Research on Acute Toxicity and the Effect of Methanol Extract Pleurotus Eous Mushroom in Rats: An In Vivo Study

Abstract

Objective: The present study was aimed to investigate the toxic effects of acute toxicity administration of methanol extract of Pleurotus Eous in wistar rats weighing (150-200g) as per OECD guidelines.
Materials & Methods: In acute toxicity the effects of single oral dose (100, 500, 1000 mg/kg) of Pleurotus Eous methanol extract have been administered. Group 1 was used as control. Mortality rate, organ weight and hematological parameters were studied.
Results: In acute toxicity study, a single dose administration of Pleurotus Eous upto 1000 mg/kg did not induced any mortality. LD50 of the Pleurotus Eous has been estimated higher than 1000 mg/kg. No significant difference were found in relative organ weight and the outcomes of the current study revealed that no significant changes in the hematological parameters between the control and the methanol extract of Pleurotus Eous administered groups in acute toxicity studies.
Conclusion: The oral administration of Pelurotus Eous did not produce any toxic effect in albino rats. Acute toxicity studied in animals is usually required for any pharmaceutical purpose. It was observed as no rats were dead at maximum dosage which indicates large therapeutic index.