Solid Pseudo-Papillary Neoplasm of Pancreas with Venous Invasionin A 9 Year Old Girl: A Case Report and Literature Review

Authors

  • Claudia P Rojas Memorial Health Care System, Joe DiMaggio Children’s Hospital. Pathology Consultants of South Broward at Memorial Pathology Services,USA. Author
  • Ernesto Martinez Duarte University of Nebraska Medical Center, Department of Pathology and Microbiology, USA. Author
  • Maryam Tahir Jackson Memorial Hospital/University of Miami, Department of Pathology and Laboratory Medicine, USA. Author
  • Monica Garcia-Buitrago Jackson Memorial Hospital/University of Miami, Department of Pathology and Laboratory Medicine, USA. Author

DOI:

https://doi.org/10.47363/JDCRS/2020(1)101

Keywords:

Solid Pseudo-Papillary Neoplasm (Spn), Beta Catenin, Progesterone Receptor (Pr), Pancreas

Abstract

Solid Pseudo-papillary neoplasm of the pancreas (SPN) is a rare entity. It represents 0.2-2.7% of all pancreatic cancers. Predominantly occurs in young females in the second to third decades of life. The etiology of SPN involves mutations in the gene that encodes beta-catenin. SPNs are typically indolent tumors, usually confined to the pancreas. We report a case of SPN in a 9-year-old female presented with intermittent abdominal pain for four months. Imaging studies demonstrated a 2.8 cm mass in the tail of the pancreas. The patient underwent a distal pancreatectomy. Pathological evaluation was diagnostic for SPN in the tail of the pancreas. Our case is distinct because of the young age of the patient, peripancreatic soft tissue, perineural, and lymphovascular invasion. The tumor cells exhibited cytoplasmic and nuclear immunoreactivity for beta-catenin and progesterone receptors.

Author Biographies

  • Claudia P Rojas, Memorial Health Care System, Joe DiMaggio Children’s Hospital. Pathology Consultants of South Broward at Memorial Pathology Services,USA.

    Claudia P Rojas, Memorial Health Care System, Joe DiMaggio Children’s Hospital. Pathology Consultants of South Broward at Memorial Pathology Services,USA.

  • Ernesto Martinez Duarte, University of Nebraska Medical Center, Department of Pathology and Microbiology, USA.

    Ernesto Martinez Duarte, University of Nebraska Medical Center, Department of Pathology and Microbiology, USA.

  • Maryam Tahir, Jackson Memorial Hospital/University of Miami, Department of Pathology and Laboratory Medicine, USA.

    Maryam Tahir, Jackson Memorial Hospital/University of Miami, Department of Pathology and Laboratory Medicine, USA.

  • Monica Garcia-Buitrago, Jackson Memorial Hospital/University of Miami, Department of Pathology and Laboratory Medicine, USA.

    Monica Garcia-Buitrago, Jackson Memorial Hospital/University of Miami, Department of Pathology and Laboratory Medicine, USA.

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Published

2020-07-02

Issue

Vol. 1 No. 1 (2020): Volume 1 Issue 1

Section

Articles