High Association between Gallstones and Incidence of Cirrhosis in Chinese Chronic Hepatitis B Patients

Authors

  • Min Liu Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China Author
  • Liyue Zheng Department of Digestive, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650100, China Author
  • Jinyang Zhang Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China Author
  • Jiawei Geng Department of Infectious Disease and Hepatic Disease, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650100, China Author
  • Xueshan Xia Kunming Medical University, Kunming, Yunnan 650500, China Author

DOI:

https://doi.org/10.47363/JIDSCR/2023(4)182

Keywords:

Chronic Hepatitis B, Cirrhosis, Gallstone, Survival Analysis

Abstract

Background: Multiple previous studies have reported that patients with cirrhosis have a higher incidence of gallstone disease, we aimed to investigate the reverse association, that is, whether CHB patients with gallstones are more likely to develop liver cirrhosis.

Methods: This was a historical cohort study. Propensity score matching (PSM) was employed to reduce baseline bias. The 5-year estimated cumulative incidences (Kaplan-Meier) and risks of liver cirrhosis (Cox proportional hazard model) were calculated.

Results: 492 patients with non-cirrhotic adult CHB between January 2014 and December 2019 were finally analyzed after PSM. 60 patients developed cirrhosis during the 3.99 years median follow-up period. Both the annual rates (4.46 cases per 100 person-years versus 1.57 cases per 100 person-years) and the 5-year estimated cumulative incidence of cirrhosis (16.7% vs. 5.7%) were significantly higher among CHB patients with gallstones versus those without gallstones (p<0.001) In addition, CHB patients with gallstones were 2.69 times more likely to develop cirrhosis (95% CI, 1.49-4.84, P= 0.001) than patients without gallstones at baseline.

Conclusion: Like the elderly and high viral load, gallstone was also the independent predictor of liver cirrhosis in CHB patients. However, the study couldn’t identify whether early cholecystectomy will benefit CHB patients with gallstones.

 

Author Biographies

  • Min Liu, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China

    Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China

  • Liyue Zheng, Department of Digestive, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650100, China

    Department of Digestive, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650100, China

  • Jinyang Zhang, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China

    Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China

  • Jiawei Geng, Department of Infectious Disease and Hepatic Disease, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650100, China

    Department of Infectious Disease and Hepatic Disease, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650100, China

  • Xueshan Xia, Kunming Medical University, Kunming, Yunnan 650500, China

    Kunming Medical University, Kunming, Yunnan 650500, China

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Published

2023-11-23

Issue

Vol. 4 No. 4 (2023): Volume 4 Issue 4

Section

Articles