Journal of Translational Medicine & Transplantation Research
Journal of Translational Medicine & Transplantation Research is an open access peer-reviewed journal from the publishers of Scientific Research and Community (SRC) which publishes articles in the form of written, video and power-point presentations from the arena of Translational Medicine & Transplantation. The journal focuses to build up accessing the complete content of articles freely from online for reader’s perusal. Article acceptance will be in the form of Research, Review, Case Reports, Analysis, Magazines, Editorials, Opinion, Communications, Mini-Review, Short Communications, Picturized, Book Review, Video Type and Power Point Presentations (PPTS). Articles can be submitted through online from https://srcpublishers.com/translational-medicine-transplan/user/register or can send through an e-mail with attachment: transplantationresearch@onlinescientificresearch.info 0.35 Impact Factor 84.5% Citations 90% Acceptance
Incidental Discovery of an Amniotic Band in a Newborn: A Case Report
Amniotic band syndrome (ABS) is a rare condition, with an incidence of about 1 in 1,200 to 1 in 15,000 live births. It results from fibrous strands of the amniotic membrane that can trap fetal parts, causing congenital anomalies of varying severity. We report the case of a full-term male newborn admitted at 3 days of life for neonatal jaundice in the context of early-onset bacterial infection. Physical examination revealed a circumferential amniotic band located at the distal third of the right leg, initially without functional impairment. The clinical outcome was complicated by signs of distal vascular compression, prompting surgical intervention consisting of simple release of the band, with a favorable evolution.
Copyright (c) 2026 Journal of Translational Medicine & Transplantation Research
Incidence of Community-Acquired Pneumonia Among Trainees of the 35th Police Cohort at Delta Hospital Center, October 5 to January 22, 2026: A Retrospective Cohort Study
Introduction: Community-acquired pneumonia remains a major cause of acute lower respiratory tract infection worldwide. Although its incidence is well documented in the general population, data remain limited in specific settings such as intensive training environments and collective living conditions, particularly among police trainees. Epidemiological information regarding community-acquired pneumonia in this population is scarce. The primary objective of this study was to estimate the cumulative incidence of community-acquired pneumonia among trainees of the 35th cohort of the Haitian National Police referred to Delta Hospital Center, their designated medical referral facility, between October 5, 2025 and January 22, 2026. Methods: We conducted a retrospective observational cohort study based on a systematic review of medical records of police trainees managed at Delta Hospital Center during the study period. The study population included 877 trainees, among whom 74 medical consultation records were reviewed. Data were extracted and analyzed using Microsoft Excel and SPSS version 20. Cumulative incidence rates and their 95% confidence intervals were calculated to provide precise estimates. Results: A total of 877 police trainees were included, comprising 156 women (17.8%) and 721 men (82.2%). During the study period, 74 medical consultations were recorded (8.4% of the total population). Among these, 28 cases of community-acquired pneumonia were diagnosed, representing 37.8% of consultation diagnoses and corresponding to an overall cumulative incidence of 3.2%. The cumulative incidence was identical in men and women (3.2%), with no statistically significant difference in risk observed between sexes. Conclusion: Community-acquired pneumonia represents a frequent reason for medical consultation among police trainees in intensive training settings, with a notable incidence despite the short duration of observation and the young, presumably healthy population. The absence of sex-related differences further underscores the need for environmental, organizational, preventive, and surveillance measures adapted to collective training environments.
A Study on Implantable and Non-Implantable Medical Textile Products
Medical textiles, including non-implantable and implantable ones, play a central role in the contemporary healthcare setting, and they are paramount in treating wounds, regeneration, and controlling infections. Implantable textiles (sutures, vascular grafts, artificial ligaments), etc., are used to stabilize tissues and guarantee their harmless incorporation with a focus on the use of biocompatible materials, such as polyglycolic acid, polyester, and collagen. Textiles that are not associated with implantation, such as bandages, wound dressings, and surgical gowns are based more on the comfort and functionality of the products, using cotton, chitosan, and calcium alginate to achieve the desired absorbency of the bandages and antimicrobial effect of wound dressings and surgical gowns. The processing modus could not be left behind, where 3D knitting allows the production of custom implants and nanotechnology increases the biocompatibility of the implant by coating them with a material such as nanosized silver. That change toward the comfort of patients can be seen in breathable and flexible materials and biodegradable dressings with as little irritation as possible. Biocompatibility is essential in that it is very important and has to be tested strictly to ascertain the safety of implants and other products that need to be skin-friendly but not implanted. The new developments incorporate smart textiles with sensors to monitor in real time, which is likely to achieve a market of 1 billion by 2024, and compostable materials that overcome environmental issues. There is a long-term study of biocompatibility, complications in regulatory stages, and trade-offs between sustainability and performance. It is recommended that biodegradable polymers need to be developed, uniform testing needs to be adopted and collaboration between the disciplines needs to be promoted. This overview emphasizes the disruptive capabilities of medical fabrics as it is important to further innovate to improve the results of patient care and sustainability within the medical industry.
Copyright (c) 2025 Journal of Translational Medicine & Transplantation Research
Serological Status of Epstein-Barr Virus in Bone Marrow Donor and Recipient and its Impact on Post-Transplant Outcomes
The Epstein-Barr Virus (EBV) is a highly immunogenic herpesvirus that infects more than 90% of healthy individuals and can remain latent in B lymphocytes for years. In this context, in immunocompromised patients, such as those undergoing Bone Marrow Transplantation (BMT), viral reactivation can occur in up to 63% of cases. Among the main risk factors for viral reactivation are donor-recipient incompatibility, EBV IgG-positive donors, and conditioning regimens using lymphodepleting drugs such as anti-thymocyte immunoglobulin, high-dose cyclophosphamide, and corticosteroids. Therefore, weekly EBV monitoring is recommended during the first 100 days post-transplant to detect viremia early and enable preemptive intervention, either by reducing immunosuppression or using anti-CD20 monoclonal antibodies. These strategies aim to reduce viremia progression and the incidence of Post-Transplant Lymphoproliferative Disease (PTLD). This study seeks to estimate the serological profile of bone marrow donors and recipients and its relationship with the incidence of post-BMT viral reactivation. Additionally, it aims to evaluate monitoring and preemptive treatment strategies for managing high-risk patients at the Walter Cantídio University Hospital from 2020 to 2024, while also defining the incidence of PTLD secondary to BMT.
Studying individual Viruses is necessary and useful. But considering that the number of supposed viruses is many orders of magnitude greater than the number of those studied, and that their “studied level” contains a large “medical” error, and medicine is not related to the exact sciences, studying only viral “individuals” is clearly not enough. After all, ELEMENTARY Combinatorics, expanded by the “Living Parameter” not yet taken into account, already brings the number of Fragments of the LIVING - Viruses closer to Infinity. Thus, the Collective State of Viruses is close to the Borderline between CHAOS and HARMONY. So, to describe both the Viruses themselves and their interaction with Living Cells, it is necessary to UNDERSTAND their INVARIANT properties based on COLLECTIVE Effects. And in everyday language, this actually means that it is necessary to understand more deeply the Ecology of the “environment” at the world and nano-level. That is why the General Phenomenology of Viruses is simply necessary, which gives a Complete Description of the Phenomenon. To describe the flows of chaotically moving particles, Phenomenology uses a system of equations for the connection of these Flows and the Forces that determine these Flows. Thus, the proposed Extended Virology is a Unified Description of the “broth” in which LIFE is smoldering. The Extended Phenomenology of Viruses, like Thermodynamics, with the help of Forces and Flows and generalized kinetic parameters that connect them, allows us to evaluate the EFFICIENCY of the Heat Engine, as well as, in principle, allows us to evaluate the “EFFICIENCY” of Viruses for LIFE in general. At the same time, for a group of Viruses, as a borderline state between Living and Inanimate Nature, it is necessary to additionally take into account the Power of LIFE, which manifests itself during the formation of any living “swarm”.
Static and Dynamic Nano-Characteristics of Individual Viruses
Characteristic Parameters of Virus Classes
Role of Dietary Polyphenols on Adult Neurogenesis and Cognition during Aging
The formation of new neurons in adults is an important function that occurs only in specific brain regions. Adult neurogenesis plays an important role in maintaining normal brain homeostasis, replacing damaged neurons, neuronal plasticity, and cognitive functions. The generation of new neurons from Neuronal Stem Cells (NSCs) occurs throughout postnatal stages; however, the process is affected during aging. The decline of the Neuronal Progenitor Cell (NPC) population and the rate of differentiation of NPCs into neurons leads to decreased adult neurogenesis and cognitive functions during aging. Several factors that contribute to the age-associated decline of adult neurogenesis are changes in hormonal and neurotransmitter levels, formation of Amyloid β (Aβ) protein plaque aggregates, oxidative stress, and neuroinflammation. Due to anti-apoptotic, antioxidant, anti-inflammatory properties and other health benefits, plant polyphenols have been widely used to recover cognitive functions in animal models as well as in human subjects. Several studies show that intake of dietary polyphenols such as resveratrol, curcumin, grapeseed, blueberry extract, etc., induces adult neurogenesis and improves learning and memory in different animal models. The present article discussed the significance of dietary polyphenols and their effects on adult neurogenesis and cognition during aging.
Universal Health Care Coverage for Aging Population
The term Universal Health Coverage (UHC) refers to a situation wherein “all people (both males and females, boys and girls) have access, without financial hardship, to the full range of type of quality health services when and where they need them, now and at times”. The UHC envisages coverage of the full range of essential health care services: from health promotion to (1) ‘Prevention’, (2) ‘Treatment’, (3) ‘Rehabilitation’, and (4) ‘Palliative care’ [aimed at improving quality of life of people (adults and children) and their families confronted with life-threatening illness]. It is pertinent to note that the UHC aligns with the SDG (Sustainable Development Goal) Target 3.8: achieve universal health coverage. The UHC is, thus, global commitment. However, in to deliver this promise, national governments and inter-governmental organizations need to have health systems that are rooted in the locations communities they serve. Also, such health systems need to be Need-based, Efficient, and Equitable. The author of this review paper argues that Primary Health Care (PHC) is the most effective and cost-efficient way to reach out to people with the UHC, with consideration of “need-based approach”. Further, it to due to this consideration of need-based theory that every country, with its own socio-economic and demographic profile, adopts a different strategy for the purpose of achieving the UHC. Furthermore, national governments decide what to cover, depending on the needs of their populations, including availability of health infrastructure (resources). Investment in the scientifically designed UHC programs has the potential to ensures that health needs of people are (a) ‘Identified’, (b) ‘Prioritized’, and (c) ‘Addressed’. The conceptual framework of the UHC is of increased relevance for aging population (individuals above the age of 65). The author of this work is of the considered research view that objective of achieving the SDG-3.8 target cannot be fully and adequately realized without transforming health care system that has significant impact on functional ability in older age people (or aging population). Objective of this evidence-based review paper is to investigate into significance and implications of the UHC for aging population. Also, it briefly outlines renewed strategies needed for the UHC for aging population. Secondary data (largely ‘qualitative’ in nature) have been used. The method of data analysis is ‘descriptive’, involving non-statistical (mathematical) techniques. The paper briefly concludes that scientifically-designed mechanism for offering the UHC for older people, without financial burden, is crucial. It is important that health financing systems of the national governments are designed to cater to health needs of older people, thereby enabling them to access the UHC services when (and where) they need, while protecting them from financial catastrophe (by abolishing “out of pocket spending”).
Sustainable Development Goal (SDG) Target 3.8
Copyright (c) 2024 Journal of Translational Medicine & Transplantation Research
The Impact of Specific High-Pathogenic Tp53 Mutations on Survival in Head and Neck Cancers
Head and neck cancers (HNC) constitute about 30-40 % of all cancers in India. tp53 tumor suppressor gene is the most common gene mutated in HNC but has not been demonstrated to have any diagnostic or prognostic significance. therefore, we hypothesize that the survival rate and prognosis of head and neck cancer patients are linked with certain specific high-pathogenic tp53 hot spot mutations. To evaluate the hypothesis, we conducted a retrospective study on a cohort of 100 HNC patients between April 2013 and April 2018. targeted deep sequencing was performed to identify specific somatic mutations. Kaplan–Meier analysis and log-rank tests were performed. Tp53 mutations were identified in 47 of the 100 cases, with dual mutations in 4 patients. Functional characteristics displayed loss of function in 54.9% and gain of function in 27.5 % of cases. the majority of cases displayed missense aberration (74.5%), followed by nonsense mutations (11.76%). Of these pathogenic mutations, 33.3% fell into 6 hot spot residues while mini hot spot residues constituted 20.5% of the mutations. There was no statistically significant difference in the median survival rate between patients with and without the out tp53 mutation. however, the median survival rate was linked with poor prognosis in patients with specific pathogenic hot spot mutations in 247, 248, 245, and 175 residues (p value= 0.028). The majority of hot spot mutations (66%) showed a gain of function which may have been contributory to the pathogenicity of the disease. Results provide evidence that the existence of high-pathogenicity hot spot residues appears to be the only mutation that warrants further research to identify the therapeutic and prognostic significance of the tp53 gene in the treatment of HNC. further systemic studies are recommended to validate this hypothesis.
In-Silico Study of Protein-Protein Interaction, Secondary Structural Analysis and Annotation of Functional Domains of Indoleamine 2,3-Dioxygenase1
Indoleamine-2,3-dioxygenase-1 (IDO1) is the first catabolizing enzyme of tryptophan. IDO1 is extensively expressed in both immune and non-immune tissues and its activation is related to inflammation as well as severity of depressive symptoms, leading neurodegeneration and anxiety like behaviors. Moreover, IDO1 acts as novel immune checkpoint protein with regulatory pathways of immune response and may interact with several proteins. In this paper, physicochemical characterization, functional characterization, subcellular localization, secondary structural analysis and domains/motif/family of IDO1 interacting proteins were done using in silico tools such as STRING, ProtParam-Expasy, SOSUI, SOPMA and MOTIF Search. Eighteen interacting proteins were obtained by STRING. Briefly, all interacting proteins were hydrophilic in nature except AANAT. MAOA and MAOB were almost similar to each other and predicted as more stable in high range of temperature. Further, all interacting proteins showed diverse secondary structure. Higher percentage of α-helix structure was present in remaining proteins except KYNU, MAOA, IL4I1, MAOB and 4930438A08RIK. These proteins showed higher percentage of random coil. Moreover, almost equal percentage of α-helix and random coil were present in TPH1. Secondary structure β-turn was low in percentage in comparison to all other secondary structures. Taken together IDO1 interacting protein or enzyme which are involved in tryptophan catabolic process to kynurenine, serotonin synthesis, tryptophan metabolism, response to corticosterone and glucocorticoids, several other biological process. Such studies are useful to understand IDO1 dependent regulation in the context of tryptophan/kynurenine pathway and helpful in therapeutics of neurological disorders.
Periodontal diseases are common inflammatory diseases that affect the gingiva and tooth supporting apparatus. In the early stages treatment of periodontal disease involves reversibility of gingivitis so that progression to periodontitis is halted. Resolution of inflammation plus the biofilm attached to the tooth surfaces removed through mechanotherapy, gingival health is restored. However, in the later stage of the disease, periodontitis is irreversible and nonresolving in nature. Therefore, it is generally accepted that etiology of periodontal disease is microbial in nature. Disease progression itself is host mediated. Various modifiable and non-modifiable risk factor contribute to development of periodontitis.
Copyright (c) 2023 Journal of Translational Medicine & Transplantation Research
Investigation of Regenerative Effects of Theranekron® and Misoprostol after Partial Hepatectomy in Rats
In the present study we were aimed to investigate/compare regenerative effects of Theranekron® (TC) and Misoprostol (MS) after Partial Hepatectomy (PH) in rats. This study was conducted in 38 rats, they were divided in to 5 groups and 7 days study periot. When considering biochemical and histopathological results; we were seen that after PH 7 days duration was not sufficient and also at least 10 days periot may be necessary. Although some literatures were reported about positive effects of TC and MS on epithelial growing, we have not seen that they have not any positive effect on liver regeneration. In the future -at different doses and durations- these may be found effective.
Impact of Age on HbA1c Level of Diabetic Patients Attending Ahmadu Bello University Teaching Hospital Zaria, Nigeria
The present study looked into the possibility of impact of age on HbA1c level of diabetic patients attending Ahmadu Bello University Teaching Hospital (ABUTH) Zaria, Nigeria, as there have been reports of correlation between age and HbA1c in some other parts of the world. Three hundred and fifty (350) diabetic patients were initially recruited over a period of 10 months, from March 2018 to December 2018. Subjects consisted of 200 female and 150 male diabetic patients. After 10-12 hours fast, 5mL of blood was drawn from volunteer patients. About 3mL was centrifuged in order to separate the serum after which the serum was then analysed for glucose. Two hundred and fifteen (215) subjects, comprising of 110 female and 105 male diabetic patients, with ages between 46 years and 84 years (mean age = 65±19 years) and mean blood glucose of 200±20 mg/dL were then selected for the study. The remaining 2mL whole blood was analysed immediately for HbA1c. Information about patient’s age was obtained via a well-designed questionnaire and matched with hospital record. There was no significant difference in the mean HbA1c levels of male and female participants. For the given blood glucose range, the HbA1c level increased by 0.2%, proportionally, with every decade (10 years) increase in age. It was concluded that HbA1c increases consistently – independent of blood glucose and gender – with increase in age of diabetic patients.
New Product Launches and Strategic Partnerships to Boost the Global Biosimilars Business
Rise in occurrence of various kinds of cancers such as brain tumor, lung cancer, and blood cancer is anticipated to boost the growth of the global biosimilars market. Escalating need for using biosimilar drugs as alternative therapy for chemotherapy for cancer patients will prop up the scope of the global biosimilars industry expansion. Increase in occurrence of autoimmune disorders such as rheumatoid arthritis and ankylosing spondylitis will provide new growth avenues for the global industry. Moreover, with key players such as Teva Pharmaceuticals and Sandoz planning to ramp up biosimilar production, the market for biosimilars is anticipated to gain traction over the years to come. The move is aimed at increasing their market share by raising production of expensive medicines used for treating chronic disorders such as cancer and arthritis. According to Allied Market Research report, the global biosimilars market is set to accrue earnings worth nearly $143.6 billion by 2031.
We deliver a 20 dB 100 Hz tone for 20 milliseconds. The ear receives it; a low tone has to be enhanced, since such a signal energy is too weak to reach the centre. There are doubts whether here active is only a mechanical amplification through an OHC contraction. For simplification’s sake, assuming 1,500 m/s as the sound speed in fluid, this means two periods of 100 Hz wave within a 20 ms. time, the wave length being 15m. The resonance of the basilaris membrana for such a frequency occurs, in the best case, nearby the cupula. In what way can such a wave length fits on the basilaris membrana (approx. 37 mm)
A Bilateral Lower Limb Deep Vien Thrombosis in A Ckd Patient Post Prophilacted Dialysis Patient
The lower extremity Deep vein thrombosis is a disorder caused by blood stasis in the veins of the lower limbs. It is a prevalent ailment in middle-aged and elderly people. It is more prevalent in males, as previously said, although it is still common in girls. Furthermore, it is often linked to immobility and cardiac illnesses such as heart failure and atrial fibrillation. Deep vein thrombosis is infrequently bilateral, and instances in youngsters are recorded in disorders such as May-Thurner syndrome. Based on the history, examination, and lower limb doppler US, the diagnosis is clearly confirmed. This study aims to look at a 78-year-old female patient who has bilateral deep vein thrombosis. The presentation will be shown, and the risk factors for her disease will be discussed.
Copyright (c) 2022 Journal of Translational Medicine & Transplantation Research
Morning glory syndrome is a birth defect that affects the optic nerve of the eye. The morning glory syndrome (MGS) or morning glory disc anomaly was named by Kindler in 1970 because of its resemblance to the morning glory flower. Morning glory syndrome can be associated with midline cranial defects and abnormal carotid circulation. We report the case of a 10-year-old adolescent, who was brought by his parents for a profound bilateral visual acuity decrease since birth. Ophthalmic examination revealed bilateral morning glory syndrome.
Different Applications of Stem Cells Therapy for Degenerative Retinal Diseases
Retinal degenerative diseases, such as Stargardt’s disease (SD), glaucoma, retinitis pigmentosa (RP), age-related macular degeneration (AMD) or diabetic retinopathy (DR), represent the main causes of a decreased quality of vision and blindness worldwide. The progression and management of these conditions have always represented a challenge, but promising new evidences about the efficacy of mesenchymal stem cells (MSCs) as therapy for these diseases has been shown. The therapeutic potential of MSCs lies on its ability to release paracrine factors with neuroprotective, immunomodulatory and anti-angiogenic properties that stimulate the retinal pigmented epithelium (RPE) and are even similar to those produced by RPE. In literature we can find many studies conducted animal models, in which MSCs proved their efficacy in stopping the progression of retinal degeneration and for rescuing photoreceptors in the dormant phase. Furthermore, they retain a differentiation potential which allow them to differentiate into various cell types, including the cells of the retina. By all of those properties it is clear how MSCs result an important therapy option in these pathologies. In this review we summarize the various properties of MSCs and their promising applications in various retinal diseases, enhanching a new clinical approach on pathologies which otherwise have a difficult managing and a unfavorable prognosis.
Rising Demand for Biopharmaceuticals Has Been Overtly Beneficial for the Downstream Processing Industry
NALCO (National Aluminium Company Limited)
Lemierre’s Syndrom Resulting from Cholesteatomatous Otitis Media and Mastoiditis: A Case Report
Lemierre’s syndrome is a rare and in some cases fatal thrombophlebitis of the internal jugular vein (IJV). It usually follows acute oropharyngeal or otologic infections in healthy, young children. Fusobacterium necrophorum is the most common bacteria that causes Lemierre’s syndrome, whereas various microorganisms are reported. We report a case of Lemierre’s syndrome secondary to chronic otitis media, which remains a rare occurrence of a very seldam disease.