A Study on the Effect of Methanolic Extract of Plumeria alba on Acetaminophen-induced Kidney Damage

Authors

  • Mbah Chikodili Adolphus Mbah Chikodili Adolphus, Department of Anatomy, Faculty of Basic Medical Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria. Author
  • Ofoego Uzozie Chikere Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria Author
  • Odo Jude Emeka Department of Humanities, School of General Studies, State University of Medical and Applied Sciences Igbo-Eno, Enugu State, Nigeria Author
  • Oyate Godwin Bernard Department of Nursing, Faculty of Nursing Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria Author

DOI:

https://doi.org/10.47363/JONE/2025(5)138

Keywords:

Renal-protection, Histoarchitecture, Renal Function, Plumeria Alba Extract

Abstract

Background: Incidence of acetaminophen-induced nephropathy is a growing concern, with limited treatments available. This study evaluated the effects of methanolic extract of Plumeria alba flower (MEPAF) in acetaminophen-induced nephrotoxicity in Wistar rats.

Materials and Methods: Twenty-five Wistar rats were divided into five groups (A - E) of five rats each. Group A (Control) received feed and water. Group B received 1800mg/kg/bwt of acetaminophen and Group C received 900mg/kg/bwt of MEPAF. Groups D-E rats received co-administration of 1800mg/kg/ bwt of acetaminophen and 180mg/kg/bwt of MEPAF, 1700mg/kg/bwt of acetaminophen and 850mg/kg/bwt of MEPAF respectively. All administrations were orally and daily for 28 days. On the 29th day, the rats were sacrificed, blood samples collected for kidney function test (urea, uric acid and creatinine evaluations) and kidneys harvested for histopathological examination.

Results: Administration of 1800mg/kg/bwt of acetaminophen for 28 days induced a significant (p<0.05) increase in body and relative organ weights, serum urea, uric acid and creatinine along with histopathological changes (acute tubular necrosis, degeneration and haemorrhage). However, co-administration with Plumeria alba flower extract ameliorated these conditions.

Conclusion: Plumeria alba flower extract could potentially provide protection against acetaminophen-induced renal toxicity. The observed nephroprotection could be attributed to the inherent antioxidant properties of Plumeria alba.

Author Biographies

  • Mbah Chikodili Adolphus, Mbah Chikodili Adolphus, Department of Anatomy, Faculty of Basic Medical Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria.

    Mbah Chikodili Adolphus, Department of Anatomy, Faculty of Basic Medical Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria.

  • Ofoego Uzozie Chikere, Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria

    Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria.

  • Odo Jude Emeka, Department of Humanities, School of General Studies, State University of Medical and Applied Sciences Igbo-Eno, Enugu State, Nigeria

    Department of Humanities, School of General Studies, State University of Medical and Applied Sciences Igbo-Eno, Enugu State, Nigeria.

  • Oyate Godwin Bernard, Department of Nursing, Faculty of Nursing Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria

    Department of Nursing, Faculty of Nursing Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria.

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Published

2025-12-05

Issue

Vol. 5 No. 2 (2025): Volume 5 Issue 2

Section

Articles