High-Grade Metastatic Pleomorphic Rhabdomyosarcoma in a TP53 Germline Mutation Patient: A Rare Presentation in Adults

Authors

  • Shervin Zoghi Department of Hematology and Oncology at the University of California, Davis, USA Author
  • Aaron Tsumura Department of Hematology and Oncology at the University of California, Davis, USA Author
  • Rashmi Verma Department of Hematology and Oncology at the University of California, Davis, USA Author
  • Morgan Angus Darrow Department of Pathology and Laboratory Medicine at the University of California, Davis, USA Author

DOI:

https://doi.org/10.47363/JCCSR/2024(6)274

Keywords:

AIM Chemotherapy, Metastasis, Pleomorphic Rhabdomyosarcoma, Sarcoma, Soft-Tissue Tumor

Abstract

Pleomorphic Rhabdomyosarcomas (PRMS) in adults are an exceptionally rare and aggressive soft-tissue tumor arising from undifferentiated mesenchymal cells. While more common in children, rhabdomyosarcomas in adults are associated with poorer outcomes and require immediate, aggressive intervention. Here we present a case of high-grade pleomorphic rhabdomyosarcoma of the left thigh in a 58-year-old male with metastases to the lungs and pelvis. Due to the limited diagnostic and treatment protocols of this rare disease and subtype, the goal of this case study is to highlight a comprehensive clinical approach to this disease.

Author Biographies

  • Shervin Zoghi, Department of Hematology and Oncology at the University of California, Davis, USA

    Shervin Zoghi, Department of Hematology and Oncology at the University of California, Davis, USA

  • Aaron Tsumura, Department of Hematology and Oncology at the University of California, Davis, USA

    Aaron Tsumura, Department of Hematology and Oncology at the University of California, Davis, USA

  • Rashmi Verma, Department of Hematology and Oncology at the University of California, Davis, USA

    Rashmi Verma, Department of Hematology and Oncology at the University of California, Davis, USA

  • Morgan Angus Darrow, Department of Pathology and Laboratory Medicine at the University of California, Davis, USA

    Morgan Angus Darrow, Department of Pathology and Laboratory Medicine at the University of California, Davis, USA

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Published

2024-03-05

Issue

Vol. 6 No. 3 (2024): Volume 6 Issue 3

Section

Articles

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