Oncocytic Cell Activity in Hashimoto’s Thyroiditis and PTC Thyroid Parenchyma: Immunohistochemical Profile

Authors

  • Tamuna Gvianishvili Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia Author
  • Liana Gogiashvili Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia Author
  • Maguli Chkhobadze Akaki Tsereteli Kutaisi State University, Kutaisi, Georgia Author
  • Elene Nikobadze Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia Author
  • Zurab Tsagareli Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia Author
  • Tinatin Kvachadze Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia Author

DOI:

https://doi.org/10.47363/823zqh72

Keywords:

Thyroid Pathology, Oncocytic Cell , Immunohistochemistry

Abstract

Oncocytic cell neoplasia makes a challenge in diagnosis and treatment, because It’s known that oncocytic cell neoplasms have unique molecular mechanisms. Oncocytic cells can be seen in many types of thyroid disease, including benign tumors, low-risk neoplasms, and malignant neoplasms. Thyroid tumors are classified as oncocytic cell neoplasms when more than 75% of the tumor consists of oncocytic cells. We studied oncocytic cells in cases of Hashimoto’s thyroiditis and Papillary Thyroid Carcinoma with different markers (Protein S-100, CD56, p63 and Cyclin D1). Based on the obtained results, we can conclude that these markers have different expression in different diseases and is more accurate for oncocytic cell carcinoma than for PTC. However, each marker has different sensitivity and specificity among the diseases studied.

Author Biographies

  • Tamuna Gvianishvili, Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia

    Tamuna Gvianishvili, Liana Gogiashvili, Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia. 

  • Liana Gogiashvili, Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia

    Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia.

  • Maguli Chkhobadze, Akaki Tsereteli Kutaisi State University, Kutaisi, Georgia

    Akaki Tsereteli Kutaisi State University, Kutaisi, Georgia.

  • Elene Nikobadze, Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia

    Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia. 

  • Zurab Tsagareli, Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia

    Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia.

  • Tinatin Kvachadze, Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia

    Researcher of Department of clinical and experimental pathology at Alexandre Natishvili Institute of Morphology, Tbilisi State University, Georgia.

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Published

2025-12-05

Issue

Vol. 3 No. 3 (2023): Volume 3 Issue 3

Section

Articles