Cardiac Amyloidosis in Aortic Stenosis: A Higher Risk Population?

Abstract

In recent decades, with an aging population, an increase in the prevalence of numerous cardiovascular pathologies have become evident, including aortic stenosis and infiltrative cardiomyopathies such as cardiac amyloidosis. The coexistence of both conditions is not uncommon, and since they share overlapping symptoms, echocardiographic findings, and biomarkers of myocardial damage, the diagnosis of infiltrative cardiomyopathy often remains masked. This underdiagnosis of cardiac amyloidosis in patients with symptomatic aortic stenosis can result in untimely and insufficient treatment. The objectives of this monograph are to analyze the predictors of cardiac amyloidosis caused by senile or wild type transthyretin in patients with symptomatic aortic stenosis, determine whether they constitute a higher-risk population, and explore the available therapeutic alternatives.