Interleukin-28B (IL-28B) and Interferon –Gamma (INF-γ) Levels in Patients with Chronic Hepatitis C Viral (HCV) Infection

Authors

  • Samira Z A Eid Department of Parasitology and Blood research, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt 12654 Author
  • Nourtan F. Abdeltawab Department of Microbiology and Immunology,Faculty of Pharmacy, Cairo University, Cairo, Egypt 11562 Author
  • Samuel T. Melek1 Department of Biochemistry , Faculty of Pharmacy, Delta University for science and technology El Dawly El Sahely St., Gamasa, El Mansoura , Egypt. Also, Parasitology and blood research department ,  National organization for drug control and research (NDCAR) , Giza , Egypt  Author
  • Magdy A. Amin Department of Microbiology and Immunology,Faculty of Pharmacy, Cairo University, Cairo, Egypt 11562 Author

DOI:

https://doi.org/10.47363/6fbrr086

Keywords:

Hepatitis C Virus, Schistosoma Mansoni, IFN-γ, IL-28B, Chronic Liver Diseases

Abstract

Objectives: We aimed to studythe effect of Schsitosoma mansoni co-infection with hepatitis C virus (HCV) on IL-28B levels.

Design: We collected plasma from107outpatients(range30–81 years old) from six governates of Delta, Egypt attending Kasr Al-Aini Hospital, Cairo, Egyptin 2012–2014. Subjects were divided to three groups, 35 healthy controls, 50naïve chronic HCV patientsand 22S. mansoni/HCVco-infected patients.For all participants,anti-schistosomal antibodies levels, hepatitis B surface antigens (HBsAg), HCV viral loadand routine liver function tests were measured. We assayed IL-28B and IFN-γ plasma levels for all participants.

Results: We found that IL-28B levelsweresignificantly higher in S. mansoni/HCV co-infected patients than in HCV mono-infection. IFN-γ and IL-28B levels showed positive correlation in both infected groups. Patients with high HCV viral load had significantly higher IFN-γ and IL-28B levelswhether suffering from mono- or co-infection.

Conclusions: A strong link between IFN-γ and IL-28B in naïve chronic HCV patients whether mono- or co-infected with S. mansoni. This suggeststhat co-infection with S. mansoni might not affect IFN-γ levels, however, significantly increases IL-28B levels. Therefore, IL-28B plasma levels might be a useful novel biomarker forprognosis and therapy ofS. mansoni/HCV co-infection.

Author Biographies

  • Samira Z A Eid, Department of Parasitology and Blood research, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt 12654

    Samira Z A  Eid Department of Parasitology and Blood research, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt 12654

  • Nourtan F. Abdeltawab, Department of Microbiology and Immunology,Faculty of Pharmacy, Cairo University, Cairo, Egypt 11562

     Nourtan F. Abdeltawab Department of Microbiology and Immunology,Faculty of Pharmacy, Cairo University, Cairo, Egypt 11562

  • Samuel T. Melek1, Department of Biochemistry , Faculty of Pharmacy, Delta University for science and technology El Dawly El Sahely St., Gamasa, El Mansoura , Egypt. Also, Parasitology and blood research department ,  National organization for drug control and research (NDCAR) , Giza , Egypt 

    Samuel T. Melek1 Department of Biochemistry, Faculty of Pharmacy, Delta University for science and technology  El Dawly El Sahely St., Gamasa , El Mansoura , Egypt,

  • Magdy A. Amin, Department of Microbiology and Immunology,Faculty of Pharmacy, Cairo University, Cairo, Egypt 11562

     Magdy A. Amin Department of Microbiology and Immunology,Faculty of Pharmacy, Cairo University, Cairo, Egypt 11562

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Published

2019-09-11

Issue

Vol. 1 No. 1 (2019): Volume 1 Issue 1

Section

Articles