Update on Infectious Mononucleosis in Children

Authors

  • Li Huirong Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China. Author
  • Li Yao Professor, Chief Physician Department of Child Health, Yuyang District Maternal and Child Health Hospital, Yulin City, China. Author
  • He Qiaoli Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China. Author
  • Wang Qiang Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China. Author
  • Gao Caiwei Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China. Author
  • Jiao Fuyong Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China. Author

DOI:

https://doi.org/10.47363/JJCMR/2025(5)197

Keywords:

Infectious Mononucleosis, Childhood, Genetic Susceptibility, Immune Response, Environmental Factor, Epstein- Barr Virus

Abstract

Infectious Mononucleosis (IM) is an acute lymphoproliferative disease predominantly caused by Epstein-Barr Virus (EBV) infection, with children and
adolescents being the most vulnerable groups. The pathogenesis of IM is not fully elucidated, and recent studies have increasingly focused on the interactive effects of genetic susceptibility, immune dysfunction, and environmental factors in driving childhood IM susceptibility. This review summarizes the latest advances in basic research on childhood IM, systematically analyzes the roles of key genetic variants, immune response disorders, and environmental triggers in disease initiation and progression, and discusses the synergistic mechanisms underlying host susceptibility. Finally, we prospect the direction of translational research to provide theoretical support for the development of targeted prevention and treatment strategies.

Author Biographies

  • Li Huirong, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

    Li Huirong, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

  • Li Yao, Professor, Chief Physician Department of Child Health, Yuyang District Maternal and Child Health Hospital, Yulin City, China.

    Li Yao, Professor, Chief Physician Department of Child Health, Yuyang District Maternal and Child Health Hospital, Yulin City, China.

  • He Qiaoli, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

    He Qiaoli, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

  • Wang Qiang, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

    Wang Qiang, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

  • Gao Caiwei, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

    Gao Caiwei, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

  • Jiao Fuyong, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

    Jiao Fuyong, Children’s Hospital of Shaan xi Provincial People’s Hospital of Xian Jiaotong Univeristy, China.

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Published

2025-11-30

Issue

Vol. 5 No. 6 (2025): Volume 5 Issue 6

Section

Articles