Case Report of Acute Liver Failure Induced By Isotretinoin Medication

Authors

  • Hassan Akouch MD Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon Author
  • Malek Michael Bouhairie MD Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon Author
  • Sabrina Nasreddine MD Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon Author
  • Racha Seblani MD Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon Author
  • Maryam Bouhairie Kreidly PharmD Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon Author
  • Ahmad Mroue MD Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon Author

DOI:

https://doi.org/10.47363/JGHR/2021(2)109

Keywords:

Acute Liver Failure, Ro-Accutane/Isotretinoin Therapy, Liver Transplant, Hepatitis, Encephalopathy, Drug Induced Liver Failure, Case Report

Abstract

Drug induced liver injury or DILI is any injury to the liver by a medication, herb, or dietary supplement. Ranking as the first cause of acute liver failure in the USA and Europe, spectrum of clinical presentation may range from asymptomatic elevated liver function test to ALF. Approximately 20 new cases of DILI per 100,000 persons occur each year worldwide. Classified as intrinsic (with the most common cause being acetaminophen), and idiosyncratic adverse drug reaction (including mostly those related to antibiotics, NSAID drugs, and isoniazid). Isotretinoin is indicated to treat severe inflammatory acne that is refractory to antibiotics or topical agents; Although it has a high margin of safety, adverse effects include transaminasitis, like many retinoids, but unlike acitretin and etretinate, isotretinoin has not been clearly implicated in cases of clinically apparent acute liver failure.

Author Biographies

  • Hassan Akouch MD, Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

    Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

  • Malek Michael Bouhairie MD, Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

    Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

  • Sabrina Nasreddine MD, Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

    Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

  • Racha Seblani MD, Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

    Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

  • Maryam Bouhairie Kreidly PharmD, Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

    Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

  • Ahmad Mroue MD, Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

    Sahel General Hospital, Gastroenterology Department, Lebanese University, Lebanon

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Published

2021-02-21

Issue

Vol. 2 No. 1 (2021): Volume 2 Issue 1

Section

Articles