Confronting Leptospirosis: A Tropical Illness Presenting with Thrombotic Microangiopathy and Multiorgan Dysfunction

Authors

  • Ajinkya Rahatgaonkar Junior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India  Author
  • Arnab Choudhury Senior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India Author
  • Sahil Kumar Senior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India Author
  • Jithesh G Senior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, Indi Author
  • Mukesh Bairwa Associate Professor, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India Author
  • Ravi Kant Professor and Head of Department, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India Author

DOI:

https://doi.org/10.47363/JMHC/2023(5)244

Keywords:

Leptospirosis, Thrombocytopenia, Thrombotic Microangiopathy, Plasmapharesis, Acute Respiratory Distress Syndrome (ARDS)

Abstract

This case report outlines the presentation and clinical course of a 28-year-old lady with previously unremarkable health, who developed symptoms including fever, headache, gastrointestinal distress, and jaundice. Her condition rapidly deteriorated, culminating to multisystem involvement in the form of severe anaemia, acute kidney injury, thrombocytopenia, and acute respiratory distress syndrome (ARDS). The aetiology was confirmed as leptospirosis. Despite optimum therapeutic measures, including mechanical ventilation and plasmapheresis in view of suspected thrombotic microangiopathy, the patient succumbed to the complications of severe ARDS. This case underscores the imperative of early identification and tailored management strategies for intricate multi-system involvement in conditions like leptospirosis.

Author Biographies

  • Ajinkya Rahatgaonkar, Junior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India 

    Junior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India 

  • Arnab Choudhury, Senior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India

    Senior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India

  • Sahil Kumar, Senior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India

    Senior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India 

  • Jithesh G, Senior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, Indi

    Senior Resident, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, Indi

  • Mukesh Bairwa, Associate Professor, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India

    Associate Professor, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India 

  • Ravi Kant, Professor and Head of Department, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India

    Professor and Head of Department, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, India 

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Published

2023-10-13

Issue

Vol. 5 No. 10 (2023): Volume 5 Issue 10

Section

Articles