Journal of Oncology Research Reviews & Reports
type: channel
description: Journal of Oncology Research Reviews & Reports is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Oncology Research Reviews & Reports. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Articles acceptance will be in the form of Research, Review, Case Reports, Analysis, Magazines, Editorials, Opinion, Communications, Mini-Review, Short Communications, Picturized, Book Review, Video Articles and Power Point Presentations (PPTs). You can submit articles through online https://www.onlinescientificresearch.com/submit-online or can send through an e-mail with attachment for: oncologysciences@onlinescientificresearch.info
publisher: Scientific Research and Community
language: en
publication name: Journal of Oncology Research Reviews & Reports
issn: 2755-0117
items: Pancreatic Cancer Therapeutics are we doing things Right?
items: Dosimetry of Three-Dimensional Conformal Radiotherapy (3D-CRT) Versus Volumetric Modulated Arc Therapy (VMAT) in Hypopharyngeal Cancer
items: Dosimetric and Clinical Outcomes of Volumetric Modulated ArcTherapy for Prostate Cancer
items: High Dose Rate Intracavitary Brachytherapy in Locally Advanced Cervical Cancer: A Retrospective Serie Analysis
items: Survival Outcomes in Ovarian and Uterine Cancer Patients Receiving Neoadjuvant Chemotherapy: A Retrospective Comparison of Inpatient Versus Outpatient Settings
items: Post Burn Squamous Cell Carcinoma
items: Surgical Treatment of Giant Hepatic Hemangioma in a Patient with Congenital Thoracic Scoliosis: A Case Report
items: Fatal Outcome in Lung Cancer with Rare Nasal Metastatic Spread:A Clinical Perspective
items: Radiopharmaceuticals and Theranostics: The High Road Ahead
items: From War to Compassion-A New Paradigm in Understanding Cancer
items: A Rare Case of Non-Hodgkin Lymphoma Presenting as Chronic Nasolacrimal Duct Obstruction
items: Case Report: Hyperacute GVHD Presenting Solely with Genital Erosion in a 17-Year-Old Female
items: Comparison of Arccheck and Portal Dosimetry in dose Verification for Intensity Modulated Radiotherapy (IMRT) and Rapidarc Plans
items: Improving the Aqueous Solubility of Taxol Through AlteringXLogP3
items: Giant Bilateral Adrenal Leiomyoma Case Report
items: Can Osmolytes TMAO and Glycerol Rescue Destabilized Temperature-Sensitive Mutants of P53?
items: Advancement in Cancer Chemotherapy - An approach towards treatment with Traditional remedies
items: Pembrolizumab and Campylobacter Jejuni Induced Guillain-Barré Syndrome in a Patient with Advanced Duodenal Adenocarcinoma: A Case Report and Literature Review
items: Revolutionizing Oncology Solutions with AI on Low-Code Platforms
items: Recurrent Medulloblastoma: Complete Response and > than 21 Years and Five Months Overall Survival in a One-Year and Seven Month-Old Male Treated with Antineoplastons
items: A Case of an Ulcerative Plaque and Disruption of the Main Pulmonary Artery Architecture
items: Gastrointestinal Stromal Tumor of Esophageal Location: A Rare Case with Surgical Discussion. Case Report and Literature Review
items: Synchronous Multifocal Early Gastric Cancer: How Important is A Meticulous Endoscopic Examination? A Case Report and Literature Review
items: Evaluation and Speech Therapy in Oncological Dysphagia and Paralysis of Recurrential Nerve: Case Report
items: https://srcpublishers.com/index.php/oncology-research-reviews-report/article/view/2050
items: A Pilot Study to Analyse the Effectiveness of Dendritic Cell Immunotherapy in Ovarian Cancer
items: Colon Cancer with Thyroid Metastasis – A Case Report
items: Reconstruction of Composite and Complex Head and Neck Defect Post Supra Major Oncological Resection by using Bilateral Pectoralis Major Myocutaneous Flap
items: Case Presentation MEN2A
items: Management of Chemotherapy-Induced Nausea and Vomitting in Breast Cancer Patients: A Prospective Cohort Study

Pancreatic Cancer Therapeutics are we doing things Right?
type: item
description: Pancreatic adenocarcinoma (PDAC) is one of the most lethal cancers. Among su-pramesocolic cancers, PDAC carries the worst prognosis because early detection re-mains a difficult task. Many treatment regimens failed to show improvement in terms of OS and DFS. In this review, we try to focus on PDAC from a molecular perspective. We identified how the 10 hallmarks of cancer apply in PDAC. K-ras mutation (the setter) was the triggering factor for all of them. Moreover, G12D mutation is a crucial step for PDAC to occur. Since this gene has many downstream pathways (spikers), it’s hard to hope for an effective treatment for each downstream mutation. Therefore, further re-search is required to find therapeutic drugs to target this mutation, the K-ras G12D.
subject: Articles
  topic: section
subject: Pancreatic Cancer
  topic: keywords
subject: Therapeutics
  topic: keywords
creator: Haydar A Nasser
creator: Amal A Nasser
creator: Sarah M Assaf
creator: Abdul Karim Ghaith
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-11-13
publication date: 2025-11-13
starting page: 1
ending page: 9

Dosimetry of Three-Dimensional Conformal Radiotherapy (3D-CRT) Versus Volumetric Modulated Arc Therapy (VMAT) in Hypopharyngeal Cancer
type: item
description: Objectives: IMRT or VMAT is the standard for curative treatment of hypopharyngeal carcinoma. In our setting, 3D-CRT is widely used due to limited IMRT availability. This study aimed to compare dosimetry between these techniques. Methods: A retrospective, bicentric study included 30 patients with hypopharyngeal squamous cell carcinoma (15 3D-CRT, 15 VMAT). Prescribed doses were 70 Gy/35 fractions for 3D-CRT and 64–70 Gy for VMAT. Target volumes and organs at risk were analyzed per ICRU 50 standards. Results: PTV coverage at V95% was comparable. VMAT reduced hot spots (V107%: 0.10% vs 47.46%, p < 0.001) and improved dose homogeneity (HI: 0.08 vs 0.81, p < 0.001). VMAT also lowered spinal cord maximum dose (40.85 vs 47.40 Gy, p < 0.001) and parotid mean doses (left: 28.12 vs 38.01 Gy, right: 28.27 vs 38.57 Gy; p < 0.05). Conclusion: In resource-limited settings, 3D-CRT ensures adequate tumor coverage. VMAT provides better dose homogeneity and spares organs at risk, potentially reducing toxicity and improving quality of life.
subject: Articles
  topic: section
subject: Hypopharynx
  topic: keywords
subject: Carcinoma
  topic: keywords
subject: Radiotherapy
  topic: keywords
subject: VMAT
  topic: keywords
subject: 3D-CRT
  topic: keywords
creator: Fatimatou Néné Sarr
creator: Mouhamadou Bachir Ba
creator: Awa Sadikh Badiane
creator: Rachidou Hamadou
creator: Moussa Diallo
creator: Massamba Diène
creator: Kanta Ka
creator: Maimouna Mané
creator: Mamadou Moustapha Dieng
creator: Papa Macoumba Gaye
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2025(6)191

Dosimetric and Clinical Outcomes of Volumetric Modulated ArcTherapy for Prostate Cancer
type: item
description: Objectives: To evaluate the dosimetric aspects through dose coverage and tolerance as well as the clinical outcomes of radiation therapy for prostate cancer by a technique of Volumetric Modulated Arc Therapy (VMAT). Methodology: This is a retrospective study of 71 patients treated for prostate cancer consecutively at the International Cancer Center of Dakar (CICD) from July 2020 to December 2023. All patients received radiation therapy in intensity modulation by VMAT technique. The diagnostic data, treatment information including dosimetric and results were collected and analyzed. Results: The average age was 68.9 ± 6.1 years. The circumstance of discovery was fortuitous by PSA assay in 42.3% and symptomatic in 57.7% of cases. The median initial PSA level was 20 ng/ml (3.7–662). Adenocarcinoma was the histological type in all patients. Pelvic node involvement was found in 12.6% of patients and 5.6% were metastatic. For localized forms, high risk was predominant (49.3%). First-line radiotherapy was performed in 94.4% of cases. The average doses of the D95% and Dmax of the high-risk forecast target volume were 70.69 ± 5.2Gy and 77.06 ± 5.88Gy, respectively. All dose constraints have been met on the target volumes and organs at risk. No Grade 3 acute toxicity was observed. With a median follow-up of 20.67 months, the overall survival (OS) and biochemical relapse-free survival (BFS) rates at 2 years were 98.6% and 92.9%, respectively. Conclusion: Radiotherapy occupies a prominent place in the treatment of prostate cancer. New techniques by intensity modulation allow better oncological results and improve the tolerance of treatments.
subject: Articles
  topic: section
subject: Cancer
  topic: keywords
subject: Prostate
  topic: keywords
subject: Radiotherapy
  topic: keywords
subject: Dosimetry
  topic: keywords
subject: Senegal
  topic: keywords
creator: Mouhamadou Bachir BA
creator: Joël Nguessan
creator: El Hadji Malick M. Diallo
creator: Rachidou Hamadou
creator: Ibrahima Thiam
creator: Kanta Kalra
creator: Mamadou Moustapha DIENG
creator: Abdoul Aziz Kasse
creator: Papa Macoumba Gaye
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-10-07
publication date: 2025-10-07
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2025(6)190

High Dose Rate Intracavitary Brachytherapy in Locally Advanced Cervical Cancer: A Retrospective Serie Analysis
type: item
description: Introduction: The treatment of locally advanced cervical cancer is based on radio chemotherapy followed by brachytherapy. The aim of this study was to evaluate the tolerance and efficacy of image-guided high dose rate (HDR) intracavitarybrachytherapy in a context of limited resources. Materials and Methods: The clinical and dosimetric data of 60 patients with locally advanced cervical carcinoma treated by concomitant radio-chemotherapy (RCC) follow-up of brachytherapy between January 2019 and December 2023 at the CHU Dalal Jamm in Dakar were retrospectively analyzed. The toxicities of brachytherapy had been evaluated according to the Common Terminology Criteria for Adverse Events V4.0 (CTCAE) criteria. Estimates of overall survival and recurrence-free survival rates were analyzed by the Kaplan-Meier method, comparisons were made with the log-rank test and the cox model, with a 95% confidence interval. The statistical analyses were carried out using SPSS software in version 21. Results: The average age was 53.8 ± 11.8 years. All patients had locally advanced tumors with FIGO stages IIB and IIIC1 respectively predominant 37.1% each. The median time from completion of external irradiation to brachytherapy was 28 days [0–124]. The dosimetry was in 3D for all patients. The average dose delivered at the high risk CTV (D90) was 82.2 Gy and 71.7 Gy at the low risk CTV. The D2cc (minimum dose received by the most irradiated 2 cm3) were 79.5 Gy for the bladder, 72.1 Gy for the rectum, 55.4 Gy for the sigmoid and 60.1 Gy for the small intestine. The main toxicities of brachytherapy were digestive (16.7%) and genitourinary (33.3%) all grades combined. With a median follow-up of 19.5 months, the evolution was marked by 12 locoregional recurrences (21.4%), 8 metastatic relapses (14.5%) and 6 deaths (10%). Overall survival and local relapse-free survival rates were 76.6% and 64.5% at 3 years, respectively. Conclusion: Brachytherapy is essential in the optimal management of cervix …
subject: Articles
  topic: section
subject: Cervix Cancer
  topic: keywords
subject: Brachytherapy
  topic: keywords
subject: Senegal
  topic: keywords
creator: Elhadji Malick Mokhsine Diallo
creator: Mouhamadou Bachir BA
creator: Latifatou Gueye
creator: Fatimatou Néné Sarr
creator: Wilfried Sanou
creator: Papa Macoumba Gaye
creator: Mamadou Moustapha Dieng
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-10-07
publication date: 2025-10-07
starting page: 1
ending page: 6
doi: 10.47363/JONRR/2025(6)189

Survival Outcomes in Ovarian and Uterine Cancer Patients Receiving Neoadjuvant Chemotherapy: A Retrospective Comparison of Inpatient Versus Outpatient Settings
type: item
description: Objectives: Chemotherapy administration has largely shifted from inpatient to outpatient settings, offering benefits like increased patient comfort, fewer hospitalizations, and reduced costs. However, inpatient care remains crucial for patients needing direct observation, intensive side effect management, or those with significant medical comorbidities. Despite clinicians using their judgment and available guidelines to determine the best treatment setting, there's a notable scarcity of literature on outcomes between these settings, especially within gynecologic oncology. This study aimed to evaluate the survival differences of patients with endometrial and ovarian cancer who received neoadjuvant chemotherapy (NACT) in either outpatient or inpatient settings. Methods: We identified and reviewed charts for 146 endometrial or ovarian cancer patients treated with NACT at Montefiore Medical Center between 2010 and 2023. This cohort comprised 47 patients in the inpatient group and 99 in the outpatient group. Results: Our findings indicated that the inpatient group had a higher mean ECOG performance status, received fewer chemotherapy cycles, and were less likely to undergo surgery. While initial analysis suggested poorer survival for the inpatient group (p = 0.019), this difference became statistically insignificant after controlling for various confounders. Conclusions: Despite initial indications of poorer outcomes for inpatient NACT, this difference was not statistically significant once confounding factors were addressed. These results provide important reassurance that inpatient chemotherapy, when clinically indicated, does not lead to inferior oncologic outcomes. Further research is essential to better understand optimal chemotherapy delivery and to identify and address obstacles to patient care.
subject: Articles
  topic: section
subject: Neoadjuvant Chemotherapy
  topic: keywords
subject: Ovarian Cancer
  topic: keywords
subject: Uterine Cancer
  topic: keywords
subject: Inpatient Chemotherapy
  topic: keywords
subject: Survival Outcomes
  topic: keywords
creator: Mia Kim BA
creator: Rupal Bhana
creator: Sherron Thomas BA
creator: Nicole Nevadunsky
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-08-07
publication date: 2025-08-07
starting page: 1
ending page: 8
doi: 10.47363/JONRR/2025(6)187

Post Burn Squamous Cell Carcinoma
type: item
description: Introduction: Squamous cell carcinoma is the second most common skin cancer, ranking behind basal cell carcinoma. Its incidence is approximately 20–25% of that of basal cell carcinoma. Squamous cell cancer arising in injured areas have a high propensity for metastases and local recurrence. Treatment options for squamous cell carcinoma are generally divided into excisional therapies and superficial ablative therapies. Tumor location, size, depth of invasion, and histologic differentiation affect treatment choices. All patients with squamous cell cancer require close follow-up to monitor for local recurrence and metastases. The chance of developing a second skin cancer within 5 years after treatment of the original basal cell or squamous cell cancers as high as 50%. Objective To assess the relation between the degree of the burn and skin squamous cell carcinoma cancer. To assess the latent period between burn and the developed skin squamous cell carcinoma cancer. To assess the incidence of metastasis from skin squamous cell carcinoma after burn, and the mostly site of metastasis. Materials and Methods: During the study period, fifty patients were targeted from 2200 burn patient who get skin cancer after burn. who were admitted to Al- Amal Oncology Center, Taiz, Yemen, between June 2014 and May 2017. Patients were eligible for inclusion (Any patient of any age and any gender, who had skin cancer after burn), for an descriptive cross-sectional. excluded based on the presence of synochronouse/ metachronous cancer. The statistical analysis was performed using SPSS (statistical package for social science), version 25. Data exhibited in figures and tables and summarized as percentages, frequencies, means and standard deviations. Results: 50 patients who have SCC from 2200 burn patients examined retrospectively. The number of SCC developing on burn scars among the 2200 burn cases was 50 (2.3%), The mean age was 45 ± 15.5 years, The highest percentage of patients ages was 50%…
subject: Articles
  topic: section
subject: (SCC) Squamous cell Carcinoma
  topic: keywords
subject: Post Burn Skin Cancer
  topic: keywords
subject: Metastasis
  topic: keywords
creator: Al-Daqaf Mohammad
creator: Eman Al-Daqaf
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-07-10
publication date: 2025-07-10
starting page: 1
ending page: 5
doi: 10.47363/JONRR/2025(6)186

Surgical Treatment of Giant Hepatic Hemangioma in a Patient with Congenital Thoracic Scoliosis: A Case Report
type: item
description: Background: Hepatic Hemangioma (HH) is the most common benign primary hepatic neoplasm, which is usually asymptomatic and does not require intervention. The definition of a Giant HH is an HH with a size of more than 5 cm and symptomatic abdominal pain due to compression of adjacent organs. In this study, we report a rare case of giant HH in a young woman with congenital thoracic scoliosis, successfully treated via primary surgical resection guided by three-dimensional (3D) simulation. Case Report: We present the case of a 30-year-old woman who complained of various gastrointestinal symptoms occurring 4 months after the delivery of her second child. A series of examinations was done, which revealed two giant hemangiomas. The patient was planned for surgery, and the tumors were successfully resected. The patient was discharged after eight days of hospitalization without any severe complications. Conclusions: Giant HH patient with congenital thoracic scoliosis has not been reported in previous studies, we suggest that patients with giant HH should undergo surgical treatment when the diagnosis is made to reduce symptoms and prevent the risk of traumatic or iatrogenic rupture and this operation is not affected by her thoracic scoliosis. But we should make a detailed plan before surgery to performed liver resection.
subject: Articles
  topic: section
subject: Hepatic Hemangioma
  topic: keywords
subject: Giant Hemangioma
  topic: keywords
subject: Case Report
  topic: keywords
subject: Surgical Treatment
  topic: keywords
creator: Thuan Vo Duy
creator: Song Huy Nguyen-Dinh
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-06-09
publication date: 2025-06-09
starting page: 1
ending page: 5
doi: 10.47363/JONRR/2025(6)185

Fatal Outcome in Lung Cancer with Rare Nasal Metastatic Spread:A Clinical Perspective
type: item
description: Cutaneous metastases to the nose are a rare manifestation of metastatic squamous cell carcinoma (SCC) of the lung. These metastases can present as either solitary or multiple lesions on the skin, and they may appear either fixed or mobile. Reports of cutaneous metastases from lung cancer specifically affecting the nose occur in 1-12% of cases [1]. In some instances, these cutaneous metastases can be the first indication of an underlying solid epithelial malignancy, often associated with a poor prognosis [2]. When these metastases occur on the nasal tip, they are sometimes referred to as “clown nose” due to their resemblance to a red, fake nose.
subject: Articles
  topic: section
subject: Cutaneous Metastases
  topic: keywords
subject: Tip of the Nose
  topic: keywords
subject: Squamous Cell Carcinoma of the Lung
  topic: keywords
creator: Dibangkar Das
creator: Vikas Sharma
creator: S Hari Kumar
creator: Manoj Gopal Madakshira
creator: Deepak S Mulajker
creator: Vinay Kumar Tripathi
creator: Zia Zafar
creator: V Bala Krishnan
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-05-21
publication date: 2025-05-21
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2025(6)183

Radiopharmaceuticals and Theranostics: The High Road Ahead
type: item
description: Radiopharmaceuticals and Theranostics are transforming the medical landscape by offering precise, targeted diagnostic and therapeutic solutions. Implementing a successful radiopharmaceutical program in any institutional practice or trial setting requires meticulous planning across several domains and seamless integration with oncology workflows for timely and accurate patient care. This article explores the landscape, applications, regulatory considerations, infrastructural and operational requirements along with future directions for expanding these therapies into clinical settings.
subject: Articles
  topic: section
subject: Radiopharmaceuticals
  topic: keywords
subject: Theranostics
  topic: keywords
creator: Divya S Mishra
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-06-02
publication date: 2025-06-02
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2025(6)184

From War to Compassion-A New Paradigm in Understanding Cancer
type: item
description: For decades, the prevailing narrative around cancer has been framed as a war a relentless battle between medicine and malignant cells. We speak of “fighting cancer,” “killing tumors,” and “defeating the disease,” projecting onto it an identity of hostility and invasion. While this language has served to mobilize research and treatment efforts, it may have also blinded us to a more profound and compassionate understanding of the biological and energetic nature of cancer.
subject: Articles
  topic: section
subject: Paradigm
  topic: keywords
subject: Cancer
  topic: keywords
creator: Nader Butto
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-05-07
publication date: 2025-05-07
starting page: 1
ending page: 8
doi: 10.47363/JONRR/2025(6)182

A Rare Case of Non-Hodgkin Lymphoma Presenting as Chronic Nasolacrimal Duct Obstruction
type: item
description: Leukemic infiltration of the optic nerve is a rare but serious complication of hematologic malignancies, often leading to visual impairment. It can present with symptoms such as diplopia, vision loss, and proptosis, sometimes mimicking common ophthalmologic conditions like nasolacrimal duct obstruction. Due to its rarity, it is often misdiagnosed, delaying appropriate treatment.
subject: Articles
  topic: section
subject: Nasolacrimal Duct Lymphoma
  topic: keywords
subject: Chemotherapy
  topic: keywords
subject: IHC
  topic: keywords
subject: PET-CT
  topic: keywords
creator: Erdenechimeg T
creator: Sugar E
creator: Duurenjargal TS
creator: Nansalmaa A
creator: Oyundelger N
creator: Otgonbat A
creator: Saruul T
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-04-24
publication date: 2025-04-24
starting page: 1
ending page: 2
doi: 10.47363/JONRR/2025(6)181

Case Report: Hyperacute GVHD Presenting Solely with Genital Erosion in a 17-Year-Old Female
type: item
description: We report a case of a 17-year-old Saudi female who developed hyperacute graft-versus-host disease (GVHD) presenting primarily with genital erosions. While genital GVHD has been documented in the literature, this case is unique as it presents with genital lesions as the primary and sole manifestation. We hope this report sheds light on other cases that might be underreported and emphasizes the importance of considering genital GVHD in similar patients.
subject: Articles
  topic: section
subject: Hyperacute
  topic: keywords
subject: Genital Erosion
  topic: keywords
creator: Amnah Almulhim
creator: Abeer Adel Alshamlan
creator: Lenah Yassir Shaikh
creator: Ayed Alqarni
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2025-01-25
publication date: 2025-01-25
starting page: 1
ending page: 2
doi: 10.47363/JONRR/2025(6)180

Comparison of Arccheck and Portal Dosimetry in dose Verification for Intensity Modulated Radiotherapy (IMRT) and Rapidarc Plans
type: item
description: This study compares Portal Dosimetry with the ArcCheck phantom for patient-specific QA of RapidArc and IMRT plans. The Electronic Portal Imaging Device (EPID) from Varian and the Eclipse Treatment Planning System (TPS) were used for portal dosimetry, while the ArcCheck cylindrical phantom from Sun Nuclear was used for phantom studies. Eclipse-TPS facilitated RapidArc and dynamic IMRT treatment planning and portal dosimetry (PD) for planar dose calculations. Two verification plans were created for each of the 12 patient plans, totaling 24 arcs delivered on two QA systems. The 12 plans, each with two arcs, were delivered on the EPID of the Varian TrueBeam Linac and the ArcCheck phantom. Planar dose matrices were analyzed using the global Gamma Index criteria of 2mm DTA and 2% dose difference. Measurements were performed using the Varian TrueBeam Linac mounted EPID (aS1200) with Portal dosimetry and the ArcCheck phantom with its software. The QA results from both methods were evaluated and compared. The maximum deviations of dose points (γ>1) were 2.9% and 2.2 CU in the ArcCheck phantom and Portal dosimetry, respectively. Mean and standard deviation values were lower in portal dosimetry than in phantom studies, attributed to the closely embedded chambers in the EPID compared to the detector spacing in the phantom. Both dosimetric QA systems are suitable for patient-specific QA of RapidArc or VMAT and IMRT treatments. With a 2%/2mm criterion, the average γ passing rates were over 98% for PD and over 95% for ArcCheck, with PD showing slightly higher consistency.
subject: Articles
  topic: section
subject: Radiation Therapy
  topic: keywords
subject: Arccheck
  topic: keywords
subject: Portal Dosimetry
  topic: keywords
subject: IMRT
  topic: keywords
subject: VMAT
  topic: keywords
subject: Dose Verification
  topic: keywords
subject: Quality Assurance
  topic: keywords
subject: Rapidarc
  topic: keywords
subject: Dosimetry Systems
  topic: keywords
creator: Priya Jacob
rights: Copyright (c) 2024 Journal of Oncology Research Reviews & Reports
date: 2024-12-24
publication date: 2024-12-24
starting page: 1
ending page: 5
doi: 10.47363/JONRR/2024(5)179

Improving the Aqueous Solubility of Taxol Through AlteringXLogP3
type: item
description: Taxol (generic name paclitaxel) is an antineoplastic drug used to treat breast, lung, and ovarian cancer. It performs exceptionally well against a wide variety of tumors, including B16 melanoma, L1210 and P388 leukemias, MX-1 mammary tumor, and CX-1 colon tumor xenografts. However, despite Taxol’s efficacy in antitumor activity, its aqueous solubility is extremely poor, decreasing its bioavailability and making it difficult for the body to absorb. The objective of this study is to improve the solubility of taxol, thus increasing the bioavailability of the drug in preventing cancer. By modifying the structure of taxol, four novel taxol derivatives were created with improved solubilities. Two of the derivatives were given an additional hydrogen donor and acceptor, and thus showed a pronounced positive change in solubility. The results of this work solve the issue of Taxol’s inadequate solubility and show potential in increasing absorption of the drug.
subject: Articles
  topic: section
subject: Taxol
  topic: keywords
subject: Solubility
  topic: keywords
creator: Arianna Zhu
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2024-09-16
publication date: 2024-09-16
starting page: 1
ending page: 3
doi: 10.47363/JONRR/2024(5)177

Giant Bilateral Adrenal Leiomyoma Case Report
type: item
description: Introduction: Adrenal leiomyoma is extremely rare and is thought to arise from the smooth muscle wall of the central adrenal vein and its branches; Clinically they may present as abdominal pain or flank pain. These tumors generally have a low biological potential. The surgical indication for adrenal tumors is based mainly on functionality and the risk of malignancy. Clinical Case: 39-year-old male, with no significant history. Who comes to the general surgery outpatient clinic due to the presence of progressive abdominal distension and long-term abdominal pain. An abdominopelvic CT scan was performed, which revealed bilateral, well-circumscribed tumor with heterogeneous characteristics located in the left and right adrenal area, negative functional tests. An exploratory laparotomy was performed, revealing two giant adrenal tumors, definitive study reporting bilateral adrenal leiomyoma. Conclusion: We present a rare case of bilateral primary adrenal leiomyoma of which no similar case was found in the reviewed literature. These tumors are very difficult to diagnose preoperatively. as they are often not counted in adrenal samples and clinical suspicion is very low. As a result, they are diagnosed postoperatively after pathological examination of the surgical specimen. At the moment, early and complete surgical resection is the main treatment.
subject: Articles
  topic: section
subject: Adrenal Gland
  topic: keywords
subject: Bilateral
  topic: keywords
subject: Leiomyoma
  topic: keywords
subject: Surgery
  topic: keywords
creator: María A Calderón González
creator: Ana K Mena Zenteno
creator: Isis Silva De la Vega
creator: Alejandra Brindis Soto
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2024-09-30
publication date: 2024-09-30
starting page: 1
ending page: 3
doi: 10.47363/JONRR/2024(5)176

Can Osmolytes TMAO and Glycerol Rescue Destabilized Temperature-Sensitive Mutants of P53?
type: item
description: Some 30-40% of oncogenic mutants of p53 are inactive because of low stability. Stabilization of such mutants is one route for novel anti-cancer drugs. The osmolytes glycerol and trimethylamine N-oxide stabilize all proteins by a combination of effects on solvent water and by direct interactions with proteins. It has been reported that protein instability defects in temperature-sensitive p53 mutants can be rescued in cell lines by the addition of low concentrations of those compounds. We measured the effects of glycerol and trimethylamine N-oxide on the thermal and kinetic stability of wild-type p53 and temperaturesensitive mutants in vitro and found that there were just negligible increases in stability at the concentrations reportedly used in cell lines. We found no rescue of mutants in H1299 cell lines at those reported concentrations. There was some stabilization at higher concentrations of glycerol and trimethylamine N-oxide in vitro but these concentrations were toxic to the cells. It would seem unlikely that the use of general osmloytes would be an effective strategy for the rescue of unstable mutants because even if they were effective at stabilizing p53, they would alter the proteostasis of the cell.
subject: Articles
  topic: section
subject: Protein Stabilization
  topic: keywords
subject: Oncogenic Mutant
  topic: keywords
subject: Osmolytes
  topic: keywords
subject: Fluorescence Denaturation
  topic: keywords
creator: Gaurav Jaggi
creator: Fiona M Townsley
rights: Copyright (c) 2024 Journal of Oncology Research Reviews & Reports
date: 2024-08-10
publication date: 2024-08-10
starting page: 1
ending page: 5
doi: 10.47363/JONRR/2024(5)175

Advancement in Cancer Chemotherapy - An approach towards treatment with Traditional remedies
type: item
description: Cancer is a global health problem responsible for one in twenty deaths worldwide. Advancement in cancer chemotherapy includes surgery and radiotherapy have been in use while significant advances are being made in recent times including stem cell therapy, natural antioxidants, targeted therapy, radionics, nanoparticles, chemodynamic therapy, sonodynamic therapy and ferroptosis based therapy. The search for effective treatment has gained much significance in the development of modern chemotherapy and the use of herbal medicines in the treatment of cancer. These approaches offer different perspectives on cancer treatment each with its own set of advantages and disadvantages. In this chapter, we explore the potential of modern chemotherapy and herbal remedies, exploring their differences, effectiveness, side effects, accessibility, and potential for consolidation in the treatment of cancer.
subject: Articles
  topic: section
subject: Chemotherapy
  topic: keywords
subject: Radionics
  topic: keywords
subject: Herbal Medicine
  topic: keywords
subject: Natural Antioxidants
  topic: keywords
subject: Effectiveness
  topic: keywords
creator: Srivastava Vaibhav
creator: Pal Vivek
rights: Copyright (c) 2024 Journal of Oncology Research Reviews & Reports
date: 2024-04-30
publication date: 2024-04-30
starting page: 1
ending page: 5
doi: 10.47363/JONRR/2024(5)174

Pembrolizumab and Campylobacter Jejuni Induced Guillain-Barré Syndrome in a Patient with Advanced Duodenal Adenocarcinoma: A Case Report and Literature Review
type: item
description: Neurological Immune Related Adverse Events (irAEs) secondary to Immune Checkpoint Inhibitors (ICI) are unncommon with an incidence of 1% to 5%. Among them, the Guillain Barré syndrome may be life-threatening and must be diagnosed early. We describe a clinical case of Guillain Barré Syndrom with a concomitant Campylobacter Jejuni colitis occurring after the first intravenous injection of pembrolizumab. A review of literature regarding the Guillain Barré syndrome after ICI use is added as a complementary source.
subject: Articles
  topic: section
subject: Oncology
  topic: keywords
subject: Pembrolizumab
  topic: keywords
subject: Guillan Barré Syndrome
  topic: keywords
subject: Campylobacter Jejuni
  topic: keywords
subject: Ipilimumab
  topic: keywords
subject: Review of Literature
  topic: keywords
creator: Théophile Perrod
creator: Asmahane Benmaziane
creator: Karine Aure
creator: Laure Ladrat
creator: Nassiba Heba
creator: Jaafar Bennouna
rights: Copyright (c) 2024 Journal of Oncology Research Reviews & Reports
date: 2024-01-15
publication date: 2024-01-15
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2024(5)178

Revolutionizing Oncology Solutions with AI on Low-Code Platforms
type: item
description: Advancements in Artificial Intelligence (AI) have the potential to transform oncology, enabling personalized treatment, early detection, and improved patient outcomes. However, the traditional development of AI-driven solutions is often hindered by high costs, long development cycles, and the need for specialized expertise. Low-code platforms offer a promising solution by allowing healthcare professionals and developers to rapidly create, test, and deploy AI applications with minimal coding. This paper explores the integration of AI with low-code platforms in oncology, examining the benefits, challenges, and future implications. By leveraging these technologies, the healthcare industry can overcome significant barriers, making cutting-edge oncology solutions more accessible and scalable.
subject: Articles
  topic: section
subject: Low-Code Platforms
  topic: keywords
subject: AI
  topic: keywords
subject: Oncology
  topic: keywords
subject: Use of AI in Oncology
  topic: keywords
subject: and Low-Code Platform
  topic: keywords
creator: Preeti Tupsakhare
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2023-12-21
publication date: 2023-12-21
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2023(4)E101

Recurrent Medulloblastoma: Complete Response and > than 21 Years and Five Months Overall Survival in a One-Year and Seven Month-Old Male Treated with Antineoplastons
type: item
description: Medulloblastomas arise in the posterior fossa, primarily in the region of the fourth ventricle. Recurrent medulloblastomas are high-risk and have a bad prognosis. Objectives: the case of a male child with recurrent, disseminated medulloblastoma is presented to detail the efficacy of ANP therapy (Antineoplaston A10 {Atengenal} and Antineoplaston AS2-1 {Astugenal}) in the treatment of high-risk medulloblastoma. This child was treated at the Burzynski Clinic (BC), as a Special Exception, according to Protocol BT-12, “Phase II Study of Antineoplastons A10 and AS2-1 in Children with Primitive Neuroectodermal Tumors”, with intravenous (IV) ANP therapy via a subclavian catheter and infusion pump. Tumor response was measured by sequential magnetic resonance imaging (MRI) of the brain with gadolinium enhancement. Findings: This child initially underwent tumor resection, placement of ventricular shunts, and chemotherapy, all performed elsewhere. Baseline MRI at the BC revealed recurrent, disseminated, and enhancing disease measuring 9.10 cm2 in total. IV ANP therapy began in March 2001 and ended in December 2002 after a complete response (CR) was achieved based on MRI criteria. Subsequently, the child received oral Antineoplastons as maintenance therapy, which were discontinued after eight months. At last follow-up, > 21 years and eight months since diagnosis and > 21 years and five months since the start of IV ANP therapy, the patient was well and showing no evidence of tumor recurrence. Conclusions: The utilization of ANP therapy to cure a patient with recurrent medulloblastoma is presented. We conclude that ANP therapy is an attractive therapeutic option for children with medulloblastoma.
subject: Articles
  topic: section
subject: Antineoplastons
  topic: keywords
subject: Childhood Medulloblastoma
  topic: keywords
subject: Brain Tumor
  topic: keywords
subject: Medulloblastoma
  topic: keywords
subject: Phase II Studies
  topic: keywords
creator: Stanislaw R Burzynski
creator: Gregory S Burzynski
creator: Tomasz Janicki
creator: Samuel Beenken
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2023-11-15
publication date: 2023-11-15
starting page: 1
ending page: 6
doi: 10.47363/JONRR/2023(4)172

A Case of an Ulcerative Plaque and Disruption of the Main Pulmonary Artery Architecture
type: item
description: A 75-year-old Caucasian male with no remarkable past medical history presented to the emergency department complaining of shortness of breath, chest pain, and dyspnea on exertion. His presentation prompted a computed tomography angiogram with reconstruction of the mediastinum (CTPA) and upon review of the image, a splitting or dissection of the main pulmonary artery was seen (Figure 1). This case is unique because it is potentially the first discussion of MPA dissection not due to COPD or CHF but lymphadenopathy caused by neoplasms and great vessel remodeling. Generally, main pulmonary artery (MPA) dissection is seen in patients with congenital heart defects and primary pulmonary hypertension but in this case, lymphoma is viewed as a possible cause due to the patient’s medical history indicating abdominal aorta lymphadenopathy and ulcerative plaques. MPA dissection has been linked to congestive heart failure or COPD in past cases but our patient in this case did not present with any findings linked to those conditions. The patient had little evidence of MPA dissection on prior readings on images done 6 months and 12 months ago– and the current presentation was only discovered incidentally. Our patient was stable and presented with unrelated symptomatology associated with MPA ulceration. It can explain otherwise labeled idiopathic causes of MPA dissection and has the potential to inform physicians and save lives.
subject: Articles
  topic: section
subject: Ulcerative Plaque
  topic: keywords
subject: Main Pulmonary Artery
  topic: keywords
subject: Splitting of the Great Vessels
  topic: keywords
subject: Interventional Radiology
  topic: keywords
creator: Iya Agha
creator: Ryan Cornell
creator: Jaskaran Ghotra
creator: Noor Asif
creator: Emmanuel Khodra
creator: Saif Aldeen Agha
creator: Ayad KM Agha
creator: Dabr DO
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2023-11-12
publication date: 2023-11-12
starting page: 1
ending page: 2
doi: 10.47363/JONRR/2023(4)171

Gastrointestinal Stromal Tumor of Esophageal Location: A Rare Case with Surgical Discussion. Case Report and Literature Review
type: item
description: Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms. They arise from the intestinal wall and usually present as subepithelial neoplasms in the stomach and small intestine; however, they can appear anywhere in the gastrointestinal (GI) tract. Most of these tumors have mutations in KIT or platelet-derived growth receptor alpha (PDGFRA), while mutations in succinate dehydrogenase (SDH) or other genes are less frequent. New molecules have shown promising results in the therapy of these tumors.
subject: Articles
  topic: section
subject: Gastrointestinal Stromal Tumor
  topic: keywords
subject: Gist
  topic: keywords
subject: Esophageal Gist
  topic: keywords
creator: Augusto Leite Canguçu
creator: Virginia dos Santos Silva Neta
creator: Sergio Tadeu Lima Fortunato
creator: Igor Campos da Silva
creator: Rodrigo Antônio Vieira Guedes
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2023-08-10
publication date: 2023-08-10
starting page: 1
ending page: 2
doi: 10.47363/JONRR/2023(4)173

Synchronous Multifocal Early Gastric Cancer: How Important is A Meticulous Endoscopic Examination? A Case Report and Literature Review
type: item
description: Introduction: The incidence rate of synchronous early gastric cancer is reported to be 5% to 15%, and several risk factors that increase its incidence have already been identified. Synchronous lesions are reported to be neglected in 32.4% of early gastric neoplasia cases. Method: Case report of a 75-year-old woman, with mucosa atrophy, intestinal metaplasia, with early gastric adenocarcinoma in antrum, CT staging without alterations, underwent surgical treatment using endoscopic submucosal dissection (ESD). Results: The anatomopathological result demonstrated a lesion of 2 cm, a well-differentiated non-ulcerated adenocarcinoma, without lymphatic-vascular invasion, with a positive deep submucosal margin, eCURE C-2. A D1+ complementary laparoscopic partial gastrectomy was performed. The analyzes of the surgical specimens showed an ESD area of ulcer scar without tumor and another early gastric cancer (T1a) at 2.2 cm distance with normal mucosa between them. Thirty six lymph nodes were free of disease. Conclusion: In this case, the patient had 3 risk factors for synchronic injury, but it was only discovered during the salvage gastrectomy. Thorough endoscopy should be performed in all patients and even more so in patients with risk factors. Failure to recognize these lesions can result in evolution to advanced cancer.
subject: Articles
  topic: section
subject: Gastric Cancer
  topic: keywords
subject: Synchronous Multifocal
  topic: keywords
creator: Flávio Silano
creator: Vanessa Costa Neves
creator: Ricardo Bandeira de Melo Amaral
creator: Rodolfo Carvalho Santana
creator: Paulo Cezar Galvão do Amaral
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2023-07-31
publication date: 2023-07-31
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2023(4)170

Evaluation and Speech Therapy in Oncological Dysphagia and Paralysis of Recurrential Nerve: Case Report
type: item
description: Background: Dysphagia is a frequent and serious complication of oncological pathologies. It can occur in head and neck neoplasms undergoing demolitive surgery; but also as a complication of radiotherapy treatments of the same district. Aim: The description of this clinical case highlights how rehabilitation and speech therapy can improve oral nutritional skills. Materials and Methods: An intensive multidisciplinary rehabilitation was performed initially in hospitalization and then in an outpatient setting with postural and pharyngo-laryngeal district exercises. Conclusion: The results demonstrated an improvement in swallowing ability and maintenance of oral nutrition, albeit with modification of food consistency. There have been excellent results in improving the quality of life and maintaining the patient’s social and family skills.
subject: Articles
  topic: section
subject: Dysphagia
  topic: keywords
subject: Aspiration Pneumonia
  topic: keywords
subject: Recurrential Paralysis
  topic: keywords
subject: Speech Therapy
  topic: keywords
creator: Giorgio Mandala
creator: Valentina La Mantia
creator: Giorgio Sanguedolce
creator: Manfredi Martorana
creator: Antonina Palermo
creator: Marylena Chiappone
creator: Alessandra Sorrentino
creator: Gabriella Scaccianoce
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2023-07-15
publication date: 2023-07-15
starting page: 1
ending page: 3
doi: 10.47363/JONRR/2023(4)169

https://srcpublishers.com/index.php/oncology-research-reviews-report/article/view/2050
type: item
title: Synergistic Effect of Simultaneous Testosterone Reduction and Selective Killing of Prostate Cancer Cells with Oral Bioavailable Curcumin Capsules May Ensure a Significant Drop in PSA Levelsfrom Abnormally High Levels Due to Confirmed MetastasizedProstate Cancer
description: In this century there have been 1000s of Pubmed listed publications making multiple claims about the potential health benefits of curcumin found in the curry spice, turmeric. A baby boomer male who was diagnosed with benign prostate hyperplasia (BPH), later after difficulty in urination, constriction of Urethra was treated with urethral catheterization. A year after BPH diagnosis, the PSA rose to 64 ng/ml and bone biopsy revealed prostate cancer cells, at which time a simultaneous combination treatment of Lupron depot and turmeric capsules from a pharmacy, containing curcumin was administered. 6 months after the combination treatment, the PSA level have remained well below average normal, around 0.3 ng/ml and the urination difficulties were resolved. While the noninvasive treatment without surgical removal of the prostate gland, has worked quite exceptionally for the time being, this report and review should be of broad interest for those who are involved in timely care of patients with enlarged prostate due to BPH, prostatitis, prostate cancer, and metastasized prostate cancer.
subject: Articles
  topic: section
subject: Synergistic
  topic: keywords
subject: Prostate Cancer Cells
  topic: keywords
creator: Girish J Kotwal
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2023-06-30
publication date: 2023-06-30
starting page: 1
ending page: 2
doi: 10.47363/JONRR/2023(4)168

A Pilot Study to Analyse the Effectiveness of Dendritic Cell Immunotherapy in Ovarian Cancer
type: item
description: After breast and cervical cancers, ovarian cancer ranks third among gynaecological cancers in terms of prevalence. Those with metastatic ovarian cancer have a five-year survival rate of less than 27%. The likelihood of survival is almost 90% for people with confined or primary illness. In reality, only 20% of cancers are found at that early stage. Others were found after the tumour had already invaded the whole peritoneal cavity. Chemotherapy is ineffective against cancer cells at this stage, resulting in low survival rates and high recurrence rates. The ability of immune cells to eradicate cancerous cells is inhibited by ovarian tumours’ severe immunosuppressive nature and many immune-suppressing mechanisms. In addition to conventional therapy, dendritic cell immunotherapy has been shown to be one of the most effective ways to prevent recurrence and improve overall survival by utilising the immune system’s capacity to attack malignant cancers. We conducted a study on individuals with ovarian cancer while keeping in mind the tumour microenvironment and dendritic cell functionality in ovarian cancer. Individualized autologous dendritic cell immunotherapy was given to each patient. With regard to the response rate and overall survival, the study’s findings and ramifications are examined.
subject: Articles
  topic: section
subject: Ovarian Cancer
  topic: keywords
subject: Dendritic Cell
  topic: keywords
subject: Immunotherapy
  topic: keywords
creator: Jamal A Khan
creator: Sharmin Yaqin
creator: Rakesh Reddy
creator: Raman Yadav
creator: Monika Deswal
creator: Shahzad Hoda
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2023-02-06
publication date: 2023-02-06
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2023(4)167

Colon Cancer with Thyroid Metastasis – A Case Report
type: item
description: Introduction: Metastasis in the thyroid itself, is unusual, represents 1.5-7.5% of malignant thyroid lesions and the original site of the colon is rare, around 0.1% incidence. The objective is to report the case of a patient diagnosed with colorectal cancer which progressed to thyroid disease. Case Report: It is a 62-year-old male patient who was being followed up at the Cancer Hospital of Londrina due to the resected colon neoplasm, which evolved with disease recurrence for the liver and lung and was controlled with systemic chemotherapy. It evolved with progression to thyroid and it was opted for diagnostic surgical resection. Conclusion: In the case demonstrated, it is a rare presentation of colon cancer metastasis and there is no current literature which would be a better therapeutic approach; surgery or palliative systemic chemotherapy. In this scenario, the importance of reporting cases little described in the literature may help in the decision of future conduct.
subject: Articles
  topic: section
subject: Colon Neoplasm
  topic: keywords
subject: Thyroid Neoplasm
  topic: keywords
subject: Thyroid Metastasis
  topic: keywords
subject: Metastasis
  topic: keywords
creator: Rafael Ricci Ferrari Manéa
creator: Rivadavio Antunes M. de Oliveira
creator: Gustavo Conrado Brassaroto
creator: Eni Martins Medeiros
creator: Stephanie Pedrazza
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2023-01-23
publication date: 2023-01-23
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2023(4)166

Reconstruction of Composite and Complex Head and Neck Defect Post Supra Major Oncological Resection by using Bilateral Pectoralis Major Myocutaneous Flap
type: item
description: Aim: The aim of study is to identify the outcome of Bilateral PMMC flaps for major Head and Neck defects following supra major oncological excision of growth. Study: Hospitals in India get many T4 Head & Neck malignancy. They are operated by Oncosurgeons but its reconstruction becomes challenging for the Plastic surgeons. We present a case series of reconstruction of major Head and Neck composite defect resulting from major post oncological resection where we have used Bilateral pectoralis major Myocutaneous flap to cover the resultant defect. Although microsurgical technique is available, but it’s costly. Pectoralis major flap is a robust flap, it requires lesser learning curve and lesser anaesthesia time, so the complications are less and healing is also faster. It is single stage surgery so that after healing Radiotherapy could be started as early as possible. Method: Fifteen patients since 2013 operated by chief surgeon were included in this study. After supra major excision of growth the inner lining was covered by contralateral PMMC and ipsilateral PMMC was used to cover the external defect. Conclusion: Bilateral PMMC flap is an answer to cover the defect following supra major excision of T4 Oral Malignancy. It is a pedicled flap, time taken is lesser than Microvascular Reconstruction and it could be done where microsurgical expertise is lacking. It is single stage surgery so radiation could be started early. So it’s a good answer to cover major post oncological surgical defect.
subject: Articles
  topic: section
subject: Major Complex Oral Defect
  topic: keywords
subject: Double Pectoral Flap
  topic: keywords
subject: Pectoralis Major Myocutaneous Flap
  topic: keywords
subject: Supra Major Reconstruction
  topic: keywords
creator: Shailendra B Singh
creator: Sruja D Narola
creator: Ranjit R Zapadiya
creator: Archana Thakur
creator: Rahul kaushik
creator: Deepanjali Kalra
creator: Manisha Singh
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2022-11-15
publication date: 2022-11-15
starting page: 1
ending page: 4
doi: 10.47363/JONRR/2022(3)165

Case Presentation MEN2A
type: item
description: Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder that can be distinguished as three different syndromes: multiple endocrine neoplasia type 2A (MEN2A). MEN2B and familial medullary thyroid carcinoma (FMTC). This disorder is usually caused by the mutations of the rearranged during transfection protooncogene gene (RET) or the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1).
subject: Articles
  topic: section
subject: MEN2A
  topic: keywords
creator: Hazem Rayyan
creator: Yousof Al Alawi
creator: Atyya Alzahrani
creator: Ismail Gurbal
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2022-10-15
publication date: 2022-10-15
starting page: 1
ending page: 2
doi: 10.47363/JONRR/2022(3)164

Management of Chemotherapy-Induced Nausea and Vomitting in Breast Cancer Patients: A Prospective Cohort Study
type: item
description: Through a prospective cohort study we aimed to optimize prevention and management of chemotherapy-induced nausea and vomiting (CINV) in the emergence of new therapies for breast cancer patients. We included breast cancer patients treated with moderate emetogenic (MEC) or highly emetogenic chemotherapy (HEC) all stages combined, from April 2021 to November 2021. Patients were required to answer a survey of 32 questions in order to analyze the potential involvement of known and unknown risk factors in the occurrence of CINV. The acute phase of CINV was defined as nausea and vomiting that developed ≤ 24 hours after the start of chemotherapy. Delayed phase of CINV was defined as nausea and vomiting that developed > 24 hours after the start of chemotherapy. The severity of nausea and vomiting was evaluated with common terminology criteria for adverse events (CTCAE) v5.0; publish to date: November 27, 2017. Analysis and results were performed using JAMOVI statistical software. In total, 177 patients received chemotherapy, 103 patients(58%) received (HEC), and 74 patients (42%) received (MEC). All patients were female (100%). Risk factors associated to occurrence of CINV included previously known factors: Younger age than 50 years (29,8%), history of pregnancy-related nausea and vomiting (74,7%), alcohol use (no patient reported previous alcohol consumption), failure to adhere to antiemetic treatment guidelines (9,6%). The compliance with treatment score (90,4%) showed a good commitment of the patients in the process of their medical healthcare. Other potential risk factors have been also explored to determine their involvement or not in the occurrence of CINV (cancer stage, performance status, education level, chemotherapy protocols, the use of traditional herbs known as an antibacterial agent and immunity booster in our context). In the acute phase, (78%) of patients experienced nausea and (47,8%) experienced vomiting. In the delayed phase, (37,1%) of patients experience…
subject: Articles
  topic: section
subject: Breast Cancer Patients
  topic: keywords
subject: Chemotherapy InducedNausea and Vomiting
  topic: keywords
subject: Prevention
  topic: keywords
creator: Imane Benali
creator: Tarik Mahfoud
creator: Najib Alidrissi
creator: Fayssal Jhilal
creator: Mohammed Amine Saad
creator: Anouar Mokhlis
creator: Rachid Tanz
creator: Samir Ahid
rights: Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
date: 2022-09-30
publication date: 2022-09-30
starting page: 1
ending page: 6
doi: 10.47363/JONRR/2022(3)163