An Unusual Entity: Giant Cell Tumour of Soft Tissue in the Nasal Cavity

Abstract

Giant cell tumour of soft tissue (GCT-ST) are rare soft tissue tumours, with the first case reported in the 1970s. Involvement of the head and neck region, particularly in the nasal cavity is extremely uncommon. GCT-ST are considered the bone counterpart given the striking histological and immunohistochemical resemblance. Despite that, GCT-ST and GCT of bones are genetically distinct. Microscopically, GCT-ST exhibit numerous osteoclast-type multinucleated giant cells within a background of mononuclear stromal cells. They are locally aggressive and can potentially recur. It is important to distinguish GCT-ST from giant cell reparative granuloma (GCRG) as they both share similar clinical and morphological characteristics, however, they have different treatment modalities. We report a case of GCT-ST occurring in the nasal cavity, an unusual site of presentation.