Japan Journal of Clinical & Medical Research
type: channel
description: Japan Journal of Clinical & Medical Research is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Clinical & Medical Research. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Article acceptance will be in the form of research, review, case reports, analysis, magazines, editorials, opinion, communications, mini-review, short communications, picturized, book review, video type and power point presentations (PPTS). You can submit your articles through online: https://www.onlinescientificresearch.com/submit-online or can send through an e-mail with attachment for: jjcmr@onlinescientificresearch.info
publisher: Scientific Research and Community
language: en
publication name: Japan Journal of Clinical & Medical Research
issn: 2755-0141
items: Progress in Building a “Silicon Valley” Ecosystem in Kansai
items: Involvement of the Gasotransmitter Hydrogen Sulfide in the Effect of Ozone on the Hemoglobin Oxygen Affinity
items: Ms. Abdullakhodzhaeva. Principles of the Organization of the Pathology service. Tashkent: Meditsina, 1986: 199 p.
items: Keypoints in Cells and Atherogenesis
items: DPP4 valorphin activate NR4As pathway and OPA1 that protect from CoQ10 deficiency from OPA1 dysfunctions and from WMH
items: Healing Rate for Radiolucent Lesions following Root Canal Treatment
items: https://srcpublishers.com/japan-journal-of-clinical-medica/article/view/4352
items: Tibio-Fibular Fusion by Posterolateral Approach to Treat Nonunion of Tibia
items: Evaluation of Major Adverse Cardiac Events After Cardiac Surgery in Gaza
items: Psychological Approaches to Suicidal Tendencies
items: New Perfection of Original Xx-Xy (Female-Male) Gender Theory and Beyond: Assuring Mother and Father Care Umbrella for Japanese Happy Life and Survival of Social Legacies Forever
items: Outcome of Long Segment Posterior Spinal Stabilization Incorporating the Fractured Vertebra for Unstable Thoraco-Lumbar Junctional Brust Fracture
items: Neuroleptic Malignant Syndrome and its Clinical Look-Alikes: Diagnostic Insights
items: Oncocytic Cell Activity in Hashimoto’s Thyroiditis and PTC Thyroid Parenchyma: Immunohistochemical Profile
items: Cardiac Risk Marker Obesity and Psychological Background
items: Plant Fungus Gloeotinia SP: A Rare Finding in a Case of Mesial Temporal Sclerosis with Medical Refractory Epilepsy
items: Our Anesthesia Experience in a Pediatric Patient with Ruptured Lung Hydatid Cyst
items: A Phenomenological Study on The Understanding of Adolescent Decision-Making About Reproductive Health by School Nurses in Ijebu Ode Local Government of Nigeria
items: Vision-Boosting Nutrition: Exploring the Benefits of Nutritional Supplements for Eye Health
items: Unraveling the Knot: Noninvasive Strategies to Combat Stress for a Healthier Heart by Artificial Intelligence Innovations
items: Analising the Organ-Injury and Lastest Treatments for New Variants of SARS-COV-2 in Ederly and Immunocompromised Patients with Severe Comorbility
items: Computational Prediction of COVID-19 Transmission in Internal Air-Conditioned Environments
items: Predicting Indeterminate Lesion Turned to Distance Metastasis in Patients with Rectal Cancer Undergoing Curative Resection after Preoperative Chemoradiotherapy
items: Enhanced Detection and Prediction of Lung Cancer using CNN and RNN Techniques on Text Dataset
items: DCs- IL2 Necessary for Glucocorticoids Which Necessary for Interferons Synthesis and Serotonin Synthesis then Promote Ang2-At2 and VEGF-A for Anti-Inflammatory Growth
items: Pyrimidine TAT TAC Kinases Promote B-Arrestins and Rac1 forAdopting Myocardial Constrictions and Gpcrs Ratio by Ang2-AT2Synthesis and Anti-Inflammatory Growth
items: Review and Proposals Regarding Organ Donation Education
items: Curious Case of Acute Abdomen
items: Eye Injuries in Infants and Babies during Breast Feeding
items: School Bullying and Cyberbullying Update on Theoretical Models and Effective Interventions of Health Promotion

Progress in Building a “Silicon Valley” Ecosystem in Kansai
type: item
description: Unfortunately, networking still lags what is needed. Two things are needed for it to be successful and both of those are difficult in Japan. One is for potential entrepreneurs to introduce themselves to someone who does not know them. The second is the need to follow up an introduction over time to maintain the relationship. The problem in Japan is compounded by the different levels of hierarchy and whether it would be impolite to make a selfintroduction.
subject: Articles
  topic: section
subject: Capital Investment
  topic: keywords
subject: Training Entrepreneurs
  topic: keywords
subject: Company Creation
  topic: keywords
creator: Jack Moorman
rights: Copyright (c) 2026 Japan Journal of Clinical & Medical Research
date: 2026-02-17
publication date: 2026-02-17
starting page: 1
ending page: 3
doi: 10.47363/JJCMR/2026(6)201

Involvement of the Gasotransmitter Hydrogen Sulfide in the Effect of Ozone on the Hemoglobin Oxygen Affinity
type: item
description: This paper presents current data on the blood oxygen transport function and the gasotransmitters system (hydrogen sulfide and nitric oxide) and their interconnection. Hydrogen sulfide contributes to the modification of hemoglobin oxygen affinity, which is achieved through various mechanisms: the formation of sulfhemoglobin, modulation of the intraerythrocytic 2,3-DPG system, the L-arginine-NO system, and also indirectly through systemic mechanisms of hemoglobin functional properties. Based on an analysis of literature and our own data, the role of hydrogen sulfide as a gasotransmitter in the formation of blood oxygen transport function and the development of oxidative damage and hypoxic conditions is discussed.
subject: Articles
  topic: section
subject: Oxygen
  topic: keywords
subject: Blood
  topic: keywords
subject: Hypoxia
  topic: keywords
subject: Gasotransmitters
  topic: keywords
subject: Hydrogen sulfide
  topic: keywords
subject: Nitric oxide
  topic: keywords
creator: Victor Zinchuk
creator: Elena Biletskaya
rights: Copyright (c) 2026 Japan Journal of Clinical & Medical Research
date: 2026-01-19
publication date: 2026-01-19
starting page: 1
ending page: 4
doi: 10.47363/JJCMR/2026(6)200

Ms. Abdullakhodzhaeva. Principles of the Organization of the Pathology service. Tashkent: Meditsina, 1986: 199 p.
type: item
description: The reviewed monograph is devoted to an important problem the organization of the pathoanatomical service. In chapter I “Pathology departments and their role in improving medical and diagnostic services” discusses the structure and role of the Pathoanatomical Service (PS) in improving medical anddiagnostic work, so it should be called that. The priority of our country in the PS organization, which began to be created in the first years of Soviet power, is briefly indicated. Definitions of the PS and the Pathology Department (PD), their tasks and those of the centralized PD (CPD) are given.
subject: Articles
  topic: section
subject: Pathology
  topic: keywords
creator: Zubritsky Alexander Nickolaevich
rights: Copyright (c) 2026 Japan Journal of Clinical & Medical Research
date: 2026-01-28
publication date: 2026-01-28
starting page: 1
ending page: 2
doi: 10.47363/JJCMR/2026(6)199

Keypoints in Cells and Atherogenesis
type: item
description: Endothelial dysfunction is the initial event in the atherogenic process, resulting from several events, such as expression of leukocyte binding sites, production of growth factors, chemotactic and vasoreactive molecules, ability to oxidize low-density lipoprotein (LDL) and respond to oxidized lipoproteins, ability to express procoagulant activity, and modulation of vascular permeability. Thus, the endothelium, when subjected to different conditions and factors, plays an active role in the development of atherosclerotic plaque. The expression of several adhesion molecules, such as intracellular adhesion molecule-1 (ICAM-1), E-selectin, vascular cell adhesion molecule-1 (VCAM-1), P-selectin in atherosclerotic plaques, mediating the interaction between endothelial cells and leukocytes, has been described. The modification of LDLs, in conjunction with other chemotactic factors produced by injured endothelial cells, recruit circulating monocytes into the subendothelial space, where they become macrophages. The proliferation of smooth muscle cells is an important event in the progression of arterial injury, occurring in 3 stages: smooth muscle cell replication still within the media layer; migration from the middle layer to the intima and proliferation within the intima. Apoptotic cells were evidenced in the atherosclerotic lesion, suggesting that apoptosis is part of the normal vascular healing process. The final stage of atherosclerotic lesion development is conversion of the fibrotic lesion to an advanced lesion, a lesion in which a thrombus forms as a result of plaque ulceration or intraplaque hemorrhage.
subject: Articles
  topic: section
subject: Atherogenesis
  topic: keywords
subject: Adhesion Molecules
  topic: keywords
subject: Macrophages
  topic: keywords
subject: Smooth Muscle Cells
  topic: keywords
subject: Lymphocytes
  topic: keywords
subject: Apoptosis
  topic: keywords
subject: Extracellular Matrix
  topic: keywords
creator: Silvia Saiuli Miki Ihara
creator: Anita L R Saldanha
creator: Ana Paula Pantoja Margeotto
creator: André Luis Valera Gasparoto
creator: Milena de Souza Vasconcelos
creator: Giulia Mitsuko Schmit Hatae
creator: Elisa Rinaldi Nunes
creator: Tania Leme da Rocha Martinez
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 5
doi: 10.47363/JJCMR/2023(3)161

DPP4 valorphin activate NR4As pathway and OPA1 that protect from CoQ10 deficiency from OPA1 dysfunctions and from WMH
type: item
description: Valorphin (known as VV-hemorphin-5 ) is nine essential amino acids: Leu_Val_Val_Tyr, _Pro _Pro _Thr_ Gln_& Arg are having important role in activating mitochondrial functions and in activating both serotonin and NR4As pathway that promote oxytocin and Nrf2 synthesis. Deficiency in Thr, Tph (TGG), Glu, Gln (cycle) and Leucine due to increasing in the polarizability in mTORC1 and in S6K genes and subunits can cause disorders or deficiency in OPA1 repair that can be the result of Primary coenzyme Q10 (CoQ10) deficiency disease that characterized by damage in the inner mitochondrial membrane which is necessary for activating glucocorticoids receptor GCR Synthesis. Mitochondrial damage or disorder can lead to accumulation in pro-inflammation which can cause mutations in subunit and protein. The reduction in tryptophan, in Gly (which considered as the mirror of tryptophan triplets), and in Arg will cause reductions in Proline synthesis and consequently reductions in tRNAs, followed by reduction in mitochondrial OPA1 repairs and functions (that reduction in Gly can cause reduction in GTPase), followed by reduction in IL17 synthesis and accumulation of proinflammatory molecules, and followed by reduction in serotonin synthesis and in all of GC-beta, oxitocin, and Nrf2 production, that will be followed by decreasing in megakaryocytes proliferation and followed by reduction in hematopoiesis which associated to white matter hyperintensity. Opioid receptors produce powerful analgesia that is effective in participating in the function of the immune cells, and effective for modulating acquired immune responses (include modulating lymphocytes functions). While tryptophan (and both leucine and Tyr kinases) is necessary to activate both serotonin and lymphocytes functions, that the reduction in tryptophan, in Tyr, and in Leu will be result in decreasing in serotonin and in Nrf2 followed by reduction in platelets production, reduction in lymphocytes functions and reductions in hemato…
subject: Articles
  topic: section
subject: Hemorphin (valorphin)
  topic: keywords
subject: Chronic Cerebral Hypoperfusion
  topic: keywords
subject: Oxidative Stress
  topic: keywords
subject: Inflammation
  topic: keywords
subject: White Matter Hyperintensity
  topic: keywords
subject: Glucocorticoid-Beta
  topic: keywords
subject: B-arrestins
  topic: keywords
subject: B-Adrenergic
  topic: keywords
subject: Oxytocin
  topic: keywords
subject: Nrf2
  topic: keywords
subject: Ang2-AT2
  topic: keywords
subject: VEGF-A
  topic: keywords
subject: Microglia
  topic: keywords
subject: Astrocytes
  topic: keywords
subject: Primary coenzyme CoQ10,01110 mTORC1
  topic: keywords
subject: S6K
  topic: keywords
subject: tyrosine
  topic: keywords
subject: Thr
  topic: keywords
subject: Leu
  topic: keywords
subject: Île
  topic: keywords
subject: Val
  topic: keywords
subject: Glu/Gln
  topic: keywords
subject: Gly
  topic: keywords
subject: Ser
  topic: keywords
subject: tryptophan
  topic: keywords
subject: Arginine
  topic: keywords
subject: Plasma glial fibrillary acidic protein (GFAP)
  topic: keywords
subject: IL6
  topic: keywords
subject: IL17
  topic: keywords
subject: T-cells
  topic: keywords
subject: Mitochondrial OPA1 disorders
  topic: keywords
subject: Severe Traumatic Brain
  topic: keywords
subject: Mineralocorticoid
  topic: keywords
subject: WMH Tissue with high cations binding
  topic: keywords
subject: Tissue with proper anions binding
  topic: keywords
subject: Cellular tissue of CoQ10 deficiency contains high cations binding
  topic: keywords
subject: GTPase
  topic: keywords
subject: ATPase
  topic: keywords
subject: Dopamine
  topic: keywords
subject: Serotonin
  topic: keywords
subject: Melatonin
  topic: keywords
creator: Ashraf Marzouk El Tantawi
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 29
doi: 10.47363/JJCMR/2023(3)160

Healing Rate for Radiolucent Lesions following Root Canal Treatment
type: item
description: Objectives: This study was done to evaluate the healing rate of a radiolucent lesion in root canal treated teeth done at Hospital Universiti Sains Malaysia (HUSM) dental clinics by the students and dentists. Materials and Methods: Seventy-eight patient’s case sheets who attended HUSM dental clinic from January 2013 to December 2018 that met the inclusion criteria were collected, assessed, and compiled. The information was collected related to the period of treatment and radiolucency size by measurement through radiograph. Healing rate of radiolucent lesions for 56 root canal treated teeth were calculated and recorded. Result: The result showed that the healing rate for radiolucent lesions of RCT treated by student involving 39 teeth (22 anteriors, 3 premolars, 14 molars) was 1.904mm2/month and by dentist involving 17 teeth (6 anterior, 2 premolar, 9 molar) is 0.947 mm2/month.
subject: Articles
  topic: section
subject: Healing Rate
  topic: keywords
subject: Root Canal Treatment
  topic: keywords
subject: Radiolucency Lesions
  topic: keywords
creator: Nurul Haziqah Ali
creator: Wan Zaripah Wan Bakar
creator: Mohamad Syahrizal Halim
creator: Huwaina Abd Ghani
creator: Arbaz Sajjad
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2023-10-06
publication date: 2023-10-06
starting page: 1
ending page: 3
doi: 10.47363/JJCMR/2023(3)171

https://srcpublishers.com/japan-journal-of-clinical-medica/article/view/4352
type: item
title: Femoral Preparation Before Head Dislocation in Hip Hemiarthroplasty for Fractured Neck of Femur Saves Time and Keeps the Acetabulum Clean of loose bone fragments: A Retrospective Study and Technical Report
description: Introduction: Femoral neck fractures are the most common traumatic injuries associated with increasing age and osteoporosis, occurring most in older females. The femoral neck is under constant strain from externally and internally generated forces, approximately 500 – 200 micro-strains from daily activities. Common causes are falls in the elderly and road traffic accidents in younger patients. There is a significant in-house mortality and one-year mortality rate associated with femoral fractures. Fractures can be classified using the Garden Classification or the 2018 AO/OTA classification. Management includes open reduction and internal fixation, cannulated or sliding screws and hemiarthroplasty or total hip arthroplasty. This study examines the benefits of femoral preparation before head dislocation in hip hemiarthroplasties by assessing differences between pre-operative and post-operative haemoglobin levels and surgical times. Methods: We report the surgical techniques of hip hemiarthroplasty where the femur is prepared before the femoral head is removed and the hip is reduced in the flexion position. A retrospective review of electronic patient records of patients who underwent hemiarthroplasties from June 2022 to June 2023 was conducted. Results: Surgical times for this surgical technique were 30 minutes faster than traditional methods while the differences in haemoglobin levels were minimal. Conclusion: Longer surgical times are associated with adverse events such as infections and wound dehiscence while increasing risks via surgeon fatigue and longer anaesthesia durations. Innovations in surgical techniques should thus aim to minimise surgical time without compromising procedures. This technique saves 30 min on average while having similar levels of blood loss to traditional techniques, maintaining standards, and not compromising on patient safety. Femoral preparation before dislocating the femoral head reduces the steps taken in leg repositioning which saves …
subject: Articles
  topic: section
subject: Hip Fracture
  topic: keywords
subject: Femoral Fracture
  topic: keywords
subject: Hip Hemiarthroplasty
  topic: keywords
subject: Femoral Preparation
  topic: keywords
creator: Mohamed Shaalan
creator: Brandon Lim
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 4
doi: 10.47363/JJCMR/2023(3)159

Tibio-Fibular Fusion by Posterolateral Approach to Treat Nonunion of Tibia
type: item
description: A 30- year- old male has sustained open fracture of left leg and undergone 4 surgeries for four years (1. debridement and external fixator, 2. removal of external fixator, 3. vascularized contrafibular autograft plus change new plate/screws of ipsifibula, 4. flap surgery to cover the wound). At the time of examination: unability to walk, abnormal movements of leg, tibial bone loss 8 cm, especially the soft tissue of almost total anterior leg was so bad: no more subcutaneous tissue, skin very next to bone decouraging any attempt anterior approach. Diagnosis: pseudarthrosis of left leg with tibial large bone loss in the status of seriously damaged soft tissue of anterior leg surface. Technique operation chosen: Posterolateral. Appoach, Tibiofibular Fusion with massive autocancellous bone graft harvested from posterior iliac pelvis. Casting 4 months (from midthigh to metatarsal head). Postoperative walking with two crutches, Full Weight Bearing allowed after 14 weeks. Removal of cast after 16 weeks. Full knee flexion obtained 8 weeks after cast removal. Review at tenth month: normal walk, slight running, complete knee Range of Motion, 5 degree loss of dorsiflexion of ankle. X-rays: good fusion proximal and distal tibiofibular spaces and partly fusion the tibio-tibial gap. By this case,we can resumably conclude Tibiofibular Fusion through Posterolateral Approach should be strongly indicated for the leg nonunion in which the soft tissue of anterior surface is not favorable for nearby approach.
subject: Articles
  topic: section
subject: Tibiofibular Fusion
  topic: keywords
subject: Posterolateral Approach
  topic: keywords
subject: Tibial Pseudarthrosis
  topic: keywords
subject: Bone Loss
  topic: keywords
subject: Autocancellous Bone Graft
  topic: keywords
subject: Full Weight Bearing
  topic: keywords
subject: Range of Motion
  topic: keywords
creator: Le Phuc
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2023-09-11
publication date: 2023-09-11
starting page: 1
ending page: 3
doi: 10.47363/JJCMR/2023(3)158

Evaluation of Major Adverse Cardiac Events After Cardiac Surgery in Gaza
type: item
description: Background: The present study assessed the major adverse cardiac events (MACE) (hospital mortality rate, major stroke and reintervention) after cardiac surgery du to coronary artery bypass grafting or valve surgery or both in the Ministry of health hospitals (MOH) in Gaza Strip at 2022 by either Local or Expert cardiac surgery team. Method: Retrospective cohort study including all patients who underwent cardiac surgery by local or expert cardiac surgery team with cardiopulmonary bypass and /or valve surgery in the MOH hospitals at Gaza Strip during 2022. Result: Among the 98 patients (26 female and 72 male) with mean age 56±12 years, 38 patients was operated by local team, and 60 patients was operated by expert cardiac surgeon during 2022 in Gaza. The comparison of end points (mortality, major stroke and reintervention) between local and expert cardiac surgeons, was significantly low in patients operated by expert surgeon was 9 patients (23.7%) in local team surgery and in 4 patients (6.7%) in expert team. (P 0:015) Conclusions: The combination end points included Hospital mortality, major stroke and reintervention rate was higher in patients operated by local cardiac surgery team.
subject: Articles
  topic: section
subject: Cardiac Events
  topic: keywords
subject: Cardiac Surgery
  topic: keywords
creator: Mohammed Habib
creator: Abdelaziz Abu Samara
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 5
doi: 10.47363/JJCMR/2023(3)156

Psychological Approaches to Suicidal Tendencies
type: item
description: Elements obtained in the course of psychotherapy suggest that errors in childhood education, the aforementioned traumas in the molding periods, are of capital importance in the genesis of suicidal ideas, as they exacerbate the already existing manifestations of innate death instinct; that circumstantial factors of old age - loneliness, abandonment and scarcity of vital stimuli - reactivate unconscious conflicts and the manifestation of the death instinct already existing in the periods of molding, and that the hypothesis of psychosomatic fantasy would contribute to clarify the intimate mechanism of the suicidal act. We can come to formulate the following hypotheses about the suicidal act that is psychosomatic. This hypothesis is based not only on psychoanalysis but also on phenomenology, on modern structuralism. In order to carry out this psychosomatic hypothesis about the origins of suicidal ideas in depressive states about the psychogenic etiopathogenesis of thanatisms, there is the need to consider the following theories: 1) Gestaltism; 2) The new psychoanalytic currents; 3) New phenomenological currents; 4) The new currents of structuralism; 5) The philosophy defended by Duns Scotus; 6) Specificity and object relations.
subject: Articles
  topic: section
subject: Suicide
  topic: keywords
subject: Psychology
  topic: keywords
subject: Etiology
  topic: keywords
subject: Gestalt
  topic: keywords
subject: Neurotic
  topic: keywords
creator: Alina MAPN da Silva
creator: Luiz Carlos de Paiva Nogueira da Silva
creator: Anita L R Saldanha
creator: Ana Paula Pantoja Margeotto
creator: André Luis Valera Gasparoto
creator: Tania Leme da Rocha Martinez
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 3
doi: 10.47363/JJCMR/2024(4)181

New Perfection of Original Xx-Xy (Female-Male) Gender Theory and Beyond: Assuring Mother and Father Care Umbrella for Japanese Happy Life and Survival of Social Legacies Forever
type: item
description: Japanese are highly regarded for their lifestyles, wisdoms and aged survival gentry population among the developed countries of the world. There are lot of worries for the developing aging and low fertility among the populations. No improving situation to cope up with such natural phenomena seems to be coming up. Following new perfection of the original xx-xy (female-male) gender theory and beyond further studies were conducted on how to enable reducing aberrations causing misbalance in family genders. Such aberrations in the family genders were also found associated with early death of either one of the parents or causing non curable health ailments, impairing the life courses in the families. Objective of the present study was that in addition to making balanced families also create mother and father care umbrella for the family to maintain happy life courses of Japanese. The study fixed bio factors, produced cause and effects and developed prismatic gender balanced families, needed for reaching unforeseen and unimaginable acme. Thus, the study ushered a new prestige to the Japanese life known for its novelty to new niche in exemplary long life and harnessing plenty benefits by making survival of social legacies forever. Upcoming of the results of this study will help overcoming disabled children becoming parents to produce offspring free of genetic disabilities. This study opens a new dimension of high geographical areas of Japan under hill and forests, considered as a limiting setback for the country in to a plus point in enhancing gender balanced families and revamping population sustainability.
subject: Articles
  topic: section
subject: Aberrations in Family Gender
  topic: keywords
subject: Bio-Factors
  topic: keywords
subject: Cause and Effect
  topic: keywords
subject: Community and Society Genetic Disabilities
  topic: keywords
subject: Initial Indications
  topic: keywords
subject: Long Life Span and Survival of Social Legacies
  topic: keywords
creator: Yadav RC
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2023-07-31
publication date: 2023-07-31
starting page: 1
ending page: 7
doi: 10.47363/JJCMR/2023(3)170

Outcome of Long Segment Posterior Spinal Stabilization Incorporating the Fractured Vertebra for Unstable Thoraco-Lumbar Junctional Brust Fracture
type: item
description: Objectives: To evaluate the outcome of long segment posterior spinal stabilization incorporating the fractured vertebra with posterolateral fusion for unstable thoraco-lumbar junctional brust fracture. Background: Thoracolumbar junction is the commonest site of traumatic spinal injury. Now a days, it is managed surgically most of the time because it is often associated with the spinal cord injury. Its mode of surgical management is a field of controversy. Huge debate is still going on between the superiority of long & short segment stabilization. In this study, we evaluated the outcome of long segment posterior spinal stabilization incorporating the fractured vertebra. Materials & Method: This prospective interventonal study included 30 case of thoraco-lumbar junctional unstable brust fractures was carried out in the Spine unit of Orthopaedic surgery department of Bangabandhu Sheikh Mujib Medical University, Dhaka and other private hospital in Dhaka City, Bangladesh, from January 2016 to July 2022. All the patients with positive clinical findings, X-ray, MRI & CT scan findings and underwent long segment posterior spinal stabilization incorporating the fractured vertevra with posterolateral fusion. Average follow-up period was 12 months. Pre & Post-operatively, neurological assessment was done by the ASIA Impairment Score, improvement of pain control by VAS score, fusion rate by Bridwell’s criteria, Kyphotic angle was measured by Cobb’s angle measurement method & Overall functional assessment by modified Odom’s score. Results: Total number of patients was 30. Average age was 34 years (range 21- 47). ASIA score improved from B to C in 5 patients, B to D in 5 patients, C to D in 8 patients , C to E in 3 patients, patients, D to E in 7 patients. 2 patient did not improved following surgery. Fusion was achieved in 29 patients & 1 patient developed pseudoarthrosis. Pre & Post- operative VAS score was 7.30±1.9 & 3.3±1.8 respectively. The average kyphotic correction was 15 …
subject: Articles
  topic: section
subject: Thoraco-Lumbar Junction
  topic: keywords
subject: Brust Fractures
  topic: keywords
subject: Long Segment Including Fractured Vertebra
  topic: keywords
subject: Posterior Stabilization
  topic: keywords
subject: Posterolateral Fusion
  topic: keywords
creator: Anowarul Islam
creator: Suvradev Saha
creator: Naiemuzzaman Siddique
creator: Mahima Biswas Misi
creator: Afia Ibnat Islam
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 7
doi: 10.47363/JJCMR/2023(3)157

Neuroleptic Malignant Syndrome and its Clinical Look-Alikes: Diagnostic Insights
type: item
description: Neuroleptic malignant syndrome (NMS) is a rare but life-threatening neurological emergency associated with the idiosyncratic reaction to dopamine receptor antagonist medications or with rapid withdrawal of dopaminergic medications. While uncommon, this condition can mimic various other acute conditions presenting with acute dysautonomia, fever, and altered mental status, which can lead to delayed recognition and increased morbidity such as residual catatonia, parkinsonism, renal, or cardiopulmonary complications. Therefore, high vigilance, early recognition, and prompt treatment are necessary. In this review article, we aim to elaborate the pathophysiology, clinical features, and comprehensive management of NMS, with a special focus on its various mimicking conditions.
subject: Articles
  topic: section
subject: Neuroleptic Malignant Syndrome
  topic: keywords
creator: Ritesh Bhandari
creator: Muhammad M Javaid
creator: Pratima Gurung
creator: Adel Ekladious
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 5
doi: 10.47363/JJCMR/2024(4)180

Oncocytic Cell Activity in Hashimoto’s Thyroiditis and PTC Thyroid Parenchyma: Immunohistochemical Profile
type: item
description: Oncocytic cell neoplasia makes a challenge in diagnosis and treatment, because It’s known that oncocytic cell neoplasms have unique molecular mechanisms. Oncocytic cells can be seen in many types of thyroid disease, including benign tumors, low-risk neoplasms, and malignant neoplasms. Thyroid tumors are classified as oncocytic cell neoplasms when more than 75% of the tumor consists of oncocytic cells. We studied oncocytic cells in cases of Hashimoto’s thyroiditis and Papillary Thyroid Carcinoma with different markers (Protein S-100, CD56, p63 and Cyclin D1). Based on the obtained results, we can conclude that these markers have different expression in different diseases and is more accurate for oncocytic cell carcinoma than for PTC. However, each marker has different sensitivity and specificity among the diseases studied.
subject: Articles
  topic: section
subject: Thyroid Pathology
  topic: keywords
subject: Oncocytic Cell
  topic: keywords
subject: Immunohistochemistry
  topic: keywords
creator: Tamuna Gvianishvili
creator: Liana Gogiashvili
creator: Maguli Chkhobadze
creator: Elene Nikobadze
creator: Zurab Tsagareli
creator: Tinatin Kvachadze
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 3
doi: 10.47363/823zqh72

Cardiac Risk Marker Obesity and Psychological Background
type: item
description: The psychopathology of appetite excess reveals that there are several causes of obesity; even essential obesity, constitutional obesity or obesity due to metabolic error present a plurality of factors, which makes it more difficult to understand. However, our clinical experience highlights the capital importance of prophylactic medicine. We believe, therefore, that it is essential to adopt combined treatment: psychotherapy, endocrinology, physiotherapy, nutrition and social assistance. It is evident that in certain obese people, exercise increases polyphagia and in others it burns more calories. In the latter type, physical exercise should be prescribed. The psychotherapist with analytical training should be in a neutral position to receive both the good and the bad from the patient, but should always return the good, to enhance the individual’s security and so that he does not use somatizations. The treatment of obesity would therefore be eclectic and, mainly, prophylactic, avoiding in the family the maladjustments of the parents that can traumatize the individual during the periods of molding. In this way, emotional confusions that cause excess appetite would be avoided. Psychoanalysis or psychoanalytic group psychotherapy and the associated diet are, nowadays, the greatest weapons available to combat this social evil, because the obese person is the victim of sarcastic and jocular attitudes, which causes disgust and unhappiness.
subject: Articles
  topic: section
subject: Bulimia
  topic: keywords
subject: Obesity
  topic: keywords
subject: Psychology
  topic: keywords
subject: Appetite
  topic: keywords
subject: Hunger
  topic: keywords
creator: Alina MAPN da Silva
creator: Luiz Carlos de Paiva Nogueira da Silva
creator: Anita L R Saldanha
creator: Ana Paula Pantoja Margeotto
creator: André Luis Valera Gasparoto
creator: Tania Leme da Rocha Martinez
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 4
doi: 10.47363/JJCMR/2024(4)168

Plant Fungus Gloeotinia SP: A Rare Finding in a Case of Mesial Temporal Sclerosis with Medical Refractory Epilepsy
type: item
description: We report a case of a 38-year-old gentleman who diagnosed since the age of 11 with medical refractory epilepsy. Semiology began with symptoms of automatism followed by deviation of eyes and unpurposeful movement of left hand. Patient would then experience loss of consciousness and generalised tonic seizure involving all four limbs. These episodes tend to last for 1-2 minutes and post ictal drowsiness frequently follows. Electroencephalography (EEG) displayed findings compatible with right temporal epilepsy with secondary generalisation. Magnetic resonance imaging (MRI) of brain confirmed right hippocampal sclerosis as culprit for the seizures while neuropsychological tests displayed poor memory. Otherwise, patient had no neurological deficit or any history of long-term infection. After a long history of anti-epileptic drug polypharmacy with poor control of seizures, surgical treatment was opted for. Right amygdala-hippocampectomy was performed by neurosurgeon which was uneventful. Histopathology of surgical specimen was reported as sections of neuronal loss, suggestive of sclerosis and diffuse fungal infiltration at brain surface and blood vessels. This was then confirmed as Gloeotinia sp. Via BLAST (basic local alignment search tool) method. Patient remains fit free after surgery.
subject: Articles
  topic: section
subject: Central Nervous System
  topic: keywords
subject: Mesial Temporal Sclerosis
  topic: keywords
creator: Nur Nazleen Said Mogutham
creator: Zamzuri Idris
creator: Sanihah Abdul Halim
creator: Anani Aila Mat Zin
creator: Siti Suraiya Md Noor
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 5
doi: 10.47363/JJCMR/2024(4)178

Our Anesthesia Experience in a Pediatric Patient with Ruptured Lung Hydatid Cyst
type: item
description: Hydatid cyst is a parasitic disease caused by Echinococcus granulosus and transmitted to humans mostly through canine feces. Although it can settle in every organ in the body, the lung is the most frequently involved organ in children. As well as being asymptomatic, a pulmonary hydatid cyst may cause complaints such as chest pain, cough, shortness of breath, pneumothorax, and hemoptysis. A child patient was admitted to the pediatric emergency service with complaints of severe respiratory distress, hemoptysis, and pneumothorax in the right lung. Hydatid cyst treatment is primarily surgical. With the rupture of the cyst during the operation, anaphylactic shock and even death can be seen. In case of sudden onset of tachycardia and a decrease in mean arterial pressure during hydatid cyst operation, the possibility of anaphylaxis should be kept in mind after excluding other possibilities. We think that keeping in mind that anaphylaxis may develop in patients who will undergo surgery for hydatid cysts and being prepared for this will have a significant positive effect on mortality and morbidity. In this case report, we aimed to present our anesthesia experience of anaphylactic reaction following cyst rupture during surgical excision of lung hydatid cyst.
subject: Articles
  topic: section
subject: Pulmonary Hydatid Cyst
  topic: keywords
subject: Rupture
  topic: keywords
subject: Anaphylaxis
  topic: keywords
subject: Pediatric Anesthesia
  topic: keywords
creator: Bilge Aslan
creator: Yıldız Güneş Özlem
creator: Topçu İbrahim
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 5
doi: 10.47363/JJCMR/2023(3)169

A Phenomenological Study on The Understanding of Adolescent Decision-Making About Reproductive Health by School Nurses in Ijebu Ode Local Government of Nigeria
type: item
description: This study examined the understanding of adolescent decision-making in their reproductive health making by school nurses. School nurses are expected to provide guidance to the adolescents in reproductive health to help them make informed decisions. Adolescence is a transitional stage imbued with a lot of intrigues and risks. These risks, sometimes, if not well managed may disrupt the process of growth and development of adolescents. The school nurses need to understand how the adolescents make their decision as this will enable them to discharge their professional duties effectively. The study adopted an exploratory, descriptive, and contextual qualitative design aimed at revealing what school nurses understand about how adolescents make decisions in reproductive health. The setting of the study was Ijebu Ode Local Government of Nigeria. The semi-structured interviews were conducted on the school nurses, school teachers, and the school health coordinator, while focus group discussion was used with school-based adolescents. Data analysis employed inductive content analysis. The subthemes that described the understanding of adolescent reproductive health decision-making by school nurses were inadequate knowledge of the concept of adolescence, and lack of adequate knowledge of reproductive health. The study concluded that school nurses would require an intervention programme in this direction.
subject: Articles
  topic: section
subject: Phenomenological
  topic: keywords
subject: Adolescent
  topic: keywords
creator: Oluwatoyin A Ogunyewo
creator: Cletus Daniel
creator: Naomi Yakubu
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 5
doi: 10.47363/JJCMR/2023(3)152

Vision-Boosting Nutrition: Exploring the Benefits of Nutritional Supplements for Eye Health
type: item
description: Oxidative stress, defined by an imbalance in free radical generation and antioxidant defense, serves as a pivotal risk factor for multiple ocular pathologies, including glaucoma, cataracts, and age-related macular degeneration (AMD). Under normal physiological conditions, endogenous mechanisms adequately regulate reactive oxygen species (ROS) levels. However, excessive ROS accumulation, surpassing the body’s antioxidative capacity, initiates oxidative stress, precipitating macromolecular damage and potentially accelerating disease progression in ocular tissues. This review delineates the significance of dietary antioxidants in mitigating oxidative stress specifically within the context of eye health. Focus is directed towards the bioactive compounds, polyphenolic flavonoids and anthocyanosides, prevalent in various foods such as Nigella sativa, tea, chocolate, fruits, and vegetables (polyphenolic flavonoids), as well as blueberries and bilberries (anthocyanosides). These compounds engage distinct mechanistic pathways to neutralize ROS; polyphenolic flavonoids donate electrons, whereas anthocyanosides scavenge free radicals. The current synthesis aims to elucidate the molecular interactions and therapeutic potential of these antioxidants in preserving ocular health and preventing the onset or progression of related diseases, providing a comprehensive understanding for future research and clinical applications.
subject: Articles
  topic: section
subject: Oxidative Stress
  topic: keywords
subject: Ocular Diseases
  topic: keywords
subject: Antioxidants
  topic: keywords
subject: Polyphenolic Flavonoids
  topic: keywords
subject: Anthocyanosides
  topic: keywords
subject: Eye Health
  topic: keywords
subject: Nutritional Therapeutics
  topic: keywords
subject: Nigella Sativa
  topic: keywords
creator: Bochatay T
creator: Fetian IR
creator: Maneli Mozaffarieh
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 8
doi: 10.47363/JJCMR/2024(4)167

Unraveling the Knot: Noninvasive Strategies to Combat Stress for a Healthier Heart by Artificial Intelligence Innovations
type: item
description: Stress is a prevalent factor in modern life that significantly impacts cardiovascular health. This paper explores the intricate relationship between stress and heart health, detailing the physiological mechanisms through which stress affects the cardiovascular system. Various noninvasive strategies for reducing stress in daily life are examined, including mindfulness and meditation, physical activity, breathing techniques, social support, and nutritional interventions. Additionally, the role of Artificial Intelligence (AI) in enhancing stress management is discussed, highlighting AI innovations such as personalized stress monitoring, predictive analytics, virtual health coaches, cognitive behavioral therapy (CBT) apps, and social connection platforms. By integrating these noninvasive methods with AI technologies, individuals can effectively manage stress, thereby promoting better heart health and overall well-being. Case studies illustrate practical applications of these strategies, demonstrating significant improvements in stress levels and cardiovascular health. The paper concludes that proactive stress management, supported by AI, is essential for maintaining heart health and enhancing quality of life.
subject: Articles
  topic: section
subject: Stress Management
  topic: keywords
subject: Heart Health
  topic: keywords
subject: Chronic Stress
  topic: keywords
subject: Mindfulness Meditation
  topic: keywords
subject: Physical Activity
  topic: keywords
subject: Breathing Techniques
  topic: keywords
subject: Social Support
  topic: keywords
subject: Nutritional Interventions
  topic: keywords
subject: Cardiovascular Health
  topic: keywords
subject: Noninvasive Strategies
  topic: keywords
subject: Artificial Intelligence
  topic: keywords
creator: Shiva Dalili
creator: Bahman Zohuri
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 3
doi: 10.47363/JJCMR/2024(4)176

Analising the Organ-Injury and Lastest Treatments for New Variants of SARS-COV-2 in Ederly and Immunocompromised Patients with Severe Comorbility
type: item
description: The global pandemia of Omicron and the lastest Variants again puts all the scientific community in big problems.
subject: Articles
  topic: section
subject: Organ- Injury
  topic: keywords
subject: Comorbility
  topic: keywords
subject: New Treatment
  topic: keywords
subject: SARSCov-2
  topic: keywords
subject: Ederly
  topic: keywords
subject: Immunocompromised
  topic: keywords
creator: Weimer LE
creator: Cattari G
creator: Belasio Fanales E
creator: Cuccuru E
creator: Vidili Gianpaolo
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 10
doi: 10.47363/JJCMR/2024(4)177

Computational Prediction of COVID-19 Transmission in Internal Air-Conditioned Environments
type: item
description: COVID-19 has had destructive consequences for health, economy and has altered every aspect of everyday human activity. The outbreak was first identified in December 2019 in Wuhan, China. The declaration of the disease as a “Public Health Emergency of International Concern” for the World Health Organization took place on January 30, 2020. Furthermore, 105,5 million cases have been reported until 06 February 2021. Public distancing in internal environments has been applied as a safety measure to prevent transmission. A controversial topic is the safe distance from person to person. The social distancing regulation, for internal public places, has been arbitrarily defined ignoring the potential aerodynamics effects of inlets, such as air-conditioning units, windows and doors. The velocity of the intake airflow has the potential to transfer a droplet from the nose or the mouth of a patient in greater than the indicated distance. The present study focuses on a model of a supermarket that includes a ventilation system and open doors. For the transmission of COVID-19 in an air-conditioned internal space, two different designs were implemented and studied. Internal shelving, furnishing and human models are also being considered. The numerical results obtained are compared with those obtained by two well-known empirical models related to the effective velocity of incoming air and the virus concentration. It is concluded that the computational results obtained in the present study are in acceptable agreement with those obtained by simple empirical models, especially when the standard k-ε model of turbulence is used. Thus, for the cases of coughing and sneezing patients, where we studied the largest particles that sediment onto the floor, the 6-foot (≈1,82 m) rule applies well. However, pathogen-laced particles, coming for example from asymptomatic patients, travel through the air indoors when people breathe and talk. Therefore, there is not much benefit to the 6-foot rule bec…
subject: Articles
  topic: section
subject: COVID-19
  topic: keywords
subject: Spatial Discretization
  topic: keywords
subject: Public Health Emergency of International Concern
  topic: keywords
creator: Ioannis Rentoumis
creator: NC Markatos
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2022-12-23
publication date: 2022-12-23
starting page: 1
ending page: 10
doi: 10.47363/ccvsq683

Predicting Indeterminate Lesion Turned to Distance Metastasis in Patients with Rectal Cancer Undergoing Curative Resection after Preoperative Chemoradiotherapy
type: item
description: Objectives: It is controversial about factors associated with indeterminate lesion turned to be malignant lesion after preoperative concurrent chemoradiotherapy(CCRT) in rectal cancer that may cause over-treating and over-diagnosing. So, The aim of this study was to evaluate the prevalence of indeterminate pulmonary nodules or liver nodule at primary staging CT and risk of indeterminate lesion being malignant to help better understanding of indeterminate lesion in rectal cancer undergoing preoperative CCRT and proper treatment. Methods: A total of 679 patients with rectal cancer were assessed from January 2015 to December 2019. 152 patients with rectal cancer undergoing curative resection after preoperative CRT were included. Associated factors were reviewed for their effect on metastasis. The median follow-up time was 28 months. Results: Of 152 patients, The prevalence of indeterminate lesion was 3.29% and turned to be malignant around 40% of patients. The clinical N2, preoperative FOLFOX regimen, No clinical response were significantly higher in malignant group (p 0.03, <0.001 and 0.003, respectively). Conclusions: Such a low incidence of indeterminate lesion should not cause further preoperative diagnostic workup besides routine regimens. In addition, it is not necessary to perform excessive surveillance routinely for all rectal cancer patients underwent preoperative CCRT who have indeterminate lesion. Intensive follow up chest CT or invasive diagnosis modalities should be considered in patients who had clinical stage N2, receiving preoperative FOLFOX4 regimen and no clinical response after preoperative CCRT.
subject: Articles
  topic: section
subject: Rectal Cancer
  topic: keywords
subject: Indeterminate Lesion
  topic: keywords
subject: Preoperative Chemoradiotherapy
  topic: keywords
creator: Puttiporn Naovaset
creator: Chairat Supsamutchai
creator: Puvee Punmeechao
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 8
doi: 10.47363/JJCMR/2024(4)165

Enhanced Detection and Prediction of Lung Cancer using CNN and RNN Techniques on Text Dataset
type: item
description: Lung cancer remains one of the leading causes of cancer-related mortality globally, highlighting the urgent need for precise and reliable detection methods. This research introduces a novel approach to improving lung cancer detection and prediction by combining Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs) on an extensive text dataset. Our methodology tackles several common issues in current deep learning techniques used for lung cancer detection. A major problem is the dependence on small sample sizes, which often results in overfitting and limited generalization. To address this, we applied extensive data augmentation and transfer learning techniques, improving the model’s ability to perform well on new, unseen data. Additionally, we reduced the over-reliance on previous studies by developing innovative model architectures that merge CNNs’ ability to extract spatial features with RNNs’ capability to capture temporal dependencies, creating a more robust predictive framework. We also emphasized the importance of validating our model on independent datasets by rigorously testing it on a variety of external datasets, ensuring its robustness and generalizability. To address the resource-intensive nature of training deep learning models, we utilized advanced computational resources to optimize both model training and deployment efficiency. Another challenge is the potential bias in training data, which can lead to skewed predictions. We minimized these biases by carefully selecting and preprocessing our dataset, ensuring our model’s applicability across different populations. Moreover, incorporating longitudinal data allowed our model to better understand disease progression, enhancing long-term outcome predictions. Our system also considers practical aspects for clinical integration, ensuring that the models can be easily adopted in healthcare settings. By maintaining high-quality, standardized imaging and expanding our dataset to include mo…
subject: Articles
  topic: section
subject: Lung Cancer Detection
  topic: keywords
subject: Convolutional Neural Networks (CNNs)
  topic: keywords
subject: Recurrent Neural Networks (RNNs)
  topic: keywords
subject: Deep Learning
  topic: keywords
subject: Data Augmentation
  topic: keywords
subject: Transfer Learning
  topic: keywords
subject: Longitudinal Data
  topic: keywords
subject: Clinical Integration
  topic: keywords
creator: Bodicherla Siva Sankar
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 15
doi: 10.47363/JJCMR/2024(4)173

DCs- IL2 Necessary for Glucocorticoids Which Necessary for Interferons Synthesis and Serotonin Synthesis then Promote Ang2-At2 and VEGF-A for Anti-Inflammatory Growth
type: item
description: Dendritic cells (DCs) play an important role in improving and adapting immune responses, and development of chronic inflammation through producing Interleukin-2 which stimulate beta oxidation processes by OPA1 synthase for promoting both IFN-beta and GC-beta production followed by alpha oxidations for TLR4 and SIRPα1 production and for nucleocytosolic acetyl-CoA alpha production which considered as signature of a “growth specifically for anti-inflammatory growth. Glucocorticoids and glutamine are the basic tools for increasing immune efficiency (regulated by OPA1 enzymes) and the main for regulating the adopted Interferons, that the deficiency in glucocorticoids synthesis and glutamine will suppress immune activities and will lead to deficiency in Interferons productions followed by decreasing in macrophages and T-cells functions. The formation of Glucocorticoid-gamma and IFN-gamma started by the effects of Cox2 on inflammatory sources followed by cytokine kinases production for IL2 synthesis upon synthetase functions followed by synthase for glucocorticoid-beta and IFN-beta productions which followed by phospholipase effect for producing PD-L1 synthesis which promote the progression of ovarian cancer.
subject: Articles
  topic: section
subject: Anti-inflammatory processes
  topic: keywords
subject: GPCRs and on cholesterol
  topic: keywords
creator: Ashraf Marzouk El Tantawi
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2022-12-15
publication date: 2022-12-15
starting page: 1
ending page: 24
doi: 10.47363/JJCMR/2022(2)142

Pyrimidine TAT TAC Kinases Promote B-Arrestins and Rac1 forAdopting Myocardial Constrictions and Gpcrs Ratio by Ang2-AT2Synthesis and Anti-Inflammatory Growth
type: item
description: The orphan nuclear pathway (regulated by pyrimidine TAT and TAC kinases and OPA1 enzymes) has the roles of producing the Beta-subunit (fatty Acyl-COAbeta) upon the effects of synthase which regulate B-arrestins synthesis for adopting ACE for Ang2-AT2 synthesis from Ang1-AT1 (that adopt GPCRs ratio) . The inhibition in synthase and in pyrimidines kinases will reflect Inhibition in Acyl-COA-beta synthesis followed by cholesterol and long fatty chains accumulations with high affinity to bind with k and Na salts that can precipitated and cause lipotoxicity. B-arrestins play a well established role in the dampening of G-protein coupled receptors (GPCRs) accumulation, that prevent their increasing through its adopting to ACE for activating Ang2-AT2 synthesis from Ang1-AT1. The absence of pyrimidine kinases or Ser and Leu with availability of purines kinases produced from Thr phosphorylation can convert the agonist characters of MR to antagonist due to decreasing in adopting MR functions (decreasing in building proper promoters in the active MR molecules). The Glucocorticoidbeta and Estrogen Receptors are so important for producing B-arrestin in Myocardial layer for adopting ACE which placed particularly on ECs for adopting Ang2-AT2 synthesis (adopt Ang1-AT1 ratio to prevent accumulation of GPCRs ), and activate the regulated VEGF-A “regulated basically pyrimidine kinases “.
subject: Articles
  topic: section
subject: Hyperkalemia
  topic: keywords
subject: kinasemediated mechanisms
  topic: keywords
creator: Ashraf Marzouk El Tantawi
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2022-10-13
publication date: 2022-10-13
starting page: 1
ending page: 19
doi: 10.47363/JJCMR/2022(2)141

Review and Proposals Regarding Organ Donation Education
type: item
description: The global persistence of organ shortage justifies a study of the current state of this social emergency and a rational discussion of the possible alternatives for a necessary solution. Analyses of the results and the conclusions of authors who have studied this problem in depth have suggested the following preponderant factors as responsible for this reality and generated possible solutions to this health and well-being crisis: •Review of inhibitory factors of social behaviour towards organ donation •Evaluation and changes in social and professional educational programs on transplants and organ donation •Discussion of specific, potentially controversial legal proposals •Review of the relative global compliance with the ethical-economic standards established in relation to the costs of organ transplants
subject: Articles
  topic: section
subject: Organ Donation Programs
  topic: keywords
subject: Children Organ Donation
  topic: keywords
subject: Organ Donation a Social Duty
  topic: keywords
subject: Cremation and Organ Donation
  topic: keywords
subject: Organ Donation Challenging Proposal
  topic: keywords
creator: Félix Cantarovich
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2022-09-06
publication date: 2022-09-06
starting page: 1
ending page: 6
doi: 10.47363/JJCMR/2022(2)139

Curious Case of Acute Abdomen
type: item
description: A 35 year old male bank employee by profession presented with c/o pain in abdomen with abdominal distension and fullness since last 4 weeks. Intensity of pain had increased over the past 15 days. He had a history of fever intermittently for the past 3 months for which he had been taking medication initially .Off recent fever started subsiding even without medication. He complained of anorexia and weight loss over these 3 months.
subject: Articles
  topic: section
subject: Peritoneal Tuberculosis
  topic: keywords
subject: Ascitis
  topic: keywords
subject: Abdominal Distension
  topic: keywords
subject: Diagnostic Laparoscopy
  topic: keywords
creator: Shivani Desai
creator: Neil Sheth
creator: Sanjay Chatterjee
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2022-09-22
publication date: 2022-09-22
starting page: 1
ending page: 3
doi: 10.47363/JJCMR/2022(2)140

Eye Injuries in Infants and Babies during Breast Feeding
type: item
description: An awareness study about the Eye safety while breast feeding in small children and infants, as there are always chances of an eye injury to the baby with the hook of mother’s blouse. In India blouse is a traditional top women used to wear mostly.
subject: Articles
  topic: section
subject: Blouse
  topic: keywords
subject: Breastfeeding
  topic: keywords
subject: Infants
  topic: keywords
subject: Lid Laceration
  topic: keywords
subject: Corneal Tear
  topic: keywords
creator: Shripat Dixit
creator: Reva Kanash
creator: Parvez Parvez
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2022-07-29
publication date: 2022-07-29
starting page: 1
ending page: 1
doi: 10.47363/JJCMR/2022(2)138

School Bullying and Cyberbullying Update on Theoretical Models and Effective Interventions of Health Promotion
type: item
description: Bullying represents a social problem, widely diffuse in the school age. Amost 10% of young people at school is involved in bullying behavior, and up to 25% report victimization. Although a trend in decreasing prevalence is generally observed in the transition across school levels, the impact of bullying in social relationships and in mental health is dramatic. Several forms of bullying are possible, and different explanatory models have been proposed for accounting to this phenomenon. An accreditate model gives importance to social roles beyond bully and victim (i.e., bystanders, victim defensor and bully supporter), but also to the dynamics in the whole social circle (vicious circle of bullying). Cyberbullying is an increasing phenomenon, in which aggressive behaviors are catalyzed by anonymity and amplified by digital means. Cyberbullying shares some features with traditional bullying, but it represents a diverse, unique entity. This mini-review aimed to be an updated narrative report of the current theoretical and explanatory models of bullying and cyberbullying, with references to social psychology and health psychology. Lastly, some intervention models of health promotion to reduce bullying and cyberbullying are discussed, with particular emphasis on peer education.
subject: Articles
  topic: section
subject: Bullying
  topic: keywords
subject: Cyberbullying
  topic: keywords
subject: Moral Disengagement
  topic: keywords
subject: Health Promotion
  topic: keywords
subject: Life Skills
  topic: keywords
subject: Peer Education
  topic: keywords
creator: Nicola Salvadori
creator: Elisa
creator: Giada Fioretti
creator: Marco Cristofori
rights: Copyright (c) 2025 Japan Journal of Clinical & Medical Research
date: 2025-12-05
publication date: 2025-12-05
starting page: 1
ending page: 8
doi: 10.47363/JJCMR/2024(4)174