Journal of Oncology Research Reviews & Reports
Editor-in-chief: Gianluca Franceschini Professor Department of Medicine and Translational Surgery Fondazione Policlinico Universitario Agostino Gemelli IRCCS Italy ORCID: https://orcid.org/0000-0002-2950-3395 Journal of Oncology Research Reviews & Reports is an international, open-access, peer-reviewed journal dedicated to advancing scientific communication in oncology and cancer research. The journal provides a professional platform for researchers, clinicians, academicians and healthcare professionals to share valuable research and emerging scientific developments. Special Issue on New Horizons in Oncology: Emerging Therapies and Precision Medicine Journal of Oncology Research Reviews & Reports invites clinicians, oncologists, researchers, scientists, academics and healthcare professionals to contribute original and high-quality manuscripts to our upcoming Special Issue on “New Horizons in Oncology: Emerging Therapies and Precision Medicine.” Articles acceptance will be in the form of Research, Review, Case Reports, Analysis, Magazines, Editorials, Opinion, Communications, Mini-Review, Short Communications, Picturized, Book Review, Video Articles and Power Point Presentations (PPTs). You can submit articles through online https://srcpublishers.com/oncology-research-reviews-report/user/register or can send through an e-mail with attachment for: oncologysciences@onlinescientificresearch.info 1.5 Impact Factor 84.5% Citations 65% Acceptance
Diffuse Large B Cell Lymphoma of Hard Palate-A Rare Case Entity with Literature Review
Introduction: The most common Non-Hodgkin’s Lymphoma in the oral cavity is Diffuse Large B Cell Lymphoma (DLBCL), followed by mantle cell lymphoma, extranodal marginal zone lymphoma of Mucosa-Associated Lymphoid Tissue (MALT lymphoma) and Burkitt lymphoma. The literature shows a very few case reports of primary MALT lymphoma. Primary involvement of the oral cavity by NHL is very rare. Extranodal DLBCL of the palate are extremely rare, with isolated case reports in the literature. Case Report: Here we are discussing about a case of an 84-year-old male known case of Hepatitis B infection (since 2014) and a chronic tobacco chewer for the last 9 years presented with a complaint of toothache (bilateral lower molar) of 06 months duration and a non-healing ulcer on the hard palate of 04 months duration. Patient underwent an incisional biopsy and was diagnosed with extra-nodal diffuse large B-cell lymphoma, GCB type. Conclusion: DLBCL have several subtypes with different clinical courses. Identification of these subtypes has prognostic and therapeutic significance. They are aggressive tumours that can be rapidly fatal if left untreated. So early diagnosis plays an important role. Complete remission can be achieved with early diagnosis and intensive chemotherapy.
Copyright (c) 2026 Journal of Oncology Research Reviews & Reports
Huge Renal Angiomyolipoma: A Case Report
Renal angiomyolipoma (AML), are rare solid benign renal tumors, referred to as renal hamartoma. The inheritance pattern of renal AML is autosomal dominant. Although renal angiomyolipoma is a rare benign neoplasm, it may still impose significant morbidity and mortality due to the tumor’s unique vascular characteristics and the possible complications associated with treatment. We presented here a case of giant renal AML in a 28-year-old female patient, who presented with Right-sided abdominal swelling for 4 months. Following radiological investigation by abdominal ultrasound and computed tomography examination, the patient underwent nephron sparing surgery. The resected mass was sized 25×15x10 cm. Postoperative histopathological examination confirmed the lesion as a giant renal AML. In conclusion, it is believed that surgery will continue to play important roles in the treatment of AML by nephron sparing surgery or by nephrectomy and preserving normal renal function is the main therapeutic target.
Successful Resection of Ewing Sarcoma Involving the Whole Fibula in a Pediatric Patient with Long Vascular Bypass and Reconstruction of Knee and Ankle Ligaments: A Case Report and Literature Review
Introduction: Ewing sarcoma is the second most prevalent primary malignant bone tumor affecting pediatric and adolescent patients. Ewing sarcoma can affect any bone, but it primarily affects bones in the lower limb and pelvis. The femur is the most commonly affected bone. Approximately 8% of primary Ewing sarcoma originates from the fibula, and involvement of the entire fibula is a rare presentation. The standard treatment of Ewing sarcoma involves neo-adjuvant multimodal chemotherapy followed by local treatment using wide local resection (with or without radiation) and adjuvant chemotherapy. Case Presentation: A nine-year-old male patient, who is medically free, presented to the orthopedic oncology clinic complaining of left leg pain and swelling, accompanied by nighttime pain and weight loss. Clinical examination revealed swelling and tenderness in the entire leg, particularly the lateral aspect, and distal neurovascular examination was normal. Radiographic assessment, including plain X-rays and whole leg MRI with contrast, suggested the presence of a potentially malignant lesion affecting the entire fibula. CT-guided biopsy and histopathology confirmed the diagnosis of Ewing Sarcoma of bone. CT Angiogram of the left lower limb was performed to assess vascular involvement, which revealed the anterior tibial artery and peroneal artery were found be encased by the tumor. Following neo adjuvant chemotherapy, the patient underwent total fibular resection, long vascular bypass and reconstruction of the ankle and knee ligaments. Postoperative follow-up and recovery yielded maintained ankle and knee stability, resulting in a satisfactory functional outcome. Conclusion: Ewing sarcoma involving the entire fibula is exceptionally rare, with limited experience reported in the literature. In the present pediatric case, complete tumor resection, long segment vascular bypass, and concurrent reconstruction of the ankle and knee ligaments were performed, resulting in durable stability of both joints. This experience underscores that, when guided by a multidisciplinary team, total fibular resection can offer an effective and function-preserving procedure in pediatric bone sarcoma.
Reconstruction of Ankle and Knee Ligaments
Study on the Feasibility of Promoting the Hyperthermia Effect on Superficial Skin Tumors Based on Outdoor Thermal Environment
This study examines whether outdoor thermal conditions can help patients with superficial skin tumors reach the temperatures needed for hyperthermia after hospital discharge. A completely new mathematical model of bio-heat transfer was established to predict temperature changes in skin tissue. The predicted temperature distribution aligns closely with results from the traditional model, indicating that the analytical solution of the new model is meaningful and applicable. Using the tissue temperature profile and the known threshold for hyperthermia, we identified the effective hyperthermia depth for superficial skin tumors. The results of experimental measurements show that in certain outdoor thermal conditions, the skin surface temperature can rise above 39.0C, a level known to suppress tumor growth. Based on these findings, we conclude that some outdoor environments can allow superficial tumors to reach therapeutic temperature levels. This approach may offer patients a more convenient and economical way to support recovery.
Surviving in Hereditary Metastatic Lung Cancer
Metastatic lung cancer remains the leading cause of cancer-related mortality worldwide, despite advances in chemotherapy, targeted therapy, radiotherapy, and immunotherapy. Although modern oncologic treatments have improved symptom control and modestly prolonged survival, durable remission in advanced-stage cancer remains rare, and the underlying mechanisms of treatment resistance and spontaneous regression are still poorly understood. Conventional biomedical models primarily emphasize genetic mutations, molecular signaling pathways, and the tumor microenvironment, while largely overlooking potential spiritual and karmic dimensions of disease. This simplified framework may contribute to incomplete etiologic understanding and suboptimal therapeutic outcomes. We previously reported a case of complete remission in a patient with late-stage lung cancer who experienced a 37.5% loss of body weight and severe, generalized pain lasting 24 hours, without undergoing surgery, radiotherapy, or chemotherapy, following sustained practice of the Three Golden Buddhist Practices of the Guan Yin Citta Dharma Door. Here, we report another case of complete recovery from metastatic lung cancer in a patient with a strong familial cancer predisposition, achieved through sustained Buddhist practice after medical therapies failed. This case further supports a dual physical–spiritual model of cancer pathogenesis and suggests that integrative medical–spiritual approaches may offer complementary therapeutic potential for advanced malignancies, warranting further systematic investigation.
AI-Driven Advancements in Breast Cancer: Transforming Detection, Diagnosis, Treatment, and Monitoring
Artificial Intelligence (AI) is transforming the fight against breast cancer. It helps in early detection and accurate diagnosis through analysis of large volumes of medical data. It allows personalized treatments, optimizes radio-oncology, and contributes to the discovery of new drugs. AI-powered chatbots assist healthcare professionals with administrative tasks. Although it offers great promise, ethical challenges need to be addressed and ensure that it complements, not replaces, physicians. Multidisciplinary collaboration is key to harnessing its potential in today’s medicine.
Copyright (c) 2025 Journal of Oncology Research Reviews & Reports
Novel QRN Substance Effect of Non Small Cell Lung Cancer Cells
Quantification of cell viability and proliferation form the fundamental for numerous in vitro assays in response to external factors. An MTT assay is a colorimetric assay based on assessing the cell metabolic activity [1]. A549 Lung adenocarcinoma cell line was used to see the cytotoxic potential of a new drug for initial screening of apoptosis or necrosis. The biochemical mechanism behind the MTT assay involves NAD(P)H-dependent cellular oxidoreductase enzyme that converts the yellow tetrazolium MTT [3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide] into insoluble (E,Z)-5-(4,5-dimethylthiazol-2-yl)-1,3- diphenylformazan (formazan). The formed formazan can be dissolved with dimethyl sulfoxide (DMSO) to give a purple color with characteristic absorption at 540 nm. Intensity of purple color is directly proportional to the cell number and thus indicating the cell viability. We use MTT method evaluate QRN substance effect of A549 non-small cell lung cancer cell line.
Artificial Intelligence (AI) is revolutionizing cancer research, transforming the way we diagnose, treat, and predict disease outcomes. This talk explores the ongoing advancements in AI-driven oncology, highlighting breakthroughs in precision medicine, drug discovery, and patient care optimization. From AI-powered imaging and biomarker identification to machine learning models predicting treatment responses, these innovations are accelerating research timelines and improving patient outcomes. I will also discuss the integration of AI into clinical trials, streamlining data analysis and enhancing decision-making. While AI offers immense promise, challenges such as data privacy, bias, and regulatory hurdles remain critical considerations. By examining current progress, refining processes, and envisioning future predictions, this session aims to provide insights into the evolving role of AI in cancer research and its potential to reshape the landscape of oncology.
Children’s Intellectual Development and the Impact of Cancer
This presentation explores the complex aspects of intellectual development in children, emphasizing the interplay between cognitive growth and other developmental domains: physical, social, and emotional. It also outlines the critical stages of brain growth from infancy to early childhood, highlighting the significance of neural connections (synapses) in determining learning capacity. Moreover, it also discusses the crucial window of opportunity for brain development during the first ten years of life, highlighting the significance of environmental stimulation and proper nourishment. It further examines historical contributions to intelligence measurement, particularly through the works of Alfred Binet and David Wechsler, and the evolution of terminology surrounding mental handicaps. Additionally, the PowerPoint delves into Jean Piaget’s theory of cognitive development, detailing the four stages children typically progress through as they learn which are Sensorimotor, preoperational, concrete operational, and formal operational. A key focus is also placed on the negative impact of cancer treatments on cognitive functions in children, including long-term cognitive impairments referred to as “chemobrain” and how to manage these problems. Overall, this research highlights the critical factors influencing intellectual development in children and the lasting implications of early experiences on their cognitive abilities.
Rural HIV Negative Young Women Presenting with Advanced FIGO Stages (iii and iv) of Early Onset Cancer of the Cervix Compared to their Urban Counterparts in Western Kenya – A Case Study of Jaramogi Oginga Odinga Teaching and Referral Hospital?
Background: In many Low and middle income countries, most patients present with advanced cases of cervical cancer (Figo Stages III and IV). The factors contributing to this have been studied and reported as being due to health seeking behaviours, lack of screening services and late diagnosis among others. Objective: This study aimed to explore the increase in incidences of early onset advanced cervical cancer in young HIV Negative rural women, as compared to their urban counterparts presenting at the Oncology Clinic of the hospital. Methodology: A mixed method study was undertaken of purposively recruited HIV negative patients, aged 13-35 years, presenting with Cancer of the Cervix in the 2020-2021 period of study. Findings: The study found out that, in the period 2020-2021, most patients presented to the hospital with early onset advanced cancer of the cervix, and 39 (64%) were diagnosed at FIGO Stages III and IV, while just 22 (36%) were diagnosed at Stages I and II. Conclusion: Our conclusion is that apparently due to the early routine cancer of the cervix screening of young HIV positive women, cases are being diagnosed very early, in the pre-cancer and early stages, leading to early treatment and remission, in turn leading to the increased contribution of young HIV negative women with advanced cancer of the cervix.
Sound as Medicine to Treat Oncological Issues
This study evaluated a four-week, self-administered (pre-recorded frequencies) and specific physically administered sound intervention using instruments in cancer patients to enhance well-being. Among 73 participants, passive sound therapy showed significant improvements in fatigue, social functioning, and emotional responses, while both therapies reduced pain and stress. The sleep quality changes were noticed, anxiety levels reduced, medical interventions were well accepted and the findings confirm that sound interventions are safe, feasible, and beneficial for improving quality of life in oncology care, warranting further research for optimization. Overall, Sound as Medicine works complimentary with modern medicine to bring about holistic health and wellness in Oncological issues. Few documented case studies are also published in the book,” Power of Sound” authored by Dr. Sujata Singhi which were personally treated by her.
The Whole-Exon Gene Sequence Application in Clinical Rare Cancers
In our clinical working, the multiple primary cancer (MPC) in a single patient occurred increasingly. These patients always possessed particular histopathology, physiology, and clinical symptoms, implicating that the normal treatments might not be suitable for them. To explore the tumorigenesis and prognosis of MPC, we utilized the novel whole-exon gene sequence assay to detect potential mutative genes based on paraffine tumor species from two patients: one of them was diagnosed as thyroid collision tumor (TCT), the other was diagnosed as renal cancer, breast cancer and thyroid papillary cancer. The result showed that a total of 76 single nucleotide variants (SNV), 12 insertion and deletion variants (INDEL), and 99 copy number variations (CNV) were identified in TCT, while only PCMTD with the copy number variation (CNV) was associated with the MPC patient. In summary, these clustered special genes in MPC and TCT disease give us new sight to deeply understand the tumorigenesis and prognosis of rare malignant tumours of patients.
Additional, Supportive and Non-Conventional Approaches in Cancer Therapy: Biological Properties of Snail Slime and Other Natural Bioactive Compounds in Relation to Specific Cancer Types- A Literature Review
Background: Advances in oncology have significantly improved survival outcomes; however, cancer therapies remain associated with substantial adverse effects that impair patients’ quality of life. This has increased interest in evidence-based supportive and non-conventional approaches that complement standard oncological treatment. Objective: To review current scientific evidence regarding the biological properties of snail slime (snail mucus, snail secretion filtrate) and to evaluate its potential supportive applications across specific cancer types. Methods: A narrative literature review was conducted using PubMed, Scopus, and Web of Science. Peer-reviewed articles published in English up to 2025 were included, encompassing experimental, preclinical, and clinical studies. Results: Snail slime contains bioactive compounds such as allantoin, collagen, elastin, glycolic acid, antimicrobial peptides, and antioxidants. These components exhibit regenerative, anti-inflammatory, antioxidant, antifibrotic, and wound-healing properties. Tumor-specific anticancer evidence remains limited and largely preclinical, whereas supportive-care applications are biologically plausible and supported by experimental and clinical wound-healing data. Conclusions: Snail slime may serve as a supportive adjunct in oncology, particularly for managing treatment-related skin and tissue complications across multiple cancer types. There is no evidence supporting its use as a primary anticancer therapy. Further standardized and tumor-specific studies are required.
Profile of Patients with Central Nervous System Tumors - Highand Low Grade Gliomas Seeing Clinical and HistopathologicalCharacteristics in Public Oncological Hospital in Brazil
Introduction: The incidence of neoplasms affecting the Central Nervous System (CNS) has gradually increased worldwide. Malignant CNS neoplasia occupies the 11th position in terms of incidence in Brazil. Brain tumors and other primary CNS tumors are a heterogeneous group of malignant and non-malignant tumors, presenting different signs and symptoms, with variable prognoses. The incidence of brain tumor subtypes varies according to age, with children and adults developing different pathologies. This study aimed to characterize the epidemiological profile of adult patients with low- and high-grade gliomas in a single public health center in Brazil. Methods: This retrospective, descriptive, analytical, unicentric, quantitative cohort observational study (n = 110). The medical records of patients diagnosed with high- and low-grade gliomas from January/2017 to June/2023 were evaluated. Results: Multiform glioblastoma (GBM) was predominant (60%), followed by non-GBM high-grade gliomas (20,9%), and low-grade gliomas (19,1%). The predominant sex was male (66.4%). The age group with the highest incidence was 40-64 years (57,3%). Most patients with gliomas did not have relevant comorbidities (46,4%). Most patients were ECOG 1 (Performance Status Scale - 39,1%). Conclusion: In Brazil, epidemiological data related to malignant primary intracranial tumors are still scarce; therefore, publishing epidemiological data for this challenging pathology can improve the understanding of the disease and treatment of patients.
Pancreatic Cancer Therapeutics are we doing things Right?
Pancreatic adenocarcinoma (PDAC) is one of the most lethal cancers. Among su-pramesocolic cancers, PDAC carries the worst prognosis because early detection re-mains a difficult task. Many treatment regimens failed to show improvement in terms of OS and DFS. In this review, we try to focus on PDAC from a molecular perspective. We identified how the 10 hallmarks of cancer apply in PDAC. K-ras mutation (the setter) was the triggering factor for all of them. Moreover, G12D mutation is a crucial step for PDAC to occur. Since this gene has many downstream pathways (spikers), it’s hard to hope for an effective treatment for each downstream mutation. Therefore, further re-search is required to find therapeutic drugs to target this mutation, the K-ras G12D.
Dosimetry of Three-Dimensional Conformal Radiotherapy (3D-CRT) Versus Volumetric Modulated Arc Therapy (VMAT) in Hypopharyngeal Cancer
Objectives: IMRT or VMAT is the standard for curative treatment of hypopharyngeal carcinoma. In our setting, 3D-CRT is widely used due to limited IMRT availability. This study aimed to compare dosimetry between these techniques. Methods: A retrospective, bicentric study included 30 patients with hypopharyngeal squamous cell carcinoma (15 3D-CRT, 15 VMAT). Prescribed doses were 70 Gy/35 fractions for 3D-CRT and 64–70 Gy for VMAT. Target volumes and organs at risk were analyzed per ICRU 50 standards. Results: PTV coverage at V95% was comparable. VMAT reduced hot spots (V107%: 0.10% vs 47.46%, p < 0.001) and improved dose homogeneity (HI: 0.08 vs 0.81, p < 0.001). VMAT also lowered spinal cord maximum dose (40.85 vs 47.40 Gy, p < 0.001) and parotid mean doses (left: 28.12 vs 38.01 Gy, right: 28.27 vs 38.57 Gy; p < 0.05). Conclusion: In resource-limited settings, 3D-CRT ensures adequate tumor coverage. VMAT provides better dose homogeneity and spares organs at risk, potentially reducing toxicity and improving quality of life.
Dosimetric and Clinical Outcomes of Volumetric Modulated ArcTherapy for Prostate Cancer
Objectives: To evaluate the dosimetric aspects through dose coverage and tolerance as well as the clinical outcomes of radiation therapy for prostate cancer by a technique of Volumetric Modulated Arc Therapy (VMAT). Methodology: This is a retrospective study of 71 patients treated for prostate cancer consecutively at the International Cancer Center of Dakar (CICD) from July 2020 to December 2023. All patients received radiation therapy in intensity modulation by VMAT technique. The diagnostic data, treatment information including dosimetric and results were collected and analyzed. Results: The average age was 68.9 ± 6.1 years. The circumstance of discovery was fortuitous by PSA assay in 42.3% and symptomatic in 57.7% of cases. The median initial PSA level was 20 ng/ml (3.7–662). Adenocarcinoma was the histological type in all patients. Pelvic node involvement was found in 12.6% of patients and 5.6% were metastatic. For localized forms, high risk was predominant (49.3%). First-line radiotherapy was performed in 94.4% of cases. The average doses of the D95% and Dmax of the high-risk forecast target volume were 70.69 ± 5.2Gy and 77.06 ± 5.88Gy, respectively. All dose constraints have been met on the target volumes and organs at risk. No Grade 3 acute toxicity was observed. With a median follow-up of 20.67 months, the overall survival (OS) and biochemical relapse-free survival (BFS) rates at 2 years were 98.6% and 92.9%, respectively. Conclusion: Radiotherapy occupies a prominent place in the treatment of prostate cancer. New techniques by intensity modulation allow better oncological results and improve the tolerance of treatments.
High Dose Rate Intracavitary Brachytherapy in Locally Advanced Cervical Cancer: A Retrospective Serie Analysis
Introduction: The treatment of locally advanced cervical cancer is based on radio chemotherapy followed by brachytherapy. The aim of this study was to evaluate the tolerance and efficacy of image-guided high dose rate (HDR) intracavitarybrachytherapy in a context of limited resources. Materials and Methods: The clinical and dosimetric data of 60 patients with locally advanced cervical carcinoma treated by concomitant radio-chemotherapy (RCC) follow-up of brachytherapy between January 2019 and December 2023 at the CHU Dalal Jamm in Dakar were retrospectively analyzed. The toxicities of brachytherapy had been evaluated according to the Common Terminology Criteria for Adverse Events V4.0 (CTCAE) criteria. Estimates of overall survival and recurrence-free survival rates were analyzed by the Kaplan-Meier method, comparisons were made with the log-rank test and the cox model, with a 95% confidence interval. The statistical analyses were carried out using SPSS software in version 21. Results: The average age was 53.8 ± 11.8 years. All patients had locally advanced tumors with FIGO stages IIB and IIIC1 respectively predominant 37.1% each. The median time from completion of external irradiation to brachytherapy was 28 days [0–124]. The dosimetry was in 3D for all patients. The average dose delivered at the high risk CTV (D90) was 82.2 Gy and 71.7 Gy at the low risk CTV. The D2cc (minimum dose received by the most irradiated 2 cm3) were 79.5 Gy for the bladder, 72.1 Gy for the rectum, 55.4 Gy for the sigmoid and 60.1 Gy for the small intestine. The main toxicities of brachytherapy were digestive (16.7%) and genitourinary (33.3%) all grades combined. With a median follow-up of 19.5 months, the evolution was marked by 12 locoregional recurrences (21.4%), 8 metastatic relapses (14.5%) and 6 deaths (10%). Overall survival and local relapse-free survival rates were 76.6% and 64.5% at 3 years, respectively. Conclusion: Brachytherapy is essential in the optimal management of cervix cancer in advanced stages. Our institutional experience shows that it allows good local control and better overall survival. Interstitial brachytherapy could further improves these results in our context where tumors are advanced to diagnosis.
Survival Outcomes in Ovarian and Uterine Cancer Patients Receiving Neoadjuvant Chemotherapy: A Retrospective Comparison of Inpatient Versus Outpatient Settings
Objectives: Chemotherapy administration has largely shifted from inpatient to outpatient settings, offering benefits like increased patient comfort, fewer hospitalizations, and reduced costs. However, inpatient care remains crucial for patients needing direct observation, intensive side effect management, or those with significant medical comorbidities. Despite clinicians using their judgment and available guidelines to determine the best treatment setting, there's a notable scarcity of literature on outcomes between these settings, especially within gynecologic oncology. This study aimed to evaluate the survival differences of patients with endometrial and ovarian cancer who received neoadjuvant chemotherapy (NACT) in either outpatient or inpatient settings. Methods: We identified and reviewed charts for 146 endometrial or ovarian cancer patients treated with NACT at Montefiore Medical Center between 2010 and 2023. This cohort comprised 47 patients in the inpatient group and 99 in the outpatient group. Results: Our findings indicated that the inpatient group had a higher mean ECOG performance status, received fewer chemotherapy cycles, and were less likely to undergo surgery. While initial analysis suggested poorer survival for the inpatient group (p = 0.019), this difference became statistically insignificant after controlling for various confounders. Conclusions: Despite initial indications of poorer outcomes for inpatient NACT, this difference was not statistically significant once confounding factors were addressed. These results provide important reassurance that inpatient chemotherapy, when clinically indicated, does not lead to inferior oncologic outcomes. Further research is essential to better understand optimal chemotherapy delivery and to identify and address obstacles to patient care.
Introduction: Squamous cell carcinoma is the second most common skin cancer, ranking behind basal cell carcinoma. Its incidence is approximately 20–25% of that of basal cell carcinoma. Squamous cell cancer arising in injured areas have a high propensity for metastases and local recurrence. Treatment options for squamous cell carcinoma are generally divided into excisional therapies and superficial ablative therapies. Tumor location, size, depth of invasion, and histologic differentiation affect treatment choices. All patients with squamous cell cancer require close follow-up to monitor for local recurrence and metastases. The chance of developing a second skin cancer within 5 years after treatment of the original basal cell or squamous cell cancers as high as 50%. Objective To assess the relation between the degree of the burn and skin squamous cell carcinoma cancer. To assess the latent period between burn and the developed skin squamous cell carcinoma cancer. To assess the incidence of metastasis from skin squamous cell carcinoma after burn, and the mostly site of metastasis. Materials and Methods: During the study period, fifty patients were targeted from 2200 burn patient who get skin cancer after burn. who were admitted to Al- Amal Oncology Center, Taiz, Yemen, between June 2014 and May 2017. Patients were eligible for inclusion (Any patient of any age and any gender, who had skin cancer after burn), for an descriptive cross-sectional. excluded based on the presence of synochronouse/ metachronous cancer. The statistical analysis was performed using SPSS (statistical package for social science), version 25. Data exhibited in figures and tables and summarized as percentages, frequencies, means and standard deviations. Results: 50 patients who have SCC from 2200 burn patients examined retrospectively. The number of SCC developing on burn scars among the 2200 burn cases was 50 (2.3%), The mean age was 45 ± 15.5 years, The highest percentage of patients ages was 50% and it was for the age group from 41 to 60 years. Forty-one of fifty SCCs cases with a percentage of 82% had suffered from third degree burns. Thirty of fifty SCCs cases with the percentage 60%, had 5- 10 years as latent Period between burn and carcinoma development. Twenty-nine of fifty SCCs cases with percentage of (58%) did not have metastasis, followed by 21 (42%) had a metastasis. And lung is the most common site of metastasis with about 10 (46%).
Surgical Treatment of Giant Hepatic Hemangioma in a Patient with Congenital Thoracic Scoliosis: A Case Report
Background: Hepatic Hemangioma (HH) is the most common benign primary hepatic neoplasm, which is usually asymptomatic and does not require intervention. The definition of a Giant HH is an HH with a size of more than 5 cm and symptomatic abdominal pain due to compression of adjacent organs. In this study, we report a rare case of giant HH in a young woman with congenital thoracic scoliosis, successfully treated via primary surgical resection guided by three-dimensional (3D) simulation. Case Report: We present the case of a 30-year-old woman who complained of various gastrointestinal symptoms occurring 4 months after the delivery of her second child. A series of examinations was done, which revealed two giant hemangiomas. The patient was planned for surgery, and the tumors were successfully resected. The patient was discharged after eight days of hospitalization without any severe complications. Conclusions: Giant HH patient with congenital thoracic scoliosis has not been reported in previous studies, we suggest that patients with giant HH should undergo surgical treatment when the diagnosis is made to reduce symptoms and prevent the risk of traumatic or iatrogenic rupture and this operation is not affected by her thoracic scoliosis. But we should make a detailed plan before surgery to performed liver resection.
Fatal Outcome in Lung Cancer with Rare Nasal Metastatic Spread:A Clinical Perspective
Cutaneous metastases to the nose are a rare manifestation of metastatic squamous cell carcinoma (SCC) of the lung. These metastases can present as either solitary or multiple lesions on the skin, and they may appear either fixed or mobile. Reports of cutaneous metastases from lung cancer specifically affecting the nose occur in 1-12% of cases [1]. In some instances, these cutaneous metastases can be the first indication of an underlying solid epithelial malignancy, often associated with a poor prognosis [2]. When these metastases occur on the nasal tip, they are sometimes referred to as “clown nose” due to their resemblance to a red, fake nose.
Radiopharmaceuticals and Theranostics: The High Road Ahead
Radiopharmaceuticals and Theranostics are transforming the medical landscape by offering precise, targeted diagnostic and therapeutic solutions. Implementing a successful radiopharmaceutical program in any institutional practice or trial setting requires meticulous planning across several domains and seamless integration with oncology workflows for timely and accurate patient care. This article explores the landscape, applications, regulatory considerations, infrastructural and operational requirements along with future directions for expanding these therapies into clinical settings.
From War to Compassion-A New Paradigm in Understanding Cancer
For decades, the prevailing narrative around cancer has been framed as a war a relentless battle between medicine and malignant cells. We speak of “fighting cancer,” “killing tumors,” and “defeating the disease,” projecting onto it an identity of hostility and invasion. While this language has served to mobilize research and treatment efforts, it may have also blinded us to a more profound and compassionate understanding of the biological and energetic nature of cancer.
A Rare Case of Non-Hodgkin Lymphoma Presenting as Chronic Nasolacrimal Duct Obstruction
Leukemic infiltration of the optic nerve is a rare but serious complication of hematologic malignancies, often leading to visual impairment. It can present with symptoms such as diplopia, vision loss, and proptosis, sometimes mimicking common ophthalmologic conditions like nasolacrimal duct obstruction. Due to its rarity, it is often misdiagnosed, delaying appropriate treatment.
Case Report: Hyperacute GVHD Presenting Solely with Genital Erosion in a 17-Year-Old Female
We report a case of a 17-year-old Saudi female who developed hyperacute graft-versus-host disease (GVHD) presenting primarily with genital erosions. While genital GVHD has been documented in the literature, this case is unique as it presents with genital lesions as the primary and sole manifestation. We hope this report sheds light on other cases that might be underreported and emphasizes the importance of considering genital GVHD in similar patients.
Comparison of Arccheck and Portal Dosimetry in dose Verification for Intensity Modulated Radiotherapy (IMRT) and Rapidarc Plans
This study compares Portal Dosimetry with the ArcCheck phantom for patient-specific QA of RapidArc and IMRT plans. The Electronic Portal Imaging Device (EPID) from Varian and the Eclipse Treatment Planning System (TPS) were used for portal dosimetry, while the ArcCheck cylindrical phantom from Sun Nuclear was used for phantom studies. Eclipse-TPS facilitated RapidArc and dynamic IMRT treatment planning and portal dosimetry (PD) for planar dose calculations. Two verification plans were created for each of the 12 patient plans, totaling 24 arcs delivered on two QA systems. The 12 plans, each with two arcs, were delivered on the EPID of the Varian TrueBeam Linac and the ArcCheck phantom. Planar dose matrices were analyzed using the global Gamma Index criteria of 2mm DTA and 2% dose difference. Measurements were performed using the Varian TrueBeam Linac mounted EPID (aS1200) with Portal dosimetry and the ArcCheck phantom with its software. The QA results from both methods were evaluated and compared. The maximum deviations of dose points (γ>1) were 2.9% and 2.2 CU in the ArcCheck phantom and Portal dosimetry, respectively. Mean and standard deviation values were lower in portal dosimetry than in phantom studies, attributed to the closely embedded chambers in the EPID compared to the detector spacing in the phantom. Both dosimetric QA systems are suitable for patient-specific QA of RapidArc or VMAT and IMRT treatments. With a 2%/2mm criterion, the average γ passing rates were over 98% for PD and over 95% for ArcCheck, with PD showing slightly higher consistency.
Copyright (c) 2024 Journal of Oncology Research Reviews & Reports
Improving the Aqueous Solubility of Taxol Through Altering XLogP3
Taxol (generic name paclitaxel) is an antineoplastic drug used to treat breast, lung, and ovarian cancer. It performs exceptionally well against a wide variety of tumors, including B16 melanoma, L1210 and P388 leukemias, MX-1 mammary tumor, and CX-1 colon tumor xenografts. However, despite Taxol’s efficacy in antitumor activity, its aqueous solubility is extremely poor, decreasing its bioavailability and making it difficult for the body to absorb. The objective of this study is to improve the solubility of taxol, thus increasing the bioavailability of the drug in preventing cancer. By modifying the structure of taxol, four novel taxol derivatives were created with improved solubilities. Two of the derivatives were given an additional hydrogen donor and acceptor, and thus showed a pronounced positive change in solubility. The results of this work solve the issue of Taxol’s inadequate solubility and show potential in increasing absorption of the drug.
Giant Bilateral Adrenal Leiomyoma Case Report
Introduction: Adrenal leiomyoma is extremely rare and is thought to arise from the smooth muscle wall of the central adrenal vein and its branches; Clinically they may present as abdominal pain or flank pain. These tumors generally have a low biological potential. The surgical indication for adrenal tumors is based mainly on functionality and the risk of malignancy. Clinical Case: 39-year-old male, with no significant history. Who comes to the general surgery outpatient clinic due to the presence of progressive abdominal distension and long-term abdominal pain. An abdominopelvic CT scan was performed, which revealed bilateral, well-circumscribed tumor with heterogeneous characteristics located in the left and right adrenal area, negative functional tests. An exploratory laparotomy was performed, revealing two giant adrenal tumors, definitive study reporting bilateral adrenal leiomyoma. Conclusion: We present a rare case of bilateral primary adrenal leiomyoma of which no similar case was found in the reviewed literature. These tumors are very difficult to diagnose preoperatively. as they are often not counted in adrenal samples and clinical suspicion is very low. As a result, they are diagnosed postoperatively after pathological examination of the surgical specimen. At the moment, early and complete surgical resection is the main treatment.
Can Osmolytes TMAO and Glycerol Rescue Destabilized Temperature-Sensitive Mutants of P53?
Some 30-40% of oncogenic mutants of p53 are inactive because of low stability. Stabilization of such mutants is one route for novel anti-cancer drugs. The osmolytes glycerol and trimethylamine N-oxide stabilize all proteins by a combination of effects on solvent water and by direct interactions with proteins. It has been reported that protein instability defects in temperature-sensitive p53 mutants can be rescued in cell lines by the addition of low concentrations of those compounds. We measured the effects of glycerol and trimethylamine N-oxide on the thermal and kinetic stability of wild-type p53 and temperaturesensitive mutants in vitro and found that there were just negligible increases in stability at the concentrations reportedly used in cell lines. We found no rescue of mutants in H1299 cell lines at those reported concentrations. There was some stabilization at higher concentrations of glycerol and trimethylamine N-oxide in vitro but these concentrations were toxic to the cells. It would seem unlikely that the use of general osmloytes would be an effective strategy for the rescue of unstable mutants because even if they were effective at stabilizing p53, they would alter the proteostasis of the cell.