T he Effect of Sputnik V COVID-19 vaccine on the Body Weight of Mice

Authors

  • Emhemmed Ali Food and Drug Control Centre (LFDA), Tripoli, Libya Author
  • Anton Hermann Department of Biosciences, University of Salzburg, Salzburg, Austria Author
  • Massaud Salem Maamar Zoology Department, Faculty of Science, Tripoli University, Libya Author
  • Nisreen H Meiqal Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya Author
  • Jamal Ali M. Elbakay Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya Author
  • Salah M Bensaber Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya Author
  • Abdulathim A A Alshoushan Food and Drug Control Centre (LFDA), Tripoli, Libya Author
  • Abdelmonam Hadi Elghobassa Food and Drug Control Centre (LFDA), Tripoli, Libya Author
  • Inass A Sadawe Medical Supply Organization (MSO), Tripoli, Libya Author
  • Abdul M Gbaj Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya Author

DOI:

https://doi.org/10.47363/JPRSR/2021(2)114

Keywords:

Sputnik V COVID-19 vaccine, mice, weight gain, Coronavirus disease (COVID-19)

Abstract

Background and Aim: Efforts are being made to discover the proper vaccine against COVID-19. After discovering such a vaccine, its acceptance is an essential subject for disease control. The present study aims to determine the effect of weight gain of Sputnik V COVID-19 vaccine on mice compared to control group.

Materials and Methods: This experimental study was performed on mice weighing on average of 20 g, selected by random allocation method. The mice were divided into two groups of 12 (one control group and one case group), receiving 0.5 ml Sputnik V COVID-19 vaccine.

Results: The weight gain of mice among the two groups after 15 days was significantly higher compared to the control group (p<0.05). 

Conclusion: The use of Sputnik V COVID-19 vaccine has a significant effect on body weight compared to the control group and could be related to the human adenovirus. Evaluating body composition or histopathological assessments are suggested.

Author Biographies

  • Emhemmed Ali , Food and Drug Control Centre (LFDA), Tripoli, Libya

     

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya

  • Anton Hermann, Department of Biosciences, University of Salzburg, Salzburg, Austria

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya. 

  • Massaud Salem Maamar, Zoology Department, Faculty of Science, Tripoli University, Libya

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya. 

  • Nisreen H Meiqal, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya. 

  • Jamal Ali M. Elbakay, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya. 

  • Salah M Bensaber, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya. 

  • Abdulathim A A Alshoushan, Food and Drug Control Centre (LFDA), Tripoli, Libya

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya.

  • Abdelmonam Hadi Elghobassa, Food and Drug Control Centre (LFDA), Tripoli, Libya

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya

  • Inass A Sadawe, Medical Supply Organization (MSO), Tripoli, Libya

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya

  • Abdul M Gbaj, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya

    Abdul M Gbaj, Professor of Genetics and Biochemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Libya. 

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Published

2021-07-22

Issue

Vol. 2 No. 3 (2021): Volume 2 Issue 3

Section

Articles