The Clinical Brilliance of Immunohistochemistry “IHC” in Gastrointestinal Oncology

Authors

  • Hannah Bell The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA Author
  • Thomas Grant Wichman The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA Author
  • Ernest Moses Lam The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA Author
  • Drew Mulkey The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA Author
  • Ahmed Swi The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA Author
  • Bobby Owens The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA Author
  • Faisal A Bukeirat The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA Author

DOI:

https://doi.org/10.47363/JGHR/2025(6)176

Keywords:

Immunohistochemistry, squamous cell carcinoma, Esophageal Adenocarcinoma

Abstract

Immunohistochemistry, or “IHC,” is a powerful tool in clinical diagnostics within the field of gastrointestinal oncology and anatomical pathology. It is utilized to assist in classification of neoplastic, infectious, and inflammatory diseases. The technique generally involves the specific binding between an antibody and antigen to detect and localize specific antigens within tissue samples, usually examined with light microscopy. Biopsies are collected in a number of ways, including snaring, fine needle aspiration, endoscopic mucosal resection, and more; these samples are then processed by a pathologist. This information can be vital in clinical decision making for patients with potential malignancy.

Author Biographies

  • Hannah Bell, The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

    The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

  • Thomas Grant Wichman, The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

    The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

  • Ernest Moses Lam, The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

    The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

  • Drew Mulkey, The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

    The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

  • Ahmed Swi, The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

    The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA 

  • Bobby Owens, The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

    The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

  • Faisal A Bukeirat, The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

    The University of Mississippi Medical Center, Jackson, MS, Department of Medicine, Division of Digestive Diseases, Department of Pathology, USA

Downloads

Published

2025-12-08

Issue

Vol. 6 No. 2 (2025): Volume 6 Issue 2

Section

Articles