Journal of Cancer Research Reviews & Reports
Journal of Cancer Research Reviews & Reports is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Cancer Research. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Article acceptance will be in the form of Research, Review, Case Reports, Analysis, Magazines, Editorials, Opinion, Communications, Mini-Review, Short Communications, Picturized, Book Review, Video Type and Power Point Presentations (PPTS). Articles can be submitted through online from https://www.onlinescientificresearch.com/submit-online or can send through an e-mail with attachment for cancerresearch@onlinescientificresearch.info
A Large Invasive Primary Squamous Cell Carcinoma of Colon: ACase Report and Literature Review
Primary squamous cell carcinoma (SCC) of colon is a rare histopathologic type of colon cancers. In this article we report a case of a large invasive primary colon SCC mass proven by pathologic examinations at rectosigmoid level with extensive adhesions to vasculature and hydronephrosis due to pressure effects on ureter. We excised the whole mass and dissected all para-aortic and pelvic lymph nodes. Patient was referred to oncology ward for further treatments.
Copyright (c) 2020 Journal of Cancer Research Reviews & Reports
Evaluating the Sensitivity of Sporadic Pancreatic Cancer to Poly (ADPribose) Polymerase (PARP) Inhibition (Velaparib, Olaparib, AG14361)as Single Agents and as Chemo-sensitizers
After resection of pancreatic cancer local recurrence occurs in 50%-80% of the cases while metastasis develops 75% of the time. Current, adjuvant therapy often consists of gemcitabine, cisplatin and/or 5-fluorouracil which add a modest increase in median survival by 4-5 months. In this study, we treated human pancreatic cancer cells with poly (ADP-ribose) polymerase (PARP) Inhibitors (AG14361, Veliparib and Olaparib) alone or with gemcitabine, cisplatin or 5-fluorouracil. Methods: CFPAC-1 and BXPC-3, HPAC human pancreatic cancer cell lines were treated for 72 hours with PARP inhibitors alone or in combination with gemcitabine, cisplatin, or 5 – fluorouracil. Validated MTT assays were used to form dose response curves from which the IC50 values were calculated. Results: The PARP1 IC50 values for CFPAC-1, BXPC-3 and HPAC pancreatic cancer cell lines were AG14361 (14.3 µM, 12.7 µM, 38.3 µM), Veliparib (52.6 µM, 100.9 µM 102.0 µM) and Olaparib (79.5 µM, 184.8 µM, 200.2 µM). The IC50 values of cisplatin, were decreased up to 60 fold in the presence of clinically relevant amounts of PARP inhibitor while 5-flourouracil IC50 values were decreased up to 6000 fold in the presence of clinically relevant amounts of PARP inhibitor. Gemcitabine was inhibited up to 73% by PARP inhibitors. Conclusions: Sporadic human pancreatic cancer cells are sensitive to PARP inhibition. PARP inhibitors significantly enhanced the cytotoxicity of cisplatin and 5-fluorouracil while inhibiting gemcitabine. There is little correlation between endogenous PARP activity and the effectiveness of PARP inhibitors.
Breast Cancer and Chemotherapeutic Drug Resistance: A Treatment Challenge
Breast cancer is a commonly occurring malignancy and leading cause of cancer associated deaths in women globally. It is estimated that 1.7 million new cases (25% of all types of cancers) with 521,900 death in year 2012. There are multiple risk factors associated with breast cancer in women but breast density, genetic tendency, age and estrogen dysregulation are notable. Breast cancer is a heterogeneous ailment caused by common effect of hereditary and ecological variables. Thorough understanding of breast cancer etiology results in the development of molecularly targeted novel therapies. The clinical utility of chemotherapy is based on multiple factors which include tumor size, involvement of lymph node, and presence of hormonal receptors including estrogen, progesterone and HER2. Drug resistance is one of the leading problems in cancer chemotherapy, especially in case of breast cancers. To this end, several ongoing trials are examining novel combinations of drugs that are intended to target key signaling pathways involved in in the progression of disease. These improvements in therapy will potentially overcome drug resistance in breast cancer patients. As well as, identifying other biomarkers and potential drug targets may further lead to develop new chemotherapy combinations that will eventually extend the efficacy of these combine therapies.
Intraosous Angioma of the Ocular Orbit Histologically Benign,Clinically Malignant Tumor about a Case Review and Analysis ofthe Bibliography
Although the primary intraosseous angioma or hemangioma, although it rarely affects the bones of the orbit, it should be taken into account in the differential diagnosis in those patients who present a fixed mass in the orbit or signs of progressive proptosis, sometimes not painful. For the therapeutic approach, it is critical to assess the exact location and extent of the lesion by CT and MRI, and to establish whether it has a vascular origin, since improper management can lead to severe bleeding. Surgical treatment is indicated for progressive proptosis or cosmetic deformity. We present the case of a patient with primary intraosseous hemangioma of the supralateral rim of the orbit, we review the bibliography of this very low prevalence disease and we trust that in this way, we contribute to the casuistry.
Correlation Between the Prostate-Specific Antigen Level and Bone Metastasis in Prostate Cancer. (Retrospective Study)
Background: The most common non-cutaneous malignancy for men is Prostate cancer (PCa). PCa diagnosed by biopsy and PSA detection. Bone metastasis (BM) causes a lot of complications, such as bone pain and pathological fracture that cause overall compromised quality of life. Bone scintigraphy (BS) is commonly used for monitoring and detection of (BM). Objective: To correlate between serum PSA level and BM in PCa patients on series of 250 patients through detecting PSA levels and BSs. Patients and Methods: In the present study Patients were stratified (group A) & (group B) according to BM. Out of the 250 patients, 180 patients (Group A localized PCa) were with age range from 57 -92 years, the remaining 70 patients (Group B metastasis PCa) the age range was 53-88 years. Prostate specific antigen (PSA) level for both groups were detected. Results: By comparing group A and group B there was a highly significant difference in PSA value in favor of positive BS group (p-value < 0.001). The present study recommends BS in asymptomatic patients with PSA above 60 Ng/ml. Conclusion: PCa is the most common malignant non-cutaneous tumor for men. The most common spread for PCa is bone spread. Age doesn’t correlate with BM in PCa patients. PSA total show highly significance with BM in PCa patients. PSA cut-off value for BM in PCa patients was 60 Ng/ml so it was recommended to perform BS for asymptomatic patients with PSA total above 60 Ng/ml.
Weight Control Trend Analysis and Progressive Behavior Modification of a T2D Patient Using GH-Method: Math-PhysicalMedicine (No. 307)
In this article, the author used 10-years’ worth of data of glucoses and prominent lifestyle details such as diet and exercise to address weight reduction trend pattern and his progressive lifestyle behavior modifications. The research methodology used is the GH-Method: math-physical medicine (MPM) approach which has been developed by the author over the past decade. This “Progressive Behavior Modification” concept is also a part of his Mentality-Personality Modeling (MPM). He addresses the quantitative linkage between obesity physiological phenomena and behavior psychological influences of an obese patient.
Textile Scaffolds: A Review of Some Significant Breakthroughs inTissue Engineering
The article reviews some significant attempts in textile scaffolds related to developments in tissue engineering. The benefits offered by micro fibrous scaffold architectures fabricated by textile manufacturing techniques have been explored. Established and novel fiber-processing techniques can be exploited in order to generate templates matching the demands of the target cell niche. The problems related to the development of biomaterial fibers (especially from nature-derived materials) ready for textile manufacturing are addressed. Attention is also paid on how biological cues may be incorporated into microfibrous scaffold architectures by hybrid manufacturing approaches (e.g. nanofiber or hydrogel functionalization). Textile technologies have recently attracted great attention as potential biofabrication tools for engineering tissue constructs. Using current textile technologies, fibrous structures can be designed and engineered to attain the required properties that are demanded by different tissue engineering applications. Tissue engineering often uses synthetic scaffolds to direct cell responses during engineered tissue development. Since cells reside within specific niches of the extracellular matrix, it is important to understand how the matrix guides cell response and then incorporate this knowledge into scaffold design. The goal of this review is to review elements of cell–matrix interactions that are critical to informing and evaluating cellular response on synthetic scaffolds. Therefore, this review examines fibrous proteins of the extracellular matrix and their effects on cell behavior, followed by a discussion of the cellular responses elicited by fiber diameter, alignment, and scaffold porosity of two dimensional (2D) and three dimensional (3D) synthetic scaffolds.
3D Conformal Radiotherapy for Nephroblastoma: Unusual Techniquein Dalal Jamm Hospital
Nephroblastoma, or Wilms tumor, is the most common kidney tumor in children, most commonly occurring between one and five years of age with a peak incidence around three and a half years. Multidisciplinary treatment (chemotherapy-surgeryradiotherapy) allows an overall survival of 90% at 10 years (1). Intensity-modulated radiation therapy (IMRT) either with a particle accelerator or with helical tomotherapy can deliver an optimal dose of radiation while preserving healthy developing organs in this subject (2). This irradiation technique was not available in ourpractice setting. We report the case of a nephroblastoma treated by a three-dimensional conformational radiotherapy (RC3D) technique with respect to the dose constraints decreed by the IMRT.
3D Conformal Total Liver Radiotherapy for Locally Advanced Hepatocarcinoma: A Case Report
Hepatocarcinoma is the third localization of cancer in Senegal (1). More than 90 per cent of cases in Senegal are painfull locally advanced stages (2). Radiation therapy may not be a good option for some patients whose liver has been greatly damaged by diseases such as hepatitis or cirrhosis. Although liver cancer cells are sensitive to radiation, much care is taken when planning the treatment to avoid damaging normal liver tissue. External Beam Radiation therapy (EBRT) can be indicated for: unresectable tumors, bad response after embolization, metastatic disease, thrombus blocking the portal vein and remaining pain after morphinic treatment. EBRT treatments are small doses of radiation given 5 days a week for several weeks in the curative situation or in single dose for palliative option. Newer radiation techniques, such as stereotactic body radiation therapy (SBRT) target liver tumors while reducing the radiation to nearby healthy tissues (3). These new techniques are note available in our institution. We report one case of total liver radiotherapy for hepatocarcinoma done by 3D conformal ( 3DCRT) techniques in Dalal Jamm hospital of Dakar.
Long-Term Survival of a Patient with Glioblastoma Multiforme
Glioblastoma multiforme (GBM) remains the most aggressive brain tumor in adults despite the advances in diagnosis and treatment over the past few decades[1]. Standard treatment for patients with newly diagnosed GBM consists of maximal safe resection followed by postoperative radiation with concomitant and adjuvant temozolomide [2]. Despite that, recurrence is common and the prognosis remains poor with a median survival of 12–15 months [3].
Comparison between Home Cooked Meals and Dine-Out Meals Using both Glucose and Associated Energy via GH-Method: MathPhysical Medicine
In this paper, the author describes his research results for the comparison between home cooked meals versus dine-out meals using both postprandial plasma glucose (PPG) level and the relative energy associated with it. Methods Since 6/1/2015, the author has collected all of his meal-related data, including carbs/sugar amount, post-meal waking steps, finger PPG at two-hours after the first bite of food, country and location of each meal, and key contents of each meal. From 5/5/2018 to 6/11/2020, he collected his glucoses via a continuous glucose monitor (CGM) sensor device at 80-96 data per day. The difference of 16 between 80 and 96 is due to his measurements during sleep hours. Starting from 2/19/2020, he increased his night glucose measurements from every hour to every 15-minute interval.
Cancer Incidence in Wild Animals and the Rejection of Peto’s Paradox Theory
Cancer affects all animals containing eukaryote cells. Less is known about the cancers that affect wild animals, since they move around and may not be easily observed for a long period of time. This review about cancers in wild animals contains useful data for the study of human cancers as well. Certain cancers in dinosaurs show that this metabolic disease is primitive and may have been around since the beginning of the multicellular organisms. This data also shows there has been some cancer types in naked mole rats and wild sharks as well. Nowadays, Tasmanian Devils are plagued by an infectious cancer known as Tasmanian devil facial tumor disease (DFTD). Since the emergence of the disease in 1996, the population has declined by more than 60 percent. This type of cancer has an allograft transmission. It seems earthworms contain an anti-cancer agent which could be of great interests in the treatment of cancer. In the discussion part of our review we have discussed how Peto’s Paradox theory of cancer is not true and we have mentioned many data of the cancer incidences in whales.
Copyright (c) 2025 Journal of Cancer Research Reviews & Reports
Survival Analysis: A Hospital Based Retrospective Life Span Study of Breast Cancer Patients after First Recurrence
Background Overall survival of breast cancer patients has been calculated many times but there is no precise research available regarding the survival time of breast cancer patients after recurrence. We investigated the effects factors on mortality due to breast cancer. Methods All Factors were analyzed using statistical tools and techniques to find out rate of mortality after recurrence. Descriptive statistics, cox proportional hazard models were used to find statistical significant variables. In the present study recurrence is considered as an important event which may play a role in study of breast cancer progression. In this study, we evaluated breast cancer risk factors in relation to mortality due to this disease among 1028 women with breast cancer in Lahore, Pakistan. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between risk factors and mortality due to breast cancer were estimated in subtype-specific Cox regression models. Results Survival of breast cancer patients depends upon many factors. A total of 581 alive and 447 deaths due to breast cancer occurred during a median follow-up period of 1977 days. Median survival time after recurrence was 3 years. Significant factors were included post- menopausal women who diagnosed and had recurrence at the age < 45 of molecular subtype estrogen receptor positive, progesterone receptor negative, Her2.neu positive with tumor size ≥ 3 & involved lymph nodes >5. Radiotherapy has increased life span of patients even after recurrence. Conclusion Younger women had higher risk of mortality after recurrence even gone through chemotherapy while lower grade tumor had good prognosis. Radiotherapy played a major role in increasing life time of breast cancer women after recurrence. Our findings are consistent with those from previously published data.
Perfection of Wound Healing to Win the War on Cancer
The objective of this article is to find a right approach to win the war on cancer. To win the war on cancer, it is necessary to establish a valid concept of cancer to confront cancer successfully. Cancer evolves due to wound unhealing, which was a valid concept introduced by Virchow in 1858. Cancer establishments pursued cancer therapies by a commanding principle of creating wound to kill cancer cells (CCs) exactly opposite to the Virchow’s advice, resulting in the failure to win the war on cancer. We have unknowingly pursued cancer therapy following the guidance of Virchow’s wound healing through employment of wound healing metabolites purified from urine which we named cell differentiation agnet-2 (CDA-2) to produce excellent cancer therapy. CDA-2 is the only drug best to handle the issue of cancer stem cells (CSCs). CSCs became known in 1997. The discovery of CSCs unraveled CSCs as the most important issue of cancer to reveal CSCs as the cells to initiate tumor growth and the cells to contribute to the most fatal effects of cancer. Fatal effects of cancer such as metastasis, drug resistance, anti-apoptosis, angiogenesis, unresponsiveness and recurrence are all attributable to CSCs. The nature creates chemo-surveillance as a defense mechanism to guard the pathological build-up of CSCs and CCs by destabilizing abnormal methylation enzymes (MEs) which are the driving cause of CSCs and CCs. CDA formulations are the right drugs to turn off abnormal MEs to win the war on cancer.
The Effect of the Anomalous Magnetic Fields on Malignant Diseases
Introduction Natural earth’s magnetic field (EMF) is the promoter of mother cell division into two daughter cells. Cancer is the cell which divides unlimitedly and destroys the body. Show that cancer (Ca) occurs in anomalous magnetic field (AMF) located in diseased people’s beds. Move the diseased away from the AMF and follow their health conditions. Explain etiopathologic unclearances from medical literature and improve therapy. Explain that the risk factors, as causes of Ca, are interpreted incorrectly in medical literature, prove that these are effects of the AMF existence in dwelling places. The Materials and Methods Measuring of AMF in patients’ beds was performed by a proton magnetometer, (precision 100 nano Teslas). Measuring points are on square net, 10x10 cm. The results are shown with contour lines on the drawings. The health status of residence in the Earth’s natural magnetic field (EMF) was monitored. The etiological data from the literature are explained. An experiment was performed in a psychiatric hospital with 40 patients. Results and Discussion Research lasted more than 25 years. The AMF were measured in 2000 patients’ beds. There was a correlation between the AMF and the location of the diseased organ. The AMF surfaces were shown in beds where the diseased organ is, on the contrary, there were natural values of the EMF in the rest of the bed surface. Furthermore, the results found that three cases of breast cancer with metastases survived after surgical interventions and subsequent removal into the natural EMF in contrast to 26 cases with the same diagnosis and surgical interventions who died after a short period and staying in the AMF. Another example was brain malignancy (gliobastroma multiform, stage IV), which was decreased by living in the natural EMF for six years. In the same clinic, with the same diagnosis, three patients died because they were not moved away from the AMF. Those presented are the cases of breast malignant disease with metastases. The patients refused chemotherapy, accepted only surgical operation and removal of the AMF. They have all recovered. Three patients with head, prostate tumors and breast Neo are presented, who, after removing of the AMF, recovered with no medical intervention at all. Conclusion There was a visible improvement of health with patients who stayed in the natural EMF. The correlation between Az and the diseased organ was determined by measuring the AMF. Knowing the effects of the AMF and the natural EMF, all the literature ambiguities from etiopathology were explained. It was concluded that the medical risk factors are not causes of cancer. It is necessary to improve the treatment of the patients with Ca with construction of hospitals with no AMF and introduce hyperthermia therapy in the natural EMF. The AMF located in the patients’ beds are the sole cause of Ca. This conclusion is suggested in the experiment done in the psychiatric clinic, too.
Cancer and Peripheral Deep Vein Thrombosis are Both Independent Diseases Causes, Pathogenesis, Conclusions
There is an undisputed thesis: CANCER has an often COMPLICATION such as DEEP VEIN THROMBOSIS. Cancer is the second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018. (according to World Health Organization). Sickness rate of deep vein thrombosis is approximately 100 per 100 000 population annually. Sickness rate of cancer in different countries is approximately 130-500 per 100 000 population annually. Thus, if deep vein thrombosis is considered to be a complication of cancer we must identify both these diseases simultaneously with frequency of 20 -76.9% The Research Objective To determine whether peripheral vein thromboses are the complications of cancer. The Method of the Research Randomized prospective parallel controlled trial.
Successful Pregnancy with Placenta Accreta Spectrum and UterineAtony Following Conservative Ovarian Cancer Treatment: A CaseReport
Background: Pregnancy following ovarian cancer treatment is rare but increasingly reported due to delayed childbearing and the predominance of ovarian germ cell tumours among women of reproductive age. Fertility preservation has therefore become a critical component of management in selected cases. Case Presentation: We report the case of a 28-year-old Nigerian nulliparous woman (P0+0) previously diagnosed with a mixed germ cell ovarian tumour (embryonal carcinoma and yolk sac tumour). She underwent right ovarian cystectomy and left salpingo-oophorectomy, followed by five cycles of adjuvant chemotherapy. Remarkably, she later achieved a spontaneous conception. The pregnancy was complicated by placenta accreta spectrum disorder (placenta previa-increta), and uterine atony. She underwent an elective caesarean section at term, during which conservative surgical management of obstetric haemorrhage was successfully performed, resulting in a favourable maternal and fetal outcome. Conclusion: Previous ovarian cancer treatment, including surgery and chemotherapy, may increase the risk of abnormal placentation, while its association with uterine atony remains unclear. This case demonstrates that successful pregnancy is possible after fertility-preserving treatment for ovarian germ cell tumours, though close monitoring for placental complications is essential. Further research and long-term follow-up are needed to clarify these risks.
Earth’s Arth’s Magnetic Field is Factor that Frges CellDivsion. Reducing Cell’s Magnetic Characteristics Occurs Aging and Death
Introduction Despite many studies on cell division, formation and treatment of cancer (Ca), there is not full explication of aging and death of cells. Everything in the Earth’s magnetic field (EMF) has paramagnetic and ferromagnetic characteristics. Hence tissue cells and organs have magnetic characteristics (Mc). This paper shows that EMF is a factor that impacts cell division. Anomalous magnetic fields (AMF) and unnatural EMF contributes to continuous cell division that causes cancer. Moreover, it shows that the magnetic characteristics of the nuclei, organelles and substances are tightly related to the metabolism of the cells. The article also explains when the immune system works the best, why it fails in preventing the formation of cancerous cells, and how aging reduces the defense of the organism against intruders. Results EMF influences all parts of the cells magnetic characteristics, which in turn impact metabolism. The sequences of the nucleotides in the construction of DNA and RNA match only by magnetic code. EMF impacts the process of crossing over which causes polymorphism and contributes to the evolution. A factor that stimulates cell division is EMF which boosts the metabolism and the immune system. All manifestations of aging are clearly explained by magnetic properties of cells. Intermolecular magnetic force (Mf) in cell varies because they depend on the number of divisions and temperature. With each division, telomeres lose 100-200 nucleotides which reduce the nucleus Mf and metabolism in the cells. The immune system weakens, because of the impact of Mf. Conclusion Natural EMF is a factor that infulences cell division. Magnetic characteristics of nuclei, organelles and substances enable metabolism in cell. EMF and magnetic characteristics of cells have a decisive contribution to the world’s evolutionary process. During cell division, Mf are decreasing in nucleus so less water enters the cell, resulting in accumulation of toxins. The functions of organs and particularly hormonal activity are declining, which leads to deposition of calcium salts in cartilage (in and around chondrocytes), and lower function of the immune system. All of the above are a manifestation of aging.
Isolation and Identification of Aerobic Bacterial Pathogens from Blood Culture of Cancer Patients in Al-Zara Hospital in Khartoum, Sudan
Patients with cancer are particularly under risk of many microbial infections and even septicaemia due to the weakened immune system induced by Chemotherapy. This study was done to identify and isolate aerobic bacterial septicaemic pathogens among cancer patients. This study was performed in Radiation and Isotopes national Centre of Khartoum Hospital (previously Alzarra) during the period from September to November 2019. One Hundred Fifty blood samples were collected from cancer patients suspected to have septicemia. All samples where inculated in blood culture media and incubated aerobically. Upon detection of growth signs the bacterial isolates were subcultured and identified according to the Standard known procedure. Antimicrobial sensitivity test was done following CLSI guidelines, The study showed that Twenty two (14%) of the investigated samples were showed growth signs, while One hundred Twenty eight (86%) were showed no growth. After subculture on Blood agar, MacConky agar and Chocolate agar, all isolated pathogens were subjected to essential bacteriological biochemical tests and identified as E.coli (57.1%) , Klebsiella pneumonia (19%) ,Staphylococcus aureus( 9.5%), Pseudomonas aeruginosa (4.8%) . Citrobacter Spp (4.8%) and Streptococcus pyogens (4.8%). Septicaemia in patients with cancer was mainly caused by E.coli in patients using chemotherapy. Further study with inclusion of more sample size and focusing on multidrug resistant isolates is essential to verify the current study results.
Copyright (c) 2019 Journal of Cancer Research Reviews & Reports
Body Fat Mass Relationship with Insulin Resistance in a Populationof Algerian Adults
Obesity, a condition considered by the WHO to be an epidemic and a major public health problem due to the severe cardiometabolic complications that accompany it, requires rigorous management. Analysis of body composition, both global and segmental, could be a key element in the exploration of obesity and therapeutic strategies to combat the deleterious effects of fat mass expansion. With this in mind, we sought to examine the relationship between fat mass and certain metabolic disorders, particularly insulin resistance. Our study involved 421 adult subjects, aged 18 to 69 years, of all weights, who underwent anthropometric, bioelectrical impedance, and biological measurements to characterize their body composition and metabolic profile. Measuring body fat percentage proved more relevant than calculating body mass index in characterizing overweight and determining metabolic status, particularly insulin resistance. The body fat percentage threshold at which insulin resistance develops has been assessed; it is 40% in women and 28% in men. Changes in body composition could be a useful indicator of glycemic control, and the importance of favoring a comprehensive approach that integrates body composition into the assessment and treatment of obesity and its metabolic complications is justified.
Pembrolizumab for Gingival Melanoma: A Spectacular Responsein a Challenging Case
Malignant melanomas of the oral cavity are extremely rare tumors. The mandibular mucosa is the most frequent site for melanomas of the oral cavity. Although they are easy to detect due to their pigmentation and irregular shapes and contours, diagnosis is often delayed and only occurs in cases of ulceration or hemorrhage of the overlying epithelium. This late detection is the cause of poor prognosis. Mucosal Melanoma (MM) in general, and gingival melanoma in particular, represents a significant clinical challenge due to its aggressive nature and limited treatment options. Immunotherapy is a promising strategy for these melanomas, with a particular focus on immune checkpoint inhibitors, such as PD-1 inhibitors. We will report the case of a 70-year-old female patient who presented with gingival melanoma, and discuss through this case the diagnostic pitfalls and therapeutic options of this rare pathology
Mesenteric-Jejunal Desmoid Tumor. Incidental Finding in a Patient with Acute Appendicitis: Case Report
Desmoid tumors, formerly called aggressive fibromatosis and fibrosarcoma grade 1, are fibrous tumors that occur without predilection for any sex, in the third and fourth decade of life. They mainly occur in extremities and abdominal wall. This case is a 53-year-old female who was diagnosed with an incidental jejunal tumor due to acute appendicitis. The patient was first treated for an attack of acute appendicitis, during the physical examination an epigastric mass became evident. When abdominal CT (computed tomography) scan was performed, the diagnosis of acute appendicitis was confirmed and the presence of a solid tumor was documented, which suggested involvement of the third and fourth portion of the duodenum. Laparoscopic appendectomy was performed without complications. One week later and as an external patient, a new abdominal CT scan was performed, which suggested “GIST” (Gastrointestinal Stromal Tumor). Study protocol was completed, and exploratory laparotomy was performed with tumor and jejunal diverticulum resection. Within the surgical findings, we observed a jejunum-dependent tumor with a diameter of 7 cm that was located 10 cm away from the Treitz angle. A block resection and a primary jejunal-jejunal anastomosis were performed. The patient was discharged on her POD 10 without any surgical complications.