Journal of Clinical Medicine and Regenerative Medicine
Journal of Clinical Medicine and Regenerative Medicine is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Clinical Medicine and Regenerative Medicine. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Article acceptance will be in the form of Research, Review, Case reports, Analysis, Magazines, Editorials, Opinion, Communications, Min-review, Short Communications, Image, Book review, Video articles and Power point presentations (PPTS) You can submit articles online from https://www.onlinescientificsresearch.com/submit-online or can send through an e-mail with attachment for clinicalmedicine@onlinescientificresearch.info
Meditation a Fast Way to Reduce Fear and Stress
The meditation claims that it leads to better anti-inflammatory response and healthy aging by proper telomerase regulation. There are also benefits and positives in physical and mental health. The variety of diseases to be studied should be increased. It affects immunology, genetics and various aspects of physical and mental health including depression, substance abuse, eating disorders, conflict between couples, anxiety disorders and obsessive-compulsive disorder. Sit quietly and focus on your natural breathing or a word or mantra that you repeat silently. Let thoughts come and go without judgment and focus your attention on the breath or mantra. Physical sensations. Notice subtle physical sensations like itching or tingling without judgment and let them go. Pay attention to each part of your body sequentially from head to toe. Sensory. Pay attention to sight, sound, smell, taste and touch. Name them without judgment, such as “sights”, “sounds”, “smells”, “tastes” or “touch” and let them go. Human beings have between 12,000 and 50,000 thoughts per day, and 80 percent of them are negative. Emotional experiences deeply affect our physical states, for example, when we feel anger, our eyes close and our face burns. The training has positive effects on the physical and mental health of adults, such as reducing mood and anxiety disorders, distress and blood pressure. Magnetic alternating current stimulation applied at different frequencies (beta, theta and gamma) while theta and beta-tACS caused participants to rate emotional images as more pleasant (higher valence), while only theta-tACS reduced subjective arousal ratings (more calm). Regular practitioners have younger and brighter skin due to freedom from fear and stress.
Copyright (c) 2025 Journal of Clinical Medicine and Regenerative Medicine
Evaluation of the Effectiveness of Pharmaceutical Counselingon Therapeutic Outcomes of HIV/AIDS Patients at WaihaongCommunity Health Center
Introduction HIV/AIDS is a global health problem. Over the past 30 years, HIV/AIDS rates have increased at an alarming rate, ranking among the top 10 diseases posing a global burden. Pharmacists play a crucial role in HIV/AIDS control, including through drug counseling. Pharmacist counseling is crucial for improving patient adherence, which impacts therapy outcomes, including viral load levels and quality of life Material and Methods The study was conducted using a cross-sectional method, using questionnaires to assess patient quality of life and compliance. A retrospective approach, reviewing patient medical records, was used to determine viral load levels. The data was then processed using SPSS 's chi-square method Results A study of 234 HIV patients found that the frequency of pharmacist counseling significantly correlated with therapeutic outcomes, including viral load levels and patient quality of life. However, no significant association was found between frequency and patient adherence to therapy Conclusions: Counseling by pharmacists can impact therapeutic outcomes for HIV patients; therefore, providing effective counseling is crucial. Pharmacists should also consider providing other professionals to support consultations whenever the patient needs them, not just every three months for patients on multi-month dispensing.
HIV/AIDS, Pharmacist Counseling, Therapeutic Outcome
The Relationship between Education Level and TherapeuticOutcomes of Patients using Metformin alone and in Combinationin Ambon City
Diabetes mellitus (DM) is a chronic disease caused by problems with the pancreas to produce sufficient amounts of insulin or the body cannot use the insulin it produces properly. Socio-demographic variables such as education level, age, gender, socioeconomic such as employment and medical costs, and frequency and amount of medication are some of the factors that can affect a patient's adherence to taking medication. By knowing these factors, people at risk of developing diabetes can take preventive measures by controlling other factors related to diabetes. The purpose of the study was to evaluate the effect of DMT2 patients' education level on adherence in the use of single and combination metformin drugs, analyze differences in therapeutic outcomes, find out what factors affect therapeutic outcomes and analyze the patient's quality of life. Methods: This study involved 300 DM respondents using a cross-sectional approach that met the inclusion criteria. Data were collected through the MMAS-8 questionnaire (Morisky 8-item drug adherence scale) and EQ-5D Value set Indonesia, and were equipped with medical records. Then the Chi-Square test was used to see the relationship between education level and compliance, the Mann-Whitney non- parametric test to analyze the difference in therapeutic outcomes with the type of therapy and to see the relationship between the patient's quality of life and the type of therapy, and the Cox Regression test to determine the factors that determine the level of education to the therapeutic outcome. The results showed the relationship between education level and patient compliance (p value = 0.291), the difference in therapy results with the type of therapy in the final GDP group that was treated using single and combination metformin (p=0.013 value) while in the Cholesterol group (p=0.036 value). Determinants of education level on therapeutic outcomes for elementary school (p=0.214), junior high school (p=0.428), high school (p=0.789), high compliance (p=0.665), moderate compliance (p=0.136), type of therapy (p=0.624), Age (p=0.085), Male (p=0.948), Female (p=0.959), Private Worker (p=0.830), Entrepreneur (p=0.330), Civil servants (p= 0.499), as well as the relationship between quality of life and the type of therapy (p=0.300). Conclusions: There was no significant relationship between education levels and patient compliance. The difference in therapy outcomes with the type of therapy in patients from the final GDP and cholesterol therapy outcomes group was significant. There was no significant relationship between the quality of life and the determinants of the treatment outcome were not significant.
Diabetes Mellitus, Education Level, Metformin
Analysis of Drug Management in Relation to Drug Availability andPatient Satisfaction at Community Health Centers in Ambon City
Abstract Health services are an effort that can be implemented individually or simultaneously within an organization with the aim of maintaining and improving health, preventing and curing disease, and restoring the health of individuals, families, groups, and communities. The government's efforts to realize public health development include establishing Community Health Centers (Puskesmas). Puskesmas provide promotive, preventive, curative, and rehabilitative [1]. One of the determining factors for the success of services at Puskesmas is the availability of adequate medicines. The management of drug supplies and disposable medical materials is a series of cyclical activities, starting from selection, needs planning, procurement, receipt, storage, distribution, destruction and withdrawal, control, and administration [2]. The purpose of this study is to determine how the drug management process includes planning, procurement, storage, distribution and recording, to determine the level of drug availability, to analyze the relationship between drug management and the level of drug availability and to analyze the relationship between drug availability and patient satisfaction in Ambon City community health centers. Methods This research method involved 150 respondents. This research is quantitative research with a descriptive analytical design using a cross-sectional approach, namely measuring the variables of drug management, drug availability, and patient satisfaction at the same time to see the relationship between variables. The results of the study showed a correlation between drug management and the level of drug availability at the community health center, with the results of the Spearman coefficient test of ρ = 0.83. Drug management also correlated with patient satisfaction with a Spearman correlation of ρ = 0.86. Drug availability had a strong and significantly positive relationship with patient satisfaction with a Spearman correlation of ρ = 0.88. Conclusions From the results of the study, it can be concluded that the drug management process includes planning, procurement, storage, distribution and recording in Ambon city health centers is carried out well, Planning has an average score of 3.71, Procurement has an average score of 3.64 Storage has an average score of 3.60, Distribution has an average score of 3.63, and recording has an average score of 3.72. The level of drug availability in Ambon city health centers is included in the good category with an average score of 87%. There is a strong and significant positive correlation between drug management and the level of drug availability, drug management with patient satisfaction and drug availability with patient satisfaction.
Analysis , Drug Management, Drug Availability, Patient Satisfaction
One-Health Approach to Determine and Tackle AntimicrobialResistance in the Human Dairy Interface: A Case of Non-TyphoidalSalmonella and Lactose-Fermenting Enterobacteriaceae
Background Antimicrobial resistance (AMR) is among the top public health concerns globally. Determining the susceptibility pattern of pathogens is important in designing strategies to combat AMR. Thus, this study was designed to determine the AMR pattern of non-typhoidal Salmonella (NTS) and lactose fermenting Enterobacteriaceae (LFE) isolated from the human-dairy interface in the northwestern part of Ethiopia, where such information is lacking. Methods The study analysed 362 samples collected from humans, animals, food (milk) and the environment (sewage). The bacteria were isolated from the samples using standardized bacteriological methods. The antimicrobial susceptibility patterns and extended-spectrum beta-lactamase (ESBL) production ability were screened and confirmed by using the Kirby-Bauer disk diffusion method. The isolates were further characterized enotypically using multiplex polymerase chain reaction targeting the three ESBL-encoding genes. Results A total of 28 and 375 NTS and LFE bacterial isolates were identified. Isolates were more resistant to ampicillin and tetracycline. Forty-six point four and 70.7% of NTS and LFE were multidrug resistant (MDR), respectively. None of NTS and 21.3% of LFE were ESBL-producing. Genotypically, the majority of the isolates (97.5%), which were positive on the phenotypic test, were carrying one or more ESBL encoding genes. In conclusion, a high proportion of the bacterial isolates were resistant to commonly used antimicrobials, MDR, and were positive for ESBL production. Conclusion The findings provide evidence that the human-dairy interface is one of the important reservoirs of AMR traits and intervention points to reduce AMR. Therefore, the implementation of AMR mitigation strategies in a one-health approach is highly needed in the area.
Antimicrobial Susceptibility, Extended-Spectrum Beta-Lactamase, Lactose Fermenting Enterobacteriaceae, Human-Dairy Interface, Multidrug-Resistance, Non-Typhoidal Salmonella, Northwest Ethiopia
Achenef Melaku Beyene Achenef Melaku Beyene
Assessing Symptom Severity and Quality of Life Implications inWomen of Reproductive Age with Uterine Fibroids and RelatedConditions in Lahore
Uterine fibroids (UFs) represent the most common benign neoplasms of the uterus and an important cause of morbidity in women of reproductive age. The study is a cross-sectional study carried out in Lahore, Pakistan, between March and June 2025, to determine the symptom burden and impact on healthrelated quality of life (HRQOL) among women with UFs through a validated Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire. Among the 423 women surveyed, 81 (19.1%) had symptomatic fibroids. Most of these women experienced moderate (66%) and severe (9%) symptoms, especially excessive menstrual bleeding, pelvic pressure, and fatigue. The highest functional impairment was observed in the areas of energy/mood, concern, self-consciousness, and perceived control over daily life. The mean symptom severity score was 52.7 ± 17.3. The multivariate logistic regression model served as the predictors of fibroid diagnosis age 30-40 years, very early menarche (<10 years), and high parity, which highlighting the contribution of reproductive history to UF risk. Social, emotional, and physical functioning was seriously impaired in most of the affected women with over two-thirds of them showing moderate to very important impacts in several HRQOL domains. The results agree with global statistics and show the dire need for early diagnosis, community education, and culturally specific management options to reduce the physical and psychosocial impacts of uterine fibroids in lowand middle-income environments.
Leiomyoma, Symptom Severity, Frequency, Health Related Quality of Life (HRQL), Uterine Fibroid Symptom-Quality of Life Questionnaire (UFS-QoL), Questionnaire
Muhammad Wamiq Masood Muhammad Wamiq Masood
Obstructive Icteric Syndrome in a Patient with a History of Burkitt'sLymphoma
The patient was a 16-year-old male with a history of Burkitt's lymphoma, stage III, diagnosed at 3 years of age and treated with chemotherapy, who presented with fever, productive cough, dyspnea not associated with exertion and altered state of consciousness. On physical examination, patient in regular clinical conditions, generalized icteric tinge. He presented paraclinical findings suggestive of icteric syndrome and an abdominal tomography that reported dilatation of intrahepatic and extrahepatic ducts, so the diagnosis of obstructive icteric syndrome was made. In the case presented, the etiopathogenesis of this patient's diagnosis can be explained by an extrinsic compression of the biliary tract due to a probable recurrence of the underlying pathology 13 years after his diagnosis.
Book Overview: Reversing Osteoarthritis: The 3-Step Strategy toNaturally Healing and Recovering from Pain
Imagine a life where your body feels strong, your joints move freely, and you're no longer dependent on medications or invasive treatments. In Reversing Osteoarthritis, pain specialist Dr. Zeeshan Tayeb introduces a 3-step strategy designed to help you naturally heal your body and reclaim your quality of life.
Side Effects of Metformin in Type 2 Diabetes Mellitus: A SystematicLiterature Review
Background: Metformin is a Biguanide antihyperglycemic medication, is still considered as the best medications, and the first line of treatment either as monotherapy or in combination with other drugs for type 2 diabetes mellitus. Even though metformin has efficacy, very low risk of hypoglycemia and weight gain, and low cost, it also has side effects that can’t be ruled out. The aims of this study to evaluate of side effects of metformin in type 2 diabetes mellitus. Methods: Medline via (via Pub Med) from 2019 until 2024 in English. Term defining side effects of metformin were combined with the term type 2 diabetes mellitus during the search. The studies were chosen based on inclusion criteria. Results: There were 40 patients (53.3%) had gastrointestinal (GI) effects with persistent use of metformin tablet for 7.8 years in average, including epigastric and abdominal pain, nausea, vomiting, diarrhea, and bloating, and the other research showed that Metformin therapy can reduce testosterone levels in males with T2DM who had normalized blood control, that is indicated that the use of metformin may be another reason of the high prevalence of low testosterone levels in males with T2DM, the same thing also happens with vitamin B12 deficiency that there was a graded increase in the likelihood of vitamin B12 deficiency with increasing dose with those treated with > 2000 mg daily at nearly 40 times the odds compared with those not taking metformin. Conclusion: from systematic literature review study, it was found that there are side effects of metformin that cannot be ruled out, such as gastrointestinal (vomiting, diarrhea, bloating), decreased testosterone levels and deficiency vitamin B12.
Side Effects, Metformin, Type 2 Diabetes Mellitus
The Benefit of Melinjo Peel (Gnetum Gnemon) Ethanol Extract toPrevent Hepatocytes from Damage in Hyperuricemia Rat Model- Induced High Fructose
Introduction: Hyperuricemia can induce a dysfunctional exchange of sodium and calcium in mitochondria which will lead to the production of reactive oxygen species (ROS). ROS plays a role in aging, DNA damage, oxidation, production of inflammatory cytokines, and cell apoptosis. Uric acid metabolism is catalyzed by xanthine oxidase (XO) to produce hydrogen peroxide (H2 O2) which can form scar tissue in the liver. Alt1 and Hgf expression plays a role in reflecting hepatic cell from damage and repair. Method: It was a true experimental study with post-test only control group design using stored biological material of 32 samples, divided into four groups, K0: the control group without treatment; P1: intervention group of 86% fructose and 0.5% CMC; P2: intervention group of 86% fructose and allopurinol; P3: intervention group of 86% fructose and ethanol extract of melinjo peel. Alt1 and Hgf expression determination using real-time PCR (rt-PCR) with Livask method 2–ΔCt. Result: Alt1 expression in hyperuricemia model rats after 10 days of treatment with ethanol extract of melinjo peel was lower than the control group (p=0.001), CMC (p=0.001), and allopurinol (p=0.059). Hgf expression tends to have the same cycling threshold in all groups (p=0.065). There was no correlation between Alt1 expression and Hgf after 10 days of treatment (r=-0.08; p=0.661). Conclusion: The ethanol extract of melinjo peel has the potential to be a hepato-protector in the hyperuricemia model rat by reducing Alt1 expression better than the other treatment groups.
Melinjo Peel Ethanol Extract, Alt1, HGF, Hyperuricemia, Rat
Effectiveness of Pharmacist Counselling on Medication Adherencein Diabetes Mellitus Patients: A Systematic Review
Type 2 diabetes mellitus is a disease with a high prevalence in Indonesia. It is one of the non-communicable diseases that contributes to quite a number of complicating diseases. So type 2 diabetes mellitus must be given appropriate and consistent therapy in order to have an effect that can improve the quality of life of type 2 diabetes mellitus patients themselves. Apart from non-pharmacological therapy, patients with type 2 diabetes mellitus who have been using oral antidiabetic drugs for a long time experience many obstacles in terms of treatment. Therefore, the role of health workers, in this case pharmacists, is needed to provide counselling so that patient compliance with taking medication can be achieved which has an impact on improving the quality of life of diabetes patients.
Pharmaceutical Counselling, Type 2 Diabetes Mellitus, Patient Adherence
Copyright (c) 2024 Journal of Clinical Medicine and Regenerative Medicine
Genetic, Linguistic and Molecular Anthropological Study of theIndian Ocean Littoral in Austronesian Dispersal Across the Pacific
The Indian Ocean region is a critical route/corridor/barrier for the migration and settlement of people whose social, linguistic and genetic ancestry is of interest to anthropologists worldwide. Varying from the ‘little tradition’ of small isolated populations to the ‘great tradition’ of global and admixed heritage, in the field of collating evidences from culture, language and anthropological genetics this paper will examine the ‘Austronesian dispersal’ within the boundaries of the Indian ocean sporadically sprinkled across Pacific islanders. Littoral or near shore settlements may have simply act as ‘gateways’ as would have been the case with pre-historic settlements somewhere near a fresh water source or river bank. Physical environmental changes such as those driven by drastic ecological catastrophes including severe and acute adaptations to climatic and nutritional stressors can leave signatures providing vital clues for the dispersal of humankind. During the last two decades or more, a plethora of genomic information has surfaced tracing the genetic history of an archaic hominin group from ancient DNA. In the light of ensuing works by palaeoanthropologists and evolutionary biologists, the dispersal and migration of people, genes and languages studying human history either directly through their remains or indirectly through tools, pottery or other cultural items have provided concerns over interpretation of archaeological dates. Similarly assessing the reliability of linguistic data which may favour a close correlation between genes and languages, yet at times appear to conflict with genetic evidence. Despite these limitations, several ideas has been put forth concerning the dispersal of modern humans from Africa via the southern route, along the coast of India, eventually reaching Sahul the landmass consisting of Australia and New Guinea, which were connected until rising sea levels separated them about 8000 years ago. This putative “early southern dispersal”, as it came to be known, would now be underwater. From single versus multiple dispersal models molecular anthropologists have re-examined hypotheses about the colonization of the Pacific with different pliable approaches to understand population histories in the context of the ‘Austronesian dispersal’ across the Pacific.
Molecular Anthropology, Genetic, Linguistic, Archaeological, Migration, Dispersal, Austro-Asiatic, Austronesian, Indian Ocean, Pacific
A Comprehensive Case Report: Managing Severe HemolyticAnemia with Collaborative Medical and Nursing Interventions
Assessment: A 30-year-old woman with severe hemolytic anemia arrived at the ER with a critically low hemoglobin level of 2.1 g/dL, leading to an immediate packed red blood cell transfusion. After stabilization, she was moved to the ICU due to her deteriorating condition. The assessment covered respiratory health, cardiovascular markers, fluid/nutrition balance, physical exam, and X-ray results. Importantly, her Glasgow Coma Scale score showed altered consciousness. Diagnosis: Based on the comprehensive assessment, a range of nursing diagnoses were formulated according to the North American Nursing Diagnosis Association (NANDA) 2021-2023. These included Impaired Gas Exchange due to low Hb levels, Risk for Bleeding stemming from decreased red blood cell (RBC) count, Risk for Infection owing to compromised immunity, Activity Intolerance due to severe anemia, and Anxiety prompted by critical illness and unfamiliar surroundings. Planning: The care plan targeted interventions for each nursing diagnosis. To address Impaired Gas Exchange, we closely monitored respiration and adjusted ventilator settings. For Risk of Bleeding, we took bleeding precautions, handling gently and tracking coagulation. To prevent Infection, we prioritized aseptic methods and temperature checks. For Activity Intolerance, we used Activity Therapy and gradual progression. To ease Anxiety, we applied techniques to reduce psychological stress. Discussion: This case stressed the urgency of interventions for severe hemolytic anemia. The patient's critical state led to immediate PRC transfusion and ICU transfer. Cardiovascular and oxygen-carrying interplay showed in physiological signs. Nursing diagnoses and care planning revealed holistic care needs. Altered GCS and lab values steered interventions, urging interdisciplinary teamwork. Radiography showed heart response to chronic anemia. The discussion emphasized precise assessment, diagnoses, and planning for intricate conditions like severe hemolytic anemia.
Hemolytic Anemia, Red Blood Cell Destruction, Nursing Interventions, Interdisciplinary Collaboration
Pediatric NAFLD - The Increasing Obstacle of The New WorldRetrospective Analysis of COVID-19 Pandemic
Nonalcoholic fatty liver disease (NAFLD) is the presence of excess fat in the liver that occurs without significant alcohol consumption [1]. It is typical for the liver to have a small amount of fat. However, when fat makes up more than 5% to 10% of the liver's weight, it is called fatty liver (steatosis) [2,3].
Relationship of Health Literacy and Self-Management Behaviorin Hypertension Groups in Working Area of Public Health CenterPacellekang Gowa Regency
Background: Hypertension is the main cause of premature death worldwide. Hypertension has become a global, regional, national, and local public health problem. Hypertension requires proper self-management and health literacy in handling it. Methods: Correlational anality descriptive research design using a cross-sectional study approach. Sampling technique using non-probability sampling with purposive sampling technique. The sample obtained is 128 people. Data collection used the HELIA Questionnaire (Health Literacy Instrument for Adults) and the HBP-SCP Questionnaire (High Blood Pressure-Self Care Profile). Results: The results showed that the majority of respondents had low health literacy with a percentage of 56.3% and the majority had poor hypertension management behavior with a percentage of 54.7%. The results of the bivariate test using the Chi-Square test with a significance value of 0.006 <0.05, so that the better a person's health literacy, the better his hypertension self-management behavior. Conclusions: The conclusion of this study is there is a significant relationship between health literacy and hypertension management behavior in the community in the Pacellekang Health Center work area, Gowa Regency
Health Literacy, Hypertension, Hypertension Management Behavior
Study on the Effects of Sound and Music as Medicine onCardiovascular Health
This paper explores the dual impact of Sound frequencies and music on cardiovascular health, analyzing how sound frequencies and musical interventions influence cardiovascular risk factors and outcomes. While environmental factors have been linked to an increase in cardiovascular diseases due to stressrelated mechanisms, Sound frequencies and music therapy offer potential benefits through their calming effects on the autonomic nervous system.
Quality Assessment of the Management of Confirmed COVID-19Cases
Introduction: Health Center of Varis (H.C.V.) from 1/10/2020 has become a COVID 19 clinic. PCR tests were taken and were sent for examination to the microbiological laboratory of the University Hospital ATTIKON. All PCRs were registered at the national COVID 19 registry. The aim of this project is to evaluate the management of COVID 19 + cases in HCV. Materials and Methods: In order to evaluate the way that COVID 19 cases, were managed by health care professionals(H.C.P), of Health Center of Vari (HCV), will be used the national COVID 19 registry. We will use the data as these are recorded, from 1/10/2020 to 15/01/2022. Based on this registry a week report for covid 19 positive tests was sent to health authority. The week positiveness will be calculated for the same time. Data were processed with EXCELL 2007. Results: A. 1/10/2020-27/6/2021 1. Type of Hospitality: Of the total 542 positive cases, 486 (90%), did not require hospitalization but remained at home, 52(9%), required hospitalization at home, and 4(1%), were unclear. 2. Disease Outcome: Of the total of 542 positive cases, 3(1%) ended up, 203(37%) were cured and 305(62%) are still recorded as active cases B. 30/6/2021-15/1/2022 1. Type of Hospitality: Of the total 920 positive cases, 920 (100%), did not require hospitalization but remained at home. None of them 0(0%), required hospitalization, and none of them 0(0%), were unclear. 2. Disease Outcome: Of the total of 920 positive cases, 0(0%) ended up, 40(56%) were cured and 515(44%) are still recorded as active cases. The peak of the 2nd curve took place in the week of 16-22/11/2020, of the 3rd curve in the week from 29/3-4/4/2021 and the peak of the 4th curve in the period in the week from 23/12/2020-1/1/2021. Conclusion E-recording of the data of the patients seen at an outpatient clinic of HCV was necessary in order quality assessment and assurance at the period of Covid 19 Pandemic to be achieved.
COVID 19 Positive, Quality Assurance, Primary Care
Cost-Benefit Analysis of a Pharmacist’s Contribution in DecreasingAsthma-Related Economic and Health Burden with a Focus onthe Hispanic Population
Asthma stands as one of the most prevalent and costly health conditions in the United States. Asthma affects over 27 million people in the U.S., which translates to approximately 1 in 12 individuals [1,2]. The burden of asthma in the United States is significantly higher among individuals with low income, senior adults, and Black, Hispanic, and American Indian/Alaska Native populations, who exhibit the highest rates of asthma-related fatalities, and hospitalizations [3].
"Galeno" Neurosurgery Device for Brain Herniation aMultidisciplinary Approach to Complexity
Introduction: “Galeno” is the theoretical medical device that I designed for patients with severe stroke and herniated brain. It is shaped like a helmet, 3D printed. The design of this device combines: neurosurgery, neurotechnology, drug delivery and modern knowledge of biomedical engineering and computer science. The goal is to reduce brain edema and optimize homeostasis. Patients with brain herniation often have intracranial injuries and concomitant or habitual damage to other organs. The mortality rate can be between 60% and 84.6% in cases of TBI (traumatic brain injury) with herniated brain. More than 27 million people worldwide are affected by TBI each year. Traumatic brain injuries (TBIs) affect thousands of people in the United States every year. The economic impact of TBIs, in the United States, was estimated to be $ billion in direct and indirect costs. Traumatic brain injury (TBI) is a devastating neurological disease due to its high morbidity and mortality. Decompressive craniectomy (DC) has been used for decades to treat TBI, severe hemispheric strokes, etc. However, although DC is an effective treatment for patients with TBI, the risk of mortality and morbidity remains high, as it alone is not sufficient to ensure successful surgery and patient recovery [1]. “Galeno” medical device was created for the management of brain injury and intracranial hypertension and is placed on the brain via DC to protect, treat and monitor it until cranioplasty.
Exploring Opportunities and Developing Solutions to Address Challenges Being Faced Across Europe
May 19 is the International Day of Family Doctors. Our professional society, SSVPL, is organizing an event called "Krokovačka„ (free translation - Step by step) on his day. The idea of the „Krokovačka“ was born in 2019 at the 24th European WONCA Conference, in Bratislava where SSVPL hosted more than 2300 doctors from all over the World. The event was led by our Olympic gold medalist 50km walk, Matej Tóth. This event is usually organized in Bratislava, but this year we did it a bit differently, also on a local level, in cooperation with the representatives of the municipality of Terňa,my patients and other volunteers.
Therapeutic use of Parasites in the Treatment of InflammatoryBowel Disease
. Helminths are multicellular invertebrates that colonize the gut of many vertebrate animals including humans • This colonization can result in pathology, or it can lead to a commensal, even a symbiotic relationship • Epidemiological data have linked helminth exposure to protection from immune disorders (allergies, autoimmune illnesses, IBD) • Treatment of moderate to severe IBD involves the use of immune modulators, biologics and surgical intervention, which can cause life-threatening complications • Their safety profile makes helminths or helminth products attractive as novel therapeutic approaches to treat IBD
Chronic Kidney Disease and Oxidative Stress
Disturbance of the balance between production of oxygen free radicals (or some other radical species) and activity of antioxidative system of protection causes the so called oxidative stress Protection of an organism from oxygen free radicals implies activity of enzymatic (catalase, SOD, glutathione peroxidase, glutathione reductase etc.) and nonenzymatic (vitamin E. vitamin C. glutathione, uric acid etc.) systems of protection. An organism can tolerate a mild oxidative stress but a higher disturbance between the production of free radicals and the activity of the antioxidative protection results in lipid protein and DNA as well as numerous diseases. In this article we analyze oxidative stress role as an important cofactor contributing to endothelial dysfunction, inflammation, atherosclerosis,glomerulosclerosis, anemia, tubulointerstitial nephritis and ischemia-reperfusion injury to chronic kidney disease patients.
Oxidative Stress, Atherosclerosis, Endothelial Dysfunction, Chronic Kidney Disease, Ischemia-Reperfusion Injury
The Eyes have it: A Case of Ptosis and an Overview
Ptosis, formerly blepharoptosis, has a very broad differential which can make correct and timely diagnosis difficult. This is a fairly common presenting conundrum in a busy clinical practice. A case of ptosis and fatigablity in a young female which evaded diagnosis for nearly two years is presented highlighting some of the diagnostic challenges as well as literature overview and current treatment strategies.
Autism spectrum disorders are a variety of disorders characterized by social and psychological impairments. Difficulty switching from one activity to another, getting caught up in details, and unusual reactions to sensations, As the abilities and needs of people with autism vary and can evolve over time, some people with autism may be able to lead independent lives.
Ibrahim Ali Al-Baher Ibrahim Ali Al-Baher
Copyright (c) 2023 Journal of Clinical Medicine and Regenerative Medicine
Unconditioned Reflexes are the Basis of an Elf-Regulating System,the Structure of the Musculoskeletal Frame of the Body
Unconditioned reflexes are the main form of activity of the nervous system, which, regardless of our consciousness, reacts to external stimuli, coordinating the stable position of the body, the movement of fluid media, and the vital processes of the body. Reflex activity is formed in the spinal cord and cerebellum, controlled by the cerebral cortex.
The Importance of Interplay of Repulsive and Attractive Forces inAging
The role of repulsive and attractive forces at the molecular level in the aging process is a constant, omnipresent part that occurs over time, in all chemical processes, not just biochemical ones. The same thing happens in concrete, because as time goes by, it tends to become more and more compact, which is a result of the repulsive forces being minimized and the attractive ones being optimized. And since it is a process that happens in all or almost all molecules, our body is no exception. So, the molecules that make up us tend to compact because the molecules that make up us tend to compact over time. That is: repulsions are minimized, and attractions are optimized. This is why people tend to be smaller as they age. Life is based on the interaction between attractive and repulsive forces and is a dynamic process that is strictly regulated by millions of years of evolution. We can say that it is an amazingly accurate process, which is surprising because, the attractive and repulsive forces start from the atoms, which have positive and negative charges. And even more so because it is not understood how these charges are generated, without referring to electrons or protons, but what is it that gives charge to said subatomic particles; it is much less understood why different charges attract, and like charges repel. So, projecting the interaction of charges from the subatomic, atomic, and molecular level, until reaching the complex organic molecules, made up of very complex as well as very large molecules, then we understand why it is so difficult to understand the interaction of repulsive forces and attractive in relation to life, because in fact, this dynamic interaction, carefully regulated by millions of years of evolution, hatches until we reach what we call life. And from there we move on to another equally complex question: where do the elements and energy necessary for the cell to carry out these interactions come from? These not only have to do with cellular functions, but even with maintaining the necessary dynamic or even normal cell's shape.
Assessment of Functional Outcomes and Quality of Life in Patientswith Tongue Cancer after Partial Glossectomy
Introduction: Tongue cancer and its therapy affect significantly patients’ quality of life (QoL) and functionality. Purpose: To determine the consequences of glossectomy on patients’ QoL and functionality. Material and Methods: Between October 2021 and January 2022, we conducted a cross-sectional observational study of 40 patients with tongue cancer who underwent partial glossectomy and neck dissection in the University Clinic of Oral and Maxillofacial Surgery of General Hospital of Athens “Evangelismos”. Patients completed the EORTC QLQ-C30 and QLQ-Η&Ν43 questionnaires and the Eastern Cooperative Oncology Group Performance Status Scale (ECOG-PS). Results: Patients were aged 23-83 years. The majority were men (70%), married (55.0%), with higher education (40.0%), working (52.5%), were undergoing in postoperative radiotherapy and chemotherapy (50%) and reported the difficulty in speaking as the most serious problem (42.5%). According to the QLQ-Η&Ν43 questionnaire, fear of disease progression, problems with teeth, social eating and speech disorders had a negative influence on QoL. On the ECOG-PS, 95% of patients were grade 1 and 5% grade 2. A positive correlation was found between the increase of the number of symptoms (p<0.001), low educational level (p<0.001) and smoking (p=0.023) and low global health status/QoL. Finally, no correlation was detected between QoL and use of adjuvant therapies (p>0.05). Conclusion: The main problems at least one year after partial glossectomy are difficulty in speaking and swallowing, as well as anxiety about disease progression. However, the majority of patients reported that their functionality had improved with time and evaluated their QoL as satisfactory
ECOG Scale, Functionality, Glossectomy, Tongue Cancer, Quality of life
A 20-year-old male visited our hospital for routine ocular examination. He was a known case of Neurofibromatosis Type 1(NF1). There was no other significant history. His visual aquity was 6/6 in both the eyes. Bilateral fundus examination, colour vision, intraocular pressure, and ocular movements were within normal limits. Slit lamp examination revealed iris hamartomas (lisch nodules) in both the iris (figure 1 and 2). He was advised a regular ophthalmology followup.