Disseminated Bullous Pyoderma Gangrenosum: A Clinical Case Report

Abstract

Pyoderma gangrenosum is a neutrophilic dermatosis that is difficult to diagnose, with various clinical manifestations. Its variants include ulcerous, 
pustulous, bullous, vegetative, peristomal, and drug-induced. We present a clinical case of bullous pyoderma gangrenosum in a male patient with 
generalized dermatosis, characterized by flaccid blisters of hematopurulent content, which are subsequently unroofed and evolve into painful ulcers with 
irregular and purplish borders. Associated diseases were ruled out. The diagnosis was made by histopathological study that showed perivascular and deep neutrophilic inflammatory infiltrate, with areas of necrosis and edema. Remission of lesions was obtained with combined topical corticosteroid therapy and systemic therapy with thalidomide.