Pancytopenia Caused by Methimazole in Women with Graves Basedow Disease - Case Report

Authors

  • Carla Echart Postgraduate of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay Author
  • Florencia Dorfman Postgraduate of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay Author
  • Sofía Saccone Adjunct Professor of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay Author
  • Magdalena Otazú Assistant of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay Author

DOI:

https://doi.org/10.47363/JWHMR/2024(3)120

Keywords:

Hyperthyroidism, Agranulocytosis, Pancytopenia, Antithyroid Drugs

Abstract

Antithyroid drugs constitute one of the main pillars in the treatment of hyperthyroidism. They are associated with a variety of adverse effects, most of which are mild or minor. However, there are other rare but potentially fatal adverse effects, such as pancytopenia, of which only a few cases have been reported worldwide. This paper presents a clinical case of febrile neutropenia, associated with anemia and thrombocytopenia, secondary to treatment with methimazole.

Author Biographies

  • Carla Echart, Postgraduate of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay

    Magdalena Otazú, Assistant of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay.

  • Florencia Dorfman, Postgraduate of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay

    Magdalena Otazú, Assistant of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay.

  • Sofía Saccone, Adjunct Professor of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay

    Magdalena Otazú, Assistant of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay.

  • Magdalena Otazú, Assistant of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay

    Magdalena Otazú, Assistant of the Academic Unit of Endocrinology and Metabolism, Clinical Hospital, University of the Republic, Montevideo, Uruguay.

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Published

2025-11-24

Issue

Vol. 3 No. 5 (2024): Volume 3 Issue 5

Section

Articles