Neurological and Molecular Basis of Diabetic Neuropathy

Authors

  • Kehinde Alare Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria Author
  • Taiwo Alare Department of Mechanical Engineering, Federal University of Technology, Akure, Ondo State, Nigeria Author
  • Tope Odunitan Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria Author
  • Busayo Adetunji Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria Author
  • Oladoja Owonikoko Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria Author

DOI:

https://doi.org/10.47363/JDRR/2020(2)117

Keywords:

Diabetic Neuropathy, Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH), Demylination

Abstract

Aims: the aim of the research is to look to the neurological and molecular mechanism of diabetic neuropathy and also suggesting a better way of management.

Methods: Critical reviews of the relationship between hyperglycemia in diabetes with polyol pathway, hexose monophosphate shunt and de novo synthesis of sphingolipids and how this relationship could be involved in diabetic neuropathy.

Results: The research gave rise to some factor causing diabetic neuropathy such as osmotic stress, oxidative stress , dymelination and are gotten from the method above.

Conclusion: This research pointed out decrease NADPH available for de novo synthesis of sphingomyelin as result of increase consumption by polyol pathway and decrease production by hexose monophosphate shunt as the main factor responsible for diabetic neuropathy

Author Biographies

  • Kehinde Alare, Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

    Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

  • Taiwo Alare, Department of Mechanical Engineering, Federal University of Technology, Akure, Ondo State, Nigeria

    Department of Mechanical Engineering, Federal University of Technology, Akure, Ondo State, Nigeria

  • Tope Odunitan, Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

    Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

  • Busayo Adetunji, Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

    Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

  • Oladoja Owonikoko, Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

    Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

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Published

2020-10-30

Issue

Vol. 2 No. 4 (2020): Volume 2 Issue 4

Section

Articles