysfunction in hypercholesterolemia is played by a decrease in the synthesis of endothelial nitric oxide and an increase in its active radicals, causing modification of low-density lipoproteins and their deposition in the vascular endothelium.