A New Innovative and Transformational Approach to Treatmentof Toenail Onychomycosis: An Open Phase 2 Study

Abstract

Toenail onychomycosis has long been difficult to treat because many factors affect the treatment outcome: aging patients, longstanding infection, slow growth of thickened nails, co-morbidities, limitations of the treatment (e.g. treatment length, side effects, toxicity, physical limitations of the patient).
Hesitation in using oral medications for a non-life-threatening infection exists due to perceived risk of hepatic toxicity. Hence, physicians continue to prescribe topical drugs that are associated with limited efficacy and poor patient compliance to a daily treatment regimen that can last a year or more.