Journal of Gastroenterology & Hepatology Reports
type: channel
description: Journal of Gastroenterology & Hepatology Reports is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Gastroenterology & Hepatology Reports. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Article acceptance will be in the form of research, review, case reports, analysis, magazines, editorials, opinion, communications, mini-review, short communications, picturized, book review, video type and power point presentations (PPTS). You can submit manuscripts online at: https://www.onlinescientificresearch.com/submit-online or Email: gastroreports@onlinescientificresearch.info
publisher: Scientific Research and Community
language: en
publication name: Journal of Gastroenterology & Hepatology Reports
issn: 2754-4931
items: Endoscopy after Bariatric Surgery Case Series
items: The Difference in Metabolic and Chronological Age is Associated with Steatosis and LiverFibrosis
items: Series of Clinical Studies on the Eradication of Helicobacter Pylori with the Potassium -Competitive Acid Blocker- Amoxicillin Dual - Therapy Regimen
items: Toward an Etiology of Celiac Disease
items: Successful Surgical Treatment of Anterior Fusion Implants Injury of the Cervical Esophagus: Two Case Reports
items: Pegylated Granulocyte Colony Stimulating Factor Combined with Anti-Pd-1/Pd-L1 Inhibitors in the Treatment of Recurrent or Metastatic Biliary Tract Cancer
items: Management of Gastrointestinal Failure in the Adult Critical Care Environment
items: Polyprenol-Based Nanoformulations: Dual-Platform Innovation for Parenteral and Diagnostic Applications
items: Novel Ultrasensitive Eco-Friendly Spectrophotometric Determination of Carvedilol in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing
items: Clinical Case: Colonic Metastasis of Operated Hepatocellular Carcinoma
items: The Dermatological Manifestations of Inflammatory Bowel Disease: Looks Might be Deceiving!
items: The Clinical Brilliance of Immunohistochemistry “IHC” in Gastrointestinal Oncology
items: Life After Breast Cancer: How Lymphedema Affects the Quality of Life in Women
items: https://srcpublishers.com/index.php/gastroenterology-hepatology-repo/article/view/4508
items: Gastric Outlet Obstruction Due to Actinomycosis, An Uncommon Presentation of a Rare Disease: A Case Report
items: Pulmonary Vascular Complications in Liver Disease: A Comprehensive Review of Porto-Pulmonary Hypertension and HepatopulmonarySyndrome with Illustrative Case Studies
items: The Clinical Spectrum of Liver Masses: Know Before You Judge
items: The Significance of Biliary Anatomical Variation as a Key Indicator in Laparoscopic Bile Duct Injuries
items: Biliary Track Cancer Retrospective Analysis of Last 10 Years
items: Development of Patient Satisfaction Model in Gastrointestinal Endoscopic Procedures in Indonesia
items: Case Series of Common Omental and Mesenteric Pathologies
items: An Uncommon Cause of Elevated Liver Transaminases: Immune Reconstitution Inflammatory Syndrome from Unmasking of Occult Mycobacterium Avium Complex Infection in an HIV Infected Patient
items: Lipedema and Nutrition: High Fat Ketogenic Diet as Treatment of Choice
items: A Review on Hematological Abnormalities Related with COVID-19
items: A Case of Pancreatic Pseudoaneurysm
items: Hepatic Amyloid
items: Gastric Necrosis, A Rare Disease with a Complex Diagnostic Approach
items: Colorectal Peritoneal Metastases State of Art
items: Unveiling the Uncommon: Cocaine-Induced Budd-Chiari Syndrome- A Rare Medical Puzzle
items: Corrosive Stricture in Oral Cavity-A Rare Presentation

Endoscopy after Bariatric Surgery Case Series
type: item
description: Morbid Obesity contributes to the constellation of medical comorbidities that comprise Metabolic Syndrome. As >2/3 of America is Overweight (BMI 25-29.9) or Obese (BMI 30+). There are many treatment modalities for Morbid Obesity, but none is more effective long term than Bariatric Surgery, not even the newest GLP-1 agonists can compete with the Laparoscopic Sleeve Gastrectomy (LSG) or the Roux-en-Y Gastric Bypass (RYGB). About 300,000 Metabolic and Bariatric Surgery (MBS) procedures were performed yearly (1/1000 population of the US per year). As surgical treatment for Morbid Obesity becomes more common, we as Gastroenterologists must continue to learn about the topic and how to treat potential complications. Sleeve Gastrectomy continues to be the most performed procedure, RYGB continues to be 20-25% of the MBS volume yearly. RYGB complications that may require Endoscopic interventions may include: Leak (which is usually at the Gastro-Jejunostomy/GJ) and may require stenting, Stricture (which may require dilation with either an endoscopic balloon or with a bougie, Formation of Marginal Ulcers, Bleeding (which can require any number of methods to control endoscopically, owing to the stomach’s rich blood supply), Perforation, Pouch or GJ enlargement. The Gastrogastric Fistula (GGF) is a rare (1%) but complex problem that requires clinical insight and suspicion. GGF typically presents with: weight regain, pain, worsening GERD symptoms. It may occur because of a complication from surgery (leak, infection, bleed) where a fistula forms between the gastric pouch and the remnant stomach due to a staple line breakdown. Alternatively, it may result from iatrogenic methods.
subject: Articles
  topic: section
subject: Endoscopy
  topic: keywords
subject: Bariatric Surgery Case
  topic: keywords
creator: Inga Evelyn
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-26
publication date: 2025-04-26
starting page: 1
ending page: 5
doi: 10.47363/JGHR/ICGE2025/2025(6)5

The Difference in Metabolic and Chronological Age is Associated with Steatosis and LiverFibrosis
type: item
description: Background: The two most common types of fatty liver disease (steatosis) are nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD). NAFLD affects about 30% of people in Western countries and 10% of people in Asia. In the United States, rates are about 35%, with about 7% having severe NASH. NAFLD affects about 10% of children in the United States. Fat accumulation in the liver is accompanied by a disorder of a series of metabolic processes, i.e. metabolic dysfunction with multiple parallel metabolic shocks throughout the body. Material and Methods: A monocentric, controlled, randomized study was conducted involving 20 practically healthy individuals and 31 patients with hepatomegaly without additional specific symptoms of liver pathology. Liver steatosis degree measurement by the Controlled attenuation parameter (CAP) transient elastography. Metabological age (Met-age) was determined based on tetrapolar multifrequency bioimpedancemetry with vector analysis (BIM-V). Results and Discussion: MET-age younger to CHR-age has significantly more Body Cells Mass (BCM) proportion (50,5 (95%CI =50,0-51,1) vs. 43,9(95%CI =42,8-45,0) and less content of Fat Mass (in kg) fixed -14,7 (95%CI =13,7-15,6) vs. 27,9(95%CI =25,3-30,5. The parallel comparition analysis the MET-age, steatosis (STe) and liver fibrosis (F) show following. In practically healthy people Met-age oldest 2 years or more than CHR-age (Age Diff) was found in the subgroup with severe steatosis (S=3) in 88,9% (8 of 9)(95%CI=51,8 – 99,7) and in 1 of 11 individuals with mild.
subject: Articles
  topic: section
subject: Metabolic and Chronological
  topic: keywords
subject: Steatosis and Liver Fibrosis
  topic: keywords
creator: Marakhouski Yury
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-26
publication date: 2025-04-26
starting page: 1
ending page: 5
doi: 10.47363/JGHR/ICGE2025/2025(6)4

Series of Clinical Studies on the Eradication of Helicobacter Pylori with the Potassium -Competitive Acid Blocker- Amoxicillin Dual - Therapy Regimen
type: item
description: In recent years, the Potassium - competitive acid blocker (P-CABs) - moxicillin dual - therapy regimen has been recommended for the eradication of Helicobacter pylori (H.pylori). However, there are still uncertainties about the optimal drug dosage and treatment duration. Our research group carried out a series of multi - center clinical studies in Fujian Province, China, aiming to explore the efficacy and safety of this dual - therapy regimen for H.pylori eradication. The study covered different treatment durations (7 - day, 10 - day, and 14 - day), various types of P-CABs (vonoprazan, tegoprazan, and keprazan), and different dosages of P-CABs. The results demonstrated that the 10 - day and 14 - day dual - therapy regimens outperformed the 7 - day one, and the 10 - day regimen was non - inferior to the 14 - day one. Moreover, all dual - therapy regimens with different P-CABs achieved an eradication rate of over 90%, and the low - dose P-CABs-amoxicillin dual - therapy regimen was as effective as the high - dose one. These findings hold significant implications. In China, they can directly guide clinicians in Fujian and other regions to select more appropriate treatment options for H.pylori eradication, potentially improving the overall treatment efficiency and reducing unnecessary medical costs. On a global scale, considering the high prevalence of H.pylori infection worldwide, our research provides valuable references for international medical communities. It offers a new perspective on optimizing the P-CABs - amoxicillin dual - therapy regimen, which may contribute to the development of more standardized and effective treatment strategies for H.pylori eradication globally.
subject: Articles
  topic: section
subject: Clinical Studies
  topic: keywords
subject: Amoxicillin Dual
  topic: keywords
subject: Helicobacter Pylori
  topic: keywords
creator: Xueping Huang
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-26
publication date: 2025-04-26
starting page: 1
ending page: 5
doi: 10.47363/JGHR/ICGE2025/2025(6)3

Toward an Etiology of Celiac Disease
type: item
description: The review proposes a model of the etiology of celiac disease. It describes how an enteroviral attack by a lytic virus leads to hyper-extracellular Transglutaminase 2, (Tg2), evident at all stages of the disease by the presence of anti-tTG. The demand for Tg2 is supplied by both the cell and the lytic virus. The demand leads to excess Tg2 passing through the cell wall, excess ingress of Ca2+, the destruction of the mitochondria by Ca2+, and pyroptosis of the cell. The increase in extracellular Tg2 during the cell’s life and following pyroptosis has two effects. First, it binds a C1r inhibitor to the vascular wall, preventing C1r-LP from converting prehaptoglobin (zonulin) into haptoglobin, causing the weakening of the tight junctions among the epithelial cells and allowing the entry of extraneous luminal materials and particularly the access of Tg2 arterial and luminal, as it is now open directly to the lumen and the mesenchyme structure. It is this Tg2 that damages the villus structure as the Tg2 binds fibronectin into the mesenchyme, causing scarring, shrinkage, and turning the villi into the rigid scarred structures characteristic of CD. The model suggests why CD is a chronic lifelong disease reactivated upon the resumption of gluten consumption. A discussion of refractory CD follows. The paper explains how extracellular transglutaminase causes prehaptoglobin (zonulin) and damages the extracellular membrane. Thus, prehaptoglobin (zonulin) is a symptom, not a cause. Notably, the paper demonstrates that the basic tenet of autoimmune diseases that the cells destroy themselves is incorrect, at least for CD. Applying this etiology to other conditions may be relevant because of the almost universal glutaminolysis in cells and the substantial amount of Gluten in modern diets.
subject: Articles
  topic: section
subject: Etiology
  topic: keywords
subject: Celiac Disease
  topic: keywords
subject: hyper-extracellular Transglutaminase
  topic: keywords
creator: Williams Simon
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-25
publication date: 2025-04-25
starting page: 1
ending page: 5
doi: 10.47363/JGHR/ICGE2025/2025(6)2

Successful Surgical Treatment of Anterior Fusion Implants Injury of the Cervical Esophagus: Two Case Reports
type: item
description: We report of two patient’s cases, who underwent anterior cervical fusion for polytrauma due to car accident. The patients suffered very rare complications of the surgery: cage dislocation into the cervical esophagus in first case and injury of esophageal wall with fistulae formation in the second one. By surgical treatment the extraction of the cage, removal the ventral plate and repair of the esophageal wall defect were performed. To prevent failure of the sutures placed on the wound of the esophagus, the method of covering the suture line with a pedicled flap cut from the medial portion of the sternocleidomastoid muscle was used. Feeding gastrostomy was also created. The control X-Ray examination was performed at 6th p/o day, which reveals no extravasation and free passage of contrast to the stomach. We consider, that the method of covering the suture line by pedicled flap from sternocleidomastoid muscle in cases of difficult suturing of defects of the cervical esophagus, is a good surgical option. Surgeons should be aware of the risk of implant injury of esophageal wall and cage dislocation of cervical fusion procedure.
subject: Articles
  topic: section
subject: Surgical Treatment
  topic: keywords
subject: Anterior Fusion
  topic: keywords
subject: Implants Injury
  topic: keywords
subject: Cervical Esophagus
  topic: keywords
creator: Kiladze Merab
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-25
publication date: 2025-04-25
starting page: 1
ending page: 1
doi: 10.47363/JGHR/ICGE2025/2025(6)1

Pegylated Granulocyte Colony Stimulating Factor Combined with Anti-Pd-1/Pd-L1 Inhibitors in the Treatment of Recurrent or Metastatic Biliary Tract Cancer
type: item
description: Background: Biliary tract cancer (BTC) is a malignancy with an extremely poor prognosis. For patients with recurrent or metastatic BTC who have failed first-line chemotherapy, treatment options are limited. Although anti-PD-1/PD-L1 inhibitors have shown efficacy in various tumors, their single-agent activity in BTC is limited, particularly in previously treated patients. Preclinical evidence suggests that granulocyte-colony stimulating factor (G-CSF) may enhance the efficacy of anti-PD-1/PD-L1 inhibitors by remodeling the tumor immune microenvironment. This study aimed to evaluate whether the addition of long-acting G-CSF (pegylated recombinant human G-CSF, pegfilgrastim) could restore or enhance the efficacy of anti-PD-1/PD-L1 inhibitors in patients with resistant BTC. Methods This was a single-arm, prospective, Phase II clinical trial. The inclusion criteria were histologically confirmed recurrent or metastatic BTC that had progressed after at least one line of systemic chemotherapy. All patients received an anti-PD-1 inhibitor (sintilimab 200mg IV q3w) or an anti-PD-L1 inhibitor (atezolizumab 1200mg IV q3w). On day 2 of each cycle, pegfilgrastim (6mg subcutaneously) was administered. The primary endpoint was the Objective Response Rate (ORR) as assessed by the investigator according to RECIST v1.1. Secondary endpoints included Disease Control Rate (DCR), Progression-Free Survival (PFS), Overall Survival (OS), duration of response (DoR), and safety. Results A total of 42 patients were enrolled. The median follow-up time was 12.8 months (95% CI: 10.5-15.1 months). The confirmed ORR was 21.4% (95% CI: 10.3%-36.8%), with 1 patient achieving a complete response (CR) and 8 patients achieving a partial response (PR). The DCR was 66.7% (95% CI: 50.5%- 80.4%). The median PFS was 4.2 months (95% CI: 3.1-5.3 months), and the median OS was 11.5 months (95% CI: 9.2-13.8 months). The most common treatment-related adverse events (TRAEs) of any grade were leukopenia (45.2%), neu…
subject: Articles
  topic: section
subject: Biliary Tract Cancer
  topic: keywords
subject: Immunotherapy
  topic: keywords
subject: Anti-PD-1/ PD-L1
  topic: keywords
subject: Granulocyte-Colony Stimulating Factor
  topic: keywords
subject: Drug Resistance
  topic: keywords
subject: Prospective Study
  topic: keywords
creator: Haipeng Ren
creator: Baoheng Yan
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-10-28
publication date: 2025-10-28
starting page: 1
ending page: 4
doi: 10.47363/JGHR/2025(6)182

Management of Gastrointestinal Failure in the Adult Critical Care Environment
type: item
description: Most healthcare professionals concur on the necessity of providing nutrition to patients and acknowledge the heightened morbidity and mortality associated with malnutrition [1]. However, the delayed consequences of acute underfeeding complicate this responsibility, often relegating it to nursing staff, similar to the tasks of early mobilization and pressure injury prevention. Patients in the ICU typically present with acute organ failure(s) and the management thereof. While cardiac, pulmonary, and renal failures are routinely evaluated and monitored, gastrointestinal failure remains inadequately addressed and acknowledged. This critical organ system has, until now, been omitted from the evaluation criteria of multiple organ failure scores, such as the SOFA score, which only includes the liver to represent the entire gastrointestinal tract [2].
subject: Articles
  topic: section
subject: Gastrointestinal Failure
  topic: keywords
subject: Intensive Care Unit
  topic: keywords
subject: dysfunction
  topic: keywords
subject: Intra Abdominal Pressure
  topic: keywords
creator: Evangelia Michail Michailidou
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-10-28
publication date: 2025-10-28
starting page: 1
ending page: 6
doi: 10.47363/JGHR/2025(6)181

Polyprenol-Based Nanoformulations: Dual-Platform Innovation for Parenteral and Diagnostic Applications
type: item
description: Polyprenols, long-chain isoprenoid alcohols of plant origin, possess notable hepatoprotective, antioxidant, antiviral, and immunomodulatory properties and function as metabolic precursors to dolichols, keyessential in for glycoprotein synthesis. Despite growing pharmaceutical interest, their hydrophobic nature hampers bioavailability in aqueous systems. We address this challenge via patented liposomal and nanoemulsion technologies, enhancing solubility, stability, and controlled parenteral release. To bridge research and regulatory application, we propose three novel indices-IMMPREN, TRANSPREN, and STERILPREN—designed to quantify immunomodulatory potential, translational readiness, and sterilization resilience, respectively. IMMPREN evaluates immune traceability through macrophage polarization and Receiver Operating Characteristic (ROC)-based justification; TRANSPREN structures regulatory narratives for GRAS (Generally Recognized As Safe) and Novel Food dossiers; STERILPREN quantifies colloidal and structural integrity post- moist-heat sterilization, aligning with SAL Sterility Assurance level (SAL) standards. Each index enables formulation traceability, clarity in health claims, and stratification by cytokine/cell marker response, supporting injectable and diagnostic deployment. Collectively, our platform offers a modular, regulatory-explainable framework for polyprenol-based therapeutics—positioning these nanofor emulations as dual-use innovations in clinical translation and safety compliance.
subject: Articles
  topic: section
subject: Polyprenols
  topic: keywords
subject: Nanoemulsion
  topic: keywords
subject: Objective Assessment Indices
  topic: keywords
creator: Rubens J Rubens J
creator: Marakhouski YKh Marakhouski YKh
creator: Bartkevics V Bartkevics V
creator: Rubens A Rubens A
creator: Zajakina A Zajakina A
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-08-18
publication date: 2025-08-18
starting page: 1
ending page: 5
doi: 10.47363/JGHR/2025(6)179

Novel Ultrasensitive Eco-Friendly Spectrophotometric Determination of Carvedilol in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing
type: item
description: A simple, novel, accurate, precise, rapid, economical and sensitive Ultra violet spectrophotometric method has been developed for the determination of Carvedilol in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 242 nm in methanol. Beer’s law was obeyed in the range of 0.5 -10 μg/ ml, with molar absorptivity of 5.4467×104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.6%, and accuracy (average recovery %) was 100 ± 1.3. No interference was observed from common excipients and additives often accompany with Carvedilol in pharmaceutical preparations. The method was successfully applied to the determination of Carvedilol in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Carvedilol in true samples.
subject: Articles
  topic: section
subject: Carvedilol
  topic: keywords
subject: Spectrophotometry
  topic: keywords
subject: Pharmaceutical Preparations
  topic: keywords
subject: Environmental Samples
  topic: keywords
creator: Nief Rahman Ahmad Ahmad
creator: Naif Rahman Ghfran
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-06-26
publication date: 2025-06-26
starting page: 1
ending page: 4
doi: 10.47363/h0jbn187

Clinical Case: Colonic Metastasis of Operated Hepatocellular Carcinoma
type: item
description: Background: Hepatocellular carcinoma (HCC) is the most common liver tumor and ranks as the second leading cause of cancer-related mortality worldwide due to its poor prognosis. Its prognosis is influenced by metastatic spread, mainly intrahepatic but also extrahepatic, which carries a more unfavorable prognosis. The most frequent hepatic metastases occur in the lungs, lymph nodes, bones, and adrenal glands. Atypical sites such as colonic involvement are exceptionally rare and scarcely documented in the literature. Case Presentation: A 60-year-old female was referred for an atypical hepatic lesion in segment VII, which developed in an otherwise healthy liver. She underwent laparoscopic right hepatectomy in 2016. In 2022, she presented with tumor recurrence, elevated AFP levels, and the appearance of a tumor nodule in the right hypochondrium, suggestive of peritoneal metastatic localization from her previously operated HCC. She underwent right colectomy, and histopathological analyses confirmed the metastatic nature of the lesion, not peritoneal but colonic. Conclusion: Elevated AFP levels in the context of HCC, even after surgery, should raise suspicion of metastatic recurrence, particularly extrahepatic. Even though rare, colonic metastasis could appear, sometimes in the form of very late recurrence. This underscores the importance of lifelong biological monitoring, including abdominal-pelvic CT scans.
subject: Articles
  topic: section
subject: Hepatocellular Carcinoma
  topic: keywords
subject: Extrahepatic Metastasis
  topic: keywords
subject: Colonic Metastasis
  topic: keywords
subject: Surgery
  topic: keywords
creator: Duhamel L Duhamel L
creator: Schwarz L Schwarz L
creator: Regnier A Regnier A
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-06-18
publication date: 2025-06-18
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2025(6)177

The Dermatological Manifestations of Inflammatory Bowel Disease: Looks Might be Deceiving!
type: item
description: Inflammatory bowel diseases (IBD) is a poorly understood autoimmune clinical entity that include indeterminate colitis, Crohn’s (CD) and ulcerative colitis (UC). Being a chronic relapsing illness, IBD is a multi-system disorder than can involve the eyes, skin, joints, Liver and kidneys, but mostly characterized by chronic relapsing intestinal inflammation. Although IBD, is a chronic inflammatory disorder of the gut, the manifestations of CD and UC are not limited to the gastrointestinal tract. Extraintestinal manifestations (EIMs) are frequently observed in patients with IBD, with a reported frequency of 6-46% [1]. The skin, musculoskeletal, joints, eyes, and hepato-biliary tract are the organs most affected by EIMs.
subject: Articles
  topic: section
subject: Inflammatory Bowel Disease
  topic: keywords
subject: ulcerative colitis
  topic: keywords
subject: Erythema Nodosum
  topic: keywords
creator: Klara Missling
creator: Anna Lauren Winter
creator: Bobby Owens
creator: McCoy Matt
creator: Ahmed Swi Ahmed Swi
creator: Faisal A Bukeirat
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-04-12
publication date: 2025-04-12
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2025(6)175

The Clinical Brilliance of Immunohistochemistry “IHC” in Gastrointestinal Oncology
type: item
description: Immunohistochemistry, or “IHC,” is a powerful tool in clinical diagnostics within the field of gastrointestinal oncology and anatomical pathology. It is utilized to assist in classification of neoplastic, infectious, and inflammatory diseases. The technique generally involves the specific binding between an antibody and antigen to detect and localize specific antigens within tissue samples, usually examined with light microscopy. Biopsies are collected in a number of ways, including snaring, fine needle aspiration, endoscopic mucosal resection, and more; these samples are then processed by a pathologist. This information can be vital in clinical decision making for patients with potential malignancy.
subject: Articles
  topic: section
subject: Immunohistochemistry
  topic: keywords
subject: squamous cell carcinoma
  topic: keywords
subject: Esophageal Adenocarcinoma
  topic: keywords
creator: Hannah Bell
creator: Wichman Thomas Grant
creator: Ernest Moses Lam
creator: Drew Mulkey Mulkey
creator: Swi Ahmed
creator: Bobby Owens
creator: Faisal A Bukeirat
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-12-08
publication date: 2025-12-08
doi: 10.47363/JGHR/2025(6)176

Life After Breast Cancer: How Lymphedema Affects the Quality of Life in Women
type: item
description: According to data from the World Health Organization, more than 10 million new cases of breast cancer (BC) are diagnosed each year. This type of cancer ranks as the leading malignancy among women, accounting for up to 16% of all cancer cases. For every 100 women diagnosed with breast cancer, there is 1 man. In Europe, over 370,000 new cases are registered annually, with approximately 130,000 women succumbing to this disease. The highest mortality rates from breast cancer are observed in the United Kingdom, Denmark, and France, while countries such as India, Ethiopia, China, and Mongolia report significantly lower rates [1].
subject: Articles
  topic: section
subject: Breast Cancer
  topic: keywords
subject: Lymphedema
  topic: keywords
subject: Lymphaticovenular anastomosis
  topic: keywords
creator: Mukueva MI Mukueva MI
creator: Balayan DA Balayan DA
creator: Gugnina AS Gugnina AS
creator: Romanov DS Romanov DS
creator: Tsalko SE Tsalko SE
creator: Mchedlidze TG Mchedlidze TG
creator: Abdugaffarov SA Abdugaffarov SA
creator: Kopytich IV Kopytich IV
creator: Andreeva VA Andreeva VA
creator: Vorotnikov VV Vorotnikov VV
creator: Sharavina MV Sharavina MV
creator: Soynov AV Soynov AV
creator: Konovalova ON Konovalova ON
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-03-06
publication date: 2025-03-06
starting page: 1
ending page: 4
doi: 10.47363/JGHR/2025(6)174

https://srcpublishers.com/index.php/gastroenterology-hepatology-repo/article/view/4508
type: item
title: A Smart, Sensitive Estimation of Thiamine Chloride Hydrochloride(Vitamin B1) in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity TestingA Smart, Sensitive Estimation of Thiamine Chloride Hydrochloride(Vitamin B1) in Pharmaceutical Preparations and EnvironmentalWastewater Samples: Application to Content Uniformity Testing
description: A fast, greener, simple, accurate, precise, rapid, economical and high sensitive ultraviolet spectrophotometric method has been developed for the determination of Thiamine Chloride Hydrochloride (Vitamin B1) in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 235 nm in distilled water. Beer’s law was obeyed in the range of 2.5-30μg/ ml, with molar absorptivity of 1.028x104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.9%, and accuracy (average recovery %) was 100 ± 0. 8. No interference was observed from common excipients and additives often accompany with Thiamine Chloride Hydrochloride in pharmaceutical preparations. The method was successfully applied to the determination of Thiamine Chloride Hydrochloride in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Thiamine Chloride Hydrochloride in true samples.
subject: Articles
  topic: section
subject: Thiamine Chloride Hydrochloride (Vitamin B1)
  topic: keywords
subject: Spectrophotometry
  topic: keywords
subject: Pharmaceutical Preparations
  topic: keywords
subject: Environmental Samples
  topic: keywords
creator: Ghfran Naif Rahman
creator: Nief Rahman Ahmad
rights: Copyright (c) 2025 Journal of Gastroenterology & Hepatology Reports
date: 2025-02-27
publication date: 2025-02-27
starting page: 1
ending page: 4
doi: 10.47363/JGHR/2025(6)173

Gastric Outlet Obstruction Due to Actinomycosis, An Uncommon Presentation of a Rare Disease: A Case Report
type: item
description: Background: Actinomyces is gram positive Bacterium part of normal human flora. Even though actinomyces infect various organ systems, including the gastrointestinal tract (GIT), gastric outlet obstruction is extremely uncommon. Case Presentation: We present a case of a 66-year-old female patient who presented with nausea, vomiting and unintentional weight loss. Clinical imaging and upper GI endoscopy revealed narrowed gastric pylorus diagnosed as gastric outlet obstruction (GOO). The Patient required multiple gastroscopies with balloon dilatation and biopsy specimens. Histopathology was consistent with Actinomyces. Subsequent appropriate antibiotics therapy led to GOO resolution and clinical improvement. Discussion: Actinomyces presenting as GOO is a rarely seen clinical diagnosis that may mimic malignancy. It must be considered in the differential diagnosis of abdominal masses broadly and tumor-like infiltrative lesions of the stomach particularly. Proper antibiotic therapy renders favorable outcomes and eliminates unwarranted invasive intervention. Conclusion: Actinomyces presenting as GOO is a rare differential diagnosis of abdominal masses broadly, and tumor-like infiltrative lesions of the stomach particularly. Proper antibiotic therapy facilitates favorable outcomes and eliminates unwarranted invasive interventions. Our patient is such an example where gastric actinomycosis was managed medically and the patient improved, avoiding unnecessary surgical interventions.
subject: Articles
  topic: section
subject: Gastric Outlet Obstruction
  topic: keywords
subject: Actinomycosis
  topic: keywords
subject: Gastric Cancer
  topic: keywords
creator: Umar Saddique Muhammad
creator: Moutaz Farouk Mahmoud Derbala
creator: Ahmed Abdelmola Abdelatif Al
creator: Ahmed M Hashim Samar Mahmoud
creator: Hanan Ibrahim Farghaly
creator: Maslamani Muna A Rahman S Al
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-12-26
publication date: 2024-12-26
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2024(5)172

Pulmonary Vascular Complications in Liver Disease: A Comprehensive Review of Porto-Pulmonary Hypertension and HepatopulmonarySyndrome with Illustrative Case Studies
type: item
description: Background: Porto-pulmonary hypertension (PoPH) and hepatopulmonary syndrome (HPS) are significant pulmonary vascular complications in liver disease patients. Understanding their distinct features is crucial for optimal care. Objectives: To provide an updated overview of PoPH and HPS, compare these conditions, and highlight diagnostic and treatment challenges using illustrative case studies. Methods: A comprehensive literature review was conducted using PubMed, Embase, and Cochrane databases. Two case studies illustrate key clinical features and management considerations. Results: Orthotopic liver transplantation (OLT) generally improves outcomes more consistently in HPS than in PoPH. Appropriate bridging therapy can significantly improve PoPH prognosis prior to OLT. Case studies highlight these approaches, including an atypical HPS presentation with acute liver injury, Budd-Chiari syndrome, and portal hypertension without pre-existing cirrhosis. Conclusion: PoPH and HPS present distinct challenges in liver disease. Early recognition, accurate diagnosis, and tailored management strategies are crucial for improving outcomes. Clinicians must maintain a high index of suspicion for these complications, even in atypical presentations, to ensure timely diagnosis and optimal management.
subject: Articles
  topic: section
subject: Porto Pulmonary Hypertension
  topic: keywords
subject: Hepatopulmonary Syndrome
  topic: keywords
subject: Liver Cirrhosis
  topic: keywords
subject: Pulmonary Hypertension
  topic: keywords
subject: Liver Transplantation
  topic: keywords
creator: Ritesh Bhandari
creator: M Javaid Muhammad
creator: Shembrey Jack
creator: Pratima Gurung
creator: Adel Ekladious
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-12-24
publication date: 2024-12-24
starting page: 1
ending page: 8
doi: 10.47363/JGHR/2024(5)171

The Clinical Spectrum of Liver Masses: Know Before You Judge
type: item
description: Liver Masses present a common clinical dilemma, particularly with the wide spread use of cross-sectional imaging in the Emergency Departments. The accurate and reliable determination of the nature of the liver mass is critical, not only to reassure individuals with benign lesions but also to ensure that malignant lesions are diagnosed correctly. In general, Liver Mass can be divided into two main categories: benign lesions and malignant lesions. Benign asses are usually Inflammatory masses including an abscess which can be divided into amebic and pyogenic and truly tumor masses which can be divided into malignant or benign tumors.
subject: Articles
  topic: section
subject: Liver Masses
  topic: keywords
subject: Arterial and Venous
  topic: keywords
subject: Des-y-carboxyprothrombin
  topic: keywords
creator: Rose Lydia
creator: Ahmed Swi Ahmed Swi
creator: Yassmin Hegazy
creator: Faisal A Bukeirat
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-11-01
publication date: 2024-11-01
starting page: 1
ending page: 5
doi: 10.47363/JGHR/2024(5)170

The Significance of Biliary Anatomical Variation as a Key Indicator in Laparoscopic Bile Duct Injuries
type: item
description: Introduction: The science of Gastrointestinal (GI) endoscopy is the science and art of millimeters that has marvelously evolved over the past 30 years. Cholecystectomy, most of which is done laparoscopically, is one of the most common procedures performed today (approximately 750,000 cases are performed annually in the USA) and is considered relatively safe. However, laparoscopic cholecystectomy is associated with bile duct injuries. Several studies examining bile duct injuries have found significant rates of complication (0.39%---1.5%, that comes roughly to over 3,000 patient per year). Therefore, bile duct injuries are commonly encountered, and a clear understanding of the extensive variation in biliary anatomy is imperative to appropriately and successfully manage this common clinical problem to ultimately provide the highest level of patient care. Aim: To educate gastroenterologists, general surgeons, and Hepato-Pancreato-Biliary (HPB) surgeons regarding the definition of anatomical variation and its various anatomical markers. Materials and Methods: A Survey research about our GI department in addition to an online research of published literature was made on PubMed, Ovid Medline, Science Direct, and Springer. Results: This paper presents the various anatomical variations of the biliary tree which is critical in defining bile duct injuries during surgical hepatopancreato-biliary (HPB) procedures.
subject: Articles
  topic: section
subject: Normal Biliary Anatomy
  topic: keywords
subject: Cholecystectomy
  topic: keywords
subject: Laparoscopic
  topic: keywords
creator: Anna Lauren Winter
creator: Klara S Missling
creator: Himmat S Brar
creator: Faisal A Bukeirat
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-10-18
publication date: 2024-10-18
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2024(5)169

Biliary Track Cancer Retrospective Analysis of Last 10 Years
type: item
description: Surgical resection could offer the only chance of a long-term survival for biliary tract cancer. In fact, only a small number of these patients can undergo surgery with curative intent. The majority receive palliative chemotherapy or other systemic treatments. In patients with localized disease the only treatment is a complete resection. We present herein our experience with 33 patients the last 10 years and summarize the surgical strategies and prognostic factors focusing on the role of surgical resection.
subject: Articles
  topic: section
subject: Biliary Track Cancer (BTC)
  topic: keywords
subject: Hepatectomy
  topic: keywords
subject: Cholangiocarcinoma
  topic: keywords
creator: Spiliotis J Spiliotis J
creator: Peppas G Peppas G
creator: Karaiskos J Karaiskos J
creator: Kopanakis N Kopanakis N
creator: Charalampopoulos I Charalampopoulos I
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-09-13
publication date: 2024-09-13
starting page: 1
ending page: 5
doi: 10.47363/JGHR/2024(5)167

Development of Patient Satisfaction Model in Gastrointestinal Endoscopic Procedures in Indonesia
type: item
description: Background: Patient satisfaction is an indicator of quality and success of medical service. Improvement on the valuation model has been applied in some countries. Aim: This study aimed to test and analyse the effects of the patient satisfaction on revisit intention in patients who undergo gastrointestinal endoscopy in Indonesia. Method: A quantitative survey was conducted through a purposive sampling technique to collect data from XYZ. Results: The survey resulted in 147 responses, which were analysed through partial least squares-structural equation modelling (PLS-SEM). The direct influence on patient satisfaction was found to be the strongest from Skill and Hospital Facility. It was found that patient satisfaction positively and significantly predicted revisit intention. This study has implications for policymakers and hospital management in improving skill and hospital facility and information before endoscopy in optimizing revisit intention through patient satisfaction.
subject: Articles
  topic: section
subject: Patient Satisfaction
  topic: keywords
subject: Revisit Intention
  topic: keywords
subject: Gastrointestinal Endoscopy
  topic: keywords
subject: PLS-SEM
  topic: keywords
creator: Khaira Utia Yusrie
creator: Ferdi Antonio
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-08-30
publication date: 2024-08-30
starting page: 1
ending page: 7
doi: 10.47363/JGHR/2024(5)166

Case Series of Common Omental and Mesenteric Pathologies
type: item
description: Radiological imaging plays a crucial role in the diagnosis and management of a wide range of abdominal pathologies, including those affecting the omentum and mesentery. The omentum and mesentery are important structures in the abdominal cavity, serving a variety of functions, such as providing support to the gastrointestinal tract and facilitating the flow of lymph and blood. Pathologies affecting the omentum and mesentery can result in a wide range of clinical presentations, from mild discomfort to life-threatening complications. Omentum and mesentery are involved in various benign and malignant pathologies like omental infarction, omental torsion, encapsulated fat necrosis, fat saponification due to trauma or pancreatitis, mesenteric panniculitis, epiploic appendagitis, omental nodules and caking in infective and malignant conditions like tuberculosis, peritoneal carcinomatosis and metastasis. Sometimes, there exists a diagnostic dilemma between the benign condition like focal encapsulated fat necrosis and malignant condition like liposarcoma, localized peritoneal carcinomatosis. Therefore, Radiological imaging techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI), are invaluable tools for the diagnosis of omental and mesenteric pathologies. In this context, radiologists play a vital role in the accurate interpretation of imaging studies, enabling timely and appropriate management of these complex and often challenging conditions.
subject: Articles
  topic: section
subject: Omentum
  topic: keywords
subject: Mesentery
  topic: keywords
subject: Omental Infarction
  topic: keywords
subject: Omental Torsion
  topic: keywords
subject: Epiploic Appendagitis
  topic: keywords
subject: Omental Nodules
  topic: keywords
subject: Omental Caking
  topic: keywords
subject: Mesenteric Panniculitis
  topic: keywords
subject: Encapsulated Fat Necrosis
  topic: keywords
creator: Dhatri Kallala
creator: Balaji Varaprasad Mallula
creator: Srinadh Boppana
creator: Santhosh Jitta
creator: Govardhan Das Joel
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-06-30
publication date: 2024-06-30
starting page: 1
ending page: 5
doi: 10.47363/JGHR/2024(5)165

An Uncommon Cause of Elevated Liver Transaminases: Immune Reconstitution Inflammatory Syndrome from Unmasking of Occult Mycobacterium Avium Complex Infection in an HIV Infected Patient
type: item
description: Abnormal liver chemistry from the development of immune reconstitution inflammatory syndrome (IRIS) may reflect an unmasking of subclinical disease. We present the case of a 37-year-old female with a mixed pattern of liver injury from disseminated mycobacterium avium complex infection after starting antiretroviral therapy (ART). Presenting symptoms were fever, confusion, dysphagia, and abdominal discomfort for one week. Exam revealed a fever of 103.2°F, hypotension, encephalopathy, and abdominal tenderness. Lab work was significant for acute normocytic anemia, leukopenia, absolute CD4 count 28 cells/cmm, HIV viral load 276 viral copies/ml (vc/ml), ALT 267 U/L, AST 484 U/L, alkaline phosphatase 342 U/L, and normal total bilirubin. Imaging revealed hepatomegaly with steatosis and mesenteric and retroperitoneal lymphadenopathy. Percutaneous liver biopsy demonstrated noncaseating granulomas with AFB-positive organisms, with AFB blood cultures growing Mycobacterium avium complex (MAC), consistent with disseminated MAC infection. Clinicians must have a high index of suspicion for IRIS when determining the etiology of elevated liver transaminases in patients with HIV.
subject: Articles
  topic: section
subject: Elevated Liver Enzymes
  topic: keywords
subject: Elevated Transaminases
  topic: keywords
subject: Immune Reconstitution Inflammatory Syndrome
  topic: keywords
subject: Mycobacterium Avium Complex
  topic: keywords
subject: Human Immunodeficiency Virus
  topic: keywords
subject: Acid Fast Bacilli
  topic: keywords
subject: Opportunistic Infection
  topic: keywords
creator: John Ingram
creator: Abdallah Abdallah
creator: Zachary Field
creator: Jhaveri Tulip A
creator: Nathan Usry
creator: Neha Varshney
creator: William Daley
creator: Joydeep Chakraborty
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-04-30
publication date: 2024-04-30
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2024(5)164

Lipedema and Nutrition: High Fat Ketogenic Diet as Treatment of Choice
type: item
description: Background: Lipedema is a disease of the subcutaneous adipose tissue that was first clinically recognized in the mid-1900s. Lipedema can have a significant impact on physical appearance, mental health, and well-being: people with lipedema, lovingly called “Lippies”, not only complain about their physical appearance, but also the presence of a bunch of symptoms that worsen the quality of life, which is why it is important to study treatments that may have positive effects mainly in the affected areas. Reducing inflammation is the main target of the multidisciplinary treatment of lipedema. Many studies have shown a significant reduction in body fat and in the painful component of lipedema following integrated treatment and, above all, the high fat ketogenic diet. Therefore, we compared the efficacy of a High Fat Ketogenic Diet (HFKD) in patients suffering from lipedema to test the hypothesis that this approach is more effective than a Low Carb Antinflammatory non-ketogenic Diet (LCAD) on reducing the anthropometric measures in the affected areas and on improving symptoms. Methods: Forty-eight female patients followed two different dietary regimens, for 8 weeks. Group A (24 subjects) was assigned a HFKD, based on 1100 Kcal daily, 70% fat, 20% protein, 10% carbohydrates. Group B diet was a low carb with starchy carbohydrate, average daily Kcal around 1400, 45% fat, 25% protein, 30% carbohydrates. To evaluate the effectiveness of both dietary regimens, anthropometric measurements were carried out and a questionnaire evaluating the degree of symptoms was administered at time zero (first meeting) and at time 1 (after 8 weeks). Results: Although both regimens had a very positive effect on the analyzed parameters, HFKD proved to be more effective than LCAD in reducing the circumferences in the affected areas and in improving the main symptoms such as pain, heaviness, fatigue and swelling. Conclusions: High fat ketogenic diet led to significant fat loss in the lower limbs, th…
subject: Articles
  topic: section
subject: Lipedema
  topic: keywords
subject: Ketogenic Diet
  topic: keywords
subject: Low Carbohydrate Diet
  topic: keywords
subject: High Fat Diet
  topic: keywords
subject: Low-Glycemic Index Diet
  topic: keywords
subject: Anti-Inflammatory Diet
  topic: keywords
subject: Body Composition
  topic: keywords
creator: Pitotti Giovanna
creator: Vincenti Sara
creator: Basciani Sabrina
creator: Michelini Sandro
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-04-12
publication date: 2024-04-12
starting page: 1
ending page: 9
doi: 10.47363/JGHR/2024(5)163

A Review on Hematological Abnormalities Related with COVID-19
type: item
description: The COVID-19 outbreak caused by the SARS-CoV-2 virus began in Hubei province, Wuhan, China. SARS-CoV-2 is a highly transmissible virus that spreads rapidly around the world. At the end of 2019, and has since spread worldwide, this virus has infected over 14 million people and killed over 600,000 people, making it a major public health problem. Coronavirus disease It is now understood to be a multisystem disease with a wide range of symptoms are caused by Covid-19. In severe COVID-19 cases, symptoms may lead to acute respiratory distress syndrome (ARDS), metabolic acidosis, multi-organ failure, and shock. Patients’ conditions may deteriorate to the point of death because of these factors. Although pulmonary signs are the most common symptom, various hematological abnormalities have also been discovered. This study highlights the observed hematological abnormalities (platelet, white blood cell, and hemoglobin changes, as well as coagulation/fibrinolytic modifications), investigates their pathomechanisms, and addresses treatment options. Lymphocytopenia, thrombocytopenia, and increased D-dimer levels are all common hematological anomalies in COVID-19. These changes are more widespread and evident in patients with severe COVID-19 disease, suggesting that they could be used as a biomarker for those who require hospitalization and intensive care unit care. Coagulation anomalies should be closely monitored, and actions should be taken to prevent or lessen their negative consequences. COVID-19 effect in patients with hematological abnormalities, as well as known hematological drug toxicities of COVID-19 therapy, are also discussed.
subject: Articles
  topic: section
subject: COVID-19
  topic: keywords
subject: Hematological Abnormalities
  topic: keywords
subject: Coagulation
  topic: keywords
subject: Biomarkers
  topic: keywords
creator: Manir Hasan
creator: Runa Akter
creator: Mobinul Haque Adon
creator: Ishrat Jahan
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-03-20
publication date: 2024-03-20
starting page: 1
ending page: 11
doi: 10.47363/JGHR/2024(5)161

A Case of Pancreatic Pseudoaneurysm
type: item
description: Pancreatic pseudoaneurysm (PSA) is a rare complication of chronic pancreatitis. Diagnosis requires high index of suspicion and urgent intervention is required once diagnosed as delayed treatment leads to poor outcomes and mortality. In this report, we discuss the case of a 30 year old male with a history of chronic pancreatitis who presented with upper gastrointestinal bleed (UGIB). Physical exam was elevated blood pressure, tachycardia and epigastric tenderness. A CT angiogram of abdomen done revealed pseudoaneurysm of pancreas. Patient emergently underwent endovascular embolization and coiling with resolution of GI bleed post procedure.
subject: Articles
  topic: section
subject: Pancreatic
  topic: keywords
subject: Pseudoaneurysm
  topic: keywords
subject: Upper Gastrointestinal Bleed
  topic: keywords
subject: Embolization
  topic: keywords
creator: Isaac Opoku
creator: Raissa Nana
creator: Kikelomo Olaosebikan
creator: Amal Naji
creator: Elizabeth Soladoye
creator: Dominic Amakye
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-03-11
publication date: 2024-03-11
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2024(5)162

Hepatic Amyloid
type: item
description: The term ‘amyloidosis’ refers to the extracellular deposition of low molecular weight fibrillar proteins (amyloid) that stain positively with Congo red and exhibit apple-green birefringence under polarized light. The disease leads to a wide range of clinical manifestations depending on its type, location, and amount deposited. Primary amyloidosis is the most prevalent type of amyloidosis, and the presence of hepatic amyloid has been described in up to 90% of patients.
subject: Articles
  topic: section
subject: Hepatic Amyloidosis
  topic: keywords
subject: Hepatomegaly
  topic: keywords
creator: Ojeda M Ojeda M
creator: Ferrer MT Ferrer MT
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-02-29
publication date: 2024-02-29
starting page: 1
ending page: 2
doi: 10.47363/JGHR/2024(5)168

Gastric Necrosis, A Rare Disease with a Complex Diagnostic Approach
type: item
description: Gastric necrosis represents a rare condition and available literature is mostly in the form of case-reports being clinically under-recognized and therefore not diagnosed at an early stage. It is also a disease for which a definitive treatment has not yet been established since it can vary significantly from a conservative medical management to and aggressive surgical management, depending on the patient´s general conditions and medical history. We describe a case of gastric necrosis presented at both departments of Internal Medicine and General Surgery. We discuss possible etiology, in this case found to be multifactorial due to angiotomography ruling out a proximal occlusive event and the outcome of the patient. Conclusions: The diagnostic approach of patients presenting gastric necrosis is complex since etiology is not well established and is usually multifactorial. It continues to be a disease which we know very little about, and which represents a challenge to overcome to offer specialized treatment and reduce the morbidity and high mortality that it represents.
subject: Articles
  topic: section
subject: Gastric Necrosis
  topic: keywords
subject: Stomach
  topic: keywords
subject: Atherosclerosis
  topic: keywords
subject: Shock
  topic: keywords
subject: Upper Gastrointestinal Bleeding
  topic: keywords
subject: Endoscopy
  topic: keywords
subject: Ct Angiography
  topic: keywords
subject: CT Scan
  topic: keywords
creator: Rodríguez Correa Gustavo Iván
creator: Carrillo Hernández Melissa
creator: Gutiérrez Vargas Haydee Carolina
creator: Macías Durón Emmanuel Salomón
creator: Ponce Campos Silvia Denise
creator: Nieves Arellano Athenea
rights: Copyright (c) 2024 Journal of Gastroenterology & Hepatology Reports
date: 2024-01-16
publication date: 2024-01-16
starting page: 1
ending page: 5
doi: 10.47363/JGHR/2024(5)159

Colorectal Peritoneal Metastases State of Art
type: item
description: The presence of peritoneal metastasis (PM) in patients with colorectal cancer (CRC) is associated with an extremely poor prognosis. Recent developments in the field of treatment including new drugs, translational research for new molecules offer a future plan to achieved improved of Survival. On the other hand, numerous clinical trials regarding the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have now opened new doors in peritoneal metastasis treatment. This review presents all the controversial data and options regarding this approach.
subject: Articles
  topic: section
subject: Colorectal Peritoneal
  topic: keywords
subject: Hyperthermic Intra-Operative Intraperitoneal Chemotherapy (HIPEC)
  topic: keywords
subject: Peritoneal Cancer Growth File
  topic: keywords
creator: Spiliotis John
rights: Copyright (c) 2023 Journal of Gastroenterology & Hepatology Reports
date: 2023-12-18
publication date: 2023-12-18
starting page: 1
ending page: 3
doi: 10.47363/JGHR/2023(4)158

Unveiling the Uncommon: Cocaine-Induced Budd-Chiari Syndrome- A Rare Medical Puzzle
type: item
description: Cocaine, a potent stimulant derived from coca plant leaves, is well-documented for its adverse cardiovascular effects. Among these complications, thrombosis has gained prominence as a significant concern, leading to thrombotic events in various vascular beds throughout the body, highlighting cocaine’s systemic pro-thrombotic impact. However, its role in hepatic vascular disorders remains relatively underrecognized. This case report details the clinical presentation of a 23-year-old male with Budd-Chiari syndrome linked to cocaine use disorder, emphasizing the critical need for healthcare providers to recognize hepatic vascular disorders as possible outcomes of cocaine abuse.
subject: Articles
  topic: section
subject: Budd-Chiari Syndrome
  topic: keywords
subject: Cocaine
  topic: keywords
subject: Axial Anatomical
  topic: keywords
creator: Ritesh Bhandari
creator: Adel Ekladious Ekladious
creator: Javaid Muhammad M
rights: Copyright (c) 2023 Journal of Gastroenterology & Hepatology Reports
date: 2023-12-11
publication date: 2023-12-11
starting page: 1
ending page: 4
doi: 10.47363/JGHR/2023(4)157

Corrosive Stricture in Oral Cavity-A Rare Presentation
type: item
description: Introduction: Corrosive injury of the upper gastrointestinal tract has been commonly reported in medical literature. It can be due to ingestion of acid or alkali and may be accidental or suicidal. The extent of injury varies from involving the esophagus, stomach, and duodenum either individually or together but oral cavity is rarely involved. Case Report: We present a young male of twenty-six years who presented with complaint of dysphagia for last two months. He had history of incidental ingestion of corrosive six months back and was symptomatically treated for the same for one month by some local private practitioner. He remained asymptomatic after that and now developed inability to swallow solid food for last two months and was surviving on liquids only. He was seen by ENT specialist at our institute and was then referred to our department for opinion. On evaluating in detail, patient admitted that he is not able to swallow solid food into food pipe and it stucks in oral cavity and then he has to throw out the solid food but he is able to take liquid diet but in small amount and that too slowly. He was heamodynamically stable and his baseline routine investigations were essentially normal. He was subjected to upper gastrointestinal endoscopy which revealed a tight stricture in oral cavity at level of uvula and scope could not be negotiated beyond it. The patient underwent surgical intervention by parent ENT department and has now completely recovered. Conclusion: Rare presentations are rarely seen but merits vigil for timely diagnosis and proper line of management.
subject: Articles
  topic: section
subject: Dysphagia
  topic: keywords
subject: Endoscopy
  topic: keywords
subject: Corrosive Stricture
  topic: keywords
subject: Oral Cavity
  topic: keywords
subject: Esophagus
  topic: keywords
creator: Parveen Malhotra
creator: Shalini Shalini
creator: Vinay Vinay
creator: Senti Senti
creator: Nitin Sethi
creator: Lakshay Lakshay
creator: Gautam Aditya
rights: Copyright (c) 2023 Journal of Gastroenterology & Hepatology Reports
date: 2023-10-23
publication date: 2023-10-23
starting page: 1
ending page: 2
doi: 10.47363/JGHR/2023(4)160