Clinical Characteristics of Pregnant Women with Sars-Cov2 Infection in the 3rd Trimester of Pregnancy

Abstract

Objectives: The aim of our study is to present the clinical characteristics of pregnant women with SARS-COV2 infection in the 3rd trimester of pregnancy. Methods: We retrospectively reviewed the medical records of all pregnant women from March to December 2020 in Infanta Leonor University Hospital, in Madrid. Infected women during the 3rd trimester of pregnancy or at delivery time with SARS-CoV2 diagnosis composed infected group, and non-infected women with SARS-CoV2 composed non-infected group. The infection status was determined via RT-PCR of nasopharyngeal swab specimen. Women in our study were not vaccinated because in the first and second waves of the epidemic the indication for vaccination in pregnant women was not clear.

Results: 1262 non-infected pregnant women and 86 SARS-CoV2 positive pregnant women were admitted to our clinic during the study period. Within the group of infected pregnant women, they were 49 cases (56.98 %) symptomatic and 37 cases (43.02 %) asymptomatic. In the group of symptomatic infected women, the majority were mild cases (80.23 %). In the group of uninfected pregnant women, the main complication was gestational diabetes 14 (1.09 %) We did not find any complications during pregnancy in case group. Cesarean section was performed in 16.67 % of the infected pregnant women and in 21.71 % of the control group. Mean neonatal birth weight was 3.240 g in case group and 3.210 g in non-infected
group. Neonatal admission to NICU was 9.52 % in cases while in the control group was 1.19 % being the most frequent reason for admission due to respiratory distress syndrome. Conclusion: SARS-CoV2 infection in pregnant women in the third trimester does not worsen the prognosis of pregnancy in our study, although metaanalyses suggest heightened risk of COVID-19 severity and adverse pregnancy and perinatal outcomes among women with certain demographic and health profiles. The aim of our study is to present the clinical characteristics of pregnant women with SARS-COV2 infection in the 3rd trimester of pregnancy. Methods: We retrospectively reviewed the medical records of all pregnant women from March to December 2020 in Infanta Leonor University Hospital, in Madrid. Infected women during the 3rd trimester of pregnancy or at delivery time with SARS-CoV2 diagnosis composed infected group, and non-infected women with SARS-CoV2 composed non-infected group. The infection status was determined via RT-PCR of nasopharyngeal swab specimen. Women in our study were not vaccinated because in the first and second waves of the epidemic the indication for vaccination in pregnant women was not clear. Results: 1262 non-infected pregnant women and 86 SARS-CoV2 positive pregnant women were admitted to our clinic during the study period. Within the group of infected pregnant women, they were 49 cases (56.98 %) symptomatic and 37 cases (43.02 %) asymptomatic. In the group of symptomatic infected women, the majority were mild cases (80.23 %). In the group of uninfected pregnant women, the main complication was gestational diabetes 14 (1.09 %) We did not find any complications during pregnancy in case group. Cesarean section was performed in 16.67 % of the infected pregnant women and in 21.71 % of the control group. Mean neonatal birth weight was 3.240 g in case group and 3.210 g in non-infected
group. Neonatal admission to NICU was 9.52 % in cases while in the control group was 1.19 % being the most frequent reason for admission due to respiratory distress syndrome. Conclusion: SARS-CoV2 infection in pregnant women in the third trimester does not worsen the prognosis of pregnancy in our study, although metaanalyses suggest heightened risk of COVID-19 severity and adverse pregnancy and perinatal outcomes among women with certain demographic and health profiles.