The Endometrial Microbiota in Assisted Reproduction Outcomes: ANarrative Review

Authors

  • Eduardo Carvalho de Arruda Veiga Gynecology Discipline of the Department of Obstetrics and Gynecology, Clinical Hospital HCFMUSP, Faculty of Medicine, University of São Paulo, São Paulo. Dr. Eneas Carvalho de Aguiar, 455 – Central Institute – 10th Floor – Sao Paulo – SP – Brazil.  Author
  • Sandra Regina Weber GERA Institute for Teaching Reproductive Medicine São Paulo Author
  • Marise Samama Department of Gynecology at the Federal University of São Paulo Author
  • Márcia Guimarães da Silva São Paulo State University (Unesp), Botucatu Medical School, Department of Pathology, Botucatu, São Paulo, Brazil Author
  • Zsuzsanna Jarmy Di Bella Department of Gynecology at the Federal University of São Paulo Author
  • Marcos Alexandre Höher Center for Reproductive Medicine, Bruno Born Hospital, Lajeado, Rio Grande do Sul, Brazil Author
  • Antônio Jose Ribeiro Filho GERA Institute for Teaching Reproductive Medicine São Paulo Author
  • Joji Ueno Discipline of Gynecology, Department of Obstetrics and Gynecology, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo Author

Keywords:

Endometrial Microbiota, Endometrium, Assisted Reproduction, Narrative Review, Revision

Abstract

Studies of the correlation between women’s endometrial microbiota and human reproduction are still very recent. Nevertheless, this study aimed to analyze the most recent of such studies. The keywords ‘endometrial microbiota’ and ‘assisted reproduction’ were used to search for articles published in PubMed between 2017 and 2024. After applying both the inclusion and the exclusion criteria, 13 articles were selected for this narrative review. Most articles related the Lactobacillus bacteria positively to high pregnancy rates and negatively to higher miscarriage rates or recurrent implantation failures. In conclusion, the association of endometrial microbiota with Lactobacillus favors higher pregnancy rates, while several other microorganisms of various genera and species contribute to dysbiosis and thus may lead to recurrent implantation failures and miscarriages. 

Author Biography

  • Eduardo Carvalho de Arruda Veiga, Gynecology Discipline of the Department of Obstetrics and Gynecology, Clinical Hospital HCFMUSP, Faculty of Medicine, University of São Paulo, São Paulo. Dr. Eneas Carvalho de Aguiar, 455 – Central Institute – 10th Floor – Sao Paulo – SP – Brazil. 

    Eduardo Carvalho de Arruda Veiga, Gynecology Discipline of the Department of Obstetrics and Gynecology, Clinical Hospital HCFMUSP, Faculty of Medicine, University of São Paulo, São Paulo. Dr. Eneas Carvalho de Aguiar, 455 – Central Institute – 10th Floor – Sao Paulo – SP – Brazil. 

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Published

2025-01-15