Dietary Manipulation in Crohn’s Disease?

Abstract

In isolated cases of Crohn’s disease, dietary manipulations have produced what biologics and steroids have yet to document: permanent remissions/cures. The questions of how and why are addressed. The postulates advanced are 1) that clinical amelioration remissions achieved through dietary manipulation are the consequence of limiting MAP antigen/cytokine interactions at the sites of Mycobacterium avium subspecies paratuberculosis mucosal attachment and ultimately, 2) by dietary restoration and enhancement of host cellular immunity, resulting in the destruction of the MAP-template which drives the dysfunctional pro-inflammatory immune response. The syngergistic coupling of diet and biologics is discussed.