Journal of Nephrology & Endocrinology Research
type: channel
description: Journal of Nephrology & Endocrinology Research is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Nephrology & Endocrinology Research. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Article acceptance will be in the form of Research, Review, Case Reports, Analysis, Magazines, Editorials, Opinion, Communications, Mini-Review, Short Communications, Picturized, Book Review, Video Type and Power Point Presentations (PPTS). Articles can be submitted through online from https://www.onlinescientificsresearch.com/submit-online or can send through an e-mail with attachment for jner@onlinescientificresearch.net
publisher: Scientific Research and Community
language: en
publication name: Journal of Nephrology & Endocrinology Research
issn: 2755-1059
items: Comparative Efficacy and Safety of Remogliflozin 100 mg Versus Dapagliflozin 10 mg in Patients with T2DM and CKD: A Randomized, Open-Label Study
items: The Potential Impact of Collagen Supplementation in Healthy Aging and Longevity: A Mini Review
items: Kidneys with Diabetes and Ramadan Intermittent Fasting
items: Non-Pharmacological and Pharmacological Approaches to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An Overview
items: Epidemiological and Etiological Aspects of Acute Renal Failure in the Nephrology and Haemodialysis Department of the Point G University Hospital
items: The Role of ICAM-1 Expression in Renal Tissue in the Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
items: Similarities and Differences of New-Onset Hyperglycemia Secondary to Different Types of Acute Pancreatitis
items: A Rare Cause of Gastrointestinal Bleeding in a Kidney-Pancreas Transplant Recipient – Case Report
items: The Role of Self-Care Practices in Mental Health and Well-being: A Comprehensive Review
items: A Study on the Effect of Methanolic Extract of Plumeria alba on Acetaminophen-induced Kidney Damage
items: Ethical Sensitivity Issues among Certified Public Accountancy Firms in Ethiopia
items: Innovative Approach of Rapid Dissolving Tablet for Hypertensive Therapy using Box Behnken Design
items: Dietary Restriction Challenge in Esrd Cases: Let’s Walk the Path in The Patient’s Shoes
items: Is Kidney Trading the Answer for Kidney Shortage? A Case Study Based on Iran’s Experience
items: Diabetic Mortality in N’Djamena
items: Dextra Tibia Fracture Resulting from a Traffic Accident
items: Varicocelectomy in Male Subfertility Treatment: ‘‘Updated’’ Indications for Surgery
items: Incidence, Risk Factors, and Outcome of Acute Kidney Injury in Patients Admitted to Intensive Care Unit in a Tertiary Care Hospital
items: Predictive Factors for Complete Resolution of Hypertension After Adrenalectomy for Aldosteronoma
items: Importance of Renal Dietitians in Nutritional Counselling and Dietary Interventions in The Early Stages of Chronic Kidney Disease
items: Burden and Predictors of Chronic Kidney Disease in Developing Country
items: Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) and Nuclear Factor-Kappa B (NF- κB) Expression in Chronic Kidney Disease Patients (CKD) from South India
items: Is it Feasible to Completely Prevent Diabetic Kidney Disease?
items: Renal Infarction: Clinical and Evolutionary Aspects in the Nephrology Department Ibn Sina University Hospital of Rabat-Morocco
items: Scleroderma Renal Crisis in Mixed Connective Tissue Disease in a Patient: A Challenging Disease
items: Cystatin C and Chronic Complications of Diabetes Mellitus in a Subsaharian Population
items: Infant Death due to Smothering
items: Prevalence, Characteristics and Outcome of Post-Operative Acute Kidney Injury in Cameroon: A Prospective Study in Three Hospitals in Douala
items: Prevalence and Associated Factors of Chronic Kidney Disease among Diabetic and Hypertensive Patients at Ambo Town Public Hospitals of West Shewa Zone, Oromia Region, Ethiopia
items: https://srcpublishers.com/index.php/nephrology-endocrinology-researc/article/view/3527

Comparative Efficacy and Safety of Remogliflozin 100 mg Versus Dapagliflozin 10 mg in Patients with T2DM and CKD: A Randomized, Open-Label Study
type: item
description: Background: In diabetic patients, managing glycaemic control while preserving renal function is a challenge, necessitating the use of sodium-glucose cotransporter-2 inhibitors, which have demonstrated reno-protective and cardiovascular benefits. Remogliflozin, a novel sodium-glucose co transporter-2 inhibitors, has shown efficacy in glycemic control, but its renal effects in chronic kidney disease patients remain unexplored. Aim: To assess the non-inferiority of remogliflozin compared to dapagliflozin in terms of renal and glycaemic parameters in patients with Type 2 diabetes mellitus and chronic kidney disease. Methods: A prospective, multicentre, randomized, open-label, active-controlled, non-inferiority study was conducted in patients diagnosed with Type 2 diabetes mellitus and chronic kidney disease. Participants were assigned to receive either remogliflozin or dapagliflozin over a treatment period of 24 weeks. Primary endpoints included changes in renal parameters such as estimated glomerular filtration rate, urinary albumin-to-creatinine ratio, serum creatinine, blood urea nitrogen, and uric acid. Secondary endpoints included measures of glycemic control, body weight, and safety outcomes. Results: Both treatment groups showed significant improvement in renal parameters from baseline to weeks 12 and 24 (p<0.001), with no significant difference between groups. Glycaemic parameters also improved significantly in both groups, with similar mean % reductions in HbA1c [Remogliflozin: 8.46% to 7.40%; Dapagliflozin: 8.11%to 7.49%]. The incidence of a ≥50% sustained decline in eGFR was comparable (Remogliflozin: 9.46%; Dapagliflozin: 6.67%; p>0.05). End-stage renal disease was observed in 4.05% and 2.67% of patients in the remogliflozin and dapagliflozin groups, respectively. No cases of cardiovascular or renal death were reported. Both groups demonstrated reductions in body weight and body mass index. Adverse events were mild and comparable between groups, with no seri…
subject: Articles
  topic: section
subject: Diabetes Mellitus
  topic: keywords
subject: Chronic Kidney Disease
  topic: keywords
subject: Remogliflozin
  topic: keywords
subject: Dapagliflozin
  topic: keywords
subject: Glycemic Control
  topic: keywords
subject: Reno-Protective
  topic: keywords
creator: Chaitanya Sawant
creator: Saiprasad Patil
creator: Sanjay Choudhari
creator: Mayur Jadhav
creator: Rujuta Gadkari
creator: Sumit Bhushan
creator: Rahee Borulkar
creator: Aashay Pandya
creator: Hemant Gupta
creator: Hanmant Barkate
rights: Copyright (c) 2026 Journal of Nephrology & Endocrinology Research
date: 2026-02-05
publication date: 2026-02-05
starting page: 1
ending page: 9
doi: 10.47363/2v1xaz38

The Potential Impact of Collagen Supplementation in Healthy Aging and Longevity: A Mini Review
type: item
description: Collagen supplementation has garnered attention as a promising intervention to support healthy aging and longevity. The synthesis of collagen, the body’s primary structural protein, decreases by approximately 1% per year after age 25, contributing to an aging phenotype characterized by skin wrinkling, joint degeneration, and impaired tissue integrity. This mini-review critically evaluates the potential benefits of collagen supplementation, exploring its multifaceted mechanisms of action that extend beyond simply providing amino acids. Specifically, exogenous collagen peptides stimulate dermal fibroblasts, increasing the synthesis of elastin and fibrillin, key collagen types. Additionally, recent findings in model organisms highlight specific collagen genes as vital mediators of longevity, suggesting a regulatory role in cellular senescence and oxidative stress pathways prevalent in aging. This review aims to provide a comprehensive overview of the effects of collagen supplementation in the areas of skin, musculoskeletal, and metabolic health by synthesizing contemporary clinical evidence and mechanistic information. Furthermore, addressing safety concerns and research limitations, it questions whether collagen peptides, beyond their superficial benefits, can be proven as a legitimate component of longevity medicine to influence fundamental biological aging processes.
subject: Articles
  topic: section
subject: Collagen Supplementation
  topic: keywords
subject: Oral Collagen Peptide
  topic: keywords
subject: Overall Healthy Aging and Longevity
  topic: keywords
creator: Onur Oral
creator: Iyanuloluwa Ojo
creator: Naima Badid
creator: Asmita Sunar
rights: Copyright (c) 2026 Journal of Nephrology & Endocrinology Research
date: 2026-01-29
publication date: 2026-01-29
starting page: 1
ending page: 4
doi: 10.47363/JONE/2026(5)142

Kidneys with Diabetes and Ramadan Intermittent Fasting
type: item
description: Diabetes mellitus (DM) is growing tremendously all over the world especially in the Middle–East and North Africa (MENA) and diabetic nephropathy is one of the important microvascular complications ending up with dialyses necessiating kidney transplantation so giving rise to another follow-up program [1,2].
subject: Articles
  topic: section
subject: Diabetes
  topic: keywords
subject: Intermittent Fasting
  topic: keywords
creator: Mehmet Akif Buyukbese
rights: Copyright (c) 2026 Journal of Nephrology & Endocrinology Research
date: 2026-01-29
publication date: 2026-01-29
starting page: 1
ending page: 3
doi: 10.47363/JONE/2025(5)141

Non-Pharmacological and Pharmacological Approaches to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An Overview
type: item
description: Metabolic dysfunction-associated steatotic liver disease (MASLD) closely associates with obesity and type 2 Diabetes. Lifestyle interventions, aiming at substantial weight loss, are cornerstones of MASLD, treatment by improving the histological outcomes. Originally developed as antidiabetic drugs, Incretin Mimetics and SGLT2 Inhibitors also reduce steatosis and fibrosis. Certain Incretin agonists effectively improve histological features of MASLD. On the other hand, despite moderate weight gain, one PPARγ agonist was found to improve MASLD with certain benefit on fibrosis in the RCT. We here discuss liver-related outcomes, induced by different MASLD treatment options and their association with weight loss. As such, we have compared results from clinical trials on drugs acting via weight loss (Incretin Mimetics, SGLT2 Inhibitors) with those exerting no weight loss (Pioglitazone). Furthermore, other drugs in development, which directly target hepatic lipid metabolism (lipogenesis inhibitors, FGF21 analogs), have also been addressed.
subject: Articles
  topic: section
subject: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
  topic: keywords
subject: Metabolic Dysfunction-Associated Steatohepatitis (MASH)
  topic: keywords
subject: Drug Treatment
  topic: keywords
subject: Weight Loss
  topic: keywords
subject: Obesity
  topic: keywords
subject: MUO (Metabolically Unhealthy Obese)
  topic: keywords
subject: MHO (Metabolically Healthy Obese)
  topic: keywords
subject: RCT ( Randomised Control Trial)
  topic: keywords
creator: Mariya Tabassum
rights: Copyright (c) 2026 Journal of Nephrology & Endocrinology Research
date: 2026-01-28
publication date: 2026-01-28
doi: 10.47363/JONE/2025(5)140

Epidemiological and Etiological Aspects of Acute Renal Failure in the Nephrology and Haemodialysis Department of the Point G University Hospital
type: item
description: Introduction: Acute renal failure (ARF) represents a major public health problem associated with high mortality. The incidence is increasing with the emergence of multiple risk factors. In Mali, there are currently no data on the extent and severity of this condition in either hospital or community settings. The aim of our study was to describe the epidemiological, therapeutic and prognostic aspects of ARF in adults treated at the University Hospital Centre (CHU) of Bamako. Patients and Methods: This was a retrospective and descriptive study that took place from 1 July 2021 to 30 June 2022 at the CHU du Point G in Bamako. It focused on patients hospitalised and/or followed up on an outpatient basis in the nephrology department during the study period. Results: The prevalence of acute renal failure was 11.55% with a sex ratio of 1.49. The mean age was 42.37±20.7 (range 6-88 years). Elevated plasma creatinine was the main reason for consultation. Creatinine levels were above 500µmol/l in 65.21% of cases. High blood pressure was the main presenting condition in 33.7% of cases. Acute renal failure was organic, obstructive and functional in 72.8%, 15.2% and 12% respectively. Rehydratation was used in 97.8% of cases. Dialysis was indicated in 40% of cases. Age over 60 years was a major risk factor for ARF. The outcome was favourable in 81.5% of cases. Conclusion: Mortality in dialysis patients with ARF remains high. Several factors influence the prognosis of these patients, including the severity of ARF and pre-existing comorbidity
subject: Articles
  topic: section
subject: Acute renal failure
  topic: keywords
subject: Nephrology
  topic: keywords
subject: CHU du Point G
  topic: keywords
creator: Hamadoun Yattara
creator: Alkaya Touré
creator: Magara Samake
creator: Aboubacar Sidiki Fofana
creator: Mahamadoun Kougoulba
creator: Seydou Sy
creator: Djeneba Maiga
creator: Atabieme Kodio
creator: Karamoko Djiguiba
creator: Alhadji Mamadou Guindo
creator: Sidi Seck
creator: Nouhoum Coulibaly
creator: Moustapha Tangara
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 6
doi: 10.47363/JONE/2024(4)131

The Role of ICAM-1 Expression in Renal Tissue in the Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
type: item
description: Introduction: Diabetic nephropathy is the main microvascular complication of diabetes mellitus (DM). Intercellular adhesion molecule 1 (ICAM-1) plays a critical role in the development of morphological changes in renal tissue in patients with type 2 (T2DM) diabetes mellitus. The work is devoted to studying the role of ICAM-1 (CD54) expression in renal tissue in the development and progression of morphological changes in diabetic kidney disease (DKD) in patients with T2DM. Objective: The examination was carried out in 50 patients with T2DM (mean age 66.58±3.27 years). There were 35 women, 14 men. The duration of disease in patients with diabetes was 17.70 ± 0.35 years. The duration of DKD from the moment of detection of microalbuminuria to the morphological examination of the renal tissue and diagnosis was 1.65±0.34 years. Methods: All patients underwent light and immunofluorescence microscopy of kidney tissue biopsies. Morphological changes in tissue were assessed according to the latest international classification of diabetic nephropathy, developed in 2010. CD54 (ICAM-1) expression was determined using monoclonal antibodies labeled FITC (anti-human CD54 Antibody) (USA). Results: According to light microscopy, class IIa (mild mesangial expansion) was detected in 12 patients, class IIb (severe mesangial expansion) in 14 patients, class III (Kimmelstiel-Wilson lesions) in 19 patients and in 5 patients – class IV (advanced diabetic glomerulosclerosis). It has been shown that there is a regression model between the expression of ICAM-1 in the glomerular endothelium with the development of expansion of the mesangial matrix, thickening of the basement membrane and arteriolar hyalinosis. Expression in peritubular capillaries is associated with the development of tubulointerstitial fibrosis and progression of diabetic kidney disease in patients with T2DM. Conclusions: Based on the data obtained, it was suggested that the study of ICAM-1 expression in kidney tissue can be u…
subject: Articles
  topic: section
subject: Type 2 Diabetes Mellitus
  topic: keywords
subject: Diabetic Kidney Disease
  topic: keywords
subject: Intercellular Adhesion Molecule-1 (Icam-1)
  topic: keywords
subject: Renal Tissue Biopsy
  topic: keywords
creator: TS Ryabova
creator: IA Rakityanskaya
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-03-30
publication date: 2025-03-30
starting page: 1
ending page: 8
doi: 10.47363/JONE/2024(4)132

Similarities and Differences of New-Onset Hyperglycemia Secondary to Different Types of Acute Pancreatitis
type: item
description: With the increasing incidence of acute pancreatitis (AP), new-onset hyperglycemia (prediabetes and diabetes) secondary to AP attracts more attention as one of chronic complications. There are numerous causes of AP, including cholelithiasis, hypertriglyceridemia, alcoholism and so forth, which are both diabetic high-risk factors. Unfortunately, it is still unknown whether the hazards of secondary glucose metabolism impairment resulting from different types of AP are equal. In addition, person suffered from pancreatitis or diabetes is with high-risk for future pancreatic cancer. Thus, identification and analyzation on factors for different types of pancreatogenic diabetes is crucial. The literature review summarizes the incidence of
subject: Articles
  topic: section
subject: Acute Pancreatitis
  topic: keywords
subject: New-Onset Hyperglycemia Secondary
  topic: keywords
creator: Wang Yiman
creator: Li Tuo
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-05
publication date: 2025-12-05
doi: 10.47363/JONE/2024(4)130

A Rare Cause of Gastrointestinal Bleeding in a Kidney-Pancreas Transplant Recipient – Case Report
type: item
description: Kidney-pancreas transplantation is the preferable therapeutic option for patients with type 1 diabetes mellitus and end-stage kidney disease. We describe the case of a 35-year-old pancreas-kidney transplant recipient with dual-graft failure that presents with massive hematochezia and hemodynamic instability, evolving into hemorrhagic shock. The diagnostic assessment revealed a fistula between a pseudoaneurysm of the right common iliac artery and the adjacent transplanted duodenum segment, a rare but life-threatening cause of gastrointestinal bleeding in these patients. An endoprosthesis was placed into the iliac artery, prophylactic antibiotics were instituted, and a pancreatic transplantectomy was performed in a second procedure. This case highlights that the diagnostic workup of gastrointestinal bleeding in pancreas-kidney transplant recipients must include the possibility of arterio-enteric fistulas, which is more frequent in the presence of pancreatic graft failure, as was the case of our patient. Endovascular exclusion is the advocated treatment. Pancreatic graft transplantectomy could also be a possible approach for patients with a failed pancreas but it is highly controversial due to potential risks.
subject: Articles
  topic: section
subject: Transplantation
  topic: keywords
subject: Graft Rejection
  topic: keywords
subject: Diabetes Mellitus
  topic: keywords
subject: Type 1 - Kidney Transplantation
  topic: keywords
subject: Pancreas Transplantation
  topic: keywords
creator: Sofia Ventura
creator: João Oliveira
creator: Cátia Figueiredo
creator: Círia Sousa
creator: La Salete Martins
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 3
doi: 10.47363/JONE/2024(4)129

The Role of Self-Care Practices in Mental Health and Well-being: A Comprehensive Review
type: item
description: This paper investigates the significant role of self-care practices in promoting mental health and enhancing overall well-being. While many individuals turn to short-term fixes like caffeine and sleep to recover from stress, self-care goes beyond recovery and encompasses holistic practices that nurture the body and mind. By examining relevant scientific literature, this study explores how different self-care activities such as mindfulness, physical activity, nature exposure, and social connection influence mental health outcomes like anxiety, depression, and stress. The paper aims to clarify the distinction between recovery and self-care and emphasize the importance of making self-care an integral part of daily life.
subject: Articles
  topic: section
subject: Self-Care
  topic: keywords
subject: Mental Health
  topic: keywords
subject: Mindfulness
  topic: keywords
subject: Burnout Prevention
  topic: keywords
subject: Well-Being
  topic: keywords
subject: Lifestyle Habits
  topic: keywords
subject: Recovery
  topic: keywords
subject: Stress Management
  topic: keywords
subject: Nature Therapy
  topic: keywords
subject: Psychological Health
  topic: keywords
creator: Mirela Tushe
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-09-30
publication date: 2025-09-30
starting page: 1
ending page: 3
doi: 10.47363/JONE/2025(5)139

A Study on the Effect of Methanolic Extract of Plumeria alba on Acetaminophen-induced Kidney Damage
type: item
description: Background: Incidence of acetaminophen-induced nephropathy is a growing concern, with limited treatments available. This study evaluated the effects of methanolic extract of Plumeria alba flower (MEPAF) in acetaminophen-induced nephrotoxicity in Wistar rats. Materials and Methods: Twenty-five Wistar rats were divided into five groups (A - E) of five rats each. Group A (Control) received feed and water. Group B received 1800mg/kg/bwt of acetaminophen and Group C received 900mg/kg/bwt of MEPAF. Groups D-E rats received co-administration of 1800mg/kg/ bwt of acetaminophen and 180mg/kg/bwt of MEPAF, 1700mg/kg/bwt of acetaminophen and 850mg/kg/bwt of MEPAF respectively. All administrations were orally and daily for 28 days. On the 29th day, the rats were sacrificed, blood samples collected for kidney function test (urea, uric acid and creatinine evaluations) and kidneys harvested for histopathological examination. Results: Administration of 1800mg/kg/bwt of acetaminophen for 28 days induced a significant (p<0.05) increase in body and relative organ weights, serum urea, uric acid and creatinine along with histopathological changes (acute tubular necrosis, degeneration and haemorrhage). However, co-administration with Plumeria alba flower extract ameliorated these conditions. Conclusion: Plumeria alba flower extract could potentially provide protection against acetaminophen-induced renal toxicity. The observed nephroprotection could be attributed to the inherent antioxidant properties of Plumeria alba.
subject: Articles
  topic: section
subject: Renal-protection
  topic: keywords
subject: Histoarchitecture
  topic: keywords
subject: Renal Function
  topic: keywords
subject: Plumeria Alba Extract
  topic: keywords
creator: Mbah Chikodili Adolphus
creator: Ofoego Uzozie Chikere
creator: Odo Jude Emeka
creator: Oyate Godwin Bernard
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 6
doi: 10.47363/JONE/2025(5)138

Ethical Sensitivity Issues among Certified Public Accountancy Firms in Ethiopia
type: item
description: Background and Justification: In different developing nations, managers, leaders and business owners are exposed to money corruption. The root cause of this corruption is unethical decisions made by Public Accountants. This paper focuses on identified areas of ethical dilemma and the most important demographic factors that affect the ethics of professional accountancy. Methodology: The research selected 317 certified public accountants as a sample based on probability sampling techniques. The study used demographic factors as an independent variable and ethical dilemma as a dependant variable. To test the statistical significance of each mean difference, the study used independent samples t test and One-way ANOVA parametric test. Result and suggestions: The finding of the study summarize that Presentation of the financial reports, audit time by tax auditors and tax-related matters are the three most difficult areas of professional conflict of interest that affect professional activities. Result showed demographic variables of gender, age, level of education and professional experiences were a mean significance variations in each group for exposing of ethical dilemma
subject: Articles
  topic: section
subject: Demographic Factors
  topic: keywords
subject: , Ethical Dilemma
  topic: keywords
subject: Professional Accountancy
  topic: keywords
subject: Professional Ethics
  topic: keywords
creator: Bamlaku Kassie Aragie
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2024-08-30
publication date: 2024-08-30
starting page: 1
ending page: 11
doi: 10.47363/JONE/2024(4)133

Innovative Approach of Rapid Dissolving Tablet for Hypertensive Therapy using Box Behnken Design
type: item
description: The development of oral disintegrating tablets (ODTs) for antihypertensive drugs represents a promising approach to improve patient adherence, especially for those with difficulty swallowing traditional tablets. This study focuses on the formulation and optimization of hydrochlorothiazide (HCTZ) ODT using Box-Behnken design (BBD) for process optimization. The research employs excipients such as fenugreek seed powder as a superdisintegrant, Locust bean gum and banana powder as binders, corn starch as a glidant, magnesium stearate as a lubricant, microcrystalline cellulose (MCC) as a filler, and aspartame as a sweetener. Additionally, polyethylene glycol 4000 (PEG-4000) is used as a solubility enhancer through solid dispersion techniques. The BBD method investigates the effect of concentrations of fenugreek seeds, robusta gum and PEG-4000 on tablet properties such as disintegration time, dissolution rate, hardness, friability etc. The optimized formulation exhibits rapid disintegration (within 30 seconds), improved dissolution profile and enhanced bioavailability of hydrochlorothiazide due to the solubility-enhancing properties of PEG-4000. The results indicate that the combination of excipients and solid-phase dispersion methods can significantly improve the efficacy of ODT, providing a potential solution to improve therapeutic outcomes in the treatment of Hypertension.
subject: Articles
  topic: section
subject: Hypertension
  topic: keywords
subject: Oral Disintegrating Tablets (ODTs)
  topic: keywords
subject: Hydrochlorothiazide
  topic: keywords
subject: Box- Behnken Design (BBD)
  topic: keywords
subject: Superdisintegrants
  topic: keywords
subject: Solid Dispersion
  topic: keywords
subject: Solubility Enhancement
  topic: keywords
creator: Akash Yadav
creator: Aman Kumar
creator: Tushar Sonare
creator: Krutika Mandloi
creator: Kratika Khadsondni
creator: Dinesh Kumar Jain
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-03-31
publication date: 2025-03-31
starting page: 1
ending page: 14
doi: 10.47363/JONE/2025(5)136

Dietary Restriction Challenge in Esrd Cases: Let’s Walk the Path in The Patient’s Shoes
type: item
description: Dietary recommendations for dialysis-dependent children with end-stage renal disease (ESRD) include potassium, phosphorus, and sodium limitations. The patient must take phosphate binders with their meals. Adherence issues might pose a challenge to renal diet compliance. The goal of this study was to investigate the effect of adherence to a two-week renal diet on empathy levels among healthcare providers who care for children with ESRD on dialysis. Taking a patient-centric approach, this abstract emphasises the importance of empathy and communication in supporting ESRD patients. By walking in the patient’s shoes, healthcare providers can gain valuable insights into the challenges faced by these individuals. Understanding their perspectives, preferences, and struggles fosters a collaborative approach to managing dietary restrictions, promoting better adherence and overall well-being. Moreover, this abstract underscores the need for tailored interventions and support systems that address the unique needs of pediatric ESRD patients. From dietary counselling and psychosocial support, a holistic approach is essential for empowering these young patients to navigate nutritional restrictions successfully. In conclusion, this abstract advocates for a patient-centred paradigm shift in managing dietary restrictions in ESRD cases. By recognizing the importance of empathy, communication, and tailored support, healthcare providers can enhance the quality of care and improve outcomes for these vulnerable patients.
subject: Articles
  topic: section
subject: End-Stage Renal Disease (ESRD)
  topic: keywords
subject: Dietary restrictions
  topic: keywords
subject: Adherence
  topic: keywords
subject: Empathy
  topic: keywords
subject: Holistic approach
  topic: keywords
creator: Urvashi Khan
creator: LakshmiKant Jha
creator: Pranav Tyagi
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 2
doi: 10.47363/JONE/2024(4)135

Is Kidney Trading the Answer for Kidney Shortage? A Case Study Based on Iran’s Experience
type: item
description: Kidney transplantation has been demonstrated to be the treatment of choice for end stage renal disease. However, most patients still end up receiving dialysis rather than receiving transplantation for the kidney as the organ source is fairly limited in most countries. We therefore explore the case of Iran where kidney trading is considered legal. As of now, Iran is also the only country worldwide that allows monetary compensation for kidney donation, whereas there are rules to refrain its abuse. We also discuss the strength and weakness of Iran’s kidney trading system and the applicability of the system to other countries to hopefully help reduce the kidney shortage in organ donation.
subject: Articles
  topic: section
subject: Kidney Trading
  topic: keywords
subject: Kidney Transplantation
  topic: keywords
subject: Kidney Shortage
  topic: keywords
subject: Organ Transplantation
  topic: keywords
subject: Organ Trading
  topic: keywords
subject: Iran
  topic: keywords
creator: Claire Liu
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-03-31
publication date: 2025-03-31
starting page: 1
ending page: 3
doi: 10.47363/JONE/2025(5)137

Diabetic Mortality in N’Djamena
type: item
description: Introduction : The diabetes pandemic is classified as the eighth leading cause of death in both sexes and the fifth leading cause of death in women. The aim of this study was to determine diabetes-related mortality in the hospital setting. Method: this was a descriptive study, based on the records of diabetic patients who died in hospital in the various departments of the “National Reference” University Hospital of N’Djamena, from January 2015 to December 2019 (i.e. 5 years). The variables studied were epidemiological, clinical, paraclinical, therapeutic and evolutionary. Data analysis was performed using SPSS.25 software. Results: During the study period, 1282 deaths occurred, 185 of them due to diabetes, i.e. a prevalence of 15.85%. The mean age of patients was 57.24 years (extremes 18 and 88 years). The age group most affected was 40 to 60, with 82 patients (44.3%). The patients were predominantly male (sex ratio 1.56). Their socio-economic level was average in 52.4% (97 cases) and low in 40.5% (75 cases). Type 2 diabetes accounted for 91% (168 patients) and type 1 for 09% (17 patients). Reasons for hospitalization were metabolic complications (23.78%), followed by hypertensive crises (13.51%) and cerebrovascular accidents (08.11%). The risk factors most frequently associated with diabetes were hypertension (57.90%), dyslipidemia (31.35%) and alcohol (22.30%). Complications associated with death were dominated by nephropathy (63.3%) and metabolic complications (61.1%). More patients died in intensive care (58.91%) than in cardiology (16.90%). Conclusion: Diabetes-related mortality in hospitals remains very high, which is why we need to step up awareness-raising to reduce diabetes-related deaths.
subject: Articles
  topic: section
subject: Mortality, Diabetes
  topic: keywords
subject: CHU-RN, N’Djamena
  topic: keywords
creator: Oumar Abba
creator: Ibrahim Hamat
creator: Allahsayim Désiré
creator: Habiba Abdoulaye Affadine
creator: Haoua Youssouf Seid
creator: Djibrine Mahamat Djibrine
creator: Houba Dallah Urbain
creator: Adjougoulta Koboy Bonté
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 3
doi: 0.47363/JONE/2024(4)134

Dextra Tibia Fracture Resulting from a Traffic Accident
type: item
description: Background: By definition, blunt force trauma is a force that is caused by a blunt object on the surface of the body, which results in injury. Blunt trauma can be caused by objects that have blunt surfaces such as stones, wood, hammers, fists and so on, which also includes falls from high places, traffic accidents and so on, which are currently increasing in severity. Case Report: It was reported that a victim, initials N, was a pedestrian who was hit by a motorbike Results: on physical and radiological examination the victim suffered an open right tibial fracture. Conclusion: The female victim was involved in a traffic accident and suffered abrasions, lacerations and broken bones due to blunt trauma which required the victim to undergo treatment.
subject: Articles
  topic: section
subject: Fractures
  topic: keywords
subject: Blunt Trauma
  topic: keywords
subject: Traffic Accidents
  topic: keywords
creator: Asan Petrus
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2023-12-31
publication date: 2023-12-31
starting page: 1
ending page: 2
doi: 10.47363/JONE/2023(3)128

Varicocelectomy in Male Subfertility Treatment: ‘‘Updated’’ Indications for Surgery
type: item
description: We analyzed the recent literature data on varicocelectomy in treatment men from infertile couples. There are still a lot of unresolved issues that require clarification. It is still unclear the exact pathogenesis of testicular malfunction in some men with varicocele. Recent European and American urological guidelines recommend varicocele repair in men from infertile couples with “abnormal” semen parameters. Although, according to the 6th ed. of WHO laboratory manual for the examination and processing of human semen it is not clear the cut-off values between normal and abnormal semen parameters. Also, still unclear why approximately third part of patients do not experience any improvement after varicocele repair. According to the recent data analysis, total progressively motile sperm count (TMSC) and sperm concentration can be the significant predictors of semen improvement and pregnancy after varicocele repair. However, it should be remarked that the mean quality of existed data from low to moderate. All mentioned issues indicate the necessity of further large-scale multicenter randomized clinical trials.
subject: Articles
  topic: section
subject: Varicocelectomy
  topic: keywords
subject: Surgery
  topic: keywords
creator: Azizbek B Shomarufov
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2023-09-30
publication date: 2023-09-30
starting page: 1
ending page: 2
doi: 10.47363/JONE/2023(3)127

Incidence, Risk Factors, and Outcome of Acute Kidney Injury in Patients Admitted to Intensive Care Unit in a Tertiary Care Hospital
type: item
description: Introduction: Acute Kidney Injury (AKI) is the major cause of morbidity and mortality in hospitalized patients. Knowing the magnitude and outcome of AKI in patients admitted to ICU will help to increase awareness and prepare the resources required in improving care. Objective: To examine the incidence and outcome of AKI in an intensive care unit in tertiary care hospital, in Tigray, Ethiopia. Method: Prospective observational type of study was carried out to assess the incidence and outcome of AKI in a tertiary hospital from November 1 to April 1, 2020, G.C. Results: Of 152 patients admitted to the ICU during the study period 51.3% were males. The most common reasons for admission were the disease of the circulatory system (35%) and all forms of injury and poisoning (15.2%). The most common comorbidities were cardiac disease (41.6%), hypertension (25.7%), and diabetes mellitus (9.9%). Hemodialysis was given for 15.2% of patients and the mortality rate after hemodialysis was high around 85.7% and the overall mortality rate of patients with AKI was 56.5 %. The presence of anemia (AOR= 3.8 95%CI 1.8, 8.03), shock (AOR= 3.2 95%CI 1.5, 6.7), any focus of infection (AOR= 1.8 95%CI 0.8, 4.05) and liver function test derangement (AOR= 3.3 95%CI 1.5, 6.9) significantly affect the occurrence of AKI. Conclusion: The incidence of AKI was high in patients admitted to the ICU, and the development of AKI was associated with poor outcomes and reduced survival.
subject: Articles
  topic: section
subject: Intensive
  topic: keywords
subject: Care
  topic: keywords
creator: Meskelu Kidu
creator: Firew Gemechu
creator: Hagazi Tesfay
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2023-06-30
publication date: 2023-06-30
starting page: 1
ending page: 6
doi: 10.47363/JONE/2023(3)126

Predictive Factors for Complete Resolution of Hypertension After Adrenalectomy for Aldosteronoma
type: item
description: Introduction: Primary hyperaldosteronism, 1st cause of secondary hypertension, 2nd cause of hypertension potentially curable by surgery. The objective of this work is to determine the predictive factors for complete resolution of hypertension after adrenalectomy. Material: We conducted a retrospective study of 25 patients with primary hyperaldosteronism operated and followed between 1985 and 2018. Results: Our patients were divided into 16 women and 9 men, mean age 54 years. 40% of our patients were smokers, 36% dyslipidemic, 68% diabetic and 76% had a BMI ≥ 25 kg / m2. Patients underwent unilateral adrenalectomy, the surgical approach was posterior lumbar in 9 cases and laparoscopic in 16 cases. No per or postoperative complication was noted. The postoperative course was marked by the HTA in 36% of the cases, an improvement in 36% of the cases and persistence in 31% of the cases. We found a significant decrease of the PAS and the PAD at six months of the surgery. The comparative study of the patients whose HTA was cured versus unhealed did not show a statistically significant correlation with the following predictors of healing: young age, female gender, lack of family history of hypertension, adenoma’s dimension, the presence of comorbidities including diabetes and dyslipidemia and the average number of antihypertensive treatment.Only the absence of overweight or obesity was a predictor of healing in our series. Conclusion: Knowing the predictive factors of healing aims to pose the operative indication and especially to improve the prognosis of hypertension after surgery by acting on certain modifiable factors.
subject: Articles
  topic: section
subject: Primary Hyperaldosteronism-Hypertension-SurgeryCure
  topic: keywords
creator: Dayssem Khelif
creator: Ibtissem Ben Nacef
creator: Imen Rojbi
creator: Nadia Mchirgui
creator: Karima Khiari
rights: Copyright (c) 2023 Journal of Nephrology & Endocrinology Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 4
doi: 10.47363/JONE/2023(3)125

Importance of Renal Dietitians in Nutritional Counselling and Dietary Interventions in The Early Stages of Chronic Kidney Disease
type: item
description: Chronic kidney disease (CKD) is becoming a public-health problem, at a global level. In CKD, patients progressively lose the ability to excrete phosphorus. Several observational studies have determined hyperphosphatemia emerging as an independent cardiovascular risk factor in CKD-Mineral and Bone Disorder (CKD-MBD). In early CKD, serum Klotho declines and fibroblast growth factor-23 (FGF‐23) starts increasing which coincides with its effects on augmenting urinary phosphate excretion with reduced serum phosphate reabsorption and decreased levels of calcitriol. The Klotho/FGF23 axis should be a novel target for renal clinicians being pathogenic contributors to CKD progression and cardiovascular disease (CVD) development. The high phosphorous load has been found to increase serum FGF-23 levels in the early stages of CKD which further leads to CVD and increased mortality. To control hyperphosphatemia, a potentially simple and effective approach of dietary phosphate control should be incorporated to reduce the early clinical consequences of CKD-MBD. Along with the amount of dietary phosphorus intake, its type (organic vs. inorganic), its source (animal vs. plant derived), phosphorus-to-protein ratio and preparation of food by boiling should also be made aware to patients which is likely a neglected aspect of dietary counselling in CKD. A kidney-friendly diet plan is needed to protect kidneys from further damage which is rather an arduous period for making patients follow a phosphate-restricted diet. Here, the role of the renal dietitian appears mandatory in counselling and educating the patients to effectively integrate dietary interventions into the therapeutic approach of CKD-MBD.
subject: Articles
  topic: section
subject: Chronic Kidney Disease
  topic: keywords
subject: Fibroblast Growth Factor-23
  topic: keywords
subject: Hyperphosphatemia
  topic: keywords
subject: Nutritional Counselling
  topic: keywords
subject: Dietary Intervention
  topic: keywords
subject: Dietary Phosphorus Intake
  topic: keywords
creator: Trisha Sachan
creator: Anita Saxena
creator: Amit Gupta
rights: Copyright (c) 2023 Journal of Nephrology & Endocrinology Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 5
doi: 10.47363/JONE/2023(3)124

Burden and Predictors of Chronic Kidney Disease in Developing Country
type: item
description: Chronic Kidney Disease (CKD) is being recognized as a global public health problem. It is a major non-communicable disease with the global prevalence varying between 10.5% and 13.1%. Diabetes and hypertension appear to be the leading causes of chronic kidney disease worldwide. An institution based cross-sectional study was undertaken from Oct 20, 2018 to Nov 20, 2019 G.C. Data was collected using a pre-tested questionnaire designed to meet the study objective. After describing variables, logistic regression was conducted to identify independent associated factors of CKD. Statistical significance was declared at P<0.05. Of the 450 studied patients, 260(57.8%) were males and more than half (54.2%) were between ages of 25 to 40 years. The prevalence of CKD among patients admitted to medical ward was 17.3% (95% CI 13 - 29.9) and 14.4% (95 % CI 6.2 – 12.3) by Cockcroft Gault and MDRD equations, respectively and majority (61.5%) of them were stage 5. Hypertension (AOR= 7.8 95%CI 4.1, 14.9), history of recurrent urinary tract infection (AOR= 3.5 95% CI 1.1, 7.3) and history of using nephrotoxic drugs (AOR=3.4 95% CI 2, 9.3) were significantly associated with CKD. The burden of CKD among patients in a medical inpatient unit was high and majority of the patients present late. Hypertension, use of nephrotoxic agents and recurrent urinary tract infections were found to be important predictors.
subject: Articles
  topic: section
subject: Chronic Kidney Disease
  topic: keywords
subject: Hypertension
  topic: keywords
subject: Nephrotoxic Agents
  topic: keywords
subject: Urinary Tract Infection
  topic: keywords
creator: Meskelu Kidu Weldetensae
creator: Migbnesh Geberemedhin Weldegebreial
creator: Measho Gebreselassie
creator: Ephrem Berhe
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-03
publication date: 2025-12-03
starting page: 1
ending page: 7
doi: 10.47363/JONE/2022(2)123

Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) and Nuclear Factor-Kappa B (NF- κB) Expression in Chronic Kidney Disease Patients (CKD) from South India
type: item
description: Aim: The present study elucidated the expression level of Nrf2 and NF-κB, in chronic kidney disease (CKD) patients from South India. Further, the expression levels of these genes are analyzed for cytokines TNF-α and IFN-γ and various subgroups of cases including dialysis, non-dialysis, diabetic and non-diabetic CKD patients, and correlation analysis performed. Methods: 133 CKD patients and 133 healthy individuals were enrolled for the evaluation of NF-κB and Nrf2 expression by qPCR. Results: Upregulated Nrf2 mRNA expression (as fold change) was observed in diabetic (Fc: 1.13), and non-diabetic (Fc: 1.30) patients. Inversely, Nrf2 mRNA expression was down regulated in non-dialysis groups (Fc: 0.80). NF-κB expression was significantly upregulated in non-diabetic (Fc:1.92), non-dialysis (Fc:1.59), dialysis (Fc: 1.36) and CKD patients (pooled) (Fc: 1.27). A dysregulated NF-κB expression was observed in diabetic groups (Fc: 0.69). Nrf2 mRNA expression were positively correlated with IFN-γ expression in diabetes (r = 0.28, p = 0.05) and non-diabetic CKD patients (r = 0.37, p < 0.002). Likewise, TNF-α expression was positively correlated with Nrf2 expression in CKD (pooled) patients (r = 0.33, p < 0.000). A negative correlation was observed in Nrf2 and NF-κB expression in CKD (pooled) (r = -0.028, p = 0.833). Conclusion: The study concluded the down regulated Nrf2 and upregulated NF-κB expressions in non-dialysis patients. On the contrary, in diabetic CKD patients, the expression level of NF-κB was downregulated and Nrf2 was upregulated. Thus, a negative correlation was observed between Nrf2 and NF-κB genes with respect to their expression patterns.
subject: Articles
  topic: section
subject: Nrf2
  topic: keywords
subject: NF-κB
  topic: keywords
subject: Gene Expression
  topic: keywords
subject: Cytokines
  topic: keywords
subject: Glomerular Filtration
  topic: keywords
creator: Vandit Sevak
creator: Rathika Chinniah
creator: Sasiharan Pandi
creator: Padma Malini Ravi
creator: Radha Venkatesan
creator: Sampathkumar K
creator: Dinakaran T
creator: Balakrishnan Karuppiah
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-03
publication date: 2025-12-03
starting page: 1
ending page: 9
doi: 10.47363/JONE/2022(2)122

Is it Feasible to Completely Prevent Diabetic Kidney Disease?
type: item
description: When SGLT2Is were first introduced as hypoglycemic agents during the year 2008, no body was aware about their protective action on the heart, kidney, and retina of patients suffering type 2 diabetes mellitus (T2DM). SGLT2Is have revolutionized the treatment of T2DM patients with established or at risk for diabetic kidney disease (DKD). When Dapagliflosin was studied in T2DM patients with estimated glomerular filtration rate [eGFR] >90 mL/min/1.73m2, and normal urine albumin excretion, these cases were still susceptible to develop the renal end points. These results have raised the question about the ideal time to use SGLT2Is to completely abort the incidence of DKD. This review will try to answer this question.
subject: Articles
  topic: section
subject: Type 1 DM
  topic: keywords
subject: Type 2DM
  topic: keywords
subject: Diabetic Kidney Disease
  topic: keywords
subject: Heart Failure
  topic: keywords
subject: Diabetic Nephropathy
  topic: keywords
subject: Sodium Glucose Cotransporters-2 Inhibitors
  topic: keywords
subject: SGLT2 Inhibitors
  topic: keywords
subject: Empagliflozin
  topic: keywords
subject: Canagliflozin
  topic: keywords
subject: Dapagliflozin
  topic: keywords
creator: Usama AA Sharaf El Din
creator: Mona M Salem
creator: Dina O Abdulazim
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-03
publication date: 2025-12-03
starting page: 1
ending page: 4
doi: 10.47363/JONE/2022(2)121

Renal Infarction: Clinical and Evolutionary Aspects in the Nephrology Department Ibn Sina University Hospital of Rabat-Morocco
type: item
description: Introduction: Renal infraction is a rare medical-surgical emergency that should be evoked before any lumbar pain syndrome. We report in this work, two cases of renal infraction with their clinical evolution. Clinical Observation: These patients, aged respectively 48 and 70 years, were hospitalized in our department concomitant for low back pain. Emboligenic heart disease was responsible for the renal infraction in both cases. Diagnostic certainty was established by a CT scan with injection of contrast medium. Renal function was normal in the young patient versus renal insufficiency at 20mg/l creatinine for a GFR estimated at 35ml/minute according to MDRD in the elderly patient. We had a clinical and biological improvement with a curative anticoagulant treatment relayed by a long term treatment with an anti vitamin K in both cases but the elderly man kept a sequential renal insufficiency. Conclusion: Acute renal infarction is a rare pathology which must be systematically evoked in front of a lumbar pain syndrome. Angioscan with injection of contrast medium allows to make the diagnosis. Heparinization at an effective dose is the mainstay of treatment in the case of unilateral involvement, or surgery if bilateral.
subject: Articles
  topic: section
subject: Renal Infarction
  topic: keywords
subject: Lumbar Pain
  topic: keywords
subject: Emboligenic Cardiopathy
  topic: keywords
subject: Chu Ibn-Sina-Rabat
  topic: keywords
creator: Djiguiba K
creator: Ouzeddoun N
creator: Bayahia R
creator: Ezaitouni F
creator: Benamar L
creator: Fongoro S
creator: Sy S
creator: Kodio A
creator: Coulibaly A
creator: Toure M
creator: Doumbia M
creator: Yattara H
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-03
publication date: 2025-12-03
starting page: 1
ending page: 3
doi: 10.47363/JONE/2022(2)120

Scleroderma Renal Crisis in Mixed Connective Tissue Disease in a Patient: A Challenging Disease
type: item
description: A 52-year-old woman with Raynaud syndrome diagnosed less than 1 year ago, consulted the emergency room due to 4 months of progressive symmetrical edema in the lower limbs, muscle weakness, dyspnea, hypertension crisis, and dark urine. Investigations revealed left ventricular dysfunction (ejection fraction 14%) without coronary artery disease and acute renal injury. Mixed Connective Tissue Disease was diagnosed and because of the renal and systemic findings in the patient a renal biopsy was performed confirming scleroderma renal crisis. To the best of our knowledge, this is the tenth patient who reported scleroderma renal crisis as a complication in patients with Mixed Connective Tissue Disease, from these 4 patients who became hemodialysis dependent, 1 died, and 4 responded to therapy. The treatment chosen was Angiotensin-converting-enzyme inhibitors and steroids based on what is known in renal scleroderma crisis with a substantial recovery of the left ventricular function and stabilization of the glomerular filtration rate followed by discharge from hospitalization.
subject: Articles
  topic: section
subject: Scleroderma renal crisis
  topic: keywords
subject: Mixed Connective Tissue Disease
  topic: keywords
subject: Acute Renal Failure
  topic: keywords
subject: Angiotensin-Converting Enzyme Inhibitor
  topic: keywords
subject: Hypertension
  topic: keywords
subject: Heart Failure
  topic: keywords
creator: Jennifer Garay Guerrero
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-02
publication date: 2025-12-02
starting page: 1
ending page: 3
doi: 10.47363/JONE/2022(2)118

Cystatin C and Chronic Complications of Diabetes Mellitus in a Subsaharian Population
type: item
description: Background: Type 2 diabetes (T2D) is a chronic and progressive condition whose early management is crucial in preventing the occurrence of its chronic degenerative complications. Cystatin C (CysC) is a biomarker that may have a beneficial interest in the early detection of microvascular and macrovascular complications of T2D. Methods: We carried out a cross-sectional analytic study at the National Obesity Center of the Yaounde Central Hospital. We recruited 135 patients with T2D and performed a neurologic physical exam using the Toronto clinical score, a fundoscopy, ECG, ABI, and the following paraclinicals: dosage of serum levels of Cystatin C, lipid profile (with determination of Atherogenic indexes), Creatinine (with calculation of glomerular filtration rate using CKD-EPI formula) and hs-CRP. Results: Prevalences of diabetic retinopathy, nephropathy, neuropathy and PAD were 3.0%, 8.9%, 38.5%, 28.1% respectively. Electrocardiographic signs of myocardial ischemia were present in 5.9 % of the participants. We found 0.3[0.5-0.3] mg/l as median levels of the HDL-cholesterol and 0.9[1.2-0.7] mg/l for LDL-cholesterol. The median value of GFR was 105.7[119,0-85.7] ml/min/1.73m². The median serum CysC level was 0.8[0.9-0.6]mg/l and varied with age (p=0.01), A1C (p=0.016) and high blood pressure (HBP) (p=0.006). There was a relationship between serum CysC and diabetic nephropathy (p=0.01) and neuropathy (p=0.025). There was no significant relationship with diabetic retinopathy (p=0.225), PAD (p=0.169) and ECG signs of myocardial ischemia (p=0.669). Conclusion: Chronic microvascular and macrovascular complications of type 2 diabetes are common and in our study are predominantly represented by diabetic neuropathy and PAD. Serum CysC can be useful in the diagnosis of chronic complications of T2D.
subject: Articles
  topic: section
subject: CysC
  topic: keywords
subject: Type 2 Diabetes
  topic: keywords
subject: Chronic Complications
  topic: keywords
subject: Relationship
  topic: keywords
creator: Thérèse Mbezele-Essomba
creator: Bertille Elodie E Edinga
creator: Martine Claude Etoa
creator: Antoinette Assiga-Ntsama
creator: Vicky Ama-Moor
creator: Eugène Sobngwi
creator: Jean-Claude Mbanya
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-02
publication date: 2025-12-02
starting page: 1
ending page: 6
doi: 10.47363/JONE/2022(2)119

Infant Death due to Smothering
type: item
description: Background: Infanticide has varying terminology and definitions in different jurisdictions. It is usually defined as the murder of a child in the first 24 hours of life, whereas in the US it is defined as the murder of a person one week or less. In the UK, the adultery of a baby, who is not yet one year old by his own mother is referred to as infanticide and is given a lighter sentence due to considerations of mental status. Meanwhile, in Indonesia, the basis for consideration used is the motive for fear of being caught giving birth to a child and the murder is carried out immediately during childbirth. As for determining that murder is the murder of one’s own child or ordinary murder, a forensic examination is required. Case: A case was reported with the victim of a baby boy in a cardboard box on the road around the housing complex and an examination of the body was carried out in the autopsy room of the Forensic Medicine and Medicolegal Medical Installation of Bhayangkara General Hospital, TK II Medan City according to the Visum Request Letter. Results: it was found that the baby was born alive, viabel, did not get treatment with the estimated age of the baby in the womb was 9-10 months (mature). The cause of death is due to exposure that causes suffocation due to the obstruction of air entering the respiratory tract. Discussion: On examination, the baby was estimated to be aged 9-10 months in the womb (viable). There is no sign of treatment. Bruises were found on the upper and lower lips of the outer and inner parts which indicated the presence of closure of the baby’s mouth by the perpetrator. There are also signs of asphyxia. On internal examination, a positive pulmonary buoyancy test was found and the results of pulmonary histopathology showed that the baby was viable and quite a month. Conclusion: The baby is a victim of murder, so the perpetrator must be held accountable for his actions and can be prosecuted under articles 341, 342 of the Criminal Code if th…
subject: Articles
  topic: section
subject: Smothering
  topic: keywords
subject: Murder of one’s own child
  topic: keywords
creator: Asan Petrus
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-02
publication date: 2025-12-02
starting page: 1
ending page: 4
doi: 10.47363/JONE/2022(2)116

Prevalence, Characteristics and Outcome of Post-Operative Acute Kidney Injury in Cameroon: A Prospective Study in Three Hospitals in Douala
type: item
description: Objective: Post-operative acute kidney injury (AKI) is a frequent surgical complication. Data on this disorder are scare in our setting. We aimed to study the prevalence, characteristics and outcome of postoperative AKI in Cameroon. Methods: A prospective and analytical study from December 2020 to Mai 2021 including all consenting adults’ patients admitted in the departments of surgery, obstetrics/gynecology and intensive care unit (ICU) of 3 referral hospitals in Douala. For each patient, 3 serum creatinine assays were done on admission before the surgery, on days 2 and 7 after surgery. Postoperative AKI was defined and classified according to the modified KDIGO 2012 criteria. Outcome measure were kidney recovery at day 7 and mortality. Kidney recovery was total if serum creatinine on day 7 was less or equal to the preoperative value, partial if less than diagnostic value of day 2 but not the preoperative value and absent if creatinine on day 7 did not decrease or if the patient required dialysis. p <0.05 was considered significant. Result: Out of 203 patients included, 52 developed postoperative AKI, giving a prevalence of 26.6%. Mean age of AKI patients was 35.34 (13.74) years with 61.6% being (32/52) male; AKI stage 1 accounts for 55.7% (29/52), 19.3% (10/52) stage 2 and 25% (13/52) stage 3. AKI was functional in 61.5% (32/52) of cases mainly due to hypovolemia 42.5% (22/52) and sepsis 34.6% (18/52). For the 40 patients diagnosed on D2, kidney recovery was known in 75% (30/40); with 66.6% (20/30) total recovery, 23.4% (7/30) partial recovery and 10 % (3/30) without recovery. Mortality rate was 19% (10/52) mainly due to hemorrhagic shock. Intra operative hypotension (aOR: 6.09; CI: 1.4 - 26.33; p = 0.016) and dirty surgery (aOR: 6.22; CI: 1.35 - 28.75; p = 0.019) were factors associated with AKI. Conclusion: Postoperative AKI occurred in 1/4 of patients in our setting. It is mainly due to hypovolemia and sepsis, renal recovery and mortality were high.
subject: Articles
  topic: section
subject: Prevalence
  topic: keywords
subject: Post operative
  topic: keywords
subject: Acute kidney injury
  topic: keywords
subject: Outcome
  topic: keywords
subject: Douala
  topic: keywords
creator: Halle Marie Patrice
creator: Takam Lancyn Debelmond
creator: Mahamat Maimouna
creator: Dzana Victorine
creator: Nda Mefo’o Jean Pierre
creator: Fouda Hermine Danielle
creator: Ashuntantang Enow Gloria
creator: Ngowe Ngowe Marcelin
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-02
publication date: 2025-12-02
starting page: 1
ending page: 7
doi: 10.47363/JONE/2022(2)117

Prevalence and Associated Factors of Chronic Kidney Disease among Diabetic and Hypertensive Patients at Ambo Town Public Hospitals of West Shewa Zone, Oromia Region, Ethiopia
type: item
description: Background: Chronic kidney disease is a global public health important disease that is associated with life threatening outcomes including renal failure and premature mortality unless diagnosed and treated promptly. Diabetes Mellitus and hypertension are the two major causes of chronic kidney disease worldwide. This study is aimed to determine prevalence and associated factors of chronic kidney disease among diabetes mellitus and hypertensive patients at Ambo town public hospitals, Ethiopia. Methods: A cross-sectional study was conducted at Ambo University referral and general hospitals on 308 study participants. The participants were interviewed using interviewer administered questionnaire when they come for follow up at a chronic illness follow-up clinic. The patient charts were reviewed to retrieve information regarding medications, blood pressure, serum Creatinine and glucose level. A chronic kidney disease epidemiology collaboration equation was used to estimate Glomerular filtration rate from serum Creatinine. Data were analyzed SPSS version 23 for statistical analysis. Binary logistic regression analysis was used to identify factors associated with chronic kidney disease. Variables with a p-value below 0.2 at bivariable analysis were entered into the multivariable logistic regression model. Multivariable logistic regression analysis was used to examine the association between dependent and independent variables and p-value less than 0.05 was used to declare statistical significance. Results: A total of 308 diabetic and hypertensive patients were included in the study. Of which 156 (50.6%) participants were female with mean (± SD) age of 47.15 ± 12.06 years. The prevalence of chronic kidney disease (stage 3-5) was 20.5% with (95% CI: 16%-25%). Long duration of hypertension (AOR=4.89, 95% CI=1.93-12.40), elevated systolic blood pressure (>140mmHG) (AOR=3.20, 95% CI=1.36-7.51), family history (AOR=3.36, 95% CI=1.56-7.24) and age greater than 55 years (AOR=2.17, …
subject: Articles
  topic: section
subject: Chronic Kidney Disease
  topic: keywords
subject: Diabetic
  topic: keywords
subject: Hypertensive
  topic: keywords
creator: Belachew Dinku
creator: Haimanot Ewnetu Hailu
creator: Jimmawork Wondimu
creator: Bilisuma Girma
creator: Wegene Hailu
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-02
publication date: 2025-12-02
starting page: 1
ending page: 5
doi: 10.47363/JONE/2022(2)115

https://srcpublishers.com/index.php/nephrology-endocrinology-researc/article/view/3527
type: item
title: Viscoelastic or Viscoplastic Glucose Theory (VGT #65): Estimated Risk Probability Percentages of Having Kidney Cancer and its Moving Trend over a 7+ Year Period from 1/1/2015 To 4/20/2022 Using a Combined Score of Hyperglycemia (Hyperg or Hg for T2d), Insulin Resistance (Ir), Hypertension (Bp), and Albumin-To-Creatinine Ratio(Acr), Obesity, Diet, and Exercise as the 4 Key Influential Factors for Developing Kidney Cancer Based on GH-Method: Math-Physical Medicine (No. 654-A)
description: Recently, the author read a few published medical articles regarding kidney cancer. He then lists these articles in the Reference section.
subject: Articles
  topic: section
subject: Viscoelastic
  topic: keywords
subject: Viscoplastic Glucose Theory
  topic: keywords
subject: Kidney Cancer
  topic: keywords
subject: Hyperglycemia
  topic: keywords
creator: Gerald C Hsu
rights: Copyright (c) 2025 Journal of Nephrology & Endocrinology Research
date: 2025-12-02
publication date: 2025-12-02
starting page: 1
ending page: 3
doi: 10.47363/JONE/2022(2)114