Comparison of Hematological Indices in Patients before and After Coronary Artery Bypass Grafting (CABG)

Authors

  • Hamid Hoseinikhah Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran Author
  • Daryoush Hamidi-Alamdari Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Author
  • Parisa Asadyian-sohan Department of Metabolic Syndrome research center, Mashhad University of Medical Sciences, Mashhad, IR Iran Author
  • Omid Javedanfar Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran Author
  • Farshad Samadie Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran Author
  • Hamed Banpou Department of Metabolic Syndrome research center, Mashhad University of Medical Sciences, Mashhad, IR Iran Author
  • Ali Javandoost Department of Metabolic Syndrome research center, Mashhad University of Medical Sciences, Mashhad, IR Iran Author
  • Aliasghar Moeinipour Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran Author
  • Malihe Aghasizadeh Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Author

DOI:

https://doi.org/10.47363/JCCEM/2024(3)151

Keywords:

Hematological Indices, Bypass

Abstract

Subject: Clinically, a reduction in hematocrit (Hct) or hemoglobin (Hb) levels is a notable condition commonly observed in patients undergoing coronary artery bypass grafting (CABG). Postoperative anemia is a risk factor for mortality in patients undergoing CABG, affecting both the early and late stages of recovery. However, the underlying mechanisms remain incompletely elucidated. We aimed to investigate the relation between the hematologic indices with two surgery methods (on-pump & off-pump).

Methods: Fifty consecutive CABG cases were randomly assigned to group I (On-pump, n= 24) and group II (Off-pump, n = 26). General clinical and surgery parameters, hematologic incidence were measured in two blood samples, the first sample was taken from each patient on the morning of the day of surgery after 12-hr fasting, and the second sample on the first postoperative day at 24-hr after surgery. Statistically assessing serum levels pre- and post-CABG and comparing between the two groups was analyzed and the correlation between parameters was evaluated.

Result: In the baseline, there were significant differences between the on-pump and off-pump groups regarding heart rate (HR) (p = 0.002). Investigation after surgery showed that the difference in HR and urea levels in pre- and post-CABG was significant when compared between the two groups. A significant difference was observed in the white blood cell, it became less after the operation. The decrease in platelet and PT level in patients who underwent the on-pump and off-pump surgery (diff = -23.5 and diff = -0.62, respectively) was shown and this difference remained significant between the two groups.

Conclusion: We achieve the on-pump method places greater stress on blood cells, resulting in reduced levels of white blood cell in patient outcomes. It can be suggested that it should be adjusted for patients undergoing both on-pump and off-pump surgeries.

Author Biographies

  • Hamid Hoseinikhah, Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran

    Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran.

  • Daryoush Hamidi-Alamdari, Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

  • Parisa Asadyian-sohan, Department of Metabolic Syndrome research center, Mashhad University of Medical Sciences, Mashhad, IR Iran

    Department of Metabolic Syndrome research center, Mashhad University of Medical Sciences, Mashhad, IR Iran.

  • Omid Javedanfar, Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran

    Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran.

  • Farshad Samadie, Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran

    Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran.

  • Hamed Banpou, Department of Metabolic Syndrome research center, Mashhad University of Medical Sciences, Mashhad, IR Iran

    Department of Metabolic Syndrome research center, Mashhad University of Medical Sciences, Mashhad, IR Iran.

  • Ali Javandoost, Department of Metabolic Syndrome research center, Mashhad University of Medical Sciences, Mashhad, IR Iran

    Department of Metabolic Syndrome research center, Mashhad University of Medical Sciences, Mashhad, IR Iran.

  • Aliasghar Moeinipour, Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran

    Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran. 

  • Malihe Aghasizadeh, Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Malihe Aghasizadeh, Ph.D, Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

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Published

2025-12-03

Issue

Vol. 3 No. 9 (2024): Volume 3 Issue 9

Section

Articles