Hemophagocytic Lymphohistyocytosis associated with Hoghkinlymphoma

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation and tissue destruction due to abnormal immune activation. This is a hyper inflammatory/dysregulated immune state caused by the uncontrolled proliferation of activated lymphocytes and histiocytic with massive release of inflammatory cytokines. Secondary HLH is associated with, and thought to be emerged by malignant and non-malignant diseases. Malignant disorders associated with secondary HLH include lymphoma, acute lymphocytic leukemia, acute myeloid leukemia, and syndrome. Many physicians in most cases make delayed diagnosis of HLH. HLH-associated cHL is an uncommon condition that can cause severe systemic symptoms acting as the perfect mimic of septic shock, deviating the clinical eye toward treating with antibiotics and not addressing in a timely manner the real aetiology of the patient’s condition.