Lipid Profile Abnormalities and Their Association with Covid-19 Severity among Patients Admitted at Covid-19 Center in Ethiopia

Authors

  • Yakob Gebregziabher Tsegay Department of Medical Laboratory Millennium COVID-19 Treatment Center, Addis Ababa, Ethiopia Author
  • Molalegne Bitew Millennium COVID-19 Care Center Research Center St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia Author
  • Assegdew Atlaw Addis Ababa University College of Health Science Department of Medical Laboratory Science Author
  • Mintsnot Aragaw Department of Medical Laboratory St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia Author
  • Shambel Araya Department of Medical Laboratory Millennium COVID-19 Treatment Center, Addis Ababa, Ethiopia Author
  • Mesay Gemechu Department of Medical Laboratory St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia Author
  • Nega Brhane Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia Author
  • Tigist workneh Millennium COVID-19 Care Center Research Center St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia Author

DOI:

https://doi.org/10.47363/JCBR/2021(3)137

Keywords:

COVID-19, Lipid Profile, LDL-C, CHOL, TG, Addis Ababa, Ethiopia

Abstract

Background: Current studies have presented and analyzed epidemiological, clinical and clinical laboratory features COVID-19 Patients. Studies suggests that patients with severe COVID-19 shows unregulated lipid metabolism and profile but adequate information is not available concerning the association of lipid parameter features with severity of disease its outcome in Ethiopia.

Objective: This study aims to determine the magnitude of lipid profile abnormalities and association of COVID-19 outcome among admitted patients at Millennium COVID-19 care center in Ethiopia.

Methods: A prospective observational cohort study was conducted among COVID-19 admitted patients to investigate lipid profile parameters from January 2021- June 2021.  A total of 500 patients confirmed with COVID-19 infection by RT-PCR were included. Dynamic alteration in lipid profiles were recorded and tracked.  Data were analyzed using SPSS version 25. P value <0.05 was considered significantly associated

Result: The median age of the 500 study participants was 55.58+7.707 years, and from these 71.3% of patients were males. This study found that high-density Lipoprotein cholesterol (HDL-C) and Total Cholesterol levels were significantly higher in the severe and Critical disease category. The total cholesterol results showed that significantly higher 25 (5.38%) in severe infection cases than that, (17 (3.4%), 12(2.4%) and 5 (1%) in moderate, mild and critical cases consecutively (P<0.000). Whereas, patients with severe infection had slightly lower of HDL than Mild and moderate infection cases (P=0.000 and P=0.000) respectively. Moreover, a significant decrement in the level of TG was detected in severe infection cases compared to mild and moderate cases (P=0.0001). Hence, the higher TG/HDL-C ratio (3.754) was found in severe infection cases, compared with mild and moderate infection (P=0.001 and P=0.002) respectively.

Conclusion: Lipid function biomarkers like CHO, TG and LDL serum value was found elevated among severe than other patients. Lipid Metabolism biomarkers are a candidate for predicting COVID-19 disease severity in order to guide clinical care and general Public. 

 

Author Biographies

  • Yakob Gebregziabher Tsegay, Department of Medical Laboratory Millennium COVID-19 Treatment Center, Addis Ababa, Ethiopia

    Yakob Gebregziabher Tsegay Department of Medical Laboratory Millennium COVID-19 Treatment Center, Addis Ababa, Ethiopia

  • Molalegne Bitew, Millennium COVID-19 Care Center Research Center St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia

    Molalegne Bitew Millennium COVID-19 Care Center Research Center St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia

  • Assegdew Atlaw, Addis Ababa University College of Health Science Department of Medical Laboratory Science

    Assegdew Atlaw  Addis Ababa University College of Health Science Department of Medical Laboratory Science

  • Mintsnot Aragaw, Department of Medical Laboratory St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia

    Mintsnot Aragaw Department of Medical Laboratory St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia

  • Shambel Araya, Department of Medical Laboratory Millennium COVID-19 Treatment Center, Addis Ababa, Ethiopia

    Shambel Araya  Department of Medical Laboratory Millennium COVID-19 Treatment Center, Addis Ababa, Ethiopia

  • Mesay Gemechu, Department of Medical Laboratory St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia

    Mesay Gemechu  Department of Medical Laboratory St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia

  • Nega Brhane, Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia

    Nega Brhane  Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia

  • Tigist workneh, Millennium COVID-19 Care Center Research Center St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia

    Tigist workneh  Millennium COVID-19 Care Center Research Center St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia

Downloads

Published

2021-08-02

Issue

Vol. 3 No. 4 (2021): Volume 3 Issue 4

Section

Articles