Sex Differences on Sars-Cov-2 Infected Patients Admitted in aSpanish Hospital
DOI:
https://doi.org/10.47363/JWHMR/2022(1)104Keywords:
COVID-19, Sar-Cov-2, Infection, Mortality, GenderAbstract
Background: Sex-dependent and advanced-age-related susceptibilities have been described as risk factors of SARS-CoV-2 infection in epidemiological studies carried out worldwide. Therefore, sex could be a determining factor in the development and outcome of the SARS-COV-2 infection, and its study may be useful for the development of therapeutic strategies aimed at improving the prognosis of the disease.
Aims: To study whether there are differences based on gender in the prognosis of SARS-COV-2 infection in hospitalized patients.
Methods: Retrospective observational cohort study carried out in a Spanish hospital. The statistical analysis determined the differences in characteristics and clinical evolution of the infection segregated by gender.
Results: A total of 255 subjects with SARS-CoV-2 infection, of whom 45% were women, were included. Over 50 years-old group of patients, the percentage of women was significantly greater than men (92.2% vs 80%) and, a higher mortality was observed (20.9% vs. 13.6%). Laboratory tests, radiologic explorations, intensive care unit (ICU) admissions, and ICU length of stay were similar in both genders. The percentage of women admitted to the ICU was higher than that of men (60% vs. 40%).
Conclusions: Women present more severe and more frequent hospital admission at older ages because of SARS-CoV-2 infection, and more risk of admission at ICU. These factors determine that mortality in women was greater than in men. However, this difference was not statistically significant.
