Captopril and Hydrochlorothiazide: Insights on Pharmacology and Analytical Chemistry Profile

Authors

  • Mahmoud M Sebaiy Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author
  • Fatima S Abdelazim Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author
  • Fatma E Amer Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author
  • Fatma H Eldossoki Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author
  • Farouk R Farouk Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author
  • Fatma H Bakry Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author
  • Fatma A Amin Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author
  • Fatma M Essam Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author
  • Alzahraa MF Ebrahim Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author
  • Karim M Hegazy Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt Author
  • Samar S Elbaramawi Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt. Author

Keywords:

Hypertension, Captopril, Hydrochlorothiazide, Pharmacological Effect, Analytical Methods

Abstract

Many categories of drugs are used today for hypertension such as captopril which belongs to ACE inhibitors family and hydrochlorothiazide which consider a diuretic drug.In this literature review, we will focus on their pharmacological effect as well as most of the recent reported analytical methods that have been established for their determination in their pure form, combination form with other medications, combined form with its
metabolites, and in biological materials

Author Biographies

  • Mahmoud M Sebaiy, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

    Mahmoud M Sebaiy, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

  • Fatima S Abdelazim, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

     Fatima S Abdelazim, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

  • Fatma E Amer, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

     Fatma E Amer, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

  • Fatma H Eldossoki, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

    Fatma H Eldossoki,Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

  • Farouk R Farouk, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

    Farouk R Farouk, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

  • Fatma H Bakry, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

    Fatma H Bakry, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

  • Fatma A Amin, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

    Fatma A Amin, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

  • Fatma M Essam, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

    Fatma M Essam, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

  • Alzahraa MF Ebrahim, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

    Alzahraa MF Ebrahim, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

  • Karim M Hegazy, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt

    Karim M Hegazy, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt

  • Samar S Elbaramawi, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

    Samar S Elbaramawi, Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Sharkia, 44519, Egypt.

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Published

2022-06-29

Issue

Vol. 1 No. 2 (2022): Volume 1 Issue 2

Section

Articles