A Comprehensive Analysis to Study the Histological and Immunohistochemical Profile of Diabetic and Non-Diabetic Human Pancreases in the Indian Population

Abstract

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to the islet β cell. Impairments in pro-peptide processing and secretory function, along with the loss of these vital cells, is demonstrable not only in those in whom the diagnosis is established but typically also in individuals who are at increased risk of developing the disease. Due to ethical and practical difficulties, genomic or pathological data in Indian population are remarkably missing. Here we report the immunohistological observations for 21 pancreases. We analyzed the pathological differences between diabetic and non-diabetic samples along with pathological changes associated with beta cell density, expression, size, and diameter. This study provides an insight into the immunopathological and histochemical mechanisms that highlight a number of–inflammatory, immunoregulatory and regenerative pathways, some of which have received relatively little attention so far.