Novel Ultrasensitive Eco-Friendly Spectrophotometric Determination of Carvedilol in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing

Authors

  • Nief Rahman Ahmad College of Environmental, University of Mosul-Iraq, Iraq Author
  • Ghfran Naif Rahman Student at Medical College, University of Mosul, Mosul-Iraq, Iraq Author

DOI:

https://doi.org/10.47363/h0jbn187

Keywords:

Carvedilol, Spectrophotometry, Pharmaceutical Preparations, Environmental Samples

Abstract

A simple, novel, accurate, precise, rapid, economical and sensitive Ultra violet spectrophotometric method has been developed for the determination of Carvedilol in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 242 nm in methanol. Beer’s law was obeyed in the range of 0.5 -10 μg/ ml, with molar absorptivity of 5.4467×104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.6%, and accuracy (average recovery %) was 100 ± 1.3. No interference was observed from common excipients and additives often accompany with Carvedilol in pharmaceutical preparations. The method was successfully applied to the determination of Carvedilol in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Carvedilol in true samples.

Author Biographies

  • Nief Rahman Ahmad, College of Environmental, University of Mosul-Iraq, Iraq

    College of Environmental, University of Mosul-Iraq, Iraq

  • Ghfran Naif Rahman, Student at Medical College, University of Mosul, Mosul-Iraq, Iraq

    Student at Medical College, University of Mosul, Mosul-Iraq, Iraq

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Published

2025-06-26

Issue

Vol. 6 No. 3 (2025): Volume 6 Issue 3

Section

Articles