Journal of Surgery & Anesthesia Research
type: channel
description: Journal of Surgery & Anesthesia Research is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Surgery & Anesthesia. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Article acceptance will be in the form of research, review, case reports, analysis, magazines, editorials, opinion, communications, mini-review, short communications, picturized, book review, video type and power point presentations (PPTS). Articles can be submitted through online from https://srcpublishers.com/surgery-anesthesia-research/user/register or can send through an e-mail with attachment for surgerysciences@onlinescientificresearch.info 1.5* Impact Factor 84.5% Citations 90% Acceptance
publisher: Scientific Research and Community
language: en
publication name: Journal of Surgery & Anesthesia Research
issn: 2755-015X
items: Refractory Chronic Abdominal Pain: An Unusual Manifestationof Superior Mesenteric Artery Thrombosis
items: Extra-Uterine Hydatidiform Mole: A Case Report
items: Transesophageal Echocardiography, A Rescue Imaging for Intraoperative Assessment of Posterior Left Ventricular Aneurysms-A Case Report
items: Development of Gender- and Age-Specific Ponderal Index (PI)Percentile Curves Using Quantile Regression (QR) in Pakistan
items: Febrile Atrioventricular Block Revealing a Trigone Abscess: A Misleading Presentation of Mitral Endocarditis
items: Metastatic Urothelial Carcinoma of Occult Primary Origin Revealed by a Necrotic Inguinal Lymph Node: A Rare Case Report
items: Continuous Lumbosacral Plexus Blocks for Hip and Femur Surgery Analgesia in Elderly Patients Using a Neurostimulator. A Retrospective Study Comparing Psoas and Inguinal Compartment Access
items: Giant Mesenteric Cyst and Ventral Hernia with Loss of Domain: Combined Approach
items: Ultrasound-Guided Airway Assessment in Obese Patients Undergoing Bariatric Surgery a Randomized Clinical Trial
items: Regional Anesthesia and Sedation. Monitoring with Oximetry and Capnography Increases Patient Safety During Procedure
items: Seconds to React: Life-Threatening Rocuronium Anaphylaxis in a High-Risk Bariatric Candidate
items: Surgical Treatment of Rhinophyma : About a Case and Literature Review
items: Safety in Spinal Anesthesia from Asepsis and Antisepsis to Total Recovery from Block
items: Nursing Care During Sleeve Gastrectomy
items: Retrospective Analysis of Clinical Characteristics, Treatment Outcomes and Risk Factors in Appendicitis and Typhlitis
items: Letter to the Editor: Advances and Challenges in Gastric Cancer Research
items: Clinical Characteristics, Treatment Outcomes, and Risk Factors for Complications in Ulcerative Colitis
items: Unraveling the Complexity of Gastric Cancer through TCGA Subtypes
items: Retrospective Analysis of Risk Factors for Complications and Treatment Outcomes in Adult Appendicitis: A Single-Center Study
items: Cellular Autophagy and Primary Liver Cancer Research Progress
items: Retrospective Analysis of Clinical Characteristics, Treatment Outcomes and Risk Factors for Complications in Appendicitis Patients
items: Oxidative Stress-Induced ADAR1/2 Dysfunction Promotes Hepatocellular Carcinoma Cell Damage via Redox Imbalance
items: Clinicopathological Features and Prognostic Factors in Colorectal Cancer
items: RNA Adenosine Deaminases Modulate Oxidative Stress-Mediated Hepatocellular Carcinoma Cell Damage via KEAP1/Nrf2 Axis
items: Retrospective Analysis of Clinical Characteristics, Treatment Outcomes, and Prognostic Factors in Hepatocellular Carcinoma Patients
items: Low-Temperature Plasma Reduces the Risk of Abdominal Infection in Hepatocellular Carcinoma Patients
items: Retrospective Analysis of Clinical Characteristics Treatment Outcomes and Risk Factors in Appendicitis and Colitis
items: RBPs Related to The Metastatic Process of Hepatocellular Carcinoma
items: Serum Claudin-18.2 Expression and Gut Microbiota Dysregulation in Hepatocellular Carcinoma: Correlation with Immune Checkpoint Inhibitor Response
items: ACTG1 Inhibits PI3K/Akt Signaling Pathway to Promote Apoptosis in Gastric Cancer Cells Through Modulating Phosphatidylinositol3-Kinase Regulatory Subunits

Refractory Chronic Abdominal Pain: An Unusual Manifestationof Superior Mesenteric Artery Thrombosis
type: item
description: Mesenteric ischemia is an uncommon but potentially life-threatening condition, associated with high morbidity and mortality when diagnosis is delayed. Thrombosis of the Superior Mesenteric Artery (SMA) is one of the main causes of arterial mesenteric ischemia and is typically characterized by sudden onset of severe abdominal pain. However, in selected cases, particularly when the obstruction is partial or develops progressively, the clinical presentation may be insidious, mimicking more common gastrointestinal disorders. Chronic postprandial abdominal pain, progressive weight loss, nausea, vomiting, and intolerance to oral intake are typical features of chronic or subacute mesenteric ischemia. The coexistence of dyspeptic symptoms or upper gastrointestinal bleeding may further obscure the diagnosis and lead to delays in appropriate management. Contrast-enhanced computed tomography currently represents the diagnostic modality of choice, allowing early detection of vascular involvement before the development of irreversible intestinal ischemia. We report a case of partial mural thrombosis of the superior mesenteric artery presenting as chronic epigastric pain and upper gastrointestinal bleeding, highlighting the diagnostic challenges and the importance of considering vascular etiologies in patients with refractory abdominal symptoms.
subject: Articles
  topic: section
subject: Superior Mesenteric Artery Thrombosis
  topic: keywords
subject: Mesenteric Ischemia
  topic: keywords
subject: Chronic Abdominal Pain
  topic: keywords
subject: Gastrointestinal Bleeding
  topic: keywords
creator: Roun Kim Kim
creator: Víctor Raúl Luraschi Centurión
creator: Montserrat Almada Ruiz Diaz
creator: Victor Daniel Orue Mequer
creator: Jorge Oscar Benitez Ramos
creator: Héctor Daniel Del Puerto Peula
rights: Copyright (c) 2026 Journal of Surgery & Anesthesia Research
date: 2026-07-23
publication date: 2026-07-23
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2026(7)268

Extra-Uterine Hydatidiform Mole: A Case Report
type: item
description: The extra-uterine Hydatidiform Mole (MH) is an extremely rare condition, with only about twenty cases reported in the literature, primarily located in the fallopian tubes or ovaries. We report here the case of a 30-year-old patient, nulligravida and nulliparous, who presented to the emergency department with clinical signs suggestive of a ruptured c (EP). Clinical examination and imaging confirmed the presence of a mass in the right fallopian tube with significant hemoperitoneum, necessitating emergency surgical intervention. The patient underwent a salpingectomy, and histopathological analysis revealed a partial mole. This case highlights the rarity and diagnostic complexity of extra-uterine MH, which requires prompt management and rigorous monitoring of βHCG levels to ensure complete remission. Chemotherapy is reserved for cases with malignant progression.
subject: Articles
  topic: section
subject: pregnancy
  topic: keywords
subject: specimen
  topic: keywords
subject: Ectopic
  topic: keywords
creator: Oumaima Fakir
creator: Amina El Alami
creator: Hanaa Lazhar
creator: Aziz Slaoui
creator: Aziz Baydada
rights: Copyright (c) 2026 Journal of Surgery & Anesthesia Research
date: 2026-06-16
publication date: 2026-06-16
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2026(7)264

Transesophageal Echocardiography, A Rescue Imaging for Intraoperative Assessment of Posterior Left Ventricular Aneurysms-A Case Report
type: item
description: Transesophageal echocardiographic visualization of left ventricular posterior aneurysms serves as a valuable tool intraoperatively in guiding management. We present a case of a 71-year-old male who presented with left ventricular pseudoaneurysm of infero-basal and posterior wall which underwent a patch closure. This paper emphasises the importance of transesophageal echocardiography in visualizing heart structures especially posterior.
subject: Articles
  topic: section
subject: Left Ventricular Aneurysm
  topic: keywords
subject: Transesophageal Echocardiography
  topic: keywords
subject: Ventricular Pseudoaneurysms
  topic: keywords
creator: Aishwarya Ghosh
creator: Shiv Kumar Choudhary
creator: Devesh Dutta
creator: Sunil Dhole
rights: Copyright (c) 2026 Journal of Surgery & Anesthesia Research
date: 2026-05-12
publication date: 2026-05-12
starting page: 1
ending page: 2
doi: 10.47363/vvxzjm59

Development of Gender- and Age-Specific Ponderal Index (PI)Percentile Curves Using Quantile Regression (QR) in Pakistan
type: item
description: Background: Accurate assessment of human growth and nutritional status is critical for early detection of malnutrition, over nutrition, and metabolic disorders. Traditional anthropometric indices such as Body Mass Index (BMI) have recognized limitations, particularly in pediatric and ethnically diverse populations, necessitating the development of more sensitive and population-specific measures. The Ponderal Index (PI), which normalizes body mass relative to height cubed, offers a potentially superior metric for evaluating proportionality, especially in neonates and children. However, population specific growth references for PI are lacking in Pakistan, where unique growth patterns influenced by genetic, environmental, and socioeconomic factors prevail. Objectives: This study aims to develop gender- and age-specific percentile reference curves for PI in the Pakistani population utilizing advanced statistical modelling techniques, specifically quantile regression, to accurately characterize the distributional properties across the lifespan. The primary objectives include establishing normative standards, comparing the performance of different percentile estimation methods, and validating the utility of PI as a growth and health risk indicator. Methods: A cross-sectional, nationally representative sample of approximately 10,000 apparently healthy Pakistani individuals aged 2 years to over 60 years was recruited via multistage stratified random sampling across diverse geographic, socioeconomic, and ethnic strata. Anthropometric measurements including weight and height were obtained following standardized protocols, and PI was calculated as body weight (kg) divided by height (m) cubed. Data quality assurance involved double data entry, validation, and outlier management. Descriptive analyses characterized the distribution of PI across subgroups. Separate gender-specific quantile regression models were fitted for key percentiles (5th, 10th, 25th, 50th, 75th, 85th, 90th, …
subject: Articles
  topic: section
subject: Ponderal Index
  topic: keywords
subject: Growth Standards
  topic: keywords
subject: Quantile Regression
  topic: keywords
subject: Anthropometric Percentiles
  topic: keywords
subject: Pediatric Nutrition
  topic: keywords
subject: Population Specific Norms
  topic: keywords
creator: Waqas Ghulam Hussain
rights: Copyright (c) 2026 Journal of Surgery & Anesthesia Research
date: 2026-04-30
publication date: 2026-04-30
starting page: 1
ending page: 11
doi: 10.47363/2026(7)262

Febrile Atrioventricular Block Revealing a Trigone Abscess: A Misleading Presentation of Mitral Endocarditis
type: item
description: Introduction: Infective Endocarditis (IE) is a life-threatening infection, often affecting damaged valves but occasionally occurring in patients without known cardiac history. Atypical presentations may delay diagnosis. Observation: We present the case of a 68-year-old man with no known heart disease, admitted for respiratory symptoms. Initial work-up suggested pneumonia. Persistent fever and symptomatic bradycardia revealed a high-grade Atrioventricular Block (AVB). Echocardiography identified mitral valve vegetation. Transesophageal echocardiography confirmed an aorto-mitral trigonal abscess. Discussion: Perivalvular abscesses, especially in the aorto-mitral region, are severe IE complications and frequently cause conduction disorders. AVB should prompt urgent evaluation with transesophageal echocardiography. Despite appropriate antibiotics and urgent surgery (mitral valve replacement, abscess drainage, pacing), the patient died from septic shock and multiorgan failure. Conclusion: This case emphasizes the need for high suspicion of IE in atypical presentations. Early imaging, multidisciplinary management, and timely surgery are key to improving outcomes in complicated IE.
subject: Articles
  topic: section
subject: Atrioventricular
  topic: keywords
subject: Mitral Endocarditis
  topic: keywords
creator: Maha Bouziane
creator: Sara Anwar
creator: Zineb Amine
creator: Abdenasser Drighil
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-11-15
publication date: 2025-11-15
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2025(6)254

Metastatic Urothelial Carcinoma of Occult Primary Origin Revealed by a Necrotic Inguinal Lymph Node: A Rare Case Report
type: item
description: Introduction: Occult primary urothelial carcinoma is an extremely rare entity that may present as isolated lymph node involvement without visible bladder or ureteral lesions, making diagnosis particularly challenging. Case Presentation: We report the case of a 91-year-old man presenting with a left inguinal swelling evolving over four years. Examination revealed a necrotic, f istulized mass with no urothelial lesions on cystoscopy. Biopsy showed a poorly differentiated carcinoma (CK7+/CK20+/p63+/p40+/GATA3−), initially suggesting squamous differentiation, but the lymphatic distribution and suspicious ureteral thickening supported an occult urothelial origin. A multidisciplinary management approach was undertaken. Systemic chemotherapy was not initiated due to age and comorbidities. Local wound care and antibiotic therapy led to partial improvement and clinical stabilization without visceral progression. is exceedingly rare. Discussion: This case illustrates the diagnostic complexity of dedifferentiated urothelial carcinomas with atypical immunohistochemical profiles. Loss of GATA3 expression, though uncommon, does not exclude urothelial origin, especially in high-grade tumors. Presentation as isolated inguinal lymphadenopathy Conclusion: Diagnosis of occult urothelial carcinoma requires multidisciplinary collaboration and careful integration of clinical, radiological, and pathological data. In elderly or frail patients, a conservative, symptom-oriented approach is often the most appropriate. Reporting such rare cases is essential to improve understanding of the atypical presentations and dissemination pathways of urothelial carcinoma.
subject: Articles
  topic: section
subject: Urothelial Carcinoma
  topic: keywords
subject: Occult Primary
  topic: keywords
subject: Inguinal Lymphadenopathy
  topic: keywords
subject: GATA3
  topic: keywords
subject: Immunohistochemistry
  topic: keywords
subject: Case Report
  topic: keywords
creator: Bjane O Bjane O
creator: Debbagh A Debbagh A
creator: Dakir M Dakir M
creator: Moataz A Moataz A
creator: Kbiro A Kbiro A
creator: Deghdagh Y Deghdagh Y
creator: El Badr M
creator: Tmiri A Tmiri A
creator: Taïbou T Taïbou T
creator: Aboutaieb R Aboutaieb R
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-11-07
publication date: 2025-11-07
doi: 10.47363/JSAR/2025(6)252

Continuous Lumbosacral Plexus Blocks for Hip and Femur Surgery Analgesia in Elderly Patients Using a Neurostimulator. A Retrospective Study Comparing Psoas and Inguinal Compartment Access
type: item
description: Background: Lumbar plexus block has been used effectively as an anesthetic technique for anesthesia and analgesia in elderly patients with femur and hip fractures. Access to the lumbar plexus can be achieved via a posterior approach (within the psoas compartment) or an anterior approach (in the inguinal compartment), with single short administration or continuous infusion of local anesthetic. The aim of this retrospective study was to compare the analgesic efficacy of an elastomeric pump in two access points, identified by neurostimulation, and its complications. Method: This study was recorded in an Excel spreadsheet from July 2010 to February 2019, including 100 patients over the age of 60 years old who underwent corrective surgery for femur or hip fractures underwent continuous lumbar plexus block for postoperative analgesia. An elastomeric pump was used with 400 ml of 0.1% levobupivacaine excess of enantiomeric solution, at a flow rate of 10 ml/hour. A pain scale (grades 0 to 3) was used, assessed in the anterior thigh region at 4, 8, 12, 16, 20, 24, 30, and 40 hours. Results: There was a predominance of females (77%) compared to males (23%). Access to both compartments was achieved with neurostimulation and catheter placement, successfully in all 100 patients. No complications occurred. The best analgesic outcome was obtained with the psoas compartment. T here was no bacterial growth upon catheter removal. Conclusion: The retrospective study showed that there was significant difference, the quality of analgesia is better with the catheter installed in the psoas compartment compared to inguinal access. In both approaches, there were no postoperative complications.
subject: Articles
  topic: section
subject: Continuous Lumbar Plexus
  topic: keywords
subject: Psoas Compartment
  topic: keywords
subject: Inguinal Compartment
  topic: keywords
subject: Orthopedic Surgery
  topic: keywords
subject: Local Anesthetic
  topic: keywords
subject: Infusion Pumps
  topic: keywords
subject: Spinal Anesthesia
  topic: keywords
creator: Luiz Eduardo Imbelloni
creator: Anna Lúcia Calaça Rivoli
creator: Sylvio Valença de Lemos Neto
creator: Ana Cristina Pinho
creator: Antonio Fernando Carneiro
creator: Felipe Bufaiçal Rassi Carneiro
creator: Geraldo Borges de Morais Filho
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-11-25
publication date: 2025-11-25
starting page: 1
ending page: 6
doi: 10.47363/JSAR/2025(6)255

Giant Mesenteric Cyst and Ventral Hernia with Loss of Domain: Combined Approach
type: item
description: Mesenteric cysts are extremely rare benign intra-abdominal tumors (1:100,000–250,000 hospital admissions). Recurrence after complete surgical resection is uncommon (0–13%), and massive recurrence more than three decades later constitutes an exceptional event. We present the case of a 59-year-old female patient with recurrence of a mesenteric cyst 33 years after the initial resection, associated with a giant ventral hernia with loss of domain (Tanaka Index 28%) and symptomatic cholelithiasis, successfully treated with a combined single-stage surgical approach.
subject: Articles
  topic: section
subject: Mesenteric Cyst
  topic: keywords
subject: Late Recurrence
  topic: keywords
subject: Incisional Hernia
  topic: keywords
subject: Loss of Domain
  topic: keywords
subject: Tanaka Index
  topic: keywords
subject: Rives Stoppa Technique
  topic: keywords
creator: Roun Kim
creator: Víctor Raúl Luraschi Centurión
creator: Pedro E Martinez S
creator: Oscar Benitez
creator: Blas Antonio Romero Dure
creator: Leticia Noemí Santacruz Benítez
rights: Copyright (c) 2026 Journal of Surgery & Anesthesia Research
date: 2026-03-21
publication date: 2026-03-21
starting page: 1
ending page: 4
doi: 10.47363/JSAR/2026(7)261

Ultrasound-Guided Airway Assessment in Obese Patients Undergoing Bariatric Surgery a Randomized Clinical Trial
type: item
description: Introduction: Anesthetic planning for obese patients must be effective to avoid unexpected adverse events. The introduction of ultrasound (USG) in medicine has made it possible to identify, assess, and predict the possibility of Difficult Airway (DA). Objective: To evaluate whether ultrasound parameters can be predictors of DA in the obese patient population. Furthermore, to establish correlations between traditional DA indicators and the parameters obtained by ultrasound, with the goal of verifying the agreement and accuracy between the methods. Method: A randomized clinical trial compared the assessment of already validated clinical indicators for predicting DA and USG parameters defined after a literature review. Results: 132 individuals were randomized, subdivided into 66 patients in the conventional airway assessment group and 53 patients in the conventional airway assessment + USG group. The evaluation of basic patient characteristics in the USG and conventional groups showed that both groups were homogeneous in terms of weight (114.3 ± 16.9 kg vs. 116.9 ± 23.8 kg, p: 0.51), height (165.6 ± 8.0 cm vs. 166.3 ± 8.9 cm, p: 0.66), and body mass index (BMI) (41.7 ± 5.7 vs. 42.0 ± 6.6, p: 0.76). USG evaluation of the airway showed that the skin-epiglottis distance (SED) was < 2.7 cm in 73.3% of patients in the USG group, and the skin-hyoid distance (SHD) was < 1.41 cm in 60.4%. The primary outcome was the occurrence of Difficult Intubation (DI), which was significantly higher in the USG group (18.9%) compared to the conventional group (4.5%, p: 0.01). There was no significant difference in the use of a videolaryngoscope (22.6% in the USG group vs. 16.7% in the conventional group, p: 0.42) or intubation-related complications. Conclusion: The integration of USG proved advantageous in clinical practice for airway assessment, reducing the incidence of intubation-related complications and improving the potential management of complex cases.
subject: Articles
  topic: section
subject: Ultrasonics
  topic: keywords
subject: Bariatric Surgery
  topic: keywords
subject: Airway Management
  topic: keywords
subject: Intubation
  topic: keywords
subject: Obesity
  topic: keywords
creator: Giulliano Gardenghi
creator: Larissa Manzan de Alcantara Borges
creator: Mateus Ferreira de Siqueira e Silva
creator: Gustavo Siqueira Elmiro
creator: André Luiz Braga das Dores
rights: Copyright (c) 2026 Journal of Surgery & Anesthesia Research
date: 2026-02-25
publication date: 2026-02-25
starting page: 1
ending page: 7
doi: 10.47363/JSAR/2026(7)259

Regional Anesthesia and Sedation. Monitoring with Oximetry and Capnography Increases Patient Safety During Procedure
type: item
description: Regional anesthesia provides numerous benefits to patients throughout the perioperative period, including improved comfort and satisfaction with pain control, less nausea and vomiting, and expeditious recovery and discharge. Sedation during surgery undern regional anesthesia plays a central role in facilitating patient comfort and anxiolysis. In recent decades the commonest medications used for sedation are midazolam, propofol, ketamine, dexmedetomidine, remimazolam and each possesses well-known pros and cons. The phrase “while some sleep, others keep watch,” along with monitoring, plays an important role in patient safety regarding sedation in regional anesthesia or other procedures. There are two important monitors during sedation: pulse oximetry and capnography. However, most anesthesiologists only use the pulse oximeter, even though capnographs are attached to all modern anesthesia machines. This article demonstrates the importance of using both pulse oximetry and capnographs for patient safety during sedation in regional anesthesia and other procedures. The combination of the two monitoring systems certainly increases patient safety.
subject: Articles
  topic: section
subject: Procedural Sedation
  topic: keywords
subject: Analgesia
  topic: keywords
subject: Types of Sedation
  topic: keywords
subject: Sedation Monitor
  topic: keywords
subject: Capnograph
  topic: keywords
subject: Pulse Oximeter
  topic: keywords
creator: Luiz Eduardo Imbelloni
creator: Felipe Bufaiçal Rassi Carneiro
creator: Antonio Fernando Carneiro
creator: Antônio Abílio de Santa Rosa
creator: Sara Pereira Lima Soares de Sá
creator: Grace Haber Haber
creator: Sylvio Valença de Lemos Neto
creator: Anna Lúcia Calaça Rivoli
creator: Aurélio Arabori
creator: Geraldo Borges de Morais Filho
rights: Copyright (c) 2026 Journal of Surgery & Anesthesia Research
date: 2026-01-08
publication date: 2026-01-08
starting page: 1
ending page: 4
doi: 10.47363/JSAR/2025(7)257

Seconds to React: Life-Threatening Rocuronium Anaphylaxis in a High-Risk Bariatric Candidate
type: item
description: Anaphylaxis during anesthesia is rare but potentially fatal. Neuromuscular Blocking Agents (NMBAs), particularly rocuronium, are among the most common triggers. We present the case of a 40-year-old male undergoing bariatric surgery who developed severe anaphylaxis immediately after Rocuronium administration during induction. The patient exhibited sudden hypotension, bronchospasm, and generalized urticaria. Rapid diagnosis and management with epinephrine, fluids, antihistamines, and corticosteroids resulted in stabilization, and surgery was postponed. Postoperative allergy testing confirmed IgE-mediated hypersensitivity to rocuronium. This case underscores the need for heightened vigilance when administering NMBAs, early recognition of anaphylaxis, and postoperative allergological evaluation in suspected cases.
subject: Articles
  topic: section
subject: Rocuronium
  topic: keywords
subject: Perioperative Anaphylaxis
  topic: keywords
subject: Neuromuscular Blocking Agents
  topic: keywords
subject: Bariatric Anaesthesia
  topic: keywords
subject: IgEMediated Hypersensitivity
  topic: keywords
subject: Intraoperative Emergency
  topic: keywords
creator: Dr. Roly Mishra
creator: Nitu Kumari
creator: Hemant Mehta
rights: Copyright (c) 2026 Journal of Surgery & Anesthesia Research
date: 2026-01-09
publication date: 2026-01-09
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2026(7)258

Surgical Treatment of Rhinophyma : About a Case and Literature Review
type: item
description: Rhinophyma is an advanced stage of rosacea affecting soft tissues and leading to disruption of the nasal architecture, obstruction of the airways, and disfigurement of the aesthetic units of the nose. It is most often found in Caucasian men over the age of 50 with a male to female ratio of 5 to 1. The exact cause of rhinophyma is unknown; the probable origin is multifactorial. The primary etiology is unregulated superficial vasodilatation. Several hypotheses suggest there may be a potential role of environmental factors and microorganisms such as Helicobacter pylori and Demodex folliculorum. Vitamin deficiency and alcohol or caffeine use may be causative or exacerbating factors.
subject: Articles
  topic: section
subject: Surgical Treatment
  topic: keywords
subject: Rhinophyma
  topic: keywords
creator: Chaimae Hmidi
creator: A Khairi
creator: S El Mazouz
creator: N Gharib
creator: A Abbassi
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2021-10-30
publication date: 2021-10-30
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2021(2)135

Safety in Spinal Anesthesia from Asepsis and Antisepsis to Total Recovery from Block
type: item
description: In the early 20th century, glucose was added to local anesthetics, making it the preferred choice of anesthesiologists worldwide. Before offering a patient spinal anesthesia, an anesthesiologist not only must be aware of the indications and contraindications of spinal anesthesia but also must be able to weigh the risks and benefits of performing the procedure. Asepsis and antisepsis of the back should be carried out with alcoholic chlorhexidine or 70% alcohol,allowing it to dry spontaneously. The MRI confirmed Jonnesco’s teachings on the safety of thoracic spinal anesthesia using puncture above T11. Likewise,when a lumbar puncture is performed, it should be performed below L3, preferably as low as possible. Subarachnoid puncture should be performed with a needle of the smallest gauge and tip preferred by the anesthesiologist. If using an introducer, make a puncture in the skin to avoid introducing skin tissue. For safety, use isobaric, hyperbaric and hypobaric solutions. Adjuvants should be injected into separate syringes, as they alter the baricity of local anesthetics. Always remember that the spinal cord was placed inside a bony tube to avoid the injection of any drugs. This educational article shows some ways to perform single shot spinal anesthesia safely for patients.
subject: Articles
  topic: section
subject: Local Anesthetics
  topic: keywords
subject: Adjuvants
  topic: keywords
subject: Spinal Anesthesia
  topic: keywords
subject: Conus Medullaris
  topic: keywords
subject: Needles
  topic: keywords
subject: Neurotoxicity
  topic: keywords
creator: Luiz Eduardo Imbelloni Luiz Eduardo Imbelloni
creator: Richa Chandra
creator: Anna Lúcia Calaça Rivoli Anna Lúcia Calaça Rivoli
creator: Sylvio Valença de Lemos Neto Sylvio Valença de Lemos Neto
creator: Antonio Fernando Carneiro
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-18
publication date: 2025-06-18
starting page: 1
ending page: 10
doi: 10.47363/JSAR/2025(6)237

Nursing Care During Sleeve Gastrectomy
type: item
description: Currently, the International Body Mass Index defines obesity; morbid obesity refers to BMI>40 obesity or BMI>35 severe obesity and has been combined with obesity-related diseases. With the vigorous development of bariatric surgery at home and abroad, more and more patients with morbid obesity received bariatric surgery and achieved good weight loss [1]. laparoscopic gastric sleeve resection is a new weight loss surgery style that has appeared on the international scene in recent years, its trauma is a small, simple surgical operation, with fewer complications, can maintain the essential structural normal function of the gastrointestinal tract after operation, without any complications [2,3]. Laparoscopic gastric sleeve resection is a new type of weight loss surgery that has emerged internationally in recent years. Which is characterized by minor trauma, simple surgical operation, fewer complications, and the ability to maintain the basic standard structure and function of the gastrointestinal tract after the operation [4,5].
subject: Articles
  topic: section
subject: Nursing Care
  topic: keywords
subject: Sleeve Gastrectomy
  topic: keywords
subject: Obesity
  topic: keywords
creator: Yanyan Hao Yanyan Hao
creator: Wenli Chen Wenli Chen
creator: Xueqin Fan Xueqin Fan
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-23
publication date: 2025-06-23
starting page: 1
ending page: 2
doi: 10.47363/JSAR/2025(6)225

Retrospective Analysis of Clinical Characteristics, Treatment Outcomes and Risk Factors in Appendicitis and Typhlitis
type: item
description: Background: Appendicitis and typhlitis are distinct gastrointestinal inflammatory conditions with overlapping symptoms, posing diagnostic challenges.This retrospective study compared their clinical features, treatments, and outcomes, and identified associated risk factors. Methods: Data from 800 appendicitis and 200 typhlitis patients treated at a tertiary hospital (2021–2023) were analyzed. Demographics, symptoms, lab results, treatments, and outcomes were examined. Univariate and multivariate logistic regressions determined risk factors. Results: Appendicitis patients were younger (median 32 years) than typhlitis patients (median 45 years). Abdominal pain was common in both (98% vs. 92%), but typhlitis patients more often had fever (88% vs. 65%) and diarrhea (75% vs. 12%). Laparoscopic appendectomy was done in 78% of appendicitis cases (10.2% complication rate), while 70% of typhlitis patients received conservative treatment (18% mortality). Multivariate analysis showed perforated appendicitis (OR = 3.2, 95% CI: 2.1–4.8, p < 0.001) and severe neutropenia (OR = 4.1, 95% CI: 2.5–6.8, p < 0.001) were key risk factors for adverse outcomes in each group. Conclusion: Appendicitis and typhlitis have distinct profiles. Early diagnosis and targeted treatment based on risk factors improve outcomes. Clinicians should distinguish between them to optimize management.
subject: Articles
  topic: section
subject: Appendicitis
  topic: keywords
subject: Typhlitis
  topic: keywords
subject: Clinical Characteristics
  topic: keywords
subject: Treatment Outcomes
  topic: keywords
subject: Risk Factors
  topic: keywords
subject: Retrospective Analysis
  topic: keywords
creator: Houhong Wang
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-20
publication date: 2025-06-20
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2025(6)234

Letter to the Editor: Advances and Challenges in Gastric Cancer Research
type: item
description: One of the significant recent findings is the discovery of the role of nociceptive neurons in gastric cancer progression. Timothy C. Wang’s team from the Digestive and Liver Diseases Research Center at Columbia University in the US published a paper in Nature in February 2025. They found that CGRP⁺ peptide - containing sensory neurons interact with gastric cancer cells through the CGRP - RAMP1 axis. In multiple mouse gastric cancer models, these neurons expand significantly in a NGF - TRK pathway - dependent manner. Activating these neurons promotes tumor growth and metastasis, while inhibition or ablation has the opposite effect. In human gastric cancer samples, the density of CGRP⁺ nerves is higher, indicating its potential as a new therapeutic target [1].
subject: Articles
  topic: section
subject: Gastric Cancer
  topic: keywords
subject: nociceptive neurons
  topic: keywords
subject: Digestive
  topic: keywords
subject: Liver Diseases
  topic: keywords
subject: CGRP - RAMP1 axis
  topic: keywords
subject: Combined with Capecitabine and Oxaliplatin (CAPOX)
  topic: keywords
creator: Changquan li Changquan li
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-16
publication date: 2025-06-16
starting page: 1
ending page: 1
doi: 10.47363/JSAR/2025(6)224

Clinical Characteristics, Treatment Outcomes, and Risk Factors for Complications in Ulcerative Colitis
type: item
description: Background: Ulcerative Colitis (UC) is a chronic inflammatory bowel disease with significant morbidity. This study aimed to characterize clinical patterns, treatment responses, and risk factors for complications in UC patients. Methods: Data from 450 UC patients (aged ≥18 years) treated at a tertiary center (2021–2023) were retrospectively analyzed. Demographics, disease severity (Montreal classification), treatment modalities (5-ASA, immunosuppressants, biologics), and complications (colonic stricture, toxic megacolon, colorectal cancer) were evaluated. Multivariate logistic regression identified risk factors for severe complications. Results: Median age at diagnosis was 32 years (IQR:25–40), with 52% male patients. Pancolitis (Montreal E3) was present in 38% (171/450), and 22% (99/450) had prior corticosteroid failure. Biologic therapy (adalimumab, infliximab) was initiated in 35% (158/450), achieving clinical remission in 68% at 12 months. Severe complications occurred in 12% (54/450), including strictures (6.7%) and toxic megacolon (3.3%). Multivariate analysis identified pancolitis (OR=2.89, 95%CI:1.62–5.16, p<0.001), corticosteroid failure (OR=2.17, 95%CI:1.28–3.68, p=0.004), and delayed diagnosis (>6 months) (OR=1.92,95%CI:1.15–3.18, p=0.013) as independent risk factors for complications. Conclusion: Pancolitis, corticosteroid failure, and delayed diagnosis increase the risk of severe complications in UC. Early initiation of biologic therapy in high-risk patients may improve outcomes.
subject: Articles
  topic: section
subject: Ulcerative Colitis
  topic: keywords
subject: Complications
  topic: keywords
subject: Biologic Therapy
  topic: keywords
subject: Risk Factors
  topic: keywords
subject: Retrospective Study
  topic: keywords
creator: Houhong Wang Houhong Wang
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-12
publication date: 2025-06-12
starting page: 1
ending page: 2
doi: 10.47363/JSAR/2025(6)233

Unraveling the Complexity of Gastric Cancer through TCGA Subtypes
type: item
description: Gastric cancer remains a significant global health burden, characterized by high heterogeneity. The Cancer Genome Atlas (TCGA) has been pivotal in classifying gastric cancer into distinct molecular subtypes, providing profound insights into its pathogenesis, prognosis, and potential therapeutic strategies.This review comprehensively explores the four TCGA - defined subtypes of gastric cancer: Epstein - Barr Virus (EBV) - positive, Microsatellite unstable (MSI), Genomically Stable (GS), and Chromosomally Unstable (CIN). By dissecting the unique molecular, genetic, and clinical features of each subtype, we aim to elucidate how this classification can enhance our understanding of gastric cancer and drive the development of more personalized treatment approaches.
subject: Articles
  topic: section
subject: Unraveling
  topic: keywords
subject: Gastric Cancer
  topic: keywords
subject: TCGA Subtypes
  topic: keywords
creator: Changquan li
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-20
publication date: 2025-06-20
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2025(6)223

Retrospective Analysis of Risk Factors for Complications and Treatment Outcomes in Adult Appendicitis: A Single-Center Study
type: item
description: Background: Appendicitis remains a common surgical emergency, but risk factors for complications and optimal treatment strategies require further clarification. This study analyzed clinical characteristics, treatment outcomes, and risk factors for complications in adult appendicitis patients. Methods: Data from 850 adult appendicitis patients (≥18 years) treated at a tertiary center (2021–2023) were retrospectively reviewed. Patient demographics, clinical features, surgical methods, and postoperative complications were analyzed. Univariate/multivariate logistic regression identified risk factors for complications. Results: Median age was 38 years (IQR: 26–52), with 56% male patients. Perforated appendicitis occurred in 28% (238/850), and 12% (102/850) had comorbidities (diabetes/hypertension). Laparoscopic appendectomy (LA) was performed in 78% (663/850), associated with lower complication rates (9.1% vs. 18.6%, p<0.001) and shorter hospital stay (3 vs. 5 days, p<0.001) compared to open appendectomy (OA). Multivariate analysis identified perforation (OR=3.21, 95%CI:2.14–4.83, p<0.001), age ≥60 years (OR=2.58, 95%CI:1.62–4.13, p<0.001), and comorbidities (OR=1.92, 95%CI:1.27–2.91, p=0.002) as independent risk factors for complications. Conclusion: Perforation, advanced age, and comorbidities increase complication risk. LA is associated with superior outcomes and should be prioritized in uncomplicated cases.
subject: Articles
  topic: section
subject: Appendicitis
  topic: keywords
subject: Complications
  topic: keywords
subject: Laparoscopic Surgery
  topic: keywords
subject: Risk factors
  topic: keywords
subject: Retrospective Study
  topic: keywords
creator: Houhong Wang Houhong Wang
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-12
publication date: 2025-06-12
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2025(6)232

Cellular Autophagy and Primary Liver Cancer Research Progress
type: item
description: The concept of cellular autophagy is that in eukaryotic cells, there are two significant organelles involved in cellular degradation, namely, lysosomes and proteasomes, whereas proteasomes usually recognize and degrade only ubiquitinated substrates in a highly selective manner, lysosomal degradation has a more complex pattern. Autophagy is a “self-feeding” phenomenon that maintains cellular homeostasis by targeting damaged organelles and misfolded proteins to the lysosome for degradation, i.e., extracellular substances and plasma membrane proteins can be delivered to the lysosome for degradation by endocytosis. In contrast, cytoplasmic components and organelles can be delivered to the lysosome for degradation by autophagy. Therefore, autophagy is an intracellular catabolic process that targets damaged and excess cellular proteins, organelles, and other cytoplasmic components and plays an essential role in maintaining cellular homeostasis and activities.
subject: Articles
  topic: section
subject: Cellular Autophagy
  topic: keywords
subject: Liver Cancer
  topic: keywords
subject: Research Progress
  topic: keywords
creator: Houhong Wang Houhong Wang
creator: Changquan li Changquan li
creator: Hao Yu
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-25
publication date: 2025-06-25
starting page: 1
ending page: 4
doi: 10.47363/JSAR/2025(6)222

Retrospective Analysis of Clinical Characteristics, Treatment Outcomes and Risk Factors for Complications in Appendicitis Patients
type: item
description: Background: Appendicitis is a common acute abdominal disease. This retrospective study aimed to analyze the clinical characteristics, treatment outcomes, and risk factors for complications in appendicitis patients. Methods: Data of 620 appendicitis patients treated at our hospital from January 2021 to December 2023 were retrospectively reviewed. Patient demographics, clinical manifestations, treatment methods, and postoperative outcomes were collected. Univariate and multivariate logistic regression analyses were used to identify risk factors for complications. Results: The median age of the patients was 35 years (IQR: 22-48), with 58.1% being male. Acute appendicitis accounted for 89.2% (553/620), and 32.1% (199/620) of patients presented with perforated appendicitis. Laparoscopic appendectomy was performed in 75.8% (470/620) of cases, showing shorter postoperative hospital stay (median: 3 days vs. 5 days, p < 0.001) and lower complication rates (12.1% vs. 21.7%, p = 0.003) compared to open appendectomy.Multivariate analysis identified advanced age (≥ 60 years, OR = 2.35, 95% CI: 1.42-3.88, p = 0.001), perforated appendicitis (OR = 3.12, 95% CI: 1.98-4.89, p < 0.001), and comorbidities (OR = 1.89, 95% CI: 1.23-2.89, p = 0.003) as independent risk factors for postoperative complications. Conclusion: Advanced age, perforated appendicitis, and comorbidities increase the risk of complications in appendicitis patients. Laparoscopic appendectomy is associated with better postoperative outcomes and should be the preferred treatment when feasible.
subject: Articles
  topic: section
subject: Appendicitis
  topic: keywords
subject: Retrospective Analysis
  topic: keywords
subject: Clinical Characteristics
  topic: keywords
subject: Treatment Outcomes
  topic: keywords
subject: Complications
  topic: keywords
subject: Risk Factors
  topic: keywords
creator: Houhong Wang Houhong Wang
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-12
publication date: 2025-06-12
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2025(6)231

Oxidative Stress-Induced ADAR1/2 Dysfunction Promotes Hepatocellular Carcinoma Cell Damage via Redox Imbalance
type: item
description: Hepatocellular Carcinoma (HCC) progression is tightly linked to oxidative stress, yet the role of RNA Adenosine Deaminases (ADARs) in this process remains unclear. Here, we demonstrate that hydrogen peroxide (H₂O₂)-induced oxidative stress downregulates ADAR1/2 expression in HCC cells, leading to reduced A-to-I RNA editing and exacerbated cell damage. Mechanistically, ADAR loss impaired antioxidant defense by dysregulating SOD2/CAT expression and disrupting Nrf2 signaling. Our findings establish ADARs as critical regulators of redox homeostasis in HCC, offering novel therapeutic opportunities.
subject: Articles
  topic: section
subject: ADAR
  topic: keywords
subject: Oxidative Stress
  topic: keywords
subject: Hepatocellular Carcinoma
  topic: keywords
subject: RNA Editing
  topic: keywords
subject: Redox Balance
  topic: keywords
creator: Changquan Li
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-21
publication date: 2025-06-21
starting page: 1
ending page: 2
doi: 10.47363/JSAR/2025(6)221

Clinicopathological Features and Prognostic Factors in Colorectal Cancer
type: item
description: Background: Colorectal Cancer (CRC) remains a major global health burden. This retrospective study aimed to analyze clinicopathological features, treatment outcomes, and prognostic factors in CRC patients. Methods: Data from 480 CRC patients treated at a tertiary center (2021–2023) were retrospectively analyzed. Patient demographics, tumor characteristics,treatment modalities, and survival data were evaluated. Survival was assessed using Kaplan-Meier method, and prognostic factors were identified via Cox regression. Results: The median age was 62 years (IQR: 55–70), with 58% male patients. Right-sided CRC (42%) showed more advanced stages (III/IV: 65%) compared to left-sided (52%, p=0.023). Surgical resection improved overall survival (OS) vs. non-surgical treatment (median OS: 62 vs. 28 months, p<0.001). Multivariate analysis identified tumor stage (HR=3.89, 95% CI: 2.71–5.61, p<0.001), lymph node metastasis (HR=2.17, 95% CI: 1.45–3.24, p=0.001), and KRAS mutation (HR=1.68, 95% CI: 1.12–2.52, p=0.013) as independent risk factors. Conclusion: Right-sided CRC exhibits more aggressive features. Surgical resection and molecular profiling (e.g., KRAS) are critical for prognosis. These findings inform personalized CRC management.
subject: Articles
  topic: section
subject: Colorectal Cancer
  topic: keywords
subject: Retrospective Analysis
  topic: keywords
subject: Prognostic Factors
  topic: keywords
subject: Survival
  topic: keywords
subject: KRAS Mutation
  topic: keywords
creator: Houhong Wang Houhong Wang
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-12
publication date: 2025-06-12
starting page: 1
ending page: 2
doi: 10.47363/JSAR/2025(6)230

RNA Adenosine Deaminases Modulate Oxidative Stress-Mediated Hepatocellular Carcinoma Cell Damage via KEAP1/Nrf2 Axis
type: item
description: This study investigates the role of RNA adenosine deaminases (ADAR1/2) in oxidative stress-induced Hepatocellular Carcinoma (HCC) cell damage. We demonstrate that hydrogen peroxide (H₂O₂)-mediated oxidative stress downregulates ADAR1/2 expression, impairing A-to-I RNA editing of antioxidant genes. Mechanistically, ADAR2 deficiency reduces KEAP1 editing, activating Nrf2 signaling and promoting HCC cell survival. These findings establish ADARs as critical regulators of redox homeostasis in HCC, providing novel therapeutic targets.
subject: Articles
  topic: section
subject: ADAR
  topic: keywords
subject: Oxidative Stress
  topic: keywords
subject: Hepatocellular Carcinoma
  topic: keywords
subject: RNA Editing
  topic: keywords
subject: KEAP1
  topic: keywords
subject: Nrf2
  topic: keywords
creator: Changquan Li Changquan Li
creator: Houhong Wang Houhong Wang
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-19
publication date: 2025-06-19
starting page: 1
ending page: 2
doi: 10.47363/JSAR/2025(6)220

Retrospective Analysis of Clinical Characteristics, Treatment Outcomes, and Prognostic Factors in Hepatocellular Carcinoma Patients
type: item
description: This retrospective study aimed to analyze the clinical characteristics, treatment outcomes, and prognostic factors of Hepatocellular Carcinoma (HCC) patients. Data from 350 HCC patients admitted to our medical center between January 2021 and December 2023 were retrospectively reviewed. Patient demographics, tumor characteristics, treatment modalities, and survival data were collected and analyzed. The results showed that surgical resection significantly improved overall survival (OS) compared to non-surgical treatments (median OS: 32 months vs. 15 months, p < 0.001). Multivariate analysis identified tumor size ≥5 cm (HR = 2.31, 95% CI: 1.56 - 3.42, p < 0.001), microvascular invasion (HR = 1.89, 95% CI: 1.21 - 2.96, p = 0.005), and Child-Pugh class B/C (HR = 1.78, 95% CI: 1.12 - 2.83, p = 0.017) as independent risk factors for poor prognosis. These findings provide valuable insights for clinical decision-making and personalized treatment strategies in HCC management.
subject: Articles
  topic: section
subject: Hepatocellular Carcinoma
  topic: keywords
subject: Retrospective Analysis
  topic: keywords
subject: Clinical Characteristics
  topic: keywords
subject: Prognostic Factors
  topic: keywords
subject: Treatment Outcomes
  topic: keywords
creator: Houhong Wang
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-12
publication date: 2025-06-12
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2025(6)229

Low-Temperature Plasma Reduces the Risk of Abdominal Infection in Hepatocellular Carcinoma Patients
type: item
description: This study aimed to explore the impact of Low-Temperature Plasma (LTP) on the risk of abdominal infection in Hepatocellular Carcinoma (HCC) patients.A total of 120 HCC patients were randomly divided into the experimental group (treated with LTP combined with traditional treatment) and the control group (treated with traditional treatment only). The incidence of abdominal infection, levels of inflammatory factors, and immune function indicators were compared between the two groups. The results showed that the incidence of abdominal infection in the experimental group was significantly lower than that in the control group (P < 0.05). The levels of inflammatory factors such as C-Reactive Protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in the experimental group were significantly lower than those in the control group at 3 days, 7 days, and 14 days after treatment (P < 0.05).The immune function indicators including CD3+, CD4+, and the CD4+/CD8+ ratio in the experimental group were significantly higher than those in the control group at 7 days and 14 days after treatment (P < 0.05). In conclusion, LTP can effectively reduce the risk of abdominal infection in HCC patients, reduce the levels of inflammatory factors, and improve immune function.
subject: Articles
  topic: section
subject: Hepatocellular Carcinoma (HCC)
  topic: keywords
subject: surgical resection
  topic: keywords
subject: liver transplantation
  topic: keywords
subject: ablation therapy
  topic: keywords
subject: chemotherapy
  topic: keywords
creator: Changquan Li
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-15
publication date: 2025-06-15
starting page: 1
ending page: 4
doi: 10.47363/JSAR/2025(6)219

Retrospective Analysis of Clinical Characteristics Treatment Outcomes and Risk Factors in Appendicitis and Colitis
type: item
description: Background: Appendicitis and colitis are common gastrointestinal inflammatory disorders with distinct etiologies and management approaches. This retrospective study compared clinical profiles, treatment modalities, and risk factors for adverse outcomes between appendicitis and colitis. Methods: Data from 1,000 patients (800 appendicitis, 200 colitis) treated at a tertiary center (2021–2023) were analyzed. Demographics, symptoms, laboratory findings, treatments, and outcomes were compared. Univariate/multivariate logistic regression identified risk factors for complications (appendicitis) and severe flares (colitis). Results: Appendicitis patients were younger (median age 32 vs. 45 years, p<0.001), with higher rates of acute abdominal pain (98% vs. 75%, p<0.001).Colitis patients more frequently had chronic diarrhea (82% vs. 15%, p<0.001) and weight loss (65% vs. 20%, p<0.001). Laparoscopic appendectomy was m performed in 78% of appendicitis cases (complication rate 10.2%), while 60% of colitis patients received biologic therapy (response rate 68%). Multivariate analysis showed perforated appendicitis (OR=3.5, 95%CI:2.3–5.2, p<0.001) and corticosteroid resistance (OR=2.8, 95%CI:1.7–4.5, p=0.002) as independent risk factors for poor outcomes. Conclusion: Appendicitis and colitis exhibit distinct clinical and therapeutic profiles. Early surgical intervention for complicated appendicitis and targeted biologic therapy for refractory colitis improve outcomes.
subject: Articles
  topic: section
subject: Appendicitis
  topic: keywords
subject: Colitis
  topic: keywords
subject: Clinical Comparison
  topic: keywords
subject: Treatment Outcomes
  topic: keywords
subject: Risk Factors
  topic: keywords
subject: Retrospective Study
  topic: keywords
creator: Houhong Wang
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-16
publication date: 2025-06-16
starting page: 1
ending page: 2
doi: 10.47363/JSAR/2025(6)235

RBPs Related to The Metastatic Process of Hepatocellular Carcinoma
type: item
description: Hepatocellular carcinoma metastasis is often the leading cause of treatment failure in hepatocellular carcinoma. It is now recognized that metastasis is a complex process involving multiple factors and that aberrant expression or dysfunction of RBP, leading to an imbalance in the expression of proto-oncogenes and oncogenes, is inextricably involved in the process of tumor metastasis, which will be discussed in the review. In this review, we will discuss the mechanism and role of RBP in the metastasis of hepatocellular carcinoma. Basic regulatory strategies of RBP most RBPs contain one or more conventional RBDs, which recognize and bind specific sequences in RNAs in order to play their roles. The RBDs, together with some repetitive sequences, form the basic modules, which, through various combinations and permutations, enable the RBPs to accurately search for RNAs for recognition in the cell and participate in regulating RNAs.
subject: Articles
  topic: section
subject: Hepatocellular Carcinoma
  topic: keywords
subject: Metastasis
  topic: keywords
subject: RBP
  topic: keywords
creator: Yanyan Hao Yanyan Hao
creator: Wenli Chen Wenli Chen
creator: Xueqin Fan Xueqin Fan
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-13
publication date: 2025-06-13
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2025(6)218

Serum Claudin-18.2 Expression and Gut Microbiota Dysregulation in Hepatocellular Carcinoma: Correlation with Immune Checkpoint Inhibitor Response
type: item
description: Background: Hepatocellular Carcinoma (HCC) remains a therapeutic challenge, with Immune Checkpoint Inhibitors (ICIs) offering limited response rates. This study investigates the prognostic value of serum Claudin-18.2 (CLDN18.2) and gut microbiota in HCC patients treated with anti-PD-1 therapy. Methods: A prospective cohort of 220 HCC patients (BCLC stage B/C) receiving camrelizumab was enrolled. Serum CLDN18.2 levels were measured by ELISA, and stool microbiota was analyzed via 16S rRNA sequencing. Primary endpoints included objective response rate (ORR), overall survival (OS), and progression-free survival (PFS). Results: High serum CLDN18.2 (>150 ng/mL) was observed in 48% of patients and correlated with larger tumor size (≥5 cm: OR=2.31, p=0.002), microvascular invasion (MVI: OR=1.89, p=0.014), and lower ORR to ICIs (18% vs. 39%, p<0.001). Multivariate analysis showed high CLDN18.2 independently predicted worse OS (HR=2.17, 95% CI: 1.38-3.42, p=0.001) and PFS (HR=1.94, 95% CI: 1.22-3.09, p=0.005) (Table 1). Gut microbiota analysis identified Ruminococcus gnavus and Alistipes indistinctus as key predictors of ICI resistance. High R. gnavus abundance was associated with reduced ORR (12% vs. 35%, p<0.001) and shorter OS (HR=2.45, 95% CI: 1.56-3.86, p<0.001) (Table 2). Combined CLDN18.2 and R. gnavus improved prognostic accuracy (C-index=0.81 vs. 0.69 for single markers, p=0.003). Patients with both high CLDN18.2 and R. gnavus had the worst outcomes (median OS=7.8 months vs. 16.5 months in low-risk groups, p<0.001) (Table 3). Mechanistically, R. gnavus promoted PD-L1 expression via TLR4/MyD88 signaling in vitro. Conclusion: Serum CLDN18.2 and R. gnavus are independent predictors of ICI resistance in HCC. Their combination may optimize patient selection for ICIs, paving the way for microbiota-targeted adjuvant therapies.
subject: Articles
  topic: section
subject: Hepatocellular Carcinoma
  topic: keywords
subject: Claudin-18.2
  topic: keywords
subject: Gut Microbiota
  topic: keywords
subject: Immune Checkpoint Inhibitors
  topic: keywords
subject: Biomarker
  topic: keywords
creator: Houhong Wang
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-12
publication date: 2025-06-12
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2025(6)228

ACTG1 Inhibits PI3K/Akt Signaling Pathway to Promote Apoptosis in Gastric Cancer Cells Through Modulating Phosphatidylinositol3-Kinase Regulatory Subunits
type: item
description: Gastric Cancer (GC) remains a leading cause of cancer-related mortality, with the PI3K/Akt pathway critically involved in its pathogenesis. This study identifies ACTG1 as a novel regulator of PI3K/Akt signaling, demonstrating its role in inducing caspase-dependent apoptosis. Through gain- and lossof-function experiments in SGC-7901 and HGC-27 cells, we show that ACTG1 overexpression reduces p-PI3K (Tyr458) by 62% and p-Akt (Ser473) by 58%, while increasing apoptotic cell populations by 2.8-3.2-fold. Clinically, ACTG1 expression negatively correlates with p-Akt levels in GC tissues (n=80, r=-0.41, p<0.01). These findings establish ACTG1 as a potential therapeutic target for PI3K/Akt-driven gastric cancer.
subject: Articles
  topic: section
subject: Apoptosis
  topic: keywords
subject: cancer
  topic: keywords
subject: Gastric cancer
  topic: keywords
subject: chemoresistance
  topic: keywords
creator: Changquan Li Li
creator: Shang Bian Shang Bian
rights: Copyright (c) 2025 Journal of Surgery & Anesthesia Research
date: 2025-06-12
publication date: 2025-06-12
starting page: 1
ending page: 3
doi: 10.47363/JSAR/2025(6)216