Journal of Pulmonology Research & Reports
type: channel
description: Journal of Pulmonology Research & Reports is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Pulmonology Research & Reports. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Article acceptance will be in the form of research, review, case reports, analysis, magazines, editorials, opinion, communications, mini-review, short communications, picturized, book review, video type and power point presentations (PPTs). Articles can be submitted through online from https://www.onlinescientificresearch.com/submit-online or can send through an e-mail with attachment for pulmonologysciences@onlinescientificresearch.info or jprr@onlinescientificresearch.net
publisher: Scientific Research and Community
language: en
publication name: Journal of Pulmonology Research & Reports
issn: 2754-4761
items: A Rare Presentation of Atrial Myxoma Leading to Stroke in a Young Female
items: Pulmonary Delivery of Aerosol Biologics for the Treatment of Eosinophilic Asthma
items: Air of Despair: Unveiling the Enigma of Dual Lung Collapse
items: Cancers in Red Sea State, Sudan: A Decade of Incidence, Distribution and Trends: Estimates for (2016 - June 2025)
items: Is it Already Time to Recognize Diabetes as an Etiology of Interstitial Lung Disease? A Short Review of the Evidence
items: Comparative Long-Term Effectiveness of Nintedanib and Pirfenidone in Idiopathic Pulmonary Fibrosis: A Systematic Literature Review
items: Mortality Predictors of COPD Exacerbation Patients in ICU
items: Massive Hemoptysis in Severe Idiopathic Pulmonary Hypertension A Rare Presentation
items: Long-Term Pulmonary Sequelae in COVID-19 Survivors: A 3-Year Prospective Cohort Study
items: Piloting Non-Payment Interventions in Tuberculosis Strategic Health Purchasing: Early Experience from Indonesia
items: “TimBre” Phase-II Pilot Study Conducted Using Multi-Country Longitudinal Training Data for Screening of Pulmonary Tuberculosis Using Cough (Acoustic Sounds), Clinical & Demographic Inputs
items: Occurrence, Sources and Prioritization of Per-and Polyfluoroalkyl Substances (PFASs) in Drinking Water from Yangtze River Delta, China: Focusing on Emerging PFASs
items: Quality of Life after Pyothorax Surgery in the Fes-Meknes Region, Morocco
items: https://srcpublishers.com/index.php/pulmonology-research/article/view/3299
items: Respiratory Tract Infections and Environmental Exposures: A Study of Rural Indonesian Communities
items: Mexican Delphi Consensus for use Immunotherapy with MV130 Vaccine in Patients with Recurrent Respiratory Infectious Diseases (Expert Panel)
items: Boon of the BPal Regime: Bane for Multi Drug Resistant Tuberculosis in India
items: Specific Biobank for Chronic Thromboembolic Pulmonary Hypertension (Perspectives and Implementation)
items: Alveolar Microlithiasis in Clinical Practice: Case Report
items: Diagnostic Performance of Bronchoscopy in Lung Cancer and/or Pulmonary Metastasis: A Real Aspect of our Country
items: COVID-19 Management Protocol
items: The Attitudes of South African Respiratory Physicians towards the Use of Electronic Cigarettes as Smoking Cessation Adjuncts
items: Clinical, Radiological and Pathological Characteristics of Hypersensitivity Pneumonitis and its Association with the Duration of Exposure in a Tertiary Centre
items: Primary Extraskeletal Pleural Osteosarcoma - A Clinical Case Report
items: Efficacy of Thoracoscopic Guided Brush Cytology in Undiagnosed Pleural Effusion
items: A Case Report of Tracheoesophageal Fistula in Esophageal Carcinoma
items: Serum KL-6 : A Predictive Marker for Post Tubercular Fibrosis
items: Thoracic Endometriosis Detected During Medical Thoracoscopy in a Tertiary Care Setting - A Retrospective Observational Study
items: Role of Mepolizumab in COVID Patients with Severe Eosinophilic Asthma
items: Clinical and Etiological Findings of Viral Pneumonia: A Single Centre Prospective Study

A Rare Presentation of Atrial Myxoma Leading to Stroke in a Young Female
type: item
description: Myxoma is a common primary tumour of the heart. The most common site is the left atrium. As per previous reports, cardioembolic stroke accounts for around one-fifth of all acute ischemic strokes. Out of which cardiac myxoma is estimated to account for only 0.5% of the cases, which is very rare. Female patients, especially in the 5th decade, are shown to have a greater predisposition. cardiovascular stroke is life-threatening, requiring urgent recanalization and resection of the tumour. Cardiac myxomas present with variable symptoms like breathing difficulty, chest pain, chest tightness, palpitations, fatigue, etc. CNS Emboli with stroke is one of the rarest presentations, making it a diagnostic challenge. Here we present a case report of a 48-year-old female patient presenting with right-sided tingling, numbness, and syncope, diagnosed with atrial myxoma.
subject: Articles
  topic: section
subject: Atrial Myxoma
  topic: keywords
subject: Embolic Shower
  topic: keywords
subject: Cerebrovascular Accidents (CVAs)
  topic: keywords
subject: Cardiac Vasculitis
  topic: keywords
subject: Case Report
  topic: keywords
creator: Karim Azmat
creator: Deepanshu Chawla
creator: Karim Aman
creator: Milind Hote
creator: Vivek Kumar
creator: Nikita Singh
creator: Bhavyaja NP
rights: Copyright (c) 2026 Journal of Pulmonology Research & Reports
date: 2026-02-09
publication date: 2026-02-09
starting page: 1
ending page: 4
doi: 10.47363/JPRR/2026(8)200

Pulmonary Delivery of Aerosol Biologics for the Treatment of Eosinophilic Asthma
type: item
description: Biological drugs (synonymous known as biologics) are a diverse group of therapeutic agents which are large and complex molecules produced through sophisticated biotechnology [1,2]. The biologics currently used to treat severe asthma are monoclonal antibodies (mAb), and antibody fragment which are administered subcutaneously, or intravenously (reslizumab). Injection of drugs is painful and inconvenient, especially when the drugs are for the treatment of chronic diseases, such as asthma, and cystic fibrosis [3,4]. Moreover, 10% of the patients worldwide suffer from needle phobia leading to poor compliance [5]. Pulmonary delivery of biologics to the lungs improves pharmacokinetics, and toxicity profiles of proteins [6]. It is a non-invasive route, and allows for self-administration, which could improve patient compliance [6,7].
subject: Articles
  topic: section
subject: Eosinophilic Asthma
  topic: keywords
subject: Aerosol Biologics
  topic: keywords
subject: Pulmonary
  topic: keywords
subject: SARS-CoV-2
  topic: keywords
subject: Airway Hyperresponsiveness
  topic: keywords
creator: Nightingale Syabbalo
rights: Copyright (c) 2026 Journal of Pulmonology Research & Reports
date: 2026-01-30
publication date: 2026-01-30
starting page: 1
ending page: 4
doi: 10.47363/JPRR/2026(8)199

Air of Despair: Unveiling the Enigma of Dual Lung Collapse
type: item
description: Thoracic Endometriosis Syndrome (TES) encompasses a wide variety of manifestations occurring in due to presence of ectopic viable endometrial tissue in thorax. Various manifestations of TES include, pneumothorax, haemoptysis, haemothorax, lung nodule/mass, catamenial chest pain, diaphragmatic hernia and pneumopericardium [1]. Pneumothorax, often catamenial pneumothorax is the commonest presentation of TES, however it’s unilateral, particularly right sided in nearly 97% of cases [2]. Here we are presenting a case of woman of reproductive age group who presented with bilateral pneumothorax secondary to TES, which is one of the rarest presentation of endometriosis with only a handful of cases being reported in literature, with the most recent being reported in 2020 by Christopher S. Sampson and Kathleen White [3].
subject: Articles
  topic: section
subject: Lung Collapse
  topic: keywords
subject: Hypothyroid
  topic: keywords
subject: VATS
  topic: keywords
creator: Vijay Kumar Chennamchetty
creator: Sricharan Yalamanchili
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-12-15
publication date: 2025-12-15
starting page: 1
ending page: 6
doi: 10.47363/JPRR/2025(7)196

Cancers in Red Sea State, Sudan: A Decade of Incidence, Distribution and Trends: Estimates for (2016 - June 2025)
type: item
description: Cancer incidence refers to the rate at which new cancer cases occur in specific population over a defined period, it is a key measure for understanding the burden of cancer and tracking trends in cancer occurrence. These are is generally regarded as an important measure for public health planning, monitoring trends and researches and resource allocation purposes. The number of new cases in a year is an indicator of the need for resources for diagnostic investigations and first-line treatment. While the prevalence of cancer in a population, the number or proportion of people alive at a specific date who have been diagnosed with cancer prior to that date. The annual number of cancer deaths is an indicator of the need for resources for palliation and terminal care. However, data on prevalence, which is generally regarded as an important measure for health planning and resource allocation, are relatively scarce. Materials and Methods: This review is the first papers that focuses up-to-date on adult cancer, its distribution, trend and cancer Prevalence in Red Sea State (RSS) at Eastern Sudan, based upon, registry data of Port Sudan Oncology Centre (POC) results in a period between 2016 up to thirty of June 2025. These reviews are meant to provide a better understanding and knowledge required to plan appropriate cancer-control and prevention strategies in this state, and whole country. this paper provided cancer statistics of 3265 patients registered from all districts of Red Sea State diagnosed at the (POC). This Centre established in 2016 to covers approximately all adult patients with cancer in this state, therefore, it considered representative for the cancer situation in this state, to develop a system that will facilitate creation and maintenance of local and regional data and assemble these data into a single centrally accessible system. Also, this study has reviewed and addressed the impact of war conflict setting of Sudan in April 2023 and the displacement of pat…
subject: Articles
  topic: section
subject: Cancer Incidence
  topic: keywords
subject: Prevalence
  topic: keywords
subject: Epidemiology
  topic: keywords
subject: NeoPlasms
  topic: keywords
subject: Red Sea State War
  topic: keywords
creator: Awad Abdalla Widaa
creator: Sara Babiker Ahmed
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-10-28
publication date: 2025-10-28
starting page: 1
ending page: 9
doi: 10.47363/JPRR/2025(7)192

Is it Already Time to Recognize Diabetes as an Etiology of Interstitial Lung Disease? A Short Review of the Evidence
type: item
description: By now it is well known amongst the Medical Fraternity that Diabetes Mellitus (DM) is not a single disease but rather a heterogenous metabolic dysfunction demonstrating increased blood glucose levels (hyperglycemia) as its major manifestation. However, Diabetes is far more complex and insidious to be labelled as a mere increase in the blood glucose levels. The dysfunction of glucose control transcends the boundaries of blood vessels, neuromuscular and various other organ systems, ultimately leading to any combination of renal, ocular, cardiac, skin, neurological and other organ damage, which makes it is a Legion of diseases, rather than a single pathology.
subject: Articles
  topic: section
subject: Lung Disease
  topic: keywords
subject: Respiratory Diseases
  topic: keywords
subject: Diabetes
  topic: keywords
subject: Diabetes Mellitus (DM)
  topic: keywords
subject: Pulmonary
  topic: keywords
creator: Upasna Agarwal
creator: Amit Sharma
creator: Poulomi Chatterjee
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-09-23
publication date: 2025-09-23
starting page: 1
ending page: 2
doi: 10.47363/JPRR/2025(7)195

Comparative Long-Term Effectiveness of Nintedanib and Pirfenidone in Idiopathic Pulmonary Fibrosis: A Systematic Literature Review
type: item
description: Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease. Pirfenidone and nintedanib slow progression, but no head-to-head randomized trials have tested their long-term effectiveness, particularly in real-world and advanced disease. Objective: To synthesize and appraise the long-term comparative effectiveness and safety of nintedanib versus pirfenidone in IPF. Methods: We conducted a systematic review (PubMed, Embase, Cochrane CENTRAL; to March 2025) of studies ≥12 months in adults with IPF. Outcomes included forced vital capacity (FVC) decline, mortality, exacerbations, hospitalizations, adverse events, and quality of life. Risk of bias was assessed with Cochrane RoB 2.0, Newcastle–Ottawa Scale, and AMSTAR-2. Results: Fourteen studies met criteria. Both agents reduced annual FVC decline by ~50% versus placebo. Long-term extensions showed sustained effects: pirfenidone ~141–150 mL/year and nintedanib ~125 mL/year. A post hoc analysis (CleanUP-IPF) favored nintedanib at 12 months for FVC (+106 mL; 95% CI, 34–178), a difference that diminished by 24 months. Mortality and exacerbation rates were broadly comparable. Safety profiles differed: pirfenidone more often produced gastrointestinal and cutaneous events; nintedanib was associated with diarrhea and transaminase elevations. Conclusions: Evidence supports broadly comparable long-term efficacy of pirfenidone and nintedanib in IPF, with distinct tolerability profiles that may guide individualized selection. Real-world data corroborate benefits in advanced disease and comorbidity. The absence of direct randomized comparisons limits certainty; adequately powered head-to-head RCTs and biomarker-guided treatment strategies are needed.
subject: Articles
  topic: section
subject: Idiopathic Pulmonary Fibrosis
  topic: keywords
subject: Pirfenidone
  topic: keywords
subject: Nintedanib
  topic: keywords
subject: Antifibrotic Agents
  topic: keywords
subject: Forced Vital Capacity
  topic: keywords
creator: Fredy Javier Pacheco Miranda
creator: Jennifer Vargas Gomez
creator: Vanessa Rocío Villanueva Guerrero
creator: Jorge Ahumada Ramirez
creator: Juan Camilo Tafur Vidal
creator: Gloria Ibis Tirado Romero
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-09-15
publication date: 2025-09-15
starting page: 1
ending page: 8
doi: 10.47363/JPRR/2025(7)194

Mortality Predictors of COPD Exacerbation Patients in ICU
type: item
description: Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of global mortality, with acute exacerbations frequently necessitating intensive care unit (ICU) admissions. Despite its significant burden, data on specific prognostic factors for ICU outcomes in COPD patients particularly in the Indian context remain limited. Objective: This study aims to identify key clinical, laboratory, and radiological predictors of outcomes in COPD patients admitted to the ICU following acute exacerbations. Methods: A prospective observational study was conducted from August 2022 to April 2024 at a tertiary centre of eastern India. Patients aged 40 years and above with a confirmed diagnosis of COPD (as per GOLD 2023/24 guidelines) and admitted for acute exacerbation were included. Exclusion criteria encompassed terminal illnesses and advanced organ failure. Data were collected using a predefined proforma with variables of demographic status, clinical findings, laboratory values, and radiological findings. Statistical analysis was performed using SPSS v26, with a p-value <0.05 considered statistically significant. Results: Among 205 patients enrolled, the mean age was 64.3 ± 11.5 years, with a predominance of males (70%). ICU mortality was significantly higher in patients aged ≥60 years (p<0.01). Malnutrition, reflected by a BMI <18.5 kg/m² in 45% of patients, was strongly associated with increased mortality (p<0.01). Most patients belonged to GOLD Group D or E, with Group E showing the highest mortality risk (p<0.01). A history of previous exacerbation within the last year was also linked to worse outcomes (p<0.01). Elevated inflammatory markers total leukocyte count >11,000/mm³ and high C-reactive protein (CRP) were significantly associated with poor prognosis (p<0.01). While non-invasive ventilation was the most commonly used modality (62%), and invasive ventilation was employed in 18%, no significant difference in mortality was found between ventilation strategies.…
subject: Articles
  topic: section
subject: COPD
  topic: keywords
subject: ICU Mortality
  topic: keywords
subject: Acute Exacerbation
  topic: keywords
subject: GOLD Classification
  topic: keywords
subject: Body Mass Index
  topic: keywords
subject: Systemic Inflammation
  topic: keywords
subject: CRP
  topic: keywords
subject: Risk Stratification
  topic: keywords
subject: Ventilation Strategy
  topic: keywords
creator: Nibedita Panda
creator: Sampat Dash
creator: Satya Mohanty
creator: Ambika Prasad Nayak
creator: Umesh Mohan Bhisade
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-08-18
publication date: 2025-08-18
starting page: 1
ending page: 5
doi: 10.47363/JPRR/2025(7)193

Massive Hemoptysis in Severe Idiopathic Pulmonary Hypertension A Rare Presentation
type: item
description: Hemoptysis is not an uncommon presentation of a disease in a pulmonologist’s usual practice. The significance of hemoptysis comes from the fact that even a minimal amount of intrabronchial bleeding can lead to life-threatening airway compromise and escalate the mortality risk. Infections such as tuberculosis and other bacterial or fungal parenchymal infectious causes are often cited as major culprits in hemoptysis cases. We present an unusual case of a young gentleman with no prior comorbidities who initially presented with nasal bleeding and over a span of 2 weeks experienced two major episodes of hemoptysis. He underwent multiple imaging studies and bronchoscopic evaluations but was eventually found to have elevated pulmonary pressures on echocardiogram and a pattern of right heart strain on electrocardiogram. These findings shed light on a rare presentation of idiopathic pulmonary hypertension being the cause of massive hemoptysis. This case was an eye-opener for many reasons including missing important cardiac examination findings during the clinical evaluation and the presence of a dilated pulmonary trunk in contrast CT images ultimately unravelling one of the rarest causes of massive hemoptysis.
subject: Articles
  topic: section
subject: Hemoptysis
  topic: keywords
subject: Pulmonary Hypertension
  topic: keywords
subject: Idiopathic Pulmonary Hypertension
  topic: keywords
subject: Bronchial Artery Embolization
  topic: keywords
subject: Lung Transplantation
  topic: keywords
creator: Kanishka Salunkhe
creator: Jolsana Augustine
creator: Vidhyapriya Sellamuthu
creator: Jamalul Azizi Bin Abdul Rahaman
creator: Fatimah Azmah Mohammad
creator: Haizal Bin Haron Kamar
creator: Redzuan Bin Ismail Mohd
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-07-07
publication date: 2025-07-07
starting page: 1
ending page: 4
doi: 10.47363/JPRR/2025(7)190

Long-Term Pulmonary Sequelae in COVID-19 Survivors: A 3-Year Prospective Cohort Study
type: item
description: Background: Individuals recovering from the initial COVID-19 infection experienced persistent symptoms and radiological lesions. This study is a longterm follow-up of COVID-19 survivors to assess the progression and persistence of pulmonary sequelae. This will provide critical insights into the natural history of post-COVID-19 syndrome. Objectives: To evaluate the long-term radiological changes in COVID-19 survivors over three years and to identify risk factors associated with it. Methodology: This is a prospective, longitudinal cohort study designed to follow a group of COVID-19 survivors over three years. Clinical data during the initial infection such as admission to the ICU, Oxygen requirement, Ventilator assistance, and length of hospital stay were collected from case records. High-resolution computed tomography (HRCT) scans were taken at one-year intervals and CT severity scores were recorded to study the interval changes. Appropriate statistical analysis was done to establish significance. Results: In this study, 40 patients with residual lung lesions on HRCT in the first follow-up visit were enrolled, out of which 6 were excluded from the final analysis. Out of the 34, 55.9% were males and 44.1% were females. The mean age of the study population was 58.26. 41.1% were treated in ICU and 58.9% in the wards. Invasive ventilation was used in 23.5%, NIV in 35.29%, and oxygen alone in 41.1%. The average length of stay was 18 days. CT severity score at presentation was mild in 44.1%, moderate in 29.4%, and severe in 26.47% of patients. During the 3-year follow up CT score improved in 76.47%, remained static in 17.64%, and progressed in 5.88% of patients (p-value <0.001). The age of the patient correlated with the initial CT score and the outcome, follow up CT severity scores improved better in young cohorts when compared to elderly patients. However, ICU admission, use of mechanical ventilation, and length of stay were not correlated with the subsequent CT severity…
subject: Articles
  topic: section
subject: COVID-19
  topic: keywords
subject: Post COVID Lung
  topic: keywords
subject: Lung Fibrosis
  topic: keywords
subject: Follow Up
  topic: keywords
creator: Ravindran Chetambath
creator: Krishnan Puthusseri
creator: Veena Das
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-06-26
publication date: 2025-06-26
starting page: 1
ending page: 4
doi: 10.47363/JPRR/2025(7)189

Piloting Non-Payment Interventions in Tuberculosis Strategic Health Purchasing: Early Experience from Indonesia
type: item
description: Although there has been a 19% decline in Tuberculosis (TB) mortality from 2007 to 2017, TB remains a major health challenge in Indonesia. In 2021, the country issued a Presidential Decree No. 67 to provide guidance on the National Health Insurance (JKN) utilization of control. In 2022, Ministry of Health Decree No. 1936 mandating primary care facilities to comprehensively treat uncomplicated TB case. However, the existing payment structure of JKN does not encourage primary-level TB service delivery. O’Connell and colleagues conducted a study in 2022 that revealed that a significant proportion (81%) of uncomplicated TB patients covered by JKN were unnecessarily referred to hospitals, resulting in suboptimal treatment outcomes and increased healthcare costs. To address these challenges, a TB strategic health purchasing (SHP) pilot program was proposed in 2019. Its objective is to incentivize primary health facilities to deliver quality TB services for individuals with drug-susceptible TB through a combination of nonpayment and payment interventions. Two districts, Medan and Denpasar, were selected to implement these interventions, and the pilot began in 2021. The non-payment components, including health facility certifications and modifications to the JKN contracting process, were successfully implemented in Medan and Denpasar districts from 2021 to 2022. Regulations governing the JKN payment mechanism require substantial modifications before implementing the payment components. Several learnings emerged through implementation and this report summarizes the learnings as a guide for government stakeholders and partners for scale up to other districts in 2023. Amongst these, is the significant level of advocacy and support from high-level government stakeholders, both at the national and sub-national levels, required to reform the regulatory environment to pave the way for implementing the complete interventions. For example, successful implementation of the non-payment…
subject: Articles
  topic: section
subject: Tuberculosis
  topic: keywords
subject: Piloting
  topic: keywords
subject: Health Purchasing
  topic: keywords
creator: Nugroho A
creator: Sukarni S
creator: Putra G
creator: Badriyah N
creator: Pakasi T
creator: Farianti Y
creator: Putri F A
creator: Hafidz F
creator: Saragih S
creator: Syed I
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-05-24
publication date: 2025-05-24
starting page: 1
ending page: 5
doi: 10.47363/JPRR/2025(7)198

“TimBre” Phase-II Pilot Study Conducted Using Multi-Country Longitudinal Training Data for Screening of Pulmonary Tuberculosis Using Cough (Acoustic Sounds), Clinical & Demographic Inputs
type: item
description: TimBre from docturnal offers screening for multiple lung diseases – Pulmonary Tuberculosis, Pneumonia & Lung Cancer. Detailed studies of TimBre in the past used a third-party Microphone Array with an XY arrangement that recorded high fidelity cough sounds with an average length of >5 seconds and basic demographic data such as Gender, Age, Height, Weight, BMI. In the current study, cough sounds were collected from 7 different countries (India, Vietnam, Philippines, Uganda, Tanzania, Madagascar, and South Africa) using Mobile Phones from different manufacturers & recorded solicited & longitudinal cough sounds for a duration of 0.5 seconds as a part of the phase-I study. We used longitudinally obtained cough sounds numbering 724,694 .WAV files with a resolution of 44.1 kHz & 16 bits. The duration was of 0.5 seconds, with the subject clinical and demographic variables added to the model, which anticipated an improved accuracy over the phase-1 study that used 10,000 plus cough files that obtained a sensitivity & specificity of 75.41% and 68.30% respectively with an AUC of 0.78. The current study (Phase-2) resulted in an overall sensitivity of 68.8%, a specificity of 70.4%, and an AUC of 70% when compared with the microbiological reference standard MRS (sputum culture or Xpert, 25% TB prevalence), and sensitivity of 73.8%, specificity of 69.5%, and an AUC of 71% compared to a sputum Xpert Ultra reference standard (22% prevalence). The phase-1 study used true labels of GeneXpert results as some of the culture results were labelled indeterminate. A comparison between the phases is unwarranted given the fact that the MRS definition is GeneXpert OR Culture while, in Phase-1 it is was strictly GeneXpert. The study and its earlier phase demonstrate the usage of mobile phone-based screening for low resource settings or home-based TB screening or countries that are addressing TB elimination or eradication goals.
subject: Articles
  topic: section
subject: Cough Sounds
  topic: keywords
subject: Pulmonary Tuberculosis
  topic: keywords
subject: Sensitivity
  topic: keywords
subject: Specificity
  topic: keywords
subject: XGB
  topic: keywords
subject: RUS
  topic: keywords
subject: Ensemble
  topic: keywords
subject: Spectral Analysis
  topic: keywords
subject: FFT. STFT
  topic: keywords
subject: XAI
  topic: keywords
creator: Rahul Pathri
creator: Sasidhar R Sannadi
creator: Samarth Tandon
creator: Aparna Sykam
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-04-30
publication date: 2025-04-30
starting page: 1
ending page: 6
doi: 10.47363/JPRR/2025(7)188

Occurrence, Sources and Prioritization of Per-and Polyfluoroalkyl Substances (PFASs) in Drinking Water from Yangtze River Delta, China: Focusing on Emerging PFASs
type: item
description: As regulations ban legacy PFASs, many emerging PFASs are being developed, leading to their release into the aquatic environment and drinking water. However, researches on these emerging PFASs in drinking water are limited, and current standards only cover a few legacy PFASs, leaving many emerging PFASs unregulated and their toxicity unknown. Therefore, a machine learning-based suspect screening method was employed to comprehensively identify and quantify both legacy and novel PFAS in drinking water from the Yangtze River Delta, and their potential sources of contamination were determined through pollutant profile analysis. Then, the identified PFASs were prioritized by integrating the PBT (persistence, bioaccumulation, and toxicity) properties of PFASs with environmental exposure data. A total of 30 PFASs were identified, including 16 legacy and 14 novel PFASs, categorized into 11 classes. The pollutant profile analysis suggested that PFASs in the Yangtze River Delta’s drinking water are more likely to originate from pollution in the upper and middle reaches of the Yangtze River rather than from local industrial emissions. In the prioritization and risk assessment process, ten high-concern PFASs had Risk Index (RIs) higher than those of ref-PFOA and ref-PFOS, including eight legacy PFASs and two novel PFASs. The drinking water of Yangtze River Delta originates from the surface water of the lower Yangtze River, which accumulates pollutants from its upper and middle reaches, affecting the health of over 20 million people. Our findings indicated the presence of emerging PFASs in the region’s drinking water and demonstrated conceptual models for integrating chemical information from suspect screening with toxicity prediction and risk assessment. Although the current levels of emerging PFASs are relatively low, legacy PFASs still dominate. Further research is needed to identify, monitor, and assess the health and environmental risks of emerging PFASs.
subject: Articles
  topic: section
subject: Per-and Polyfluoroalkyl Substances
  topic: keywords
subject: Suspect Screening
  topic: keywords
subject: Drinking Water
  topic: keywords
subject: Prioritization
  topic: keywords
subject: Risk Assessment
  topic: keywords
creator: Zixin Qian
creator: Ping Xiao
creator: Guoquan Wang
creator: Dasheng Lu
creator: Yue Jin
creator: Jinjing Ma
creator: Jingxian Zhou
creator: Hailei Qian
creator: Ziwei Liang
creator: Yuanjie Lin
creator: Yuhang Chen
creator: Chao Feng
creator: Zhijun Zhou
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-03-31
publication date: 2025-03-31
starting page: 1
ending page: 10
doi: 10.47363/JPRR/2025(7)187

Quality of Life after Pyothorax Surgery in the Fes-Meknes Region, Morocco
type: item
description: Pyothorax is defined by the presence of a purulent, cloudy, or clear fluid containing altered polymorphonuclear cells and germs between the two layers of the pleura, as observed through direct examination. The progression to chronicity in pleural empyema results from a failure in medical treatment or a delayed diagnosis. In this case, surgery aims to restore respiratory function and prevent recurrence. The objective of this work is to evaluate the quality of life of patients after pyothorax surgery, as well as the overall impact of this surgical intervention in the medium and long term, and to identify the associated factors. A cross-sectional study was conducted among patients with pyothorax who underwent surgery in the thoracic surgery department at Hassan II University Hospital in Fes during the period from December 2012 to December 2020. Quality of life was assessed using the SF-12 questionnaire, which was translated and validated in Moroccan Arabic dialect. We included 72 subjects in the study. The mean age of the patients was 38.75±15.7 years, with 69.4% being male. The most common etiology was pleuropulmonary tuberculosis, found in 38 patients (52.8%). The average mental quality of life score was 46.11 ±8.14, and the physical score was 50.12 ±6.76. There is a statistically significant association between quality of life and the presence of a history of pleural tuberculosis, secondary pyothorax following subacute pleuritis in its physical component, dyspnea stage, WHO (World Health Organization) score, pain level, occurrence of postoperative infections, weight gain in its physical component, appetite, sleep quality, hospital stay satisfaction in its physical component, and treatment response. Surgery is the ultimate therapeutic option for treating chronic pyothorax, as it can cure or improve the quality of life of these individuals in the medium and long term.
subject: Articles
  topic: section
subject: Pyothorax
  topic: keywords
subject: Surgery
  topic: keywords
subject: Quality of Life
  topic: keywords
subject: SF-12
  topic: keywords
subject: Morocco
  topic: keywords
creator: Nassiba Bahra
creator: Yassine Ouadnouni
creator: Marouane Lakranbi
creator: Nabil Tachfouti
creator: Smahi Mohamed
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-02-20
publication date: 2025-02-20
starting page: 1
ending page: 7
doi: 10.47363/JPRR/2025(7)186

https://srcpublishers.com/index.php/pulmonology-research/article/view/3299
type: item
title: Thank you for your wonderful response. At your convenience, please share your abstract, CV, a recent photograph, and the most suitable conference title for your work.We look forward to receiving the details at your earliest convenience.Have a nice day!
description: Purpose: In recent years, microbiome research has made significant progress in under-standing the relationship between human microbiota and pulmonary diseases. The lung and gut microbiota have received extensive attention in lung cancer research. Multiple studies have shown that dysregulation of the lung and gut microbiota is closely related to the occurrence and progression of lung cancer. The skin is the largest organ of the human body, as the first line of defense, it undertakes multiple functions such as de-fending against external pathogens and regulating body temperature and feeling. A complex and diverse microbial community also exists on the skin surface; however, the role of the skin microbiota in cancer has not been fully investigated. In particular, there is almost no research on the causal relationship between skin microbiota and lung can-cer. Methods: In this Two-sample Mendelian randomization (MR) analysis study, we com-piled genome-wide association studies (GWAS) data on 150 different immune cell traits from 597 individuals of European ancestry. Additionally, Data on lung cancer were ob-tained from the FinnGen GWAS database to delve deeper into the potential causal rela-tionship between skin microbiome characteristics and lung cancer. In our MR Analysis, the inverse variance weighting (IVW) method is the main method, supplemented by MR-Egger regression, weighted median (WM), Simple Mode, and weighted mode. In addition, the MR-Egger intercept test, Cochran Q test, MR-PRESSO, and remain-one analysis were used to identify heterogeneity and pleiotropy, to ensure the reliability and stability of the research results. Results: In studying the relationship between lung cancer and skin microbiota, we found that there are different interactions between lung cancer and specific types of skin microbiota. In the forward Mendelian randomization analysis, we included skin micro-biota as the exposure factor and each subtype of lung cancer (including Non-small cell l…
subject: Articles
  topic: section
subject: Lung Cancer
  topic: keywords
subject: Microbiota
  topic: keywords
subject: Mendelian Randomization
  topic: keywords
subject: Causal Relationship
  topic: keywords
subject: Lung Diseases
  topic: keywords
creator: Yizhuo Chen
creator: Xin Wang
creator: Ziqing Xu
creator: Zhouqi Zhang
creator: Dongrui Feng
creator: Ming Dong
rights: Copyright (c) 2025 Journal of Pulmonology Research & Reports
date: 2025-01-04
publication date: 2025-01-04
starting page: 1
ending page: 11
doi: 10.47363/JPRR/2025(7)185

Respiratory Tract Infections and Environmental Exposures: A Study of Rural Indonesian Communities
type: item
description: This study explores community perceptions and experiences regarding clean air and water access in rural Indonesia. Using an interpretive phenomenological analysis, we conducted in-depth interviews in three distinct rural regions. Findings reveal significant air and water quality issues, including high levels of particulate matter, ground-level ozone, fecal coliform bacteria, nitrates, and arsenic contamination. These environmental hazards have led to severe health impacts, such as increased respiratory and waterborne diseases, adverse birth outcomes, and psychological distress. Despite existing policies and community led initiatives, there are notable gaps in implementation. This study highlights the critical need for locally tailored, community-centered interventions to address these pressing environmental health challenges.
subject: Articles
  topic: section
subject: Rural Indonesia
  topic: keywords
subject: Air Quality
  topic: keywords
subject: Water Contamination
  topic: keywords
subject: Environmental Health
  topic: keywords
subject: Community Engagement
  topic: keywords
creator: Tien Zubaidah
creator: Norlaila Sofia
creator: Ratodi Muhamad
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-12-28
publication date: 2024-12-28
starting page: 1
ending page: 3
doi: 10.47363/JPRR/2024(6)186

Mexican Delphi Consensus for use Immunotherapy with MV130 Vaccine in Patients with Recurrent Respiratory Infectious Diseases (Expert Panel)
type: item
description: Background and Objectives: Recurrent respiratory infections are currently a public health problem due to their high costs and resistance to treatments as well increase morbidity and mortality. An imbalance in the homeostasis of progressive cellular and humoral immunity the application of immunotherapy with trained immunity vaccines (IvIE) is currently a therapeutic option in all patients with recurrent respiratory infections by training innate and adaptive immunity by reducing episodes of respiratory exacerbations and improving the quality of life of patients. Methods: Using Delphi method and a panel of experts, a questionnaire was developed that included questions regarding the benefit and non-benefit of the treatment of patients with persistence of recurrent respiratory infections by specific criteria, from diagnosis, identification of risk factors and comorbidities, ideal candidate by consensus to receive the therapy, follow-up, and presentation of clinical data for reduction of recurrence of the conditions. There was a consensus on determining the use of immunotherapy MV130 vaccine in patients with specific criteria as long- and short-term use. Conclusion: Immunotherapy with trained immunity vaccines (IvIE) is currently a therapeutic option in all patients with recurrent respiratory infections and associated comorbidities in patients with chronic respiratory illnesses, autoimmune diseases, hematological malignancies for improvement clinical infections and improvement quality of life.
subject: Articles
  topic: section
subject: Immunotherapy
  topic: keywords
subject: Infectious Diseases
  topic: keywords
subject: Respiratory
  topic: keywords
subject: Vaccine
  topic: keywords
creator: Herrera García JC
creator: Pech Alonso B
creator: Mondragón Guarneros F
creator: López Sánchez G
creator: Field Cortazares J
creator: Aranda López AR
creator: Gamboa Y Gamboa MA
creator: Perez Juárez LK
creator: Rosales Magallanes GF
creator: Carrasco Castillo A
creator: Landa Alvarado PD
creator: Sanchez S
creator: Hernandez Treviño V
creator: Arizpe Bravo AB
creator: Ramirez Crescencio MA
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-12-28
publication date: 2024-12-28
starting page: 1
ending page: 4
doi: 10.47363/JPRR/2024(6)187

Boon of the BPal Regime: Bane for Multi Drug Resistant Tuberculosis in India
type: item
description: A novel regime for treatment of MDR TB has been launched consisting of BDQ, PRT and LNZ. Immense potential lies in its short term (6 months), efficacious drugs and lesser adverse events. A very good cure rate of around 90% have been achieved in Clinical trials including one from India. A contingent as well as circumspect roll out of the regime in all parts of India may be momentous for MDR TB control and TB elimination.
subject: Articles
  topic: section
subject: Tuberculosis
  topic: keywords
subject: Drug Resistant
  topic: keywords
subject: Delamanid
  topic: keywords
subject: Pretomanid
  topic: keywords
creator: Amit Sharma
creator: Poulomi Chatterjee
creator: PDK Priya Darshini Dweepala
creator: Shashank Shastry
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-11-01
publication date: 2024-11-01
starting page: 1
ending page: 3
doi: 10.47363/JPRR/2024(6)184

Specific Biobank for Chronic Thromboembolic Pulmonary Hypertension (Perspectives and Implementation)
type: item
description: Chronic thromboembolic pulmonary hypertension (CTEPH) is a disease characterized by incomplete resolution of the thrombus after an acute pulmonary embolism (PE), accompanied by changes in the pulmonary vasculature with thickening of the intima, changes in pulmonary endothelial cells and subsequent fibrosis. These changes lead to an increase in pulmonary vascular resistance, right ventricular dysfunction and, ultimately, to this day we do not have a complete explanation of its pathophysiology. In recent years, knowledge of molecular mechanisms and metabolic changes have provided elements but a window remains open for further exploration. The development of Biobanks offers an opportunity as a tool in translational research in several lines. This article aims to show the development of a specific biobank for chronic thromboembolic pulmonary hypertension, its lines of work and future potential
subject: Articles
  topic: section
subject: Biobank
  topic: keywords
subject: Biorepository Chronic Thromboembolic Pulmonary Hypertension
  topic: keywords
subject: Clinical Research
  topic: keywords
creator: Aimone D
creator: Fernandez A
creator: Lanfranco N
creator: Mereles J
creator: Zorrilla M
creator: Romero E
creator: Nahin M
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-10-08
publication date: 2024-10-08
starting page: 1
ending page: 3
doi: 10.47363/JPRR/2024(6)179

Alveolar Microlithiasis in Clinical Practice: Case Report
type: item
description: Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of microliths in the alveoli due to mutations in the SLC34A2 gene. The diagnosis is made more frequently between the second and fourth decade of life incidentally in chest images, it has a progressive course, with clinicalradiological dissociation, with no known effective treatment except for lung transplantation. The case of a 37-year-old man with no personal history of exertional dyspnea is presented. Assessed by pulmonology with HRCT, which shows subpleural nodules and micronodules with diffuse pulmonary hyperdensity due to calcification, a pattern that suggests alveolar microlithiasis confirmed by histopathological study.
subject: Articles
  topic: section
subject: Pulmonary Alveolar Microlithiasis
  topic: keywords
subject: Microliths
  topic: keywords
subject: Calcinosis
  topic: keywords
subject: Computed Tomography
  topic: keywords
subject: Lung transplant
  topic: keywords
creator: Luis Eduardo Ramírez Bejarano
creator: Juan Pablo Camargo
creator: Margarita Baldion
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-09-17
publication date: 2024-09-17
starting page: 1
ending page: 3
doi: 10.47363/JPRR/2024(6)183

Diagnostic Performance of Bronchoscopy in Lung Cancer and/or Pulmonary Metastasis: A Real Aspect of our Country
type: item
description: Objective: To evaluate the diagnostic performance of different bronchoscopic sampling techniques in patients with suspected lung cancer and/or pulmonary metastasis at the General Hospital of Mexico, a center without access to endobronchial ultrasound (EBUS). Methods: A retrospective analysis was conducted on bronchoscopies performed between 2018 and 2023 in patients with suspected lung cancer. Diagnostic results obtained from endobronchial biopsies, bronchial brushing, and bronchoalveolar lavage were analyzed. Histopathological results were used to determine the efficacy of each technique. Results: A total of 122 bronchoscopies were performed, of which 100 resulted in positive diagnoses of lung cancer via bronchoscopy, and 22 cases were subsequently confirmed by surgical biopsy. The endobronchial biopsy had a success rate of 98.4% in endobronchial tumors, while bronchial brushing and bronchoalveolar lavage showed diagnostic rates of 7.8% and 1.6%, respectively. The most frequent histological types were lung adenocarcinoma (27.0%) and squamous cell carcinoma (23.8%). Postoperative complications occurred in 27.3% of patients undergoing surgery, with a mortality rate of 13.6%. Conclusions: Bronchoscopy is an essential tool in the diagnosis of lung cancer at the General Hospital of Mexico, especially in the absence of EBUS. Endobronchial biopsy demonstrated high diagnostic efficacy, in contrast to bronchial brushing and bronchoalveolar lavage, which were significantly less effective. These findings underscore the need to improve diagnostic techniques in centers with technological limitations.
subject: Articles
  topic: section
subject: Bronchoscopy
  topic: keywords
subject: Bronchial Brushing
  topic: keywords
subject: Endobronchial Biopsy
  topic: keywords
subject: Bronchoalveolar Lavage
  topic: keywords
creator: Saul J Rabadan Armenta
creator: Maria Elena Garcia Torres
creator: Mario A Hernandez Hernandez
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-09-16
publication date: 2024-09-16
starting page: 1
ending page: 3
doi: 10.47363/JPRR/2024(6)182

COVID-19 Management Protocol
type: item
description: Coronavirus disease 2019 (COVID-19) is an ongoing global threat that is associated with high risks of infection, morbidities, and mortalities. The majority of patients with severe COVID-19 disease often present with acute respiratory distress syndrome (ARDS). ARDS associated with COVID-19 represents viral pneumonia with two processes, which includes viral pneumonia that eventually leads to ARDS [1]. Patients who develop ARDS present with worsening respiratory symptoms, hypoxemia, and bilateral lungs diseases, which eventually may result in cardiac failure. The prevalence of ARDS in COVID-19 patients is high, accounting for up to 42% of the patients [1]. Up to 61-81% of the patients who develop ARDS require intensive care [1]. This article will describe evidence-based approaches that have been used for the management of ARDS in critically ill patients with COVID-19
subject: Articles
  topic: section
subject: COVID-19
  topic: keywords
subject: Mechanical Ventilation
  topic: keywords
subject: Intubation
  topic: keywords
subject: Pulmonary Vasodilators
  topic: keywords
creator: D Al Yami Mohammed
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-08-07
publication date: 2024-08-07
starting page: 1
ending page: 2
doi: 10.47363/JPRR/2024(6)181

The Attitudes of South African Respiratory Physicians towards the Use of Electronic Cigarettes as Smoking Cessation Adjuncts
type: item
description: Background: Tobacco use remains a substantial health hazard. Promotion of smoking cessation is an important healthcare intervention. Current guidelines for smoking cessation are only modestly successful. It is unclear if electronic cigarettes are effective smoking cessation adjuncts. Aim: The purpose of the study was to determine the attitudes of respiratory physicians in South Africa towards the use of e-cigarettes as smoking cessation adjuncts. Setting: Online survey of the attitudes of South African registered respiratory physicians towards e-cigarettes. Methods: The study was cross-sectional in design and consisted of a questionnaire-based online survey sent by electronic mail and completed by respiratory physicians registered with the Health Professions Council of South Africa (HPCSA), who were willing to participate. Results: Fifty-two (63.4%) responses were received. Sixty-seven percent of the participants felt that e-cigarettes were not effective smoking cessation adjuncts. Almost 79% of the respondents were of the opinion that e-cigarettes had less harmful effects on smokers compared to conventional cigarettes. Sixty-two percent of the respondents felt that e-cigarettes could be a gateway to other tobacco product use. More than 80% were in support of strict regulation of e-cigarettes. Conclusion: The majority of the respondents did not believe in the effectiveness of e-cigarettes as smoking cessation adjuncts, and would be happy with strict laws regulating the use of these products being enacted.
subject: Articles
  topic: section
subject: Electronic Cigarettes
  topic: keywords
subject: Smoking Cessation
  topic: keywords
subject: Respiratory Physicians
  topic: keywords
subject: Attitudes Advertising
  topic: keywords
subject: Legislation
  topic: keywords
creator: Manqola LL
creator: Matlawene John Mpe
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-08-31
publication date: 2024-08-31
starting page: 1
ending page: 6
doi: 10.47363/JPRR/2024(6)178

Clinical, Radiological and Pathological Characteristics of Hypersensitivity Pneumonitis and its Association with the Duration of Exposure in a Tertiary Centre
type: item
description: Background: Hypersensitivity pneumonitis (HP) has varied presentation, and it is unknown as to which individuals exposed to a potential antigen will develop HP. HP can often progress to permanent lung fibrosis, with significant social and economic consequences, besides reduced survival. To the best of our knowledge, this is the first such paper from India comparing characteristics of HP with duration of exposure. Methods and Materials: A retrospective observational study was conducted on 60 adult patients who meet the criteria of Hypersensitivity pneumonitis according to Schuyler’s criteria, at a tertiary care centre between February 2022 to June 2023. Clinical data including patient’s history, clinical manifestation, laboratory findings and HRCT findings was obtained from patient’s medical record files. Results: 73.3% patients were female. Most common offending antigen was avian droppings. In 11.7% the antigen could not be identified. 56.7% were homemakers. The most common HRCT finding was ground glass haziness (90%) and most common radiological pattern was Fibrotic Non-specific Interstitial pneumonitis (NSIP).71.67% patients had a restrictive ventilatory defect.90% had chronic HP. Longer the duration of exposure, more severe is the restriction and less distance was covered on 6minute walk test(6MWT). With increasing duration of exposure, more patients developed Unique interstitial pneumonitis (UIP) pattern rather than fibrotic or cellular NSIP. Conclusion: Continued long-term exposure causes most patients to develop parenchymal fibrosis. Longer duration of exposure is associated with worse ventilatory parameters and outcomes.
subject: Articles
  topic: section
subject: Hypersensitivity Pneumonitis
  topic: keywords
subject: Clinical Spectrum of HP
  topic: keywords
subject: HP Characteristics
  topic: keywords
creator: Sourabh Pahuja
creator: Arjun Khanna
creator: Pallavi Periwal
creator: Ankit Kumar Sinha
creator: Dhruv Talwar
creator: Satyam Agarwal
creator: Pradeep Bajad
creator: Deepak Talwar
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-08-05
publication date: 2024-08-05
starting page: 1
ending page: 8
doi: 10.47363/JPRR/2024(6)177

Primary Extraskeletal Pleural Osteosarcoma - A Clinical Case Report
type: item
description: Extraskeletal Osteosarcoma (EOS) is a rare malignant neoplasm producing osteoid in places others than bone or periosteum [1]. The proposed etiology of EOS is metaplasia of connective tissue or embryonal remnant [2]. Previously reported cases of primary thoracic osteosarcoma did not provide a comprehensive profile of clinical manifestations and were characterized by left-sided pleural effusions, recurrent bloody effusions, cough, pleuritic chest pain and progressive dyspnea [3].
subject: Articles
  topic: section
subject: Pleural Osteosarcoma
  topic: keywords
subject: Cardiopulmonary
  topic: keywords
subject: Lung
  topic: keywords
creator: E Abel Maldonado Ortiz
creator: Guadalupe Evelyn Pioquinto Gutierrez
creator: Cristobal Meneces
creator: Luis Bernardo Chavez Colunga
creator: Elizabeth Rubio Gonzalez
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-07-19
publication date: 2024-07-19
starting page: 1
ending page: 4
doi: 10.47363/JPRR/2024(6)180

Efficacy of Thoracoscopic Guided Brush Cytology in Undiagnosed Pleural Effusion
type: item
description: The accurate diagnosis of pleural effusion remains a challenging clinical problem. Medical thoracoscopy has an established role in achieving the aetiology of pleural effusion. Pleural biopsies provide best results, but if cytological results can be shown to give concordant results, therapy can be instituted early.
subject: Articles
  topic: section
subject: Thoracoscopy
  topic: keywords
subject: Pleural Effusion
  topic: keywords
subject: Brush Cytology
  topic: keywords
creator: Arpit Pandey
creator: Debasis Behera
creator: Saswat Shubhankar
creator: Chinnari Mohan Rao
creator: Swadip Mishra
creator: Pravati Dutta
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-06-01
publication date: 2024-06-01
starting page: 1
ending page: 3
doi: 10.47363/JPRR/2024(6)174

A Case Report of Tracheoesophageal Fistula in Esophageal Carcinoma
type: item
description: A tracheoesophageal fistula (TEF) is a congenital or acquired communication between the trachea and esophagus. Acquired TEFs may occur in individuals of any age, and elderly individuals are at increased risk. Causative factors of acquired TEFs include malignancy, trauma and various iatrogenic causes. The advanced esophageal carcinoma can be complicated by fistulas. Pathological communication between the esophagus and adjacent structures caused by the neoplastic process is also called a malignant esophageal fistula. According to published data, the incidence rate of malignant esophageal fistulas is about 13%.
subject: Articles
  topic: section
subject: Tracheoesophageal Fistula
  topic: keywords
subject: Esophageal Carcinoma
  topic: keywords
subject: Fibreoptic Bronchoscopy
  topic: keywords
subject: Haemoglobin
  topic: keywords
creator: Prashant Mishra
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-05-16
publication date: 2024-05-16
starting page: 1
ending page: 2
doi: 10.47363/JPRR/2024(6)176

Serum KL-6 : A Predictive Marker for Post Tubercular Fibrosis
type: item
description: The accurate diagnosis of pleural effusion remains a challenging clinical problem. Medical thoracoscopy has an established role in achieving the aetiology of pleural effusion. Pleural biopsies provide best results, but if cytological results can be shown to give concordant results, therapy can be instituted early.
subject: Articles
  topic: section
subject: Tuberculosis
  topic: keywords
subject: Fibrosis
  topic: keywords
subject: Pulmonary Diseases
  topic: keywords
subject: Respiratory
  topic: keywords
creator: Kunj Panwar
creator: Balakrishnan Menon
creator: Arya Gopi
creator: Praveen Raj
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-05-13
publication date: 2024-05-13
starting page: 1
ending page: 6
doi: 10.47363/JPRR/2024(6)175

Thoracic Endometriosis Detected During Medical Thoracoscopy in a Tertiary Care Setting - A Retrospective Observational Study
type: item
description: Background: Thoracic endometriosis is a very rare clinical situation mostly presenting with pleural diseases, that is often misdiagnosed or missed due to the lack of specific clinical features. This report aims to explore the clinical characteristics, thoracoscopic findings, histopathology, treatment, and prognosis of women with thoracic endometriosis, providing a reference for the diagnosis and management of thoracic endometriosis. Design/Methods: Clinical data of 3 patients diagnosed with pleural endometriosis from among 50 consecutive thoracoscopic procedures conducted in a tertiary care hospital in North Kerala were analysed from electronic hospital records. The clinical features, thoracoscopic findings, histopathological features, treatment process, and prognosis were summarized. Results: Among the 3 female patients with pleural endometriosis, there were 2 cases of catamenial pneumothorax and one case of catamenial haemothorax. The age ranged from 43 years to 44 years. All the 3 cases were diagnosed by thoracoscopic pleural biopsy. Conclusions: Thoracic endometriosis syndrome is extremely rare, and clinical diagnosis is always missed or delayed due to nonspecific symptoms. Diagnosis mainly relies on pathological findings and immunohistochemical detection. Most cases were managed conservatively with hormonal therapy or by inducing surgical menopause.
subject: Articles
  topic: section
subject: Catamenial
  topic: keywords
subject: Endometriosis
  topic: keywords
subject: Haemothorax
  topic: keywords
creator: Ravindran Chetambath
creator: Gayathri Karedath
creator: Shilpa Chandran
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-04-08
publication date: 2024-04-08
starting page: 1
ending page: 4
doi: 10.47363/JPRR/2024(6)172

Role of Mepolizumab in COVID Patients with Severe Eosinophilic Asthma
type: item
description: Aim: To evaluate the effect of Mepolizumab on COVID-19 patients with severe eosinophilic asthma and other comorbidities. Methods: 11 patients on Mepolizumab to treat SEA and contracted COVID-19 were taken. The retrospective clinical, demographical, and biochemical data were collected and evaluated. Results: Out of the 11 patients infected with COVID-19, 6 were males and 5 were females, with a mean age of 58. The most common risk factor was Hypertension (54%), Diabetes (36%), Obstructive sleep apnea (36%), and coronary artery disease (27%). Four out of 11 are above the age of 60, and half of the patients were overweight. Despite having multiple comorbidities, none of the patients required admission to the hospital. Conclusions: Patients who were administered mepolizumab and were diagnosed with COVID-19 only experienced mild symptoms and did not suffer from any complications despite having multiple comorbidities. This suggests that there may be a positive effect of mepolizumab on the course of COVID-19 or that it could be associated with asthma. However, further, larger-scale studies are required to determine the role of mepolizumab in COVID-19 and to explore its potential as a protective effect against the disease.
subject: Articles
  topic: section
subject: COVID-19
  topic: keywords
subject: Mepolizumab
  topic: keywords
subject: Severe Eosinophilic Asthma
  topic: keywords
subject: Comorbidity
  topic: keywords
creator: Azmat Karim
creator: Shameem Mohammad
creator: Anjana Talwar
creator: Deepak Talwar
creator: Abdul Allam Khan
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-03-26
publication date: 2024-03-26
starting page: 1
ending page: 3
doi: 10.47363/JPRR/2024(6)171

Clinical and Etiological Findings of Viral Pneumonia: A Single Centre Prospective Study
type: item
description: Introduction: Viral pneumonia is a prominent cause of illness that can occur in all age group throughout the year. Worldwide about 200 million cases of viral community acquired pneumonia occur every year of which 50% cases in children and 50% in adults [1]. Bacterial coinfection found only in 3% of cases [2]. The aim of our study is to find out most common viral pathogen causing pneumonia, most common bacterial co-infection, their typical clinical presentation, common abnormal lab parameters, CT findings, duration of ICU and hospital stay. Materials and Methods: All cases with sign and symptoms of respiratory infections with confirmed diagnosis of viral pneumonia (confirmed by BioFire FilmArray Pneumonia Panel from lower respiratory tract sample, confirmed by microscopy) were included in the study after proper consent. Demographic data, clinical history, laboratory investigations, all routine and radiological investigations are noted and evaluated. Results: Of the total 69 cases Influenza A virus (36%) is the predominant etiological agents followed by human rhinovirus (26%) in these cases. Human Rhinovirus predominate in the early part 2023 but towards end of this year Influenza A virus became the predominant cause for pneumonia. Patients of all age groups are affected but there is definitively a seasonal variation with more in the winter months. Most of the patients have typical respiratory findings like cough (83%) and fever (76%). CT scan showed bilateral ground glass opacity (56%) in most cases, and few had consolidation (29%) features. Blood CRP level (91%) was raised in most of these patients. Haemophilus Influenzae (34%) is the most common associated bacterial co-infection followed by Streptococcus Pneumoniae (26%). All patients responded well to conservative management. Conclusions: Viral pneumonia is not uncommon in the community. Though we found Influenza A followed by Human Rhinovirus are the two most common pathogens in these cases but only 59% of them h…
subject: Articles
  topic: section
subject: Etiological
  topic: keywords
subject: Pneumonia
  topic: keywords
creator: Ambika Prasad Nayak
creator: Sampat Dash
creator: Satya Ranjan Mohanty
creator: Nibedita Panda
rights: Copyright (c) 2024 Journal of Pulmonology Research & Reports
date: 2024-03-08
publication date: 2024-03-08
starting page: 1
ending page: 5
doi: 10.47363/1sek7443