Multisystem Inflammatory Syndrome in Children associated withCOVID-19: Report of four cases in Mexico across the Mexico-USBorder

Abstract

Multisystem Inflammatory Syndrome in Children (MIS-C) is a newly described autoimmune disease mostly occurring in older children, adolescents, and young adults associated with Severe Acute Respiratory Syndrome-Coronavirus type 2 (SARS-CoV-2) infection. Several MIS-C publications from Europe and North America are available, with only a few from Latin America. This is the first Mexican publication of four case reports of MIS-C. Median age at admission was of 8.2 years. All cases manifested with fever, cutaneous rash, conjunctivitis, abdominal pain, and nausea/vomiting. All were admitted with shock, developed coronary abnormalities in the echocardiogram, and had lung abnormalities in the computerized tomography scan. Three needed medical care at the Pediatric Intensive Care Unit, all were resistant to intravenous immunoglobulin, and one patient died of severe myocarditis, shock and acute myocardial infarction. All four cases had a positive SARS-CoV-2 RT-PCR from nasopharynx.