Evaluation of Brain-Derived Neurotrophic Factor Nano Therapies to Treat Alzheimer’s Diseases

Abstract

Alzheimer’s disease is a neurodegenerative disorder affecting millions across the world. It is caused by the progressive build-up of Amyloid-β plaques and tau tangles resulting in inflammation in neurons, followed by apoptosis. This paper aims to synthesize the findings of various researchers on Alzheimer’s Diseases to shed light on a treatment using molecules that promote the survival and proliferation of neurons - neurotrophic factors. Each family of neurotrophic factors has different functions and after evaluating each one, brain-derived neurotrophic factor (BDNF) was shown to have the most potential in treating Alzheimer’s disease. Nano therapy was considered as a carrier for BDNF to cross the blood-brain barrier. PolyPGLA was found to be the most effective nanocarrier for BDNF