Complete Response following Treatment with Olaparib in a Patient with BRCA-Mutant High Grade Serous Ovarian Cancer and Central Nervous System Metastases

Abstract

Ovarian cancer is the leading cause of death from gynecological cancers worldwide. High grade serous ovarian cancer is the most frequent and aggressive sub-type of ovarian cancer. Despite recent improvements in treatment, the 10-year survival rate for HGSOC is <30%. While brain metastasis is a frequent occurrence in breast, lung, and melanoma, it is rarely observed in OC. The exact incidence of brain metastasis in OC is unknown but is estimated at 1.34%. Brain metastasis represents a rare but life threatening complication due to the lack of effective drugs that are able to across the blood brain barrier.