Phytochemical Screening Toxicity and Anti-Hyperlipidemia of Punica Granatum Peel against Male Albino Mice

Abstract

Background: Hyperlipidemia (Dyslipidemia) is expressed by High levels of TC, TG, LDL, and decreased levels of HDL. Dyslipidemia as a threat agent for heart arteries complaints leads to an increase in the threat of cardiovascular mortality. Several herbal drugs have been suggested for the therapy of dyslipidemia like the one Punica Granatum peels. This research ambitious to clarify the thesis of using Punica Granatum peel extracts as an antihyperlipidemic agent.

Methodology: Three trials were done to clarify the hyperlipidemic thesis of Punica Granatum peels, screening of the phytochemical content by HPLC/ GC; half of the lethal dose LD50 measurement, and, the prophylactic effect was analyzed in high lipid diet-fed male mice with the histopathological study. 

T he Results: 33 ingredients have been identified using HPLC/GC, the LD50 was 504mg/kg of the body weight, and the anti-hyperlipidemic result revealed the capability of the acetone aqueous extract to reduce Cholesterol, LDL, HDL, VLDL, TG, ALT, AST, GGT, and ALP. Furthermore, the reason the acetone aqueous extract was able to increase antioxidant enzymes, whereas it increased T. Chol. /HDL. Chol and total protein is poly-phenolic in the extract. 

Conclusion: We suggest considering this study as a seeker for unborn studies n hyperlipidemia.